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KAWAKAMI Masanobu  川上 正

ORCIDConnect your ORCID iD *help
Researcher Number 40161286
External Links
Affiliation *help 2012 – 2013 : 自治医科大学, 医学部, 名誉教授
2013 : 自治医科大学, 医学部, 名誉教授(Emeritus Professor)
2000 – 2011 : 自治医科大学, 医学部, 教授
2007 : 自治医科大学, 医学部, 研究員
1997 – 1998 : Jichi Medical School, Professor Faculty of Medicine, 医学部, 教授 … More
1996 – 1997 : 自治医大, 医学部, 助教授
1993 – 1996 : 自治医科大学, 医学部, 助教授
1991 : 自治医科大学, 医学部, 助教授
1986 – 1988 : 国立病院医療センター, 臨床研究部, 室長
1986 : 医療セ, その他, その他 Less
Review Section/Research Field
Principal Investigator
内科学一般 / 内分泌・代謝学 / 血管生物学
Except Principal Investigator
Eating habits, studies on eating habits / Circulatory organs internal medicine / Circulatory organs internal medicine / Digestive surgery / 内分泌・代謝学 / 血管生物学 / Metabolomics / Ophthalmology / Human pathology
Keywords
Principal Investigator
TNF / サイトカイン / カケクチン / 脂肪細胞 / 悪疫質 / 単球 / IL-1 / 平滑筋 / TNF(Tumor Necrosis Factor) / cachexia … More / IFN / appetite / リポ蛋白リパーゼ / LPL(Lipoprotein Lipase) / LTBP / Lipolysis / 肥満 / ホルモン感受性リパーゼ / マクロファージ / 接着分子 / 動脈硬化 / TGFbeta / 悪液質 / 細胞分化 / ILー1 / 食欲 / 血管内皮細胞 / obesity … More
Except Principal Investigator
VEGF / TGF-β / 糖尿病 / 動脈硬化 / 血管内皮細胞 / AGE / 低酸素 / 活性酸素 / NO / アポトーシス / シグナル伝達 / MMP / HUVEC / THP-1 / TGF-beta / HGF / 血糖値 / 潜在型TGF-beta1結合タンパク(LTBP) / 単球 / ER-1 細胞 / TGF-βI型受容体 / TGF-βII型受容体 / TGF-beta type II Receptor / トコトリエノール / endoglin / Diabetic animal model / 腹部大動脈〓 / latent TGF-beta binding protein / 安定同位体 / 白内障 / Tocotrienol / 抗酸化剤 / HMG・CoAレダクターゼ / SDTラット / ER-pP 細胞 / apoptosis / REACTIVE OXYGEN SPECIES / hypoxia / ER-1 / 一酸化窒素合成酵素 / dissecting aneurysm / メバロン酸代謝 / WHHLMIウサギ / 血清メバロン酸 / 酸化LDL / ATP / セサミン / 糖尿病網膜症 / HNF-4 / 血管新生緑内障 / 糖尿病動物モデル / アゴニスト / TGF-beta type I Receptor / coronary atherrome / DNAチップ / ベトナム / ベトナム産 / SDT rat / 細胞内酸化ストレス / メイラード反応 / 過酸化脂質 / LTBP / Cataract / スルホニルウレア / ミトコンドリア電子伝達系 / oxidized LDL / TGF-β受容体 / 一酸化炭素 / GC-MS分析 / Rubeotic glaucoma / 腹部大動脈瘤 / アラキドン酸代謝経路 / Ascorbic acid / 胃癌分化度 / erythropoietin / K-ATPチャンネル / エリスロポエチン / Flavengenol / Astaxanthin / 解離性大動脈〓 / 遺伝子クローニング / Tocopherol / IGF-I / STZ rat / 解離性大動脈瘤 / NADPHオキシダーゼ / NADPH OXIDASE / 酸化ストレス / マクロファージ / トコフェロール / vascular endothelial cells / TGF-β 受容体 / SIM法 / アスコルビン酸 / STZラット / エンドグリン / IGF-1 / 癌転移 / NADPHオキシターゼ / Diabetes / oxidative stress / NO SYNTHASE / Diabetic retinopathy / NITRIC OXIDE / Diabetic cataract / Antioxidant / 血管病変 / 潜在型TGF-β1結合タンパク(LTBP) / vascular disease / Nu Voi / フラバンジェノール / ER-pP / 糖尿病モデル動物 / 一酸化窒素 / Diabetic melites / atherpsclerosis / 糖尿病白内障 / Sulfonylurea / MITCHONDRIAL ELECTRON TRANSPORT / ドリコール / ポリフェノール / 潜在型TGF-βI結合タンパク(LTBP) / monocyte / ER-1細胞 / HYPOXIA / TGF-β receptor / gene cloning / アスタキサンチン Less
  • Research Projects

    (19results)
  • Research Products

    (19results)
  • Co-Researchers

    (24People)
  •  Molecular mechanisms of suppression of macrophage foam cell formation by an erythropoietin receptor agonist

    • Principal Investigator
      UEBA HIROTO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Jichi Medical University
  •  Anti-atherosclerotic effects of an erythropoietin receptor agonist

    • Principal Investigator
      UEBA Hiroto
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Jichi Medical University
  •  糖尿病の予防・抑制におけるベトナム産Nu Voiの基礎および臨床に関する研究

    • Principal Investigator
      NGUYEN Van Chuyen
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Japan Women's University
  •  Basic and Clinical Studies on Natural Antioxidant Astaxanthin on the Inhibition of Diabetic Complication

    • Principal Investigator
      NGUYEN Van Chuyen
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Japan Women's University
  •  Analysis of antiapoptotic genes induced in vascular endothelial cells by monocyte adhesion.

