HIRATA Hajime 平田肇

Researcher Number	40049052
Affiliation (based on the past Project Information) *help	2005: 兵庫県立大学, 大学院・生命理学研究科, 教授 2005: University of Hyogo, Life Science, Professor, 大学院生命理学研究科, 教授 2004: 兵庫県立大学, 大学院・理学研究科, 教授 1991 – 2000: Himeji Inst. Tech., Faculty Sci., Prof., 理学部, 教授 1987 – 1990: 自治医科大学, 医学部, 講師 … More 1988: 自治医大, 医学部, 講師 1986: 自治医科大学, 医学部第1生化学教室, 講師 1985: 自治医科大学, 医, 講師 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / 分子遺伝学・分子生理学 / Cell biology Except Principal Investigator General medical chemistry / Functional biochemistry / Bacteriology (including Mycology) / 広領域 / Structural biochemistry / 血管生物学 / 分子遺伝学・分子生理学 / Functional biochemistry
Keywords	Principal Investigator 大量発現 / 好熱菌 / 融合タンパク質 / アミノ酸トランスポーター / リン脂質平面膜 / チャンネル / タンパク質膜透過 / イオンチャンネル / イオンポンプ / 超好熱菌 … More / 大腸菌 / アラニン能動輸送 / homologous recombination / membrane protein / hyperthermophile / amino acid transporter / 相同組み替え / 膜タンパク質 / Computer Simulation / Cryo-Electron Microscopy / Synthetic Peptide / Functional Membrane Protein / Signal Transduction / Ion Pump / Ion Channel / Phospholipid Planar Bilayer / コンピュ-タ-シミュレ-ション / クライオ電子顕微鏡 / 合成ペプチド / 生体膜機能素子 / 情報伝達 / イオンチャネル / 脂質平面膜 / IκBキナーゼ / NFκB / AP-1 / MAPギナーゼ / 活性酸素種 / Mox-1 / ES / GroEL / プロテオリポソーム / 挿入配列 / プロモーター / 活性発現 / Na^+シンポーター / 融合タンパン質 / Na^+ … More Except Principal Investigator ATP synthase / 遺伝子発現 / ホスホリパーゼC / NF-kB / SecA / SecG / SecE / SecY / PHドメイン / mitochondria / ミトコンドリア / ATP合成酵素 / biomembrane / oligomer / hsp gene / thermophilic gene / GroEL / reconstitution / thermophilic chaperonin / heat shock protein / agrオペロン / 色素産生遺伝子 / シグマB / シグマ70 / 熱応答プロモーター / 細胞壁合成阻害剤 / 薬剤応答遺伝子 / 重金属応答遺伝子 / 高血圧自然発症ラット(SHR) / 遺伝子連鎖解析 / 高血圧 / Enhancer / Thermophilic bacterium / Human / Gene structure / Molecular cloning / H^+-ATPase / signal peptide / proton translocation / thermophilic ATP ase / human gene / 部位特異的変異 / 大量発現 / 【H^+】-ATPアーゼ / 遺伝子の構造 / 大量発現部位特異的変異 / 人工二重膜 / 遺伝子操作 / H^+-ATPアーゼ / ミトコンドリアミオパチー / 培養細胞 / エンハンサー / 転写調節 / 好熱菌 / ヒト / クローニング / 遺伝子 / H^+ーATPアーゼ / Phosphatase / Oxidative stress / IKKb / Inflammation / Cancer / Redox / ネクローシス / MKP / JNK / 腫瘍壊死因子 / 活性酸素種 / MAPキナーゼホスファター / IKKBβ / ホスファターゼ / NF-κB / 酸化ストレス / IKKβ / 炎症 / がん / レドックス / Genome project / Sigma Factor / Oxidative stress gene qor / β-lactamase / Drug-response gene drp35 / Heavy metal-response gene czrAB / Stress-response proteins / Staphylococcus aureus / ゲノムプロジェクト / シグマ因子 / 酸化ストレス応答遺伝子qor / βラクタマーゼ / 薬剤応答遺伝子drp35 / 重金属応答遺伝子czrAB / ストレス応答タンパク質 / 黄色ブドウ球菌 / pleckstrin homology(PH) / phophoinositide / cytoskeleton / ameba movement / osmotic stress / nuclear import / nuclear export / phospholipase C / 緑色けい光タンパク(GFP) / 浸透圧 / 細胞内局在 / プレクストリン相同性領域(ph領域 / 脂質・タンパク相互作用 / トランスロケーション / 核外移行シグナル / 浸透圧ショック / プレクストリン相同性領域 / 細胞運動 / 緑色蛍光タンパク(GFP) / 核外移行シグナル(NES) / 核移行シグナル(NLS) / プレクストリンホモロジー(PH)ドメイン / イノシトールリン脂質 / 細胞骨格 / アメーバ運動 / 浸透圧ストレス / 核移行 / 核外移行 / Reconstitution / Prokaryote / Protein translocation / 再構成 / 原核細胞 / 蛋白質膜透過 / PH domain / Linkage analysis / Gene expression / Spontaneously Hypertensive Rat / Phospholipase / Calcium ion / Vascular cells / Hypertension / 遺伝子クローニング / 血管内皮・平滑筋細胞 / 高血圧自然発症ラット / 連鎖解析 / ホスホリパーゼ / カルシウムイオン / 血管細胞 / control by pH / F1-ATPase / transcription control / subunit composition / alternate splicing / transcription factor / enhancer / human genome / MELAS / transcriptional control / Bioenergetics / ミトコンドリア脳筋症 / 高次構造 / F_1・ATDアーゼ / 協調発現 / PHによる制御 / F,ATPアーゼ / 転写制御 / サブユニット構成 / 選択的スプライシング / 転写因子 / 安定hsp / シャペロニン / 高次構造再構成 / 好熱菌hsp / 熱ショックタンパク質 / suppression of mutation / thermophilic protein / membrane transport / conformationーbuildーup / protein renaturation / chaperonin / synchrotron radiation / 視興奮 / Naイオンチャンネル / サイクリックGMP結合蛋白質 / 桿体視細胞外節 / 視細胞 / マイクロインジェクション / 膜ターゲティング / Ca^<2+>結合 / C2領域 / プレクストリンホモロジー領域 / IP_3結合 / 細胞内カルシウム / アミノ酸置換 Less

