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YUGE Osafumi  弓削 孟文

ORCIDConnect your ORCID iD *help
… Alternative Names

弓削 盂文  ユゲ オサフミ

弓前 盂文  ユゼン オサフミ

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Researcher Number 40034128
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2007: Hiroshima University, 医療政策室, 理事
2006: 広島大学, 医療政策室, 理事・副学長
2006: 広島大学, 医療政策室・理事, 副学長
2005: Hiroshima University, Graduate School of Biomedical Science, Professor, 医歯薬総合研究科, 教授
2004 – 2005: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 … More
2004: 広島大学, 大学院・医歯薬総合研究科, 教授
2003: Hiroshima University, Medical and Dental Hospital, Professor, 医学部・歯学部附属病院, 教授
2002: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授
1991 – 2001: Hiroshima University School of medicine Professor, 医学部, 教授
1990: 広島大学, 医学部・麻酔・蘇生学, 助教授
1989 – 1990: Hiroshima University School of Medicine Associate Professor, 医学部, 助教授
1988: Associate Professor, Department of Anesthesiology, Hiroshima University, School of Medicine, 医学部麻酔学教室, 助教授
1987: 広島大学, 医学部, 助教授
1986: 広島大, 医学部, 講師
1986: Hiroshima University University Medical Hospital, Associate Proffessor, 医学部附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
麻酔学 / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Except Principal Investigator
Anesthesiology/Resuscitation studies / 麻酔学 / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
Ca-induced Ca release / 悪性高熱症 / 骨格筋細胞 / Hypoxia / Reoxygenation / c-AMP / Bmax / Kd / カルシウム動態 / 遺伝子解析 … More / Malignant Hyperthermia / カルシウム / リアノジン受容体 / カルシウムイオン / Ca-iduced Ca release / Ca-indused Ca release / ピエトレン / P.S.S豚 / 筋小胞体 / カルシウムによるカルシウム放出 / P.S.S.豚 / ピエトレン種豚 / ハロセンテスト / カルシウムによるカルシウム放出速度 / PSSブタ / スキンド骨格筋線維 / Malignant hyperthermia / Pietrain / procine stress syndrome (PSS) / Sarwplasmic Reticulum / ヒト好中球 / 浮性酸素 / 細胞内Ca^サの濃度 / NADPHオキシデース / 虚血・再灌流 / 活性酸素 / 細胞内Ca^2濃度 / 盧血・再潅流 / hypoxia / 好中球 / カルシュ-ムイオン / 虚血ー再還流 / 抗ショック薬 / チトクロ-ムC還元法 / Neutrophils / Superoxide anion / Intra-cellular Ca^<++> ion / NADPH oxidase / 心筋 / β-アドレナリン受容体 / アデニール酸シクラーゼ / セボフルレン / フオルスコリン / C-AMP / 揮発性吸入麻酔薬 / 心室筋 / β-アドレナリン受容体-共役系 / G蛋白質 / アデニル酸シクラーゼ / GTPアナログ / フォルスコリン / アデニル酸シクラーゼ活性 / GTPγS / GTP binding protein / Beta-adrenoceptor / Adenyl cyclase / Sevoflurane / GTPgammaS / Ca-inducede-Ca release / カルシウムイオン画像解析 / CICR速度 / 骨格筋リアノジン遺伝子 / スクリーニングテスト / Ca-induced-Ca Release Rate / Halothane / Caffeine / [CaィイD12+ィエD1]i / Caltured human skeletal muscle cell / Screening test of MH / Genetic linkage study / Skeletal muscle / Cell culture / Calcium homeostasis / 手術患者 / 多核白血球貪食殺菌能 / Nitroblue Tetrazolium(NBT)還元反応 / 手術疾患 / 多核白血球貧食殺菌能 / ritroblve Tetrazolivm(NBT)還元反応 / 好中球貧食殺菌能 / NBT還元反応 / Nitroblve tetrazolium還元反応 / 好中球貪食殺菌能 / 感染防禦機能 / Surgical patients / Polymorphonuclear Leuckocytes(PMNLs) … More
Except Principal Investigator
吸入麻酔薬 / ハロセン / 肝障害 / Anesthetics / Halothane / 悪性高熱症 / 静脈麻酔薬 / カテコラミン / 脂質過酸化 / 還元反応 / 四塩化炭素 / Reduction / ハロタン / PCR / リアノジン受容体 / Malignant hyperthermia / 神経因性疼痛 / マクロファージ / neuropathic pain / macrophage / TNF-α / 心筋 / 糖尿病 / 救急患者搬送システム / グラ-ツ市 / ウィ-ン市 / 広島市 / ドクタ-カ- / 動くICU / ヘリコプタ- / ランデブ-システム / emergency transport system / Graz city / Vienna city / Hiroshima city / doctor car / mobile ICU / helicopter / rendezvous system / チトクロムP450 / 肝ミクロリーム / 肝ミクロソーム / 肝ミクロソ-ム / ペンタン / 嫌気的代謝 / Lipid Peroxidation / Cytochrome P450 / Microsomes / Hepatotoxicity / Lipid peroxidation / 代謝亢進 / イソフルラン / エンフルラン / セボフルラン / 代謝活性 / Enhancement / Isoflurane / enflurane / Sevoflurane / Carbon Tetrachloride / 遺伝子 / 連鎖解析 / 骨格筋 / スキンドファイバー / Ca-induced Ca release / Gene / Genetic linkage analysis / Skeletal muscle / Skinned fiber / 培養肝細胞 / 低酸素 / ブドウ糖代謝 / 乳酸代謝 / カルシウム / ドーパミン / 虚血 / 糖付謝 / 糖代謝 / カラコールアミン / グリコーゲン / 乳酸 / 細胞研究 / Primary cultured rat hepatocytes / Hypoxia / Glucose Metabolism / Lactate Metabolism / Calcium / Dopamine / Volatile Anesthetics / 揮発性吸入麻酔薬 / ムスカリン受容体 / 受容体結合実験 / volatile anesthetics / muscarinic receptor / receptor assay / カフェイン・ハロタン拘縮法 / Ca誘発性Ca遊離法 / 出張検査 / 骨格筋生検 / カフェイン・ハロタン拘縮 / カルシウム誘発性カルシウム遊離 / malignant hyperthermia / caffeine-halothane contracture test / Ca-induced Ca release rate test / remote testing of CHCT / 細胞内カルシウム / イノシトール3リン酸 / 肝炎 / トリパンブルー / モルモット / 吸入麻酔葉 / 肝細胞内カルシウム / カルシムイオン / intracellular Ca2_+ / inositoltrisphosphate / liver injury / hepatocytes / trypan blue uptake / guinea pig / 骨格筋リアノジン受容体 / Bリンパ球 / Skeletal muscle ryanodine receptor / B lymphocytes / 橈骨動脈 / リング / ニコランジル / オリプリノン / radial artery / ring / nicorandil / olprinone / 坐骨神経緩結紮(CCI)モデル / 破骨細胞 / 大理石病(op / op)マウス / 標準マウス / 脛骨神経分布 / CGRP / ニューロパシフィックペイン / 坐骨神経結紮モデル / 熱刺激逃避反応潜時 / 免疫組織化学 / chronic constriction injury (CCI) / osteoclast / osteopetrosis (op / op) mouse / normal mouse / nerve distribution to the tibial bone / calcitonin gene related peptide / 心筋細胞 / β刺激伝達系 / intravenous anesthetic agent / myocyte / β-signaling pathway / catecholamine / CCIモデル / 不動モデル / 骨萎縮 / CCI model / immobilized model / bone atrophy / 分解 / 代謝 / イソフルレン / セボフルレン / ソーダライム / トリフルオロ酢酸 / フッ素イオン / 不純物 / Volatile Anesthetic / Isoflurane Sevoflurane / Sodalime / Decomposition Less
  • Research Projects

