sakon masato 左近賢人

… Alternative Names

SAKON Masato 左近賢人

左近賢人サコンマサト

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Researcher Number	40170659
Other IDs
External Links
Affiliation (Current)	2022: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 病院長
Affiliation (based on the past Project Information) *help	1999 – 2003: MED. SCH. OSAKA UNIV. ASSOCIATE PROFESSO, 医学系研究科, 助教授 2001: 大阪大学, 医学系研究所, 助教授 1998: Osaka University Medical School, Associate Professor, 医学部, 助教授 1996 – 1997: Osaka University, Department of Surgery II,Lecturer, 医学部, 講師 1995: 大阪大学, 医学部, 助手 1987 – 1993: 大阪大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery / Digestive surgery Except Principal Investigator Digestive surgery / General surgery / Biological Sciences / Social systems engineering/Safety system / Digestive surgery
Keywords	Principal Investigator TRAIL / 5-FU / 虚血再潅流障害 / 肝 / PGE1 / 肝細胞癌 / IFN併用化学療法 / NK細胞 / IFN-α / Fas-FasL … More / 肝癌 / 第X因子 / プロテアソーム / 血小板 / プロテアソ-ム / トロンビンレセプター / 創傷治療 / Calpain / 虚血再灌流障害 / ステロイド / ミトコンドリア / 肝切除 / カルパイン / ischemia-reperfusion injury / calpain / energy charge / calcium / hepatectomy / chronic hepatitis / 幹細胞癌 / インターフェロンα / 血管新生 / インターフェロンレセプター / TRAILレセプター / TRAIL受容体 / インターフェロン-α / 5-fluorouracil / angiopoietin / TRAIL-receptor / hepatocelluklar carcinoma / interferon-α / angiogenesis / interferon receptor / TRAIL receptor / IFN受容体 / 網羅的遺伝子解析 / 門脈内腫瘍栓 / IFN受容 / STAT-phosphoSTAT / IFN / IFNAR / 免疫組織染色 / hepatocellular carcinoma / IFN-receptor / NK cell / Gene Expression Profiling … More Except Principal Investigator カルパイン / 肝臓 / RNA / エンドトキシン / カルパスタチン / 膵癌 / LFA-1 / ICAM-1 / 拒絶反応 / rejection / ラット肝移植 / liver / 浸潤 / FAK / Rho / 癌転移 / 血管内皮細胞開裂 / microchimerism / 虚血・再潅流傷害 / RNA導入 / 蛋白導入 / HVJエンベロープベクター / bcl-2 / 遺伝子導入 / gene therapy / cDNA-microarray / マウス / IFN-α / TRAIL / Fas / FasL / HVJ Envelope Vector / PAF / 重症感染症 / 多臓器不全 / バイオアッセイ / PAF拮抗剤 / 乳癌 / 蛋白分解酵素 / 乳癌組織 / カルペプチン / MCF-7 / 肝虚血再潅流傷害 / oxidative stress / tert-butyl hydroperoxide / bleb / HuH7 / 細胞質プロテアーゼ / アンチセンス / COX-2 / 肝癌 / 胆管癌 / 食道癌 / JTE-522 / CDAA / ラット肝癌モデル / 抗接着療法 / 膵島移植 / 異種移植 / 抗原提示 / 接着分子 / 抗原認識 / 細胞接着 / モノクローナル抗体 / anti-adhesion therapy / Islet transplantation / xenotransplantation / antigen presentation / rat to mouse / 血小板 / マイクロパーティクル / 血小板活性化因子 / 遠隔臓器障害 / アスピリン / platelet / microparticle / platelet-activating factor / (遠隔)臓器障害 / 担体 / shear / mediator / microparlicle / platelet-actirating factor / Shear / mecliator / PLATELETS / MICROPARTICLES / PLATELET-ACTIVATING FACTOR / REMOTE ORGAN FAILURE / ASPIRIN / 免疫寛容 / ラット心移植 / ドナー抗原提示 / 肝網内系細胞 / immunological tolerance / rat liver transplantation / rat heart transplantation / donor antigen inoculation / 内皮細胞 / 開裂 / リン酸化 / 蛋白リン酸化 / pp125FAK / Invasion / Endothelial cell / Retraction / Phosphorylation / Pancreatic Cancer / 細胞内遊離カルシウム / 癌浸潤 / 内皮細胞開裂 / cancer invasion / cancer metastasis / EC retraction / cytoplasmic ionized Ca2+ / アロ抗原移入 / 肝内免疫応答 / マイクロキメリズム / maicrochimerism / Allo antigen inoculation / Rat liver transplantation / Immune response in the liver / HVJリポソーム / bcl / RNA購入 / 肝虚血・再潅流傷害 / mRNA / DNA / 肝細胞内導入 / HVJ-リポゾーム / ischemia / reperfusion / HVJ eavelope vector / HVJ-liposome / 網羅的遺伝子解析 / ラット / 診断 / ATAC-PCR / PCR-アレイ / PCR-array / mouse / rat / diagnosis / 肝細胞癌 / 血管新生 / TRAIL受容体 / NK細胞 / IFN併用化学療法 / Fas-L / 門脈内腫瘍栓 / IFN受容体 / STAT-phosphoSTAT / hepatocellular carcinoma / angiogenesis / TRAIL receptor / NK cell / 大学附属病院 / 運営評価方法 / タイムスタディ / 業務量分析 / 場所移動解析 / 電子カルテ / 患者看護需要度 / 長期業務傾向推計 / 業務スケジューリング / 患者看護重要度 / 国立大学 / 業務分類 / 業務効率 / 勤務実態 / 患者状態 / University Hospital / Assessment procedure of management / Time-Motion Study / Workflow study / Transit analysis / Electric medical chart / Patients care demand / Estimation of long-term work pattern / 虚血再潅流 / 移植 / 遺伝子治療 / 超音波遺伝子導入法 / 肝移植 / ex vivo / Liver / ischemia-reperfusion / transplantation / electroporation / 感染症 / DIC / MOF / 動物モデル / 多臓器障害 Less