Regulation of bioenergy by NF-kB/IKKb signaling and oxidative stress-related diseases
- Principal Investigator
  
  KAMATA Hideaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Hyogo
細胞増殖のレドックス制御-Mox1による活性酸素種産生と細胞のがん化機構の解析-Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Himeji Institute of Technology
原核生物における新しい環境応答分子シャペロンの機能
- Principal Investigator
  
  OHTA Toshiko
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Tsukuba
REGULATION AND INTRACELLULAR LOCALISATION OF PHOSPHOIN OSITIDE-BINDING PROTEINS.
- Principal Investigator
  
  YAGISAWA Hitoshi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  広領域
- Research Institution
  Himeji Institute of Technology
Molecular mechanism of environmental stress-response in Staphylococcus aureus
- Principal Investigator
  
  OHTA Toshiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  University of Tsukuba
Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
δ型ホスホリパーゼCの構造と細胞内ターゲッティング
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Himeji Institute of Technology
Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Protein translocation across the cytoplasmic membrane of bacteria
- Principal Investigator
  
  TOKUDA Hajime
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Tokyo
Structure and Function Relatioship of Amino Acid Transporter from Hyperthermophilic Bacterium.Principal Investigator
- Principal Investigator
  
  HIRATA Hajime
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HIMEJI INSTITUTE OF TECHNOLOGY
リン脂質平面膜法によるタンパク質膜透過機構の解析Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
好熱菌PS3のH^+(Na^+)/アラニンシンポーターの分子機構Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
リン脂質平面膜法によるタンパク質膜透過機構の解析Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Blood Pressure Control by Intracellular Ca2_+-Modulatory Factors in Vascular Endothelial and Smooth Muscle Cells
- Principal Investigator
  
  YAGISAWA Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Himeji Institute of Technology(HIT)
リン脂質平面膜法によるタンパク質膜透過機構の解析Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
高血圧自然発症ラット(SHR)における高血圧発症機構の分子生物学解析
- Principal Investigator
  
