KOBAYSHI Hideyuki 小林英幸

Researcher Number	40148953
Other IDs
External Links
Affiliation *help	2016 – 2018 : 産業医科大学, 医学部, 教授 2010 – 2012 : 産業医科大学, 医学部, 教授 2003 – 2006 : 宮崎大学, 医学部, 助教授 1995 – 2002 : 宮崎医科大学, 医学部, 助教授 1992 : 産業医科大学, 医学部, 講師 1989 : 産業医科大学, 医学部・薬理学, 助手
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Neurochemistry/Neuropharmacology / Applied pharmacology / General pharmacology Except Principal Investigator General pharmacology / Neurochemistry/Neuropharmacology / Obstetrics and gynecology / Biological Sciences
Keywords	Principal Investigator 脳微小血管 / 発現調節 / GTP結合蛋白質 / 脳虚血 / 脳浮腫 / アクアポリン / 受容体 / ノーザンブロット / イムノブロット / スナネズミ … More Except Principal Investigator Gene expression / Western blot / Down-regulation / Northern blot / 細胞膜発現調節 / Binding / 妊娠子宮 / Calcium / Up-and down-regulation / Sodium channel / Protein phosphatase / RAMP / Exocytosis / 胎盤 / 早産 / Calpain / Neuroprotective drug / Ca^<2+> signaling / Protein kinase / 子宮収縮抑制 / 培養副腎髄質細胞 / insulin / アドレノメデュリン / 血清除去 / 脱落膜 / Naチャネル / Protein kinases / Voltage-dependent Na^+ channels / Sodium channels / Neuroprotective drugs / lithium / Protein kinase C / Ca^<2+> oscillation / Caイオン / Ca2+ overload / 副腎髄質クロマフィン細胞 / Glia cell / 機能調節 / 電位依存性Naチャネル / 子宮平滑筋 / mRNA発現増加 / pregnant uterus / Bioactive peptide / Brain microvessels / レセプター / insulin-like growth factor / RAMP2 / Brain microvessel endothelial cell / トログリタゾン / 神経保護薬 / mRNA expression / placenta / β-アミロイド / グリア筋細胞 / C kinase family / JNK / インタ-ロイキン / Ca^<2+>過負荷 / tocolysis / 糖鎖付加 / 遺伝子発現 / Nav1.7 Na+ channel / MAPKファミリー / MAPカイネース / 電位依存性Na+チャネル / 翻訳後修飾 / Antiepileptics / IGF-I / Vascular smooth muscle cell / adrenomedullin / Voltage-dependent sodium channels / 平滑筋細胞 / lysosphosphatidic acid / 細胞内輸送 / Autocrine regulation / イムノフィリン / ^<22>Na+ influx / troglitazone / glycogen synthase kinase-3 / glycogen synthase kinase-3β / lysohosphatidic acid / SAPK / myometrium / Choroid plexus / insulin-like growth factor-I / ブラジキニン / Tyrosine hydroxylase / オキシトシン / Pregnant uterus / p38 MAPK / Adrenomedullin / C kinase isoform / Na_v1.7Na^+チャネル / Adrenal chromaffin cells / β-アミロイド・ペプタイド / CRLR / Nicotinic receptors / AMノックアウトマウス / 副腎髄質 / プロテインカイネースC / Ca-ATPase / Uterus / mRNA発現 / Oligodendroglial cells / Ca^<2+>oscillation / プリオン・ペプタイド / heat shock protein 90 / Receptor / lysophosphatidic acid / Na^+チャネル / Adrenomedullin family / 生理活性ペプチド / Hsp90 / Catecholamine / PAMP / Calcineurin / ERK / プロスタグランジンF_<2α> / Ca^<2+>signaling / 細胞膜発現 / GSK-3β / Microvessels / 脳微小血管内皮細胞 / premature labor / インターナリゼーション / Internalization / decidua / 子宮収縮制御 / p38MAPK / リチウム / cell surface expression Less

Development of prevention and treatment methods for infection by enterohemorrhagic Escherichia coli O157 based on bio-protect ive mechanismsPrincipal Investigator
- Principal Investigator
  
  KOBAYSHI Hideyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan
アドレノメデュリンの妊娠子宮・収縮抑制機序:早産治療薬としての基礎研究
- Principal Investigator
  