    • Principal Investigator
      UEBA Hiroto
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Jichi Medical School
  •  Mechanism and treatment of diabetic retinopathy

    • Principal Investigator
      KAKEHASHI Akihiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Jichi Medical School
  •  Regulation of matrix metalloprotcase-9 production induced by monocyte-vascular endothelial cell interaction - role of hepatocyte growth factor and vascular endothelial growth.

    • Principal Investigator
      UEBA Hiroto
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Omiya Medical Center, Jichi Medical School
  •  THE ELUCIDATION OF THE OXYGEN SENSING AND INTRACELLULAR SIGNALING SYSTEM.

    • Principal Investigator
      KUROKI Masatoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  The study for the mechanism of the development of diabetic retinopathy

    • Principal Investigator
      KUROKI Masatoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  Growth factors and adhesion molecules in the progression of metastasizing capability of cancer cell lines.

    • Principal Investigator
      KAI Toshihiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Jichi Medical School
  •  Roles of TNF and leptin, the ob gene product, in genetic obesity.Principal Investigator

    • Principal Investigator
      KAWAKAMI Masanobu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Jichi Medical School, Faculty of Medicine
  •  消化器癌の組織形態におけるTGF-βs, TGF-β受容体および関連タンパクの影響

    • Principal Investigator
      甲斐 敏弘
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Jichi Medical University
  •  TGF-beta and vascular diseases

    • Principal Investigator
      TAKETAZU Fumitoshi, 武田津 文俊, 武田 津文俊
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      血管生物学
    • Research Institution
      Jichi Medical School
  •  動脈硬化の成因におけるカケクチン/TNFとその関連サイトカインの役割に関する研究Principal Investigator

    • Principal Investigator
      川上 正舒, 川上 正のぶ
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      血管生物学
    • Research Institution
      Jichi Medical University
  •  動脈硬化巣のサイトカイン産生におけるアセチルLDL受容体の役割に関する研究Principal Investigator

    • Principal Investigator
      川上 正, 川上 正舒
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Jichi Medical University
  •  カケクチン/TNFによる脂肪細胞の分化抑制および細胞障害作用のメカニズムPrincipal Investigator

    • Principal Investigator
      川上 正舒
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  安定同位前駆体を用いたメバロン酸代謝物の解析とHMG-COAレダクターゼ活性

    • Principal Investigator
      大島 美恵子
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  脂肪細胞の機能と分化に及ぼす各種モノカインの影響についてPrincipal Investigator

    • Principal Investigator
      川上 正舒
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  TNF(癌壊死因子)の正常組織に対する作用Principal Investigator

    • Principal Investigator
      川上 正のぶ
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Research Institute, International Medical Center of Japan

All 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue- protective compound derived from erythropoietin2013

    • Author(s)
      Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura S, Cerami A, Kawakami M.
    • Journal Title

      Mol Med.

      Volume : 19(1) Pages : 195-202

    • Data Source
      KAKENHI-PROJECT-23591108
  • [Journal Article] Suppression of coronary atherosclerosis by helix B surface peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.2013

    • Author(s)
      Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura SI, Cerami A, Kawakami M
    • Journal Title

      Molecular Medicine

      Volume : 19 Pages : 195-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300157, KAKENHI-PROJECT-23591108
  • [Journal Article] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue-protective compound derived from erythropoietin2013

    • Author(s)
      Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakami
    • Journal Title

      Mol Med.

      Volume : in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Journal Article] Reply to Abdelwahid and Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythro- poietic activities of erythropoietin2011

    • Author(s)
      Masanobu Kawakami, Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, and Anthony Cerami
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume : 108(6)

    • Data Source
      KAKENHI-PROJECT-23591108
  • [Journal Article] Reply to Abdelwahid and Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin.2011

    • Author(s)
      Masanobu Kawakami, Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami
    • Journal Title

      Proc Natl Acad Sci USA. 108(6)

    • Data Source
      KAKENHI-PROJECT-20590887
  • [Journal Article] Reply to Abdelwahid and Smith: The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin2011

    • Author(s)
      Kawakami M, Ueba H, Brines M, Yamin M, Umemoto T, Ako J, Momomura S, and Cerami A
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume : 108(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Journal Article] Reply to Abdel Wahid, Smith : The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin2011