  YAGISAWA Hitoshi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
好熱菌PS3のH^+(Na^+)/アラニンシンポーターの分子機構Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Analysis of Functional Membrane Proteins by Planar Phospholiped Bilayers.Principal Investigator
- Principal Investigator
  
  HIRATA Hajime
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  分子遺伝学・分子生理学
- Research Institution
  Himeji Institute of Technology, Faculty of Science
  Jichi Medical University
Regulation factors in the human energy supplying system.
- Principal Investigator
  
  KAGAWA Yasuo
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  JICHI MEDICAL SCHOOL
Reactivation of proteins and membrane transport by the heat shock proteins from thermophilic bacteria.
- Principal Investigator
  
  KAGAWA Yasuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Jichi Medical School
脊椎動物の視細胞外節のcGMPに依存したカチオンチャンネルの解明
- Principal Investigator
  
  篠沢隆雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子遺伝学・分子生理学
- Research Institution
  Gunma University
人工リン脂質2分子層膜法によるイオンチャンネルの解析Principal Investigator
- Principal Investigator
  
  平田肇
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Jichi Medical University
Gene structure and Function of H^+-ATPase.
- Principal Investigator
  
  KAGAWA Yasuo
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Jichi Medical University

All 2005 2004

All Journal Article

[Journal Article] Reactive oxygen species promote TNFα-induced cell death and sustained JNK activation by oxidizing MAP kinase phosphatases2005
- Author(s)
  Hideaki Kamata, Shi-ichi Honda, Shin Maeda, Lufen Chang, Hajime Hirata, Michael Karin.
- Journal Title
  
  Cell. 120
  
  Pages: 649-661
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570121
[Journal Article] Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA.2005
- Author(s)
  Hideaki Kamata, Shin-ichi Oka, Yukinao Shibukawa, Jungo Kakuta, Hajime Hirata
- Journal Title
  
  Archives of Biochemistry and Biophysics 434
  
  Pages: 16-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570121
[Journal Article] A PLCδ1-binding protein, p122RhoGAP, is localized in focal adhesions.2004
- Author(s)
  Katsuhisa Kawai, Masaki Yamaga, Yumi lwamae, M.Kiyota, Hideaki Kamata, Hajime Hirata, Yoshimi Homma, Hitoshi Yagisawa.
- Journal Title
  
  Biochemical Society Transactions. 32
  
  Pages: 1107-1109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570121

1. KAMATA Hideaki (10233925)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
2. YAGISAWA Hitoshi (40192380)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. KAGAWA Yasuo (30048962)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. OHTA Shigeo (00125832)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HAMAMOTO Toshiro (30189625)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SONE Nobuhito (20049034)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. OHTA Toshiko (40233134)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAKANISHI Makoto (40217774)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKAGI Masayuki (20028145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SOKABE Masahiro (10093428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUDA Motoyuki (60045458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIRINO Yutaka (10012668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KASAI Michiki (40022595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. INOHARA Naohiro (60232576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ENDO Hitoshi (50221817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TOKUDA Hajime (40125943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WATANABE Makoto (20142408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YAMANE Kunio (20013336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ENDO Toshiya (70152014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ITO Koreaki (90027334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HIRATA Masato (60136471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HIGUCHI Yoshiki (90183574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KURAZONO Hisao (90186487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HAYASHI Hideo (40033203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 野島博 (30156195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 後藤直正 (30121560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 篠沢隆雄 (30025449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 石塚盛雄 (50168241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRATA Hajime 平田 肇

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細胞増殖のレドックス制御-Mox1による活性酸素種産生と細胞のがん化機構の解析-Principal Investigator

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Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator

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Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator

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Na^+/H^+駆動型アミノ酸トランスポーターの構造・機能協関Principal Investigator

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Structure and Function Relatioship of Amino Acid Transporter from Hyperthermophilic Bacterium.Principal Investigator

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リン脂質平面膜法によるタンパク質膜透過機構の解析Principal Investigator

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好熱菌PS3のH^+(Na^+)/アラニンシンポーターの分子機構Principal Investigator

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リン脂質平面膜法によるタンパク質膜透過機構の解析Principal Investigator

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HIRATA Hajime 平田肇