  和田明彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  University of Miyazaki
Regulatory mechanisms of expression and localization of aquaporin water channels in brain microvesselsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hideyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Miyazaki
Voltage-dependent Na+ channel: quality control and stress response.
- Principal Investigator
  
  WADA Akihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Miyazaki
Physiological function of voltage-dependent Na^+ channel β-subunit as an adhesion moleculePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hideyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Miyazaki
  宮崎医科大学
Inhibitory effect of adrenomedullin on uterine contraction
- Principal Investigator
  
  YANAGITA Toshihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Miyazaki Medical College
Regulatory mechanism of aquaporin expression in cerebral microvessels : its pathophysiological significancePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hideyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  宮崎医科大学
Naチャネルの細胞膜発現調節機構におけるMAPカイネースの役割
- Principal Investigator
  
  柳田俊彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  宮崎医科大学
Regulation of cell surface expression of voltage-dependent sodium channels by multiple calcium signalings : their mRNA levels and intracellular trafficking
- Principal Investigator
  
  WADA Akihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Miyazaki Medical College
Naチャネルの細胞膜発現調節:サブユニットmRNA変動と細胞内輸送・局在化機構
- Principal Investigator
  
  YANAGITA Toshihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  宮崎医科大学
Physiological function and gene expression of adremnomedullinfamily : adrenal medullary cells and isolated blood vessels
- Principal Investigator
  
  WADA Akihiko
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Miyazaki Medical College
Intracellular mechanisms regulating cell surface expression of Na channels : Na channel subunit mRNA levels and intracellular trafficking.
- Principal Investigator
  
  WADA Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Miyazaki Medical College
Cカイネースによる細胞膜Naチャネルdown-regulationの細胞内機序
- Principal Investigator
  
  和田明彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  宮崎医科大学
糖尿病による脳微小血管のGTP結合蛋白質αサブユニットの変化Principal Investigator
- Principal Investigator
  
  小林英幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  宮崎医科大学
CカイネースによるNaチャネル発現の制御と細胞応答の修飾
- Principal Investigator
  
  WADA Akihiko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  宮崎医科大学
虚血による脳GTP結合蛋白質とその遺伝子発現の変化Principal Investigator
- Principal Investigator
  
  小林英幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  宮崎医科大学
脳虚血による脳アドレナリン作動性受容体とその遺伝子発現の変化Principal Investigator
- Principal Investigator
  
  小林英幸
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Occupational and Environmental Health, Japan
副腎髄質系と免疫活性物質
- Principal Investigator
  
  泉太
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2013 2012 2011 2010 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Investigation of Encephalopathy Caused by Shiga Toxin 2c-Producing Escheriohia ooli Infection in Mice2013
- Author(s)
  Amran M. Y., Fujii J., Suzuki S. 0., Kolling G. L.,Villanueva A. M.,Kainunla M., Kobayashi H., Kanleyanla H. and Yoshida S
- Journal Title
  
  PLoS One
  
  Volume : 8
- DOI
  10.1371/journal.pone.0058959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis.2013
- Author(s)
  Osada-Oka M, Tateishi Y, Hirayama Y, Ozeki Y, Niki M, Kitada S, Maekura R, Tsujimura K, Koide Y, Ohara N, Yamamoto T, Kobayashi K, Matsumoto S
- Journal Title
  
  Microbiol. Immunol.
  
  Volume : 57 Pages : 30-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256, KAKENHI-PROJECT-23780304, KAKENHI-PROJECT-23790429
[Journal Article] Protection by recombinant Bacillus Calmette-Guérin　vaccine expression Shiga toxin 2B subunit against Shiga toxin producing Escherichia coli in mice.2012
- Author(s)
  Fujii J., Naito M., Yutsudo T., Heatherly D., Yamada T., Kobayashi H., Yoshida S. and Obrig T
- Journal Title
  
  Clin. Vaccine Immunol.
  