The Development of the Evaluation Method of University Hospital Management in the 21^<st> Century Based on the Time-motion study
- Principal Investigator
  
  OHNO Yuko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Social systems engineering/Safety system
- Research Institution
  Osaka University
The establishment of immuno-chemotherapy through the IFN-IFNAR (IFN-α receptor) signaling pathway for the intractable and advanced hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  MARUBASHI Shigeru, 左近賢人
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Suppression of hepatic ischemia/reperfusion injury by early expression of protective protein
- Principal Investigator
  
  UMESHITA Koji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
The molecular-based prediction of the allograft rejection using the gene expression profiling study
- Principal Investigator
  
  DONO Keizo, 加藤友朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
The treatment for the intractable and advanced targeffing the angiogenesis and immuno-reaction
- Principal Investigator
  
  NAGANO Hiroaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Development of a new multidisciplinary therapy for the intractable, advanced hepatocellular carcinoma, targeting the intracellular signaling molecules.Principal Investigator
- Principal Investigator
  
  SAKON Masato
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Suppression of hepatic ischemia/reperfusion injury using RNA
- Principal Investigator
  
  UMESHITA Koji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
COX-2を分子標的とした難治性消化器癌の化学予防・治療に関する研究
- Principal Investigator
  
  塩崎均
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Signal transduction system responsible for the retraction of vascular endothelial cells upon cancer cell invasion or metastasis
- Principal Investigator
  
  ARIYOSHI Hideo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Tolerance induction using unique immune response in the liver
- Principal Investigator
  
  DONO Keizo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
A multi-step approach for ischemia-reperfusion of the liverPrincipal Investigator
- Principal Investigator
  
  SAKON Masato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Study for Molecular Mechanisms of Endothelial and Methotelial Cell Retraction during Cancer Cell Invasion
- Principal Investigator
  
  NAKAMORI Shoji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Platelet Micropartiles, a Carrier of Platelet-Activating Factor, and Remote Organ Failure
- Principal Investigator
  
  KAWASAKI Tomio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Anti-allo immune response in the liver after inoculation of allogeneic antigen
- Principal Investigator
  
  DONO Keizo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
カルパイン活性化からみた許容肝虚血時間の検討Principal Investigator
- Principal Investigator
  
  左近賢人
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
内在性・外在性細胞質プロテアーゼ・インヒビターを用いた肝虚血・再潅流傷害の制御
- Principal Investigator
  
  梅下浩司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
トロンビンレセプターペプチド(SFLLRN)の創傷治癒促進効果に関する検討Principal Investigator
- Principal Investigator
  
  左近賢人
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Induction of unresponsiveness using anti-adhesion therapy
- Principal Investigator
  
  GOTOH Mitsukazu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
新しい作用機作を有する乳癌内分泌療法剤の研究
- Principal Investigator
  
  芝英一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
乳癌組織中のCa^<2T>依存性中性蛋白分解酵素(カルパイン)に関する研究
- Principal Investigator
  
  芝英一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
脾臓におけるPAF産生放出が肝障害発生及び血小板減少に与える影響についての検討
- Principal Investigator
  
  川崎富夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
肝細胞癌における第X因子活性化因子の検討Principal Investigator
- Principal Investigator
  
  左近賢人
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
多臓器障害の発生機序-動物モデルによる解析
- Principal Investigator
  
