YAGIHASHI Soroku 八木橋操六

… Alternative Names

Researcher Number	40111231
Other IDs	https://orcid.org/0000-0003-4255-774X
External Links
Affiliation (Current)	2022: 東邦大学, 医学部, 教授(寄付講座) 2022: 弘前大学, 医学研究科, 特任教授
Affiliation (based on the past Project Information) *help	2022: 東邦大学, 医学部, 教授 2019 – 2020: 東邦大学, 医学部, 教授(寄付講座) 2018: 公益財団法人額田医学生物学研究所, 総合研究室, 所長 2016 – 2018: 公益財団法人額田医学生物学研究所, その他部局等, その他 2016 – 2017: 弘前大学, 医学研究科, 特任教授 … More
Review Section/Research Field	Principal Investigator Experimental pathology / 内分泌・代謝学 / Basic Section 54040:Metabolism and endocrinology-related / Human pathology / Experimental pathology / Human pathology / Metabolomics Except Principal Investigator Neurology / Metabolomics / Human pathology / 広領域 / Medical systems
Keywords	Principal Investigator 糖尿病 / ポリオール代謝 / AGE / 合併症 / アルドース還元酵素 / 末梢神経障害 / Neuropathy / グリケーション / 2型糖尿病 / AGE(後期糖化生成物) … More Except Principal Investigator 糖尿病 / PCR / 高血圧 / 末梢神経 / 末梢神経障害 / マイクロダイセクション / 骨髄異形成症候群 / HUMARA / PGK / 細胞・組織 / 生体分子 / 生理活性 / スフィンゴ脂質 / 病理学 / 虚血性末梢神経障害 / 糖尿病性末梢神経障害 / 虚血・再灌流傷害 / マクロファージ / HGF遺伝子治療 / 虚血 / 再潅流傷害 / 遺伝子治療 / HGF治療 / 未梢神経 / 再灌流傷害 / 高血圧自然発症ラット / 細小血管障害 / 末梢神経病理 / SHR / 高血圧臓器障害 / 糖尿病合併症 / 神経伝導速度 / 細小血管症 / クリ-ン真空蒸着装置 / 凍結レプリカ法 / ディ-プ・エッチング・レプリカ法 / 集束光による表面昇華 / 生体膜 / 真空蒸着装置 / ディ-プ・エッチング法 / 網膜 / 光照射エッチング / Clean-vacuum evaporater / Freeze-fracturing replica / Deep-etching replica / Surface-sublimation by condensed-light beam / Biological membranes / クロナリティー / X染色体 / MICRODISSECTION / MYELODYSPLASTIC SYNDROME / CLONALITY / X-CHROMOSOME / DNAメチル化 / 腫瘍抑制遺伝子 / 急性白血病 / 免疫組織学 / 免疫組織化学 / MYELODYSPLASTIC SYNDROMES / DNA METHYLATION / TUMOR SUPPRESSOR GENE / ACUTE LEUKEMIA / IMMUNOHISTOCHEMISTRY / 合併症 / 神経障害 / ポリオール代謝 / アルドース還元酵素 / トランスジェニックマウス / ノックアウトマウス / polyol pathway / transgenic mice / knockout mice / aldose reductase / protein kinase C / aldose reductase inhibitor / diabetic neuropathy / 加齢現象 / サルコペニア / Klotho　マウス / 加齢 / 小径神経線維 / Klotho マウス / 神経内科 / 病理 / 医用超音波システム / 神経科学 / 量子ビーム / 生物・生体工学 Less

2型糖尿病の膵島内神経血管構築異常と糖尿病治療による修飾Principal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toho University
Altered neurovascular network in type 2 diabetes and its repairPrincipal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toho University
Development of photoacoustic imaging system for prevention of lower limb amputation induced by diabetic polyneuropathy
- Principal Investigator
  
  ISHIHARA Miya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  National Defense Medical College
Analysis of islet remodeling in type 2 diabetes and exploratory regulation of endocrine cell transdifferentiation (metaplasia)Principal Investigator
- Principal Investigator
  
  Yagihashi Soroku
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The Nukada Institute for Medical & Biological Research
Nerve ageing and sarcopenia
- Principal Investigator
  
  Nukada Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The Nukada Institute for Medical & Biological Research
Hypertensive neuropathy: underlying mechanisms
- Principal Investigator
  
  NUKADA Hitoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The Nukada Institute for Medical and Biological Reseach
Analysis of islet amyloid in Japanese type 2 diabetic patients and exploration of new treatment for diabetesPrincipal Investigator
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Hirosaki University
Ischemic neuropathy : pathogenesis and treatment
- Principal Investigator
  
  NUKADA Hitoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The Nukada Institute for Medical and Biological Reseach
Experimental therapy for diabetic complication targeting endothelium activating factor, sphingosine-1-phosphate
- Principal Investigator
  
  WADA Ryuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
全身性炎症反応症候群(SIRS)におけるポリオール代謝の役割と新規治寮法の開発Principal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University
Diabetic complications in mice transgenic and knockout for human aldose reductase.
- Principal Investigator
  
  WADA Ryuichi, 山岸晋一朗
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Exploration of pathogenesis of diabetic complications using transgenic mice and attempts of gene therapyPrincipal Investigator
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University
THE ROLE OF DNA METHYLATION ON LEUKEMIC TRANSFORMATION IN MYELODYSPLASTIC SYNDROMES
- Principal Investigator
  
  KUROTAKI Hidekachi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Hirosaki University
CLONAL ANALYSIS FOR MYELODYSPLASTIC SYNDROME BY MICRODISSECTION
- Principal Investigator
  
  KUROTAKI Hidekachi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Hirosaki University
後期糖化生成物およびその受容体の生体内分布と組織病変とのかかわりについてPrincipal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Hirosaki University
Hyperglycemic tissue injury: Pathogenesis of diabetic complications and its preventionPrincipal Investigator
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University
Fundamental studies on the pathogenesis of diabetic complications using transgenic mice expressing human aldose reductasePrincipal Investigator
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University
Studies on the pathogenesis and treatment of diabetic neuropahy ; mechanisms of impaired regeneration of peripheral nerve and tiral for its inhibitionPrincipal Investigator
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hirosaki University
Improvement and application of high-vacuum evaporater with condensed-light beam heater for deep-etching replication of TEM specimen
- Principal Investigator
  
  TONOSAKI Akira
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Yamagata University
糖尿病性神経障害の成因に関する研究-細胞骨格異常とその遺伝子についてPrincipal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hirosaki University
糖尿病性神経障害の成因に関する研究--細胞骨格及び膜異常の検討Principal Investigator
- Principal Investigator
  
