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KIHARA Fumiko  根岸 文子

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KIHARA

NEGISHI Fu  木原 文子

木原 文子  キハラ フミコ

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Researcher Number 40177902
Other IDs
Affiliation (Current) 2020: 帝京大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2006: Department of Pharmacology, Teikyo University, Lecturer, 薬学部・臨床薬学, 講師
2005: Hirosaki University, Department of Cell Genetics, Sasaki Institute, Research Fellow, 細胞遺伝部, 研究員
2004 – 2005: Sasaki institute, Cell Genrtics, Researcher, 細胞遺伝部, 主任研究員
2004: 財団法人 佐々木研究所, 細胞遺伝部, 主任研究員
2004: 財団法人 佐々木研究所, 細胞遺伝部, 研究員 … More
2002 – 2003: 財団法人佐々木研究所, 細胞遺伝部, 研究員
2000 – 2001: (財)佐々木研究所, 細胞遺伝部, 研究員
1999: 財団法人 佐々木研究所, 細胞遺伝部, 研究員
1999: Department of Cell Genetics, Sasaki Institute, Research Associate, 細胞遺伝部, 研究員
1998: 佐々木研究所, 細胞遺伝部, 研究員
1996 – 1997: (財)佐々木研究所, 細胞遺伝部, 研究員
1996: (財), 佐々木研究所, 研究員
1995: 財団法人佐々木研究所, 細胞遺伝部, 研究員
1989: 東京大学, 医科学研究所, 教務職員 Less
Review Section/Research Field
Principal Investigator
Developmental biology / Experimental pathology / Hematology
Except Principal Investigator
Hematology / Experimental pathology / Hematology / Biological pharmacy
Keywords
Principal Investigator
PU.1 / 分化 / 胚性腫瘍細胞 / 転写因子 / 赤白血病 / 転写調節 / 赤白血球 / リン酸化 / アセチル化 / 血液細胞分化 … More / 白血病 / phosphorylation / acetylation / hematonietic cell differentiation / leukemia … More
Except Principal Investigator
PU.1 / アポトーシス / 細胞分化 / 細胞増殖 / 分化 / apoptosis / 白血病 / 転写因子 / Ets / がん遺伝子 / MSSP / C-MYC / AMY-1 / transcription factor / CBP / マウス赤白血病(MEL) / PU.l / 血球分化 / Elf-1 / HoxC13 / hematopoiesis / Ets-1 / Gfi-1 / SV40 / アデノウイルス / Rb遺伝子 / エピトープタグ / 核局在性 / cDNAライブラリー / マウス / Etsがん遺伝子 / Spi-1 / 複製 / 転写 / 細胞周期 / 酵母 / DNA結合タンパク / DNAポリメラーゼ / DNAポリメラーゼα / 核移行阻止 / REPLICATION / TRANSCRIPTION / CELL CYCLE / YEAST / DNA BINDING PROTEINS / 細胞融合 / 雑種細胞 / 遺伝子発現 / T細胞 / TCR / lck / ネガティブ制御 / Etsファミリー / B細胞 / cell fusion / hybrids / gene expression / extinction / HDAC / 白血球 / leukemia / differentiation / Ets family / oncogene / GATA-1 / 赤白血病 / Diffrential Display法 / Defferential Display法 / 赤白血球 / Differential Display(DD)法 / erythroleukemia / cell differentiation / Differential Display / 分化の抑制 / 分化のスイッチ / CKLiKi遺伝子 / CKLiK遺伝子 / murine erythroleukemia (MEL) / differentiation inhibition / lineage switch / CKLiK gene / CKLiK / calcium-calmodulin-dependent kinase I-like kinase (CKLiK) / murine erythroleukemia(MEL) / cell growth / Etsファミリー転写因子 / ホメオドメイン蛋白質 / 機能的相互作用 / 物理的相互作用 / 物理酌相互作用 / Ets family transcription factors / homeodomain proteins / functional interaction / physical interaction / クロストーク / Gfi-1B / 骨髄球 / 赤血球 / 増殖 / bax / transcription factors / ETS / GfilB / cross-talk Less
  • Research Projects

    (14 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (17 People)
  •  Cross-talks between ETS and GFI family of transcription factors in hematopoietic cell differentiation

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Health Sciences University of Hokkaido
      Sasaki Institute
  •  Functional roles of interaction between Ets family transcription factors and homeodomain proteins.