  上林純一
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University

All 2004 2003

All Journal Article

[Journal Article] 進行肝細胞癌に対する化学療法の最前線2004
- Author(s)
  左近賢人, 永野浩昭, 他
- Journal Title
  
  日本内科学会雑誌 93(8)
  
  Pages: 1660-1665
- NAID
  10014292510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] 門脈腫瘍栓(Vp3)合併進行肝細胞癌に対するIFN併用肝動注化学療法2004
- Author(s)
  左近賢人, 門田守人
- Journal Title
  
  Frontiers in Gastroenterology 9(1)
  
  Pages: 90-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] Akt2 expression correlates with prognosis of human hepatocellular carcinoma.2004
- Author(s)
  Xu Xundi., Sakon M.et al.
- Journal Title
  
  Oncology Reports 11
  
  Pages: 25-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] 新しい領域-進行肝細胞癌に対する治療-2004
- Author(s)
  永野浩昭, 左近賢人, 他
- Journal Title
  
  アニムス 34
  
  Pages: 30-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] 消化器癌に対する化学療法2003
- Author(s)
  永野浩昭, 左近賢人, 他
- Journal Title
  
  癌と化学療法 30(12)
  
  Pages: 1895-1900
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] Stage IV肝癌に対する治療2003
- Author(s)
  丸橋繁, 左近賢人, 他
- Journal Title
  
  外科治療 89(2)
  
  Pages: 176-180
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] Electroporation-mediated ex vivo gene transfer into graft not requiring injection pressure in orthotopic liver transplantation.2003
- Author(s)
  Kobayashi S., Dono S., (Takahara S.), (Isaka Y.), (Imai E.), (Zhenhui L.), Nagano H., Kato T., Umeshita K., Nakamori S., Sakon M., Monden M.
- Journal Title
  
  J Gene Med 5(6)
  
  Pages: 510-517
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591404
[Journal Article] 肝細胞癌の治療方針2003
- Author(s)
  永野浩昭, 左近賢人, 他
- Journal Title
  
  コンセンサス癌治療 2(3)
  
  Pages: 140-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] 多様化する肝癌治療法. 2.外科手術の展開2003
- Author(s)
  永野浩昭, 左近賢人, 他
- Journal Title
  
  Frontiers in Gastroenterolgy 8(2)
  
  Pages: 37-44
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] II.腫瘍栓に対する治療. 2.門脈腫瘍栓合併肝細胞癌に対するinterferon α 併用動注化学療法2003
- Author(s)
  左近賢人, 永野浩昭, 他
- Journal Title
  
  外科 65(8)
  
  Pages: 901-906
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] 肝癌の化学療法2003
- Author(s)
  永野浩昭, 左近賢人, 他
- Journal Title
  
  消化器外科 26(9)
  
  Pages: 1361-1366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396
[Journal Article] インターフェロン+5-FUによる治療2003
- Author(s)
  左近賢人, 永野浩昭, 他
- Journal Title
  
  肝臓 44(6)
  
  Pages: 273-278
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390396

1. UMESHITA Koji (60252649)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
2. NAGANO Hiroaki (10294050)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
3. NAKAMORI Syoji (70294080)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. KAWASAKI Tomio (90214626)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. 上林純一 (40135687)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. DONO Keizo (60283769)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. MONDEN Morito (00127309)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
8. ARIYOSHI Hideo (60294055)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. 三好秀幸

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. OHZATO Hiroki (10273682)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. GOTOH Mitsukazu (50162160)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. MARUBASHI Shigeru (20362725)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
13. 芝英一 (90215997)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. KANEDA Yasufumi (10177537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. OHNO Yuko (60183026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. INAMURA Kiyonari (90203207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEDA Hiroshi (20127252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TESHIMA Teruki (40136049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HARAUCHI Hajime (20243256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 塩崎均 (70144475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 山本浩文 (30322184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 金俊雄 (50205051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 加藤友朗 (90324772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 笠原聡子 (30283782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 辻仲利政 (40188545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MIYOSHI Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. ARAI Isao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 欧明哲

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 横田雅之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 奥山正樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 太田博文

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 清水潤三

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

sakon masato 左近 賢人

SAKON Masato 左近 賢人

左近 賢人 サコン マサト

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The establishment of immuno-chemotherapy through the IFN-IFNAR (IFN-α receptor) signaling pathway for the intractable and advanced hepatocellular carcinomaPrincipal Investigator

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Development of a new multidisciplinary therapy for the intractable, advanced hepatocellular carcinoma, targeting the intracellular signaling molecules.Principal Investigator

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A multi-step approach for ischemia-reperfusion of the liverPrincipal Investigator

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カルパイン活性化からみた許容肝虚血時間の検討Principal Investigator

sakon masato 左近賢人

SAKON Masato 左近賢人

左近賢人サコンマサト