  八木橋操六
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Hirosaki University

[Book] 糖尿病神経障害．感覚運動神経障害．糖尿病最新の治療2013-2015（岩本安彦、羽田勝計、門脇孝編）2013
- Author(s)
  八木橋操六（分担執筆）
- Publisher
  南江堂、東京
- Data Source
  KAKENHI-PROJECT-24659158
[Book] 糖尿病性神経障害．　病気と薬．パーフェクトBook、薬局増刊号（横田千津子、池田宇一、大越教夫編）、2012
- Author(s)
  杉本一博、八木橋操六
- Publisher
  南山堂、東京
- Data Source
  KAKENHI-PROJECT-24659158
[Book] 神経障害の疫学．ヴィジュアル糖尿病臨床のすべて．糖尿病予防と治療のエビデンス、荒木栄一、植木浩二郎編2012
- Author(s)
  八木橋操六（分担執筆）
- Publisher
  中山書店、東京、
- Data Source
  KAKENHI-PROJECT-24659158
[Book] 糖尿病性神経障害の発症機序．糖尿病学イラストレイテッド．春日雅人編2012
- Author(s)
  八木橋操六
- Publisher
  洋土社、東京
- Data Source
  KAKENHI-PROJECT-24659158
[Book] 糖尿病神経障害（多発神経障害と単神経障害）の病態について教えてください．循環器医から寄せられる「糖尿病と血管合併症」に関する100の質問、小室一成、山岸昌一編、2012
- Author(s)
  八木橋操六
- Publisher
  メディカルレビュー社、東京
- Data Source
  KAKENHI-PROJECT-24659158
[Book] 糖尿病学。基礎と臨床。(門脇孝、石橋俊、佐倉宏、戸部一之、野田光彦編)2007
- Author(s)
  八木橋操六(分担執筆)
- Publisher
  西村書店(東京)
- Data Source
  KAKENHI-PROJECT-18659106
[Book] 臨床医のための糖尿病病理2004
- Author(s)
  八木橋操六
- Total Pages
  241
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and beta-cell volume density in spontaneously type 2 diabeteic Goto-Kakizaki rats.2020
- Author(s)
  Guo D, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Kudo K, Sasaki T, Yagihashi S
- Journal Title
  
  Metabolism
  
  Volume: 107 Pages: 154232-154232
- DOI
  10.1016/j.metabol.2020.154232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] What can we learn from the islet of Joslin Medalists?2020
- Author(s)
  Yagihashi S
- Journal Title
  
  J Diabetes Invest
  
  Volume: 11 Pages: 1117-1119
- DOI
  10.1111/jdi.13283
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation2020
- Author(s)
  Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 1156-1156
- DOI
  10.1038/s41598-020-57883-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-19K09036
[Journal Article] Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.2020
- Author(s)
  Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S
- Journal Title
  
  Brain Commun
  
  Volume: 2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Cutaneous microangiopathy in patients with type?2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy2019
- Author(s)
  Sugimoto Kazuhiro、Murakami Hiroshi、Deguchi Takahisa、Arimura Aiko、Daimon Makoto、Suzuki Susumu、Shimbo Takuro、Yagihashi Soroku
- Journal Title
  
  J Diabetes Invest
  
  Volume: 10 Pages: 13020-13020
- DOI
  10.1111/jdi.13020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01643, KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-19K09036
[Journal Article] Unique inflammatory changes in exocrine and endocrine pancreas in enterovirus-induced fulminant Type 1 diabetes2019
- Author(s)
  Takita M, Jimbo E, Fukui T, AIda K, Shimada A, Oikawa Y, Yagihashi S, Miura J, Babazono T, Kobayashi T
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 104 Pages: 4282-4294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice2018
- Author(s)
  Aida Kaoru、Kobayashi Tetsuro、Takeshita Akira、Jimbo Erika、Nishida Yoriko、Yagihashi Soroku、Hosoi Mitsuko、Fukui Tomoyasu、Sugawara Akira、Takasawa Shin
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 503 Pages: 963-969
- DOI
  10.1016/j.bbrc.2018.06.103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09895, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-16K09771
[Journal Article] Distinct Inflammatory Changes of the Pancreas of Slowly Progressive Insulin-dependent (Type 1) Diabetes2018
- Author(s)
  Aida Kaoru、Fukui Tomoyasu、Jimbo Erika、Yagihashi Soroku、Shimada Akira、Oikawa Yoichi、Mori Yasumichi、Fujii Takeshi、Nishida Yoriko、Koyama Rikako、Kobayashi Tetsuro
- Journal Title
  
  Pancreas
  
  Volume: 47 Pages: 1101-1109
- DOI
  10.1097/mpa.0000000000001144
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments2018
- Author(s)
  Yorek Mark、Malik Rayaz A.、Calcutt Nigel A.、Vinik Aaron、Yagihashi Soroku
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: 2018 Pages: 1-3
- DOI
  10.1155/2018/5378439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism2018
- Author(s)
  Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 144 Pages: 710-722
- DOI
  10.1111/jnc.14277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-18K06507, KAKENHI-PROJECT-15K06763, KAKENHI-PROJECT-16K07048
[Journal Article] Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation2017
- Author(s)
  Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 18056-18067
- DOI
  10.1038/s41598-017-18438-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-16K10587
[Journal Article] Diabetes and pancreas size, does it matter?2017
- Author(s)
  Yagihashi S
- Journal Title
  
  J Diabetes Investig
  
  Volume: 8 Pages: 413-415
- DOI
  10.1111/jdi.12590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] Perspective on the underlying mechanism from in vivo and in vitro experimental studies.2017
- Author(s)
  Sango K, Mizukami H, Horie H, Yagihashi S.
- Journal Title
  
  Front Endocrinol (Lausanne).
  
  Volume: 8 Pages: 12-12
- DOI
  10.3389/fendo.2017.00012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07048, KAKENHI-PROJECT-16K09771
[Journal Article] Pancreas Atrophy and Islet Amyloid Deposition in patients with elderly-onset type 2 diabetes.2017
- Author(s)
  Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 102 Pages: 3162-3171
- DOI
  10.1210/jc.2016-3735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa2017
- Author(s)
  Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M.
- Journal Title
  
  Neuroscience Research
  
  Volume: 121 Pages: 49-53
- DOI
  10.1016/j.neures.2017.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-15K10503
[Journal Article] Four-year sequential nerve conduction changes since first visit in Japanese patients with early type 2 diabetes.2017
- Author(s)
  Kobori M, Yagihashi S, Shiina N, Shiozawa N, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saitou M, Baba M, Osonoi T.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 8 Pages: 369-376
- DOI
  10.1111/jdi.12583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications2016
- Author(s)
  Yagihashi S, Inaba W, Mizukami H
- Journal Title
  