  Volume : 19 Pages : 1932-1937
- DOI
  10.1128/CVI.00473-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain2011
- Author(s)
  Naka T., Maeda S., Niki M., Ohara N, Yamamoto S., Yano I., Maeyama J., Ogura H., Kobayashi K., Fujiwara N.
- Journal Title
  
  J Biol Chem
  
  Volume : 286 Pages : 44153-44161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] Lipidphenotype of two distinct subpopulations of Vayo ohaoteri um bovis Bacillus Calmette-Guerin Tokyo 172 substrain2011
- Author(s)
  Naka T., Maeda S., Niki M., Ohara N., Yamamoto S.,Yano I.,Maeyama J.,Ogura H., Kobayashi K.,Fujiwara N
- Journal Title
  
  Biol. Chem
  
  Volume : 286 Pages : 44153-44161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] アグリン2010
- Author(s)
  小林英幸, 森井宏幸
- Journal Title
  
  日薬理誌
  
  Volume : 135 Pages : 215-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] アグリン(キーワード解説)2010
- Author(s)
  小林英幸、森井宏幸
- Journal Title
  
  日薬理誌
  
  Volume : 135 Pages : 215-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590256
[Journal Article] Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin-induced uveitis rat.2007
- Author(s)
  Liu X.Q., Kobayashi H., Jin Z.B., Wada A., Nao-I N.
- Journal Title
  
  Molecular Vision 13
  
  Pages : 309-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells2006
- Author(s)
  Kobayashi H., Yokoo H., Yanagita T., Satoh S., Kis B., Deli M., Niwa M., Wada A.
- Journal Title
  
  Brain Research 1123
  
  Pages : 12-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Induction of aquaporin 1 by dexaraethasone in lipid rafts in immortalized brain microvascular endothelial cells2006
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Brain Res. 1123
  
  Pages : 12-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Enhancement of insulin-induced PI3K/Akt/GSK-3 beta and ERK signaling by neuronal nicotinic receptor/PKC-alpha/ERK pathway : up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells.2006
- Author(s)
  Sugano T., Yanagita T., Yokoo H., Satoh S., Kobayashi H., Wada A.
- Journal Title
  
  Journal of Neurochemistry 98
  
  Pages : 20-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Constitutive activity of glycogen synthase kinase-3beta : Positive regulation of steady-state levels of insulin receptor substrates-1 and-2 in adrenal chromaffin cells.2006
- Author(s)
  Nemoto T., Yokoo H., Satoh S., Yanagita T., Sugano T., Yoshikawa N., Maruta T., Kobayashi H., Wada A.
- Journal Title
  
  Brain Research 1110
  
  Pages : 1-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells.2006
- Author(s)
  Kobayashi H et al.
- Journal Title
  
  Brain Research 1123(1)
  
  Pages : 12-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells2006
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Brain Res 1123
  
  Pages : 12-19
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells.2006
- Author(s)
  Hideyuki Kobayashi et al.
- Journal Title
  
  Brain Research 1123・1
  
  Pages : 12-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Insulin induces internalization of the 5-HT2A receptor expressed in HEK293 cells.2005
- Author(s)
  Ohkura M., Tanaka N., Kobayashi H., Wada A., Nakai J., Yamamoto R.
- Journal Title
  
  European Journal of Pharmacology 518
  
  Pages : 18-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Relaxant effect of adrenomedullin on bovine isolated iris sphincter muscle under resting conditions.2005
- Author(s)
  Uchikawa Y., Okano M., Sawada A., Asada Y., Kobayashi H., Wada A., Nao-i N., Ohkura M., Tanaka N., Yamamoto R.
- Journal Title
  
  Clinical and Experimental Pharmacology and Physiology 32
  
  Pages : 675-680
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] New twist on neuronal insulin receptor signaling in health, disease, and therapeutics.2005
- Author(s)
  Wada A., Yokoo H., Yanagita T., Kobayashi H.
- Journal Title
  
  Journal of Pharmacological Sciences 99
  
  Pages : 128-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590473
[Journal Article] Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor.2004
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Neuroscience 125
  
  Pages : 973-980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500263
[Journal Article] Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor2004
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Neuroscience 125
  
  Pages : 973-980
- Data Source
  KAKENHI-PROJECT-15500263
[Journal Article] Molecular mechanisms and drug development in aquaporin water channel diseases : Aquaporin in the brain2004
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  J.Pharmacol.Sci. 96
  
  Pages : 264-270
- Data Source
  KAKENHI-PROJECT-15500263
[Journal Article] Molecular mechanisms and drug development in aquaporin water channel diseases : aquaporins in the brain.2004
- Author(s)
  Hideyuki Kobayashi et al.
- Journal Title
  
  Journal of Pharmacological Sciences 96
  
  Pages : 264-270
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Molecular mechanisms and drug development in aquaporin water channel diseases : aquaporins in the brain.2004
- Author(s)
  Hideyuki Kobayashi et al.
- Journal Title
  