    • Author(s)
      Masanobu Kawakami, Hiroto Ueba
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume : 108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590887
  • [Journal Article] Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin.2010

    • Author(s)
      Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakami
    • Journal Title

      Proc Natl Acad Sci USA. 107(32)

      Pages : 14357-14362

    • Data Source
      KAKENHI-PROJECT-20590887
  • [Journal Article] C-Reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells : Implications for the destabilization of atherosclerotic plaque.2008

    • Author(s)
      Aoi Nabata, Masatoshi Kuroki, Hiroto Ueba, Shigemasa Hashimoto, Tomio Umemoto, Hiroshi Wada, Takanori Yasu, Muneyasu Saito, Shin-ichi Momomura, Masanobu Kawakami
    • Journal Title

      Atherosclerosis 196(1)

      Pages : 129-135

    • Data Source
      KAKENHI-PROJECT-20590887
  • [Journal Article] Effects of Thiazolidinediones on In- Stent Restenosis : A Review of IVUS Studies

    • Author(s)
      Yasu T, Ueba H, Katayama T, Kawakami M.
    • Journal Title

      Intravascular Ultrasound, Yasuhiro Honda (Ed.)

      Volume : (ISBN :978-953-307-900-4)(InTech 2012)

    • URL
      http://www.intechopen.com/books/intravascular-ultrasound/effects-of-thiazolidinedione-on-in-stent-restenosis-a-review-of-ivus-studies
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] 慢性心不全動物モデルにおける非造血性エリスロポエチン誘導体による心筋保護作用―抗アポトーシス効果による適応2013

    • Author(s)
      上羽洋人, Michael Brines, Michael Yamin, Anthony Cerami, 梅本富士, 阿古潤哉, 川上正舒, 百村伸一.
    • Organizer
      第17回日本適応医学会学術集会
    • Place of Presentation
      さいたま市
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue-protective compound derived from erythropoietin2013

    • Author(s)
      Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami
    • Organizer
      The 77th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue- protective compound derived from erythro- poietin2013

    • Author(s)
      Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
    • Organizer
      The 77th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-03-15
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] 慢性心不全動物モデルにおける非造血性エリスロポエチン誘導体による心筋保護作用―抗アポトーシス効果による適応2013

    • Author(s)
      上羽洋人, Michael Brines, Michael Yamin, Anthony Cerami,梅本富士,阿古潤哉,川上正舒,百村伸一
    • Organizer
      第17回日本適応医学会学術集会
    • Place of Presentation
      さいたま市
    • Year and Date
      2013-06-29
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] Cardioprotective Properties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011

    • Author(s)
      Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] Cardioprotective Prop- erties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011

    • Author(s)
      Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-03
    • Data Source
      KAKENHI-PROJECT-23591108
  • [Presentation] Role of osteopontin and αvβ3 integrin in the regulation of endothelial cell survival by endothelial cell-monocyte interaction.2010

    • Author(s)
      Ueba, H, Hashimoto, S, Umemoto, T, Ako, J, Momomura, S, Kawakami, M.
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-20590887
  • [Presentation] Cardiomyocyte protection by a nonerythropoietic, tissue-protective peptide derived from erythropoietin.2010

    • Author(s)
      Ueba, H, Brines, M, Yamin, M, Umemoto, T, Ako, J, Momomura, S, Cerami, A, Kawakami, M.
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2010-03-05
    • Data Source
      KAKENHI-PROJECT-20590887
  • [Presentation] Induction of endothelial cell apoptosis and monocyte matrix metalloproteinase-9 production by C-reactive protein.2009

    • Author(s)
      Ueba, H, Nabata, A, Kuroki, M, Hashimoto, S, Umemoto, T, Sugawara, Y, Kubo, N, Momomura, S, Kawakami, M.
    • Organizer
      第73回日本循環器学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-03-21
    • Data Source
      KAKENHI-PROJECT-20590887
  • 1.  KUROKI Masatoshi (90215096)
    # of Collaborated Projects : 9results
    # of Collaborated Products : 0results
  • 2.  UEBA Hiroto (80316546)
    # of Collaborated Projects : 5results
    # of Collaborated Products : 19results
  • 3.  TAKETAZU Fumitoshi (90254937)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 0results
  • 4.  NGUYEN Van Chuyen (80175322)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 5.  KAI Toshihiro (40260830)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 6.  MIYATA Michio (90048976)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 7.  大島 美恵子 (20050487)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 8.  SODA Kuniyasu (00221341)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 9.  HIKINO Hajime (60296126)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 10.  YASU Takanori (40265278)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  KAKEHASHI Akihiro (30296123)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  山本 従道 (40231675)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  高木 省治郎 (20158992)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 14.  鈴木 恵美子 (80154524)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 15.  青塚 新一 (80158716)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 16.  山田 茂樹 (80220375)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 17.  川上 正舒
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 18.  進藤 登
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 19.  石橋 俊
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 20.  小川 弘子
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 21.  武田津 文俊
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 22.  武田 津文俊
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 23.  川上 正のぶ
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 24.  Shiomi Masashi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

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