  J Diabetes Investig
  
  Volume: 7 Pages: 155-165
- DOI
  10.1111/jdi.12424
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] Pancreatic ductal hyperplasia/dysplasia with obstructive chronic pancreatitis:2016
- Author(s)
  Kobayashi T, Aida K, Fukui T, Jimbo E, Shimada A, Mori Y, Fujii T, Yagihashi S.
- Journal Title
  
  Diabetologia
  
  Volume: 59 Pages: 865-867
- DOI
  10.1007/s00125-016-3867-x
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09406, KAKENHI-PROJECT-16K09771
[Journal Article] Glucotoxic mechanisms and related therapeutic approaches2016
- Author(s)
  Yagihashi S
- Journal Title
  
  Int Rev Neuobiol
  
  Volume: 127 Pages: 121-149
- DOI
  10.1016/bs.irn.2016.03.006
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367, KAKENHI-PROJECT-16K09771
[Journal Article] Neuropathy in the spontaneously hypertensive rat; An electrophysiological and histological study2016
- Author(s)
  Nukada H, Baba M, Ogasawara S, McMorran D, Mizukami H, Yagihashi S
- Journal Title
  
  Muscle Nerve
  
  Volume: ５４ Pages: 756-762
- DOI
  10.1002/mus.25098
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367, KAKENHI-PROJECT-16K09771
[Journal Article] The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes2016
- Author(s)
  Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S
- Journal Title
  
  Diabetologia
  
  Volume: 59 Pages: 865-867
- DOI
  10.1111/jnc.13439
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implicationas2016
- Author(s)
  Yagihashi S, Inaba W, Mizukami H
- Journal Title
  
  J Diabetes Investig
  
  Volume: 7 Pages: 155-165
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] mRNA expression of delta-HER2 and its clinicopathological correlation in HER2-overexpressing breast cancer.2016
- Author(s)
  Wada R, Yagihashi S, Naito Z
- Journal Title
  
  Mol Med Rep
  
  Volume: 14 Pages: 5104-5110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09771
[Journal Article] 糖尿病性神経障害とは～その病理学的観点から～2015
- Author(s)
  八木橋操六
- Journal Title
  
  Diabetes Frontier
  
  Volume: ２６ Pages: 440-447
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy2015
- Author(s)
  Saito H, Yamaguchi T, Adachi Y, Yamashita T, Wakai Y, Saito K, Shinohara Suzuki K, Yagihashi S, Terada J, Tatsumi K. Y,
- Journal Title
  
  Intern Med
  
  Volume: 54 Pages: 1282-1296
- NAID
  130005069786
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] Clinical Utility of Skin Biopsy in Differentiating between Parkinson's Disease and Multiple System Atrophy2015
- Author(s)
  Haga R, Sugimoto K, Nishijima H, Miki Y, Suzuki C, Wakabayashi K, Baba M, Yagihashi S, Tomiyama M
- Journal Title
  
  Parkinsons Dis.
  
  Volume: 2015 Pages: 167038-167038
- DOI
  10.1155/2015/167038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] Advances in pathology of diab europathy--a tribute to Paul Langerhans.2015
- Author(s)
  Yagihashi S
- Journal Title
  
  Pathol Int
  
  Volume: 65 Pages: 157-169
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] 日本人の細小血管障害の特徴,新時代の臨床糖尿病学（下巻）2015
- Author(s)
  八木橋操六
- Journal Title
  
  日本臨床（増刊号2）
  
  Volume: 74 Pages: 15-21
- Data Source
  KAKENHI-PROJECT-15K09367
[Journal Article] Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline ofβ-cell mass in Japanese type 2 diabetic patients2014
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S
- Journal Title
  
  Diabetes Care 2014 Apr 4
  
  Volume: [Epub ahead of print](PMID:24705612)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).2014
- Author(s)
  Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Fernyhough P, Malik RA, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW
- Journal Title
  
  J Peripher Nerv Syst
  
  Volume: 19 Pages: 77-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.2014
- Author(s)
  Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Pages: 1014-1020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients2014
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S.
- Journal Title
  
  Diabetes Care
  
  Volume: 37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese2014
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
- Journal Title
  
  J Diabetes Invest
  
  Volume: 5 Pages: 38-47
- DOI
  10.1111/jdi.12118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591292, KAKENHI-PROJECT-24659158
[Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance2014
- Author(s)
  Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0084725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25860300
[Journal Article] Impaired nerve fiber re- generation in axotomized peripheral nerves in streptozotocin-diabetic rats.2014
- Author(s)
  Nishida N, Yamagishi S, Mizukami H, Yagihashi S
- Journal Title
  
  J Diabetes Invest
  
  Volume: 4 Pages: 533-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance2014
- Author(s)
  Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-ceｌl2013
- Author(s)
  Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H
- Journal Title
  
  Endocrinology
  
  Volume: 154 Pages: 4512-4524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats2013
- Author(s)
  Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S
- Journal Title
  
  Pancreas
  
  Volume: 42 Pages: 786-794
- DOI
  10.1097/mpa.0b013e318287c9b5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.2013
- Author(s)
  Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 436 Pages: 698-704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013
- Author(s)
  Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H.
- Journal Title
  
  Endocrinology
  
  Volume: 154 Pages: 4512-4524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats.2013
- Author(s)
  Sugimoto K, Baba M, Suzuki S, Yagihashi S.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Disseminated infection and pulmonary embolization of Cunninghamella bertholletiae complicated with hemophagocytic lymphohistiocytosis.2013
- Author(s)
  Hirayama Y, Yajima N, Kaimori M, Akagi T, Kubo K, Saito D, Hizawa Y, Wada R, Yagihashi S.
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 2275-2279
- NAID
  130003392582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] 糖尿病性神経障害の成因研究の進歩2013
- Author(s)
  八木橋操六、水上浩哉
- Journal Title
  
  医学のあゆみ
  
  Volume: 44 Pages: 139-145
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats2013
- Author(s)
  Sugimoto K, Baba M, Suzuki S, Yagihashi S.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Primary gastric synovial sarcoma: molecular diagnosis and prediction of prognosis.2013
- Author(s)
  Kamata K, Wada R, Yajima N, Sawada M, Wakasa H, Yagihashi S.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 6 Pages: 303-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.2013
- Author(s)
  Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S.
- Journal Title
  
  Pancreas
  
  Volume: 42 Pages: 786-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Exendin-4 improves β -cell function in autophagy-deficient β-cells2013
- Author(s)
  Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku
- Journal Title
  