  Journal of Pharmacological Sciences 96・3
  
  Pages : 264-270
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor.2004
- Author(s)
  Hideyuki Kobayashi et al.
- Journal Title
  
  Neuroscience 125・4
  
  Pages : 973-980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Molecular mechanisms and drug development in aquaporin water channel diseases : aquaporins in the brain.2004
- Author(s)
  Kobayashi H et al.
- Journal Title
  
  Journal of Pharmacological Sciences 96(3)
  
  Pages : 264-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor.2004
- Author(s)
  Kobayashi H et al.
- Journal Title
  
  Neuroscience 125(4)
  
  Pages : 973-980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300119
[Journal Article] Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells.2003
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Hypertension Research 26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500263
[Journal Article] Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells.2003
- Author(s)
  Kobayashi H. et al.
- Journal Title
  
  Hypertension Research 26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500263
[Presentation] 結核菌／BCGのストレプトマイシン耐性・依存性に関する新たな知見．2012
- Author(s)
  佐藤法仁，阿戸学，黒田誠，山崎利雄，松村隆之，関塚剛史，中山真彰，井上哲圭，本田尚子，土田耕三，小林和夫，大原直也
- Organizer
  第82回実験結核研究会
- Place of Presentation
  広島国際会議場、広島
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Lipid Phenotypes of Two Distinct Subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 Substrain and their Host Responses.2012
- Author(s)
  Naka T., Maeda S., Niki M., Ohara N., Yamamoto S., Yano I., Maeyama J., Ogura H., Kobayashi K., Shibata M., Fujiwara N.
- Organizer
  American Society for Microbiology 112th General Meeting
- Place of Presentation
  Moscone Center, San Francisco，U.S.A.
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] ストレプトマイシン依存性結核菌18bの依存性に関与する遺伝子変異の解明と新たなストレプトマイシン耐性を誘導する変異の発見．2012
- Author(s)
  佐藤法仁，山崎利雄，小林和夫，大原直也
- Organizer
  第87回日本結核病学会総会
- Place of Presentation
  広島国際会議場、広島
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] 抗酸菌のsliding motilityと非貪食細胞への取り込みの関連性．2012
- Author(s)
  岡部真裕子，大原直也，藤原永年，中崇，阿戸学，小林和夫
- Organizer
  第82回実験結核研究会
- Place of Presentation
  広島国際会議場、広島
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Lipid Phenotypes of Two Distinct Subpopulations of Mycobacterium bovis Bacillus Calnlette-Guerin Tokyo 172 Substrain and their Host Responses2012
- Author(s)
  Naka, T.,Maeda S.,Niki M., Ohara N.,Yamamoto S.,Yano I.,Maeyama J.,Ogura H.,Kobayashi K., Shibata M., and Fujiwara N
- Organizer
  American Society for Microbiology 112th General Meeting
- Place of Presentation
  Moscone Center, San Francisco, U.S.A
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] 結核菌/BCGのストレプトマイシン耐性・依存性に関する新たな知見2012
- Author(s)
  佐藤法仁,阿戸学,黒田誠,山崎利雄,松村隆之,関塚剛史,中山真彰,井上哲圭,本田尚子,土田耕三,小林和夫,大原直也
- Organizer
  第82回実験結核研究会
- Place of Presentation
  広島国際会議場、広島
- Year and Date
  2012-05-09
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] ストレプトマイシン依存性結核菌18bの依存性に関与する遺伝子変異の解明と新たなストレプトマイシン耐性を誘導する変異の発見2012
- Author(s)
  佐藤法仁,山崎利雄,小林和夫,大原直也
- Organizer
  第87回日本結核病学会総会
- Place of Presentation
  広島国際会議場、広島
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] 抗酸菌のslidingmotilityと非貧食細胞への取り込みの関連性2012
- Author(s)
  岡部真裕子,大原直也,藤原永年,中崇,阿戸学,小林和夫
- Organizer
  第82回実験結核研究会
- Place of Presentation
  広島国際会議場、広島
- Year and Date
  2012-05-09
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Analysis of the 16S rRNA gene of the streptomycin-dependent Mycobacterium tuberculosis strain 18b and phenolypic revenant strains2011
- Author(s)
  Sato N., Ato M., Yamazaki T., Kuroda M., Matsumura T., Sekizuka T., Nakayama M., Honda, N., Tsuchida, K., Kobayashi K., Ohara N
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Identification of the novel mutations in 16S rRNA gene of the substrains of a streptomycin-dependent Mycobacterium tuberculosis Strain18b which confer streptomycin resistance in Mycobacterium2011
- Author(s)
  Sato N., Ato M., Matsumura T., Yamazaki T., Sekizuka T., Kuroda M., Nakayama M., Kobayashi K., Ohara N
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology. International Union of Microbiological Societies
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Gene expression profile of in a thymidine synthase ThyX-deletion mutant of Mycobacterium bovis BCG2011
- Author(s)
  Ohara N., Satoh N., Nakayama M., Okabe M, Kobayashi K
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology. International Union of Microbiological Societies
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Streptomycin依存性結核菌における遺伝子変異の解明とStreptomycin耐性を誘導する新たな遺伝子変異2011
- Author(s)
  佐藤法仁、阿戸学、松村隆之、山崎利雄、関塚剛史、黒田誠、中山真章、井上哲圭、本田尚子、土田耕三、小林和夫、大原直也
- Organizer
  第64回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山大学(岡山)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] 抗酸菌におけるセカンドメッセンジャーの利用2011
- Author(s)
  佐藤法仁、中山真彰, 岡部真裕子, 小林和夫、大原直也
- Organizer
  第86回実験結核研究会
- Place of Presentation
  大妻講堂(東京)
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] BCG Tokyo 172株に存在するサブポピュレーション間の遺伝子発現の比較発現の比較検討2010
- Author(s)
  大原直也, 岡部真裕子, 山本三郎, 瀧井猛将, 藤原永年, 前山順一, 佐藤法仁, 井上哲圭, 小林和夫
- Organizer
  第80回実験結核研究会
- Place of Presentation
  京都テルサ(京都)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] DNAマイクロアレイを用いたBCG Tokyo 172-1に存在するサブポピュレーションの遺伝子発現の比較検討2010
- Author(s)
  大原直也, 山本三郎, 瀧井猛将, 藤原永年, 前山順一, 小林和夫
- Organizer
  第80回実験結核研究会
- Place of Presentation
  京都テルサ(京都)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22590256
[Presentation] Analysis of RD16 locus in the BCG Tokyo 172 genome.Forty-fifth Joint Research Conference on Leprosy and Tuberculosis.2010
- Author(s)
  Ohara, N., Okabe, M., Yamamoto, S., Takii, T., Fujiwara, N., Maeyama, J., Nakayama, M., Kobayashi, K.
- Organizer
  The United State-Japan Cooperative Medical Science Program
- Place of Presentation
  Broad Institute (Cambridge, Massachusetts, U.S.A.)
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22590256