    (23 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (38 People)
  •  骨格筋細胞のカルシウム動態解析による悪性高熱症発症機序の解明と素因診断Principal Investigator

    • Principal Investigator
      KAWAMOTO Masashi, 弓削 孟文
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  糖尿病を合併している心臓のβ情報伝達系に対する静脈麻酔薬の影響

    • Principal Investigator
      KUROKAWA Hiromi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  A study of neurogenic bone lesion in neuropathic pain model (2);using immobilized model mouse and osteopetrosis mouse

    • Principal Investigator
      KAWAGUCHI Kotaro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  The interaction of intravenous anesthetic agent with adrenoceptor stimulation in rat myocytes

    • Principal Investigator
      KUROKAWA Hiromi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  The effect of NO synthetase to vasodilation by anesthetic drag on model of pulmonary hypertension

    • Principal Investigator
      KURODA Masahiko
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  A study on the role of macrophages on chronic pain and neurogenic osteopathy using op/op mice

    • Principal Investigator
      MORIWAKI Katsuyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Diagnosis of malignant hyperthermia susceptibility : by measuring change in myoplasmic calcium concentration in cultured human skeletal muscle cells and genetic analysisPrincipal Investigator

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Development of diagnostic method for malignant hyperthermia with B lymphocytes stimulated by ryanodine receptor.

    • Principal Investigator
      MAEHARA Yasuhiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Toho University
      Hiroshima University
  •  Comparison of the in vitro caffeine-halothane contracture test with the Ca-induced Ca-release rate test patients suspected of having malignant hyperthermia susceptibility

    • Principal Investigator
      SAI Yoshikazu, 奥 史郎
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Shiga University of Medical Science
  •  Study on intracellular calsium on guine pig liver electron traspor system and sytosolic inositoltrisphosphate

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  THE TRIAL STUDY FOR THE MINIMUM INVASIVE DIAGNOSTIC TEST FOR MHS -THE EFFECTS OF CAFFEINE AND HALOTHANE ON CULTURED HUMAN SKELETAL MUSCLE CELL MESURING INTRA CELLULAR Ca CONCENTRATION CONCENTRATION AND GENETIC ANALYSIS-Principal Investigator