  Endocrinology
  
  Volume: 154 Pages: 4512-24
- DOI
  10.1210/en.2013-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390244, KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25860757
[Journal Article] 糖尿病性多発神経障害の成因を考える : 病理と生化学の関連 (特集糖尿病性神経障害臨床のピットフォール : 糖尿病および関連領域専門医それぞれの立場から) 。2013
- Author(s)
  水上浩哉 , 八木橋操六
- Journal Title
  
  糖尿病
  
  Volume: 5 Pages: 6-13
- NAID
  40019808899
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats2013
- Author(s)
  Sugimoto K, Baba M, Suzuki S, Yagihashi S
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0074247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa.2013
- Author(s)
  Yajima N, Wada R, Kimura S, Matsuzaki Y, Chiba D, Ebina Y, Ohkusu K, Yagihashi S.
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 219-222
- NAID
  130003365854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Imaging of insulin factory: Is it just imagination or approaching reality?2012
- Author(s)
  Soroku Yagihashi
- Journal Title
  
  J Diabetes Invest
  
  Volume: 3(5) Pages: 429-431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats2012
- Author(s)
  Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 691 Pages: 297-306
- DOI
  10.1016/j.ejphar.2012.07.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Augmented reduction of islet beta-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment2012
- Author(s)
  Mizukami H, Inaba W, Takahashi K, Inoue K, Sawanobori K, Yagihashi S
- Journal Title
  
  J Diabetes Invest
  
  Volume: 3 Pages: 235-244
- DOI
  10.1111/j.2040-1124.2011.00173.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.2012
- Author(s)
  Takahashi K, Mizukami H, Kamata K, Inaba W, Kato N, Hibi C, Yagihashi S
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0030134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Imaging of insulin factory: Is it just imagination or approaching reality?2012
- Author(s)
  Yagihashi S.
- Journal Title
  
  J Diabetes Invest
  
  Volume: 3 Pages: 429-31
- DOI
  10.1111/j.2040-1124.2012.00236.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Clinical staging od type 2 diabetes: The time has come.2012
- Author(s)
  Soroku Yagihashi
- Journal Title
  
  J Diabetes Invest
  
  Volume: 3(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Clinical staging of type 2 diabetes: The time has come2012
- Author(s)
  Yagihashi S.
- Journal Title
  
  J Diabetes Invest
  
  Volume: 3 Pages: 1-2
- DOI
  10.1111/j.2040-1124.2011.00192.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158
[Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve2012
- Author(s)
  Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
- Journal Title
  
  Brain Res
  
  Volume: 1373 Pages: 172-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591307
[Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve.2011
- Author(s)
  Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
- Journal Title
  
  Brain Res
  
  Volume: 1373 Pages: 172-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve.2011
- Author(s)
  Nukada H, McMorran PD, Baba M, Ogasawara S, Yagihashi S
- Journal Title
  
  Brain Res 1373
  
  Pages: 172-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.2010
- Author(s)
  Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S
- Journal Title
  
  J Pathol 220
  
  Pages: 530-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.2010
- Author(s)
  Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S.
- Journal Title
  
  J Pathol
  
  Volume: 220 Pages: 530-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] 簡易診断基準をベースにした糖尿病多発神経障害の臨床病期分類作成の試みと前向き疫学調査初年度における実態2009
- Author(s)
  八木橋操六、安田斉、佐藤譲、馬場正之、額田均, ら
- Journal Title
  
  末梢神経 20
  
  Pages: 159-61
- NAID
  10027267911
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] 高血圧と末梢神経障害:高血圧自然発症ラット末梢神経の虚血の対する脆弱性2009
- Author(s)
  額田均、馬場正之、小笠原早織、八木橋操六
- Journal Title
  
  末梢神経 20
  
  Pages: 172-3
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] 簡易診断基準をベースにした糖尿病多発神経障害の臨床病期分類作成の試みと前向き疫学調査初年度における実態2009
- Author(s)
  八木橋操六、安田斉、佐藤譲, ら
- Journal Title
  
  末梢神経 20
  
  Pages: 159-161
- NAID
  10027267911
- Data Source
  KAKENHI-PROJECT-20591037
[Journal Article] Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activate-gamma-ligand, in insulin-deficient diabetic rats2008
- Author(s)
  Yamagishi SI, Ogasawara S, Mizukami H, Yajima N, Wada RI, Sugawara A, Yagihashi S.
- Journal Title
  
  J Neurochem 104
  
  Pages: 491-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand in insulin-deficient diabetic rats2008
- Author(s)
  Yamagishi S, Ogasawara S, Mizukami H, Yajima N, Wada R, Sugawara A, Yagihashi S
- Journal Title
  
  J Neurochem 104
  
  Pages: 491-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591030
[Journal Article] 糖尿病神経障害の成因と治療その新たな展開は. 炎症論からみた糖尿病性神経障害 : 新しい治療の方向を目指して2008
- Author(s)
  八木橋操六
- Journal Title
  
  糖尿病 51S1
- Data Source
  KAKENHI-PROJECT-19591030
[Journal Article] Implication of proinflammatory reactions in pathogenesis of microvascul ar complications in diabetes2007
- Author(s)
  Yagihashi S, Yamagishi SI, Wada R.
- Journal Title
  
  Hirosaki Med J 59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2007
- Author(s)
  Baba M, Nukada H, McMorran D, Takahashi K, Wada R, Yagihashi S
- Journal Title
  
  Muscle Nerve 33・3
  
  Pages: 350-355
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] 基礎講座糖尿病モデル動物I神経障害2007
- Author(s)
  和田龍一、八木橋操六
- Journal Title
  
  Diabetes Frontier 18
  
  Pages: 391-398
- Data Source
  KAKENHI-PROJECT-19591030
[Journal Article] ポリオール代謝ルネサンス. ポリオール代謝の新しい展開と臨床応用に向けて2007
- Author(s)
  八木橋操六
- Journal Title
  
  糖尿病合併症 21
  
  Pages: 25-32
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2006
- Author(s)
  Baba M, Nukdada H, McMorran D, Takahashi K, Wada R, Yagihashi S.
- Journal Title
  
  Muscle Nerve 33・3
  
  Pages: 350-355
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] 2型糖尿病の膵病理2006
- Author(s)
  八木橋操六, 和田龍一, 水上浩哉, 矢嶋信久
- Journal Title
  
  病理と臨床 24・7
  
  Pages: 698-706
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2006
- Author(s)
  Baba M, Nukada H, McMorran D, Takahashi K, Wada R, Yagihashi S
- Journal Title
  
  Muscle Nerve 33
  
  Pages: 350-355
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Three-year inhibition of aldose reductase on development of symptomatic neuropathy in diabetic patients.2006
- Author(s)
  Baba M, Kimura K, Suda T, Yagihashi S
- Journal Title
  
  J Peripher Nerv Syst 11・2
  
  Pages: 176-178
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.2006
- Author(s)
  Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M
- Journal Title
  