1. WADA Akihiko (30131949)

# of Collaborated Projects : 13results

# of Collaborated Products : 7results
2. YANAGITA Toshihiko (60295227)

# of Collaborated Projects : 11results

# of Collaborated Products : 4results
3. YOKOO Hiroki (30332894)

# of Collaborated Projects : 7results

# of Collaborated Products : 4results
4. YAMAMOTO Ryuichi (10094111)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
5. UEZONO Yasuhito (20213340)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
6. KITAMURA Kazuo (50204912)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. MORII Hiroyuki (60141743)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
8. FUJII Jun (60271441)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
9. 泉太 (90028506)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 柳原延章 (80140896)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 占部正信 (00094087)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. 池ノ上克 (60232211)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 大原直也 (70223930)

# of Collaborated Projects : 1results

# of Collaborated Products : 19results
14. SAKATA Tsuneaki

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. ORBA Yasuko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 岡松正敏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KOBAYSHI Hideyuki 小林 英幸

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Development of prevention and treatment methods for infection by enterohemorrhagic Escherichia coli O157 based on bio-protect ive mechanismsPrincipal Investigator

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Regulatory mechanisms of expression and localization of aquaporin water channels in brain microvesselsPrincipal Investigator

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Physiological function of voltage-dependent Na^+ channel β-subunit as an adhesion moleculePrincipal Investigator

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Regulatory mechanism of aquaporin expression in cerebral microvessels : its pathophysiological significancePrincipal Investigator

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糖尿病による脳微小血管のGTP結合蛋白質αサブユニットの変化Principal Investigator

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KOBAYSHI Hideyuki 小林英幸

[Journal Article] Protection by recombinant Bacillus Calmette-Guérin　vaccine expression Shiga toxin 2B subunit against Shiga toxin producing Escherichia coli in mice.2012