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  THE EFFECT OF VOLATILE ANESTHETICS ON MUSCARINIC ACETYLCHOLINE RECEPTOR SIGNAL TRANSDUCTION SYSTEM IN RAT ATRIUM

    • Principal Investigator
      SERA Akihiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Study on the hypoxic glucose output in primary cultured rat hepatocytes

    • Principal Investigator
      MORIWAKI Katsuyuki
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Study on the effect of inhalation anesthetics on guine pig liver clectron traspor system

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Analysis of genetic linkage in malignant hyperthermia susceptible families in Japan

    • Principal Investigator
      KAWAMOTO Masashi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Effects of bolorile anesthetics in isolated myocordial beta-adrenergic receptor transmissionPrincipal Investigator

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Comparative study of anesthetics on microsomal lipid peroxidation

    • Principal Investigator
      MORIWAKI Katsuyuki, SATO Nobuyoshi, 盛生 倫生
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Study on lipid Reroxidation by halothane and its inhibition

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Effects of hypoxia-reoxygenation on superoxide production and change of intra-cellular Ca^<++> of neutrophilsPrincipal Investigator

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Emergency transport system by a Helicopter in local areas.

    • Principal Investigator
      MORIO Michio
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Overseas Scientific Survey.
    • Research Institution
      Hiroshima University
  •  Establishment of an animal model for Malignant hyperthermiaPrincipal Investigator

    • Principal Investigator
      YUGE Osafumi, 盛生 倫夫
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Phagocytic and Bacteriocidal Function of Polymorphnuclear Leuckocytes(PMNLs) in Surgical Patients.Principal Investigator

    • Principal Investigator
      OSAFUMI YUGE
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Studies on Impurity, Decomposition and Biotransformation of Volatile Anesthetics

    • Principal Investigator
      MORIO Michio
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY

All 2007 2006 2005

All Journal Article Book

  • [Book] 悪性高熱症2006

    • Author(s)
      分担 弓削孟文, 向田圭子
    • Total Pages
      216
    • Publisher
      克誠堂出版
    • Data Source
      KAKENHI-PROJECT-17390428
  • [Journal Article] 383 Cases of fulminant malignant hyperthermia2007

    • Author(s)
      Migita T, Mukaida K, Kawamoto M, Kobayashi M, Yuge O
    • Journal Title

      J. Anesth 21(In Press)

    • Data Source
      KAKENHI-PROJECT-17390428
  • [Journal Article] 臨床濃度のプロポフォールはカルシウム動態に影響しないのでMHの誘因とならない2006

    • Author(s)
      右田貴子, 向田圭子, 河本昌志, 小林雅子, 弓削孟文
    • Journal Title

      J. Anesth 20

      Pages: 220-220

    • Data Source
      KAKENHI-PROJECT-17390428
  • [Journal Article] スキンドファイバー法による悪性高熱症診断法2005

    • Author(s)
      向田圭子, 弓削孟文
    • Journal Title

      からだの科学 増刊

      Pages: 38-42

    • Data Source
      KAKENHI-PROJECT-17390428
  • [Journal Article] 劇症悪性高熱症の383例の集計2005

    • Author(s)
      右田貴子, 向田圭子, 河本昌志, 弓削孟文
    • Journal Title

      日本臨床麻酔薬学会誌 25(6)

      Pages: 218-218

    • Data Source
      KAKENHI-PROJECT-17390428
  • 1.  FUJII Kohyu (60034021)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  MORIO Michio (80033950)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  KAWAMOTO Masashi (40127642)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 3 results
  • 4.  MORIWAKI Katsuyuki (30157937)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  MAEHARA Yasuhiro (20238877)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  TANAKA Hiroyuki (10274086)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  SATO Nobuyoshi (30225982)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  NAKAO Masakazu (90164128)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  OOSAWA Yasuhiro (00263682)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  KIKUCHI Hirosato (40034029)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  FUKUDA Hideki (00294588)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  KUROKAWA Hiromi (20335673)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  YAMANOUE Takao (10174765)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  KEIKO MUKAIDA (20182066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  SAI Yoshikazu (50135703)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  NIINAI Hiroshi (50208112)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  ISHIHARA Shin (00106808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  HASHIMOTO Masaki (90189506)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  OHTANI Minako (10033995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  UOZUMI Tohru (20028426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MTSUBARA Toshimitu (50063954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SHIROYAMA Kazuhisa (30284201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SERA Akihiko (30243570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  AZUMA Toshiharu (60284197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  ICHIHARA Yasuko (30246699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KURODA Masahiko (50322243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KUSUNOKI Shinji (20304438)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KAWAGUCHI Kotaro (60263703)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  TUTUMI Eriko (40304422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  右田 貴子 (90403526)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 31.  濱田 宏 (10218539)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  佐々木 宏 (50235264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  金子 高太郎 (70243566)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  奥 史郎 (50073804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  EBI Shigenao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  WERNER List
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  LIST Werner
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  海老 茂直
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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