  J Pharmacol Exp Ther 318・3
  
  Pages: 1203-1210
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.2006
- Author(s)
  Ho EC, Lam KS, Chen YS, Yip JC, Arvindakshan M, Yamagishi S, Yagihashi S, Oates PJ, Ellery CA, Chung SS, Chung SK
- Journal Title
  
  Diabetes 55・7
  
  Pages: 1946-1953
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] 糖尿病性神経障害の病態生理2006
- Author(s)
  八木橋操六
- Journal Title
  
  Current Therapy 24・6
  
  Pages: 956-961
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Role of advanced glycation endproducts and their receptors in development of diabetic neuropathy.2005
- Author(s)
  Wada R, Yagihashi S
- Journal Title
  
  Ann NY Acad Sci 1043
  
  Pages: 598-604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Prolonged ischemic conduction failure after reperfusion in diabetic nerve.2005
- Author(s)
  Baba M, Yagihashi S, et al.
- Journal Title
  
  Muscle Nerve 33(3)
  
  Pages: 350-355
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Role of advanced glycation endproducts and their receptors in development of diabetic neuropathy.2005
- Author(s)
  Wada R, Yagihashi S.
- Journal Title
  
  Ann NY Acad Sci 1043
  
  Pages: 598-604
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment.2005
- Author(s)
  Toki T, Yagihashi S, et al.
- Journal Title
  
  Blood 105(8)
  
  Pages: 3100-3108
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Role of advanced glycation end products and their receptors in development of diabetic neuropathy.2005
- Author(s)
  Wada R, Yagihashi S.
- Journal Title
  
  Ann N Y Acad Sci 1043
  
  Pages: 598-604
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004
- Author(s)
  Uehara K, Yamagishi S, Chin S, Yagihashi S.
- Journal Title
  
  Diabetes 53・12
  
  Pages: 3239-3247
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, n ociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004
- Author(s)
  Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S.
- Journal Title
  
  Diabetes 53(12)
  
  Pages: 3239-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590861
[Journal Article] Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma.2004
- Author(s)
  Sugimoto K, Shoji M, Yasujima M, Suda T, Yagihashi S.
- Journal Title
  
  Acta Neuropathol 108・6(Berl)
  
  Pages: 503-514
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004
- Author(s)
  Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S
- Journal Title
  
  Diabetes 53
  
  Pages: 3239-3247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma.2004
- Author(s)
  Sugimoto K, Shoji M, Yasujima M, Suda T, Yagihashi S
- Journal Title
  
  Acta Neuropathol (Berl) 108
  
  Pages: 503-514
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells.2004
- Author(s)
  Sekido H, Suzuki T, Jomori T, Takeuchi M, Yabe-Nishimura C, Yagihashi S.
- Journal Title
  
  Biochem Biophys Res Commun 320・1
  
  Pages: 214-248
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice.2004
- Author(s)
  Uehara K, Yamagishi S, Otsuki S, Chin S, Yagihashi S.
- Journal Title
  
  Diabetes 53(12)
  
  Pages: 3239-3247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590861
[Journal Article] Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells.2004
- Author(s)
  Sekido H, Suzuki T, Jomori T, Takeuchi M, Yabe-Nishimura C, Yagihashi S
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 214-248
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.2003
- Author(s)
  Yamagishi S, Uehara K, Otsuki S, Yagihashi S:
- Journal Title
  
  J Neurochem 87
  
  Pages: 497-507
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Journal Article] Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.2003
- Author(s)
  Yamagishi S, Uehara K, Otsuki S, Yagihashi S.
- Journal Title
  
