TOYO'OKA Toshimasa 豊岡利正

… Alternative Names

豊岡利正トヨオカトシマサ

TOYOOKA Toshimasa 豊岡利正

TOYO-OKA Toshimasa 豊岡利正

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Researcher Number	40183496
Other IDs
External Links
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 特任教授
Affiliation (based on the past Project Information) *help	2017: 静岡県立大学, 薬学部, 特任教授 2012 – 2016: 静岡県立大学, 薬学部, 教授 2010: University of Shizuoka, 薬学部, 教授 2008 – 2009: University of Shizuoka, 教授 2001 – 2006: 静岡県立大学, 薬学部, 教授 1995 – 1999: 静岡県立大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator General surgery / 広領域
Keywords	Principal Investigator 液体クロマトグラフィー / 質量分析 / ESI-TOF-MS / Endo-M / キャピラリー電気泳動 / Liquid chromatography / ペプチド / D / 質量分析法 / 疾病診断 … More / バイオマーカー探索 / 光学活性誘導体化試薬 / 蛍光分析 / バイオマーカー / 光学活性代謝物 / 疾病バイオマーカー / 非侵襲的試料解析 / 非侵襲的試料 / Two dimensional HPLC / Ovalbumin / Fluorescence acceptor / Transglycosylation reaction / Oligosaccharide analysis / キャピラリー電気泳道 / TOF-MS / 糖転移酵素 / 二次元液体クロマトグラフィー / オボアルブミン / 蛍光受容体 / 糖転移反応 / 糖鎖構造解析 / Plasma analysis / HPLC / Biogenic amine / Drugs / Mass spectrometry / Fluorescence label / Hair analysis / 光学異性体 / プロプラノロール / β-遮断薬 / 医薬品分析 / 毛根分析 / 蛍光検出 / 幻覚麻薬成分 / 