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hirosaki University
      Sasaki Institute
  •  The effects of phosphorylation and acetylation-mediated modification on functional activity of PU.12Principal Investigator

    • Principal Investigator
      NEGISHI Fumiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki institute
  •  Isolation and identification of the gene induced by Ets family transcription factor PU.1 in murine erythroleukemia cells

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  Analysis of mechanisms of the differentiation inhibition in erythroid cells induced by Ets transcription factor PU. I

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  PU.1 過剰発現による赤白血病細胞の分化阻害とアポトーシス誘導の分子機構

    • Principal Investigator
      及川 恒之
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Sasaki Institute
  •  PU.1による赤白血病細胞文化の阻害の分子機構の解析Principal Investigator

    • Principal Investigator
      根岸 文子
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  Molecular Mechanisms of Inhibition of Erythroid Differentiation by Overexpression of Ets Family Oncogenes in MEL cells

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  Isolation of the genes involved in the process of differentiation inhibition and apoptosis induced by PU.1 in murine erythroleukemia cells

    • Principal Investigator
      YAMADA Toshiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Sasaki Institute
  •  赤血球系細胞の増殖・分化・アポトーシスに関わるetsファミリーがん遺伝子

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Sasaki Institute
  •  Extinction of hematopoietic specific transcription factor genes in cell hybrids between hematopoietic and non-hematopoietic cells

    • Principal Investigator
      OIKAWA Tsuneyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Sasaki Institute
  •  未分化胚性腫瘍細胞特異的転写調節因子の解析Principal Investigator

    • Principal Investigator
      根岸 文子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Sasaki Institute
  •  MOLECULAR MECHANISMS OF THE CELL CYCLE REGULATION BY REPLICATION/TRANSCRIPTION FACTORS,MSSP

    • Principal Investigator
      ARIGA Sanae
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  SV40T抗原による細胞遺伝子発現の変化

    • Principal Investigator
      菅野 純夫
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

All 2007 2006 2005 Other

All Journal Article

  • [Journal Article] Cooperative interaction between ETSl and GFI1 transcription factors in the repression of Bax gene expression2007

    • Author(s)
      Nakazawa Y, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 26

      Pages: 3541-3550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression2007

    • Author(s)
      Nakazawa Y, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 26(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Negative cross-talk between hematopoietic transcription factors PU.1 and Gfi-1B2007

    • Author(s)
      Manabe N, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene (subumitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.l and Dnmt3a/b2006

    • Author(s)
      Suzuki M, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 25

      Pages: 2477-2488

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b2006

    • Author(s)
      Suzuki M, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene 25

      Pages: 2477-2488

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.l in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Classification of neural differentiation-associated genes in P19 embryonic carcinoma cells2005

    • Author(s)
      Teramoto S, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncol. Rep. 14

      Pages: 1231-1238

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Ets family of transcription factors in normal hematopoiesis and in leukemogenesis (Review)2005

    • Author(s)
      Oikawa T, Kihara-Negishi F. et al.
    • Journal Title

      In "Molecular Genetics of Cancer".(ed by Sinnet D.)( Research Signpost, India)

      Pages: 119-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Ets family of transcription factors in normal hematopoiesis and in leukemogenesis2005

    • Author(s)
      Oikawa T, Kihara-Negishi F. et al.
    • Journal Title

      Molecular Genetics of Cancer Book

      Pages: 119-148

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 477-484

    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Impaired represser activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590967
  • [Journal Article] Ets family of transcription factros in normal hematopoiesis and in leukemogenesis.2005

    • Author(s)
      Oikawa T, Yamada T, Kihara-Negishi F, Sakurai T.
    • Journal Title

      Molecular Genetics of Cancer Research Signpost

      Pages: 119-148

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motif2005

    • Author(s)
      Kihara=NeEgishi F, Oikawa T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment.2005

    • Author(s)
      Teramoto S, Kihara-Negishi F, Sakurai T, Yamada T, Oikawa Y.
    • Journal Title

      Oncol.Rep. 14

      Pages: 1231-1238

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acethylation motifs within the ETS domain.2005

    • Author(s)
      Kihara-Negishi F, Suzuki M, Yamada T, Sakurai T, Oikawa T.
    • Journal Title

      Biochem.Biophys.Res.Com. 335

      Pages: 477-484

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b.2005

    • Author(s)
      Suzuki M, Yamada T, Kihara-Negishi F, Tenen DG, Hozumi N, Oikawa T.
    • Journal Title

      Oncogene

    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Impaired repressor activity and biological functions of PU. 1 in MEL cells induced by mutations in the acetylation motif2005

    • Author(s)
      Kihara=Negishi F, Oikawa T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 335

      Pages: 477-484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • [Journal Article] Negative cross-talk between hematopoietic transcription factors PU.1 and GFi-lB

    • Author(s)
      Manabe N, Kihara-Negishi F, Oikawa T. et al.
    • Journal Title

      Oncogene, submitted

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591019
  • 1.  YAMADA Toshiyuki (20183981)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  YAMAMOTO Hitomi (30290977)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  OIKAWA Tsuneyuki (80150241)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 15 results
  • 4.  ARIGA Sanae (90184283)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KITAURA Hirotake (10281817)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ARIGA Hiroyoshi (20143505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KONDOH Nobuo (40202072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  OHTA Toru (10223835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  菅野 純夫 (60162848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  余郷 嘉明 (60092376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  山口 宣生 (90012723)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  鈴木 光浩 (00321662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  GALLI Ivo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  WANG Teresa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  WANG Teresa S.-F.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  IVO Galli
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TERESA S.ーF.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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