  J Neurochem 87・2
  
  Pages: 497-507
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370073
[Patent] 急性腎不全の予防または治療剤2006
- Inventor(s)
  八木橋操六, 小笠原早織, 日比千尋
- Industrial Property Rights Holder
  弘前大学, 三和化学
- Industrial Property Number
  2005-362579
- Filing Date
  2006-12-15
- Data Source
  KAKENHI-PROJECT-18659106
[Presentation] ヒト2型糖尿病におけるM1マクロファージ浸潤と末梢神経病理学的変化2019
- Author(s)
  山田咲季子，遅野井祥，高橋和久，工藤和洋，板橋智映子，八木橋操六，水上浩哉
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 急性心筋梗塞合併2型糖尿病は膵島病理学的所見により亜分類される2019
- Author(s)
  水上浩哉、高橋和久、遅野井祥、郭丹陽、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第108回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] Performance validation of improved photoacoustic/ultrasound superposed imaging system for evaluation of diabetic neuropathy2019
- Author(s)
  Miya Ishihara, Kaku Irisawa,Dai Murakoshi,Takeshi Hirasawa,Shinpei Okawa,Ryuichi Azuma ,Takeshi Osonoi,Hitoshi Nukada,Soroku Yagihashi
- Organizer
  SPIE Photonics West Biomedical Optics, BiOS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02113
[Presentation] 新しい2型糖尿病亜分類の膵島病理学的所見に基づく検証2019
- Author(s)
  水上浩哉，高橋和久，遅野井祥，工藤和洋，板橋智映子，八木橋操六
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 糖尿病性神経障害におけるM1マクロファージ浸潤は逆行性軸索輸送を減弱させる2019
- Author(s)
  遲野井祥，水上浩哉，進藤陸生，高橋和久，小笠原早織，三五一憲，山本靖彦，山本博，八木橋操六
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 正常高値HbA1cは小径神経障害の危険因子である2019
- Author(s)
  板橋智映子，小笠原早織，高橋和久，遅野井祥，工藤和洋，内田知顕，梅津誠子，井川明子，八木橋操六，水上浩哉
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 膵島アミロイド沈着と低酸素関連分子の発現について2019
- Author(s)
  新井仁，遅野井祥，高橋和久，工藤和洋，板橋智映子，八木橋操六，水上浩哉
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 緩徐進行1型糖尿病（SPIDDM）における膵内外分泌腺異常2019
- Author(s)
  神保江莉加，滝田美夏子，福井智康，会田薫，島田朗，及川洋一，八木橋操六，小林哲郎
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 劇症1型糖尿病における膵病理の特徴2019
- Author(s)
  滝田美夏子，神保江莉加，福井智康，会田薫，及川洋一，島田朗，八木橋操六，小林哲郎
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 胎生期から学童期の膵島内分泌細胞は各細胞独自の容積、増殖能を示す2019
- Author(s)
  一戸寛、遅野井祥、郭丹陽、工藤和洋、水上浩哉、八木橋操六
- Organizer
  第108回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] キサンチンオキシダーゼ阻害は糖尿病性神経障害DRGを改善する2019
- Author(s)
  高橋和久，遅野井祥，小笠原早織，八木橋操六，水上浩哉
- Organizer
  第62回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 新しい2型糖尿病亜分類の膵島病理学的所見に基づく検討2019
- Author(s)
  水上浩哉、高橋和久、遅野井祥、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第62回日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] 緩徐進行1型糖尿病（SPIDDM）における膵内外分泌腺異常2018
- Author(s)
  神保江莉加，増田治美，福井智康，会田薫，八木橋操六，島田朗，小林哲郎
- Organizer
  第６１回日本糖尿病学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 小児膵島は成人と異なる機序で維持される2018
- Author(s)
  一戸寛，遅野井祥，成瀬亜純，木村ひより，高橋和久，阿部信，稲葉渉，水上浩哉，八木橋操六
- Organizer
  第６１回日本糖尿病学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 緩徐進行1 型糖尿病と急性発症1 型糖尿病膵の同異点2018
- Author(s)
  福井智康，八木橋操六，小林哲郎
- Organizer
  第６１回日本糖尿病学会学術集会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 光音響イメージングの糖尿病多発神経障害の診断病態評価への応用の試み2018
- Author(s)
  八木橋操六, 石原　美弥
- Organizer
  第61 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H02113
[Presentation] 2型糖尿病と膵導管癌CDKN2A/P16プロモーターメチル化の関連2018
- Author(s)
  阿部信，斎藤傑，内田知顕，梅津誠子，板橋智映子，工藤和洋，八木橋操六，水上浩哉
- Organizer
  第６１回日本糖尿病学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] Clinical application of photoacoustic imaging to the evaluation of diabetic polyneuropathy2018
- Author(s)
  Soroku Yagihashi,Miya Ishihara,Ryotaro Hotta,Ryuichi Azuma,Hitoshi Nukada,Hiroki Mizukami,Kaku Irisawa,Dai Murakoshi,Nana Shiozawa,Satako Douguchi,Miyoko Saitou,Atsuko Tamasawa,Takeshi Osonoi
- Organizer
  ADA2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02113
[Presentation] 2型糖尿病モデルdb/dbマウスにおけるキサンチン酸化還元酵素阻害薬による膵島病理学的変化への影響2018
- Author(s)
  吉田健一郎，高橋和久，遅野井祥，小笠原早織，八木橋操六，水上浩哉
- Organizer
  第６１回日本糖尿病学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 高血圧性末梢神経障害に対する糖尿病の影響：高血圧自然発症ラット(SHR)での検討2017
- Author(s)
  堀田亮太郎、額田　均、八木橋操六、馬場正之
- Organizer
  第40回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017
- Author(s)
  Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
- Organizer
  NeuroDiab 2017、 the European Association for the Study of Diabetes (EASD)
- Place of Presentation
  Coimbra, Portugal
- Year and Date
  2017-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017
- Author(s)
  Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S.
- Organizer
  The 9th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  名古屋
- Year and Date
  2017-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017
- Author(s)
  Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
- Organizer
  NeuroDiab 2017, the European Association for the Study of Diabetes (EASD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Adjuvant effects of diabetes on hypertensive neuropathy in spontaneously hypertensive rats.2017
- Author(s)
  Nukada H, Hotta R, Baba M, Ogasawara S, Yagihashi S
- Organizer
  The 9th Scientific Meeting of the Asian Association for the Study of Diabetes, Nagoya
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] 高血圧性末梢神経障害に対する糖尿病の影響：高血圧自然発症ラット(SHR)での検討2017
- Author(s)
  堀田亮太郎、額田　均、八木橋操六、馬場正之
- Organizer
  平成29年度糖尿病性神経障害を考える会
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Islet alterations in patients with type 2 diabetes complicated with macroangiopathic diseases2016
- Author(s)
  Takahashi K, Hiroki Mizukami, Tetsuyuki Tateda, Soroku Yagihashi
- Organizer
  American Diabetes Association 76th meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 緩徐進行1型糖尿病(SPIDDM)の病理学的検討2016
- Author(s)
  神保絵梨佳、小林哲郎、福井智朗、八木橋操六
- Organizer
  第59回日本糖尿病学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 大血管障害を有する2型糖尿病者膵島の病理学的検討2016
- Author(s)
  高橋和久、水上浩哉、八木橋操六
- Organizer
  第59回日本糖尿病学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 糖尿病性神経障害Update（教育講演）2016
- Author(s)
  八木橋操六
- Organizer
  第27回日本末梢神経学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 中高齢期の自然発症2型糖尿病GKラットの膵島変化に対するDPP-IV阻害薬効果2016
- Author(s)
  稲葉渉、水上浩哉、小笠原早織、八木橋操六
- Organizer
  第59回日本糖尿病学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-16K09771
[Presentation] 高血圧自然発症ラット（SHR）末梢神経障害に対する降圧剤の効果2015
- Author(s)
  堀田亮太郎、額田　均、八木橋操六
- Organizer
  第38回日本高血圧学会
- Place of Presentation
  愛媛
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] Progressive decline of compound muscle action potentials in motor nerve conduction studies in Japanese type 2 diabetic patients - four years follow-up study2015
- Author(s)
  Kobori M, Yagihashi S, Shiina N, ShiozawaN, Haginoya A, Ojima M, Douguchi S, Tamasawa A, Saito M, Osonoi T
- Organizer
  第25回欧州糖尿病学会末梢神経障害学会
- Place of Presentation
  Elsinore, Denmark
- Year and Date
  2015-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] The effects of angiotensin II receptor blocker (ARB) on neuropathy in spontaneopusly hypertensive rats2015
- Author(s)
  Hotta R, Nukada H, Yagihashi S
- Organizer
  第25回欧州糖尿病学会末梢神経障害学会
- Place of Presentation
  Elsinore, Denmark
- Year and Date
  2015-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] 高血圧自然発症ラット（SHR）末梢神経障害に対する降圧剤の効果2015
- Author(s)
  堀田亮太郎、額田　均、八木橋操六
- Organizer
  第26回日本末梢神経学会
- Place of Presentation
  松本
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K09367
[Presentation] 糖尿病性神経障害の成因と病態2014
- Author(s)
  八木橋操六
- Organizer
  日本糖尿病学会総会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Islet amyloid with macrophage migration correlates with augmented beta-cell deficits in type 2 diabetic patients2014
- Author(s)
  Kamata K, Mizukami H, Inaba W, Takahashi K, Yagihashi S
- Organizer
  American Diabetes Association Annual Meeting
- Place of Presentation
  San Franscisco, USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 日本人2型糖尿病の膵島アミロイド沈着と炎症反応2014
- Author(s)
  鎌田耕輔、水上浩哉、稲葉渉、高橋一徳、八木橋操六
- Organizer
  日本糖尿病学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病性末梢神経障害に対する高血圧の影響：高血圧自然発症ラット(SHR)での検討2014
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第55回日本神経学会
- Place of Presentation
  博多
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] インクレチン関連薬使用糖尿病者の膵病理2014
- Author(s)
  八木橋操六、水上浩哉、稲葉渉、坪井堅太郎
- Organizer
  日本糖尿病学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病性神経障害の成因の新たな展開2014
- Author(s)
  水上浩哉、八木橋操六
- Organizer
  日本糖尿病学会総会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 膵炎・膵臓がんの非臨床及び臨床評価（シンポジウム）2014
- Author(s)
  八木橋操六
- Organizer
  日本毒性学会学術集会
- Place of Presentation
  神戸市
- Invited
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病性末梢神経障害に対する高血圧の影響：高血圧自然発症ラット(SHR)での検討2014
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第57回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] Hypertensive neuropathy in spontaneously hypertensive rat2014
- Author(s)
  Nukada H, Baba M, McMorran D, Yagihashi S
- Organizer
  32nd World Congress of Internal Medicine
- Place of Presentation
  韓国・ソウル
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] Amelioration of neuropathic changes with correction of nerve insulin resistance in diabetic Goto-Kakizaki rats treated with DPP-IV inhibitor vildagliptin2013
- Author(s)
  Tsuboi K, Mizukami H, Inaba W, Kamata K, Ogasawara S, Yagihashi S
- Organizer
  49th Annual meeting of European Association of Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 網羅的メタボローム解析による新規糖尿病性神経障害発症機序の探索2013
- Author(s)
  水上浩哉、坪井堅太郎、三五一憲、鎌田耕輔、稲葉渉、八木橋操六
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Metabolomic analysis of glycolytic pathway responsible for diabetic neuropathy beyond polyol pathway hyperactivity2013
- Author(s)
  Mizukami H, Tsuboi K, Sango K, Chung SK, Yagihashi S
- Organizer
  73rd Annual Meeting of American Diabetes Association
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Slow and minimal decline of beta cell mass associated with aging in non-diabetic Japanese and lack of compensatory islet hyperplasia in obesity2013
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Kamata K, Uehara O, Tsuboi K, Yagihashi S
- Organizer
  49th Annual meeting of European Association of Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] ヒト2型糖尿病膵β細胞容積減少と酸化ストレス、ERストレス、オートファジーとの関連について2013
- Author(s)
  吉田太郎、水上浩哉、稲葉渉、鎌田耕輔、坪井堅太郎、八木橋操六
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Involvement of DNA damage, ER-stress and autophagy deficits in the β cell loss in Japanese type 2 diabetic patients2013
- Author(s)
  Iwashita M, Mizukami H, naba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
- Organizer
  56th Annual Meeting of Japan Diabetes Society
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Progress and perspective of diabetic neuropathy care. New approach to the pathogenesis of diabetic polyneuropathy2013
- Author(s)
  Mizukami H, Yagihashi S
- Organizer
  56th Annual Meeting of Japan Diabetic Society
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病病理学の進歩2013
- Author(s)
  八木橋操六
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Involvement of DNA damage, ER-stress and autophagy deficits in the b cell loss in Japanese type 2 diabetic patients2013
- Author(s)
  Osonoi S, Mizukami H, Inaba W, Kamata K, Tsuboi K, Yagihashi S
- Organizer
  73rd Annual Meeting of American Diabetes Association
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Hexosamine pathway in the pathogenesis of diabetic neuropathy. Effects of glucosamine on the cultured Schwann cells2012
- Author(s)
  Mizukami H, Tsuboi K, Kamata K, Takahashi K, Yagihashi S,
- Organizer
  22nd Annual Meeting of European Study Group of Diabetic Neuropathy
- Place of Presentation
  Dresden,Germany
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病性神経障害研究の進歩2012
- Author(s)
  八木橋操六
- Organizer
  第27回日本糖尿病合併症学会
- Place of Presentation
  福岡市
- Invited
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Pathogenesis of diabetic neuropathy. Sugar or beyond sugar?2012
- Author(s)
  Yagihashi S
- Organizer
  9th International Diabetes Federation Asian and West Pacific Region Congress
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Preservation of islet beta cell mass with improvement of cell proliferation signals in GK rats treated with DPP-IV inhibitor.2012
- Author(s)
  Kamata K, Mizukami H, Inaba W, Takahashi K, Yagihashi S
- Organizer
  72nd Scientific sessions of American Diabetes Association
- Place of Presentation
  Philadelphia,USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Slow and progressive age-related decline of beta cell mass and proliferation activity of beta cells in non-diabetic Japanese subjects2012
- Author(s)
  Mizukami H,Takahashi K, Inaba W, Kamata K, Tsuboi K, Yagihashi S
- Organizer
  72nd Scientific Meeting if American Diabetes Assocation
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Amelioration of neuropathic changes with correction of nerve insulin resistance in diabetic Goto-Kakizaki rats treated with DPP-IV inhibitor, vildagliptin2012
- Author(s)
  Tsuboi K, Mizukami H, Inaba W, KamataK, Ogasawara S, Yagihashi S
- Organizer
  28th Annual Meeting of Neurodiab sutyd group
- Place of Presentation
  Dresden, Germany
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012
- Author(s)
  水上浩哉、高橋一徳、稲葉渉、鎌田耕輔、小笠原早織、八木橋操六
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  於京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 網羅的メタボローム解析による糖尿病性神経障害の新しい発症機序の探索2012
- Author(s)
  水上浩哉、坪井堅太郎、三五一憲、鎌田耕輔、稲葉渉、八木橋操六
- Organizer
  第56回日本糖尿病学会年次集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Progressive age-related decline of beta cell mass and proliferation activity of beta cells in non-diabetic Japanese subjects2012
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Kamata K, Tsuboi K, Yagihashi S
- Organizer
  72nd Scientific sessions of American Diabetes Association
- Place of Presentation
  Philadelphia,USA
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] Is the skin biopsy useful to determine the severity of polyneuropathy in Japanese type 2 diabetic subjects?2012
- Author(s)
  Yagihashi S, Murakami H, Sugimoto K, Uehara O, Tamasawa N, Murakami C, Baba M
- Organizer
  22nd Annual Meeting of European Study Group of Diabetic Neuropathy
- Place of Presentation
  Dresden,Germany
- Data Source
  KAKENHI-PROJECT-24659158
[Presentation] 糖尿病ラット末梢神経の虚血・再潅流傷害に対する形態学的脆弱性とマクロファージ活性化2010
- Author(s)
  額田均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
- Organizer
  第21回日本末梢神経学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] Ischaemic susceptibility in hypertensive nerve2009
- Author(s)
  額田均, 馬場正之, 小笠原早織, McMorran PD, 八木橋操六
- Organizer
  2009 Peripheral Society Meeting
- Place of Presentation
  ドイツ、ウルツバーグ
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] 虚血・再灌流、炎症論からみた神経障害、「シンポジウム:糖尿病血管合併症の成因解明へのアプローチ」2009
- Author(s)
  額田均、八木橋操六、馬場正之
- Organizer
  第23回日本糖尿病・肥満動物学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] 高血圧と虚血性末梢神経障害:高血圧ラットでの検討2009
- Author(s)
  額田均、馬場正之、Denise McMorran、八木橋操六
- Organizer
  第52回日本糖尿病学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] 虚血・再灌流、炎症からみた末梢神経障害2009
- Author(s)
  額田均、八木橋操六、馬場正之
- Organizer
  第23回日本糖尿病・肥満動物学会、シンポジウム「糖尿病合併症の成因解明へのアプローチ」
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] Ischaemic susceptibility in hypertensive nerve.2009
- Author(s)
  Nukada H, Baba M, Ogasawara S, McMorran PD, Yagihashi S
- Organizer
  2009 Peripheral Society Meeting
- Place of Presentation
  Germany, Wurzberg
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] 高血圧と末梢神経障害:高血圧自然発症ラット末梢神経の虚血に対する脆弱性2009
- Author(s)
  額田均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
- Organizer
  第20回日本末梢神経学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] Hypertension and neuropathy : ischaemic susceptibility in SHR nerves2009
- Author(s)
  額田均, 馬場正之, 小笠原早織, McMorran PD, 八木橋操六
- Organizer
  ISDN/NEURODIAB Meeting, IDF Satellite Symposium
- Place of Presentation
  カナダ、トロント
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] Hypertension and neuropathy : ischaemic susceptibility in SHR nerves, ISDN/NEURODIAB Meeting2009
- Author(s)
  Nukada H, Baba M, Ogasawara S, McMorran PD, Yagihashi S
- Organizer
  IDF Satellite Symposium
- Place of Presentation
  Canada, Toronto
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] 高血圧と虚血性末梢神経障害:高血圧ラットでの検討2009
- Author(s)
  額田均、馬場正之、Denise McMorran、八木橋操六
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20591037
[Presentation] Escape phenomenon from polyol pathway to other metabolic cascades may operate in unprotected nerve conduction delay in severe ly hyperglycemic AR-deficient mice2007
- Author(s)
  Yagihashi S, Yamagishi SI, Ogasawara S, Sugawara A, Chung S
- Organizer
  17 Neurodiab Meeting(Congress of European Soceity of Diabetic Neuropathy Study Group)
- Place of Presentation
  オランダ、ユトレヒト市
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-18659106
[Presentation] SHR末梢神経の細小血管症
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第36回日本高血圧学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害における細小血管症
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第54回日本神経学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] Microangiopathy in hypertensive neuropathy
- Author(s)
  Nukada H, Baba M, Ogasawara S, McMorran D, Mizukami H, Yagihashi S
- Organizer
  2012 NEURODIAB Meeting
- Place of Presentation
  ドレスデン、ドイツ
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害での細小血管症
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第54回日本神経学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害：SHRでの検討
- Author(s)
  額田　均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
- Organizer
  第53回日本神経学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害：SHRでの検討
- Author(s)
  額田　均、馬場正之、小笠原早織、Denise McMorran、八木橋操六
- Organizer
  第55回日本糖尿病学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害での細小血管症
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第56回日本糖尿病学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 高血圧性末梢神経障害での細小血管症
- Author(s)
  額田　均、馬場正之、小笠原早織、水上浩哉、Denise McMorran、八木橋操六
- Organizer
  第56回日本糖尿病学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 糖尿病性神経障害の新しい展開
- Author(s)
  八木橋操六
- Organizer
  第56回日本糖尿病学会学術集会シンポジウム
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-24591307
[Presentation] 糖尿病病理学の進歩。形態と機能の相関を求めて（宿題報告）
- Author(s)
  八木橋操六
- Organizer
  第101回日本病理学会学術集会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24591307

1. WADA Ryuichi (20260408)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. YAMAGISHI Shinichiro (80301026)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. KUROTAKI Hidekachi (40215108)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. BABA Masayuki (90106849)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
5. MIZUKAMI Hiroki (00374819)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
6. NUKADA Hitoshi (60118833)

# of Collaborated Projects: 5 results

# of Collaborated Products: 41 results
7. YAGIHASHI Norito (10250622)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
8. TONOSAKI Akira (90004572)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. NARUSE Keiko (30387576)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HOTTA Ryoutarou (50747897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
11. OGASAWARA Saori

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
12. YAJIMA Nobuhisa (30443980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KOIKE Kazutomo (80234657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Hiroshi (80004662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TOKUNAGA Fumio (80025452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ONUMA Tomio (00150251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISHIHARA Miya (30505342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 鷲岳宏 (20091845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 東隆一 (00531112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 藤田真敬 (20525927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TSUTIHARA Toyokazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NEMOTO Kouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAMURA Jiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MARCUS Mueller

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TSUJI Mari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. DENIDE McMorran

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. AITA Saburo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KUDO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. INABA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 袴田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 竹下章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 菅原明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 会田薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 小林哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 三五一憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 上野伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 遅野井祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 大門真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 村上宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 長尾元嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 原朱美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 渡部和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAGIHASHI Soroku 八木橋 操六

八木橋 操六 ヤギハシ ソウロク

八木橋 繰六 ヤギハシ ソウロク

Research Projects

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Co-Researchers

2型糖尿病の膵島内神経血管構築異常と糖尿病治療による修飾Principal Investigator

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Altered neurovascular network in type 2 diabetes and its repairPrincipal Investigator

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Analysis of islet remodeling in type 2 diabetes and exploratory regulation of endocrine cell transdifferentiation (metaplasia)Principal Investigator

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Analysis of islet amyloid in Japanese type 2 diabetic patients and exploration of new treatment for diabetesPrincipal Investigator

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全身性炎症反応症候群(SIRS)におけるポリオール代謝の役割と新規治寮法の開発Principal Investigator

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Exploration of pathogenesis of diabetic complications using transgenic mice and attempts of gene therapyPrincipal Investigator

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YAGIHASHI Soroku 八木橋操六

八木橋操六ヤギハシソウロク

八木橋繰六ヤギハシソウロク

[Book] 糖尿病性神経障害．　病気と薬．パーフェクトBook、薬局増刊号（横田千津子、池田宇一、大越教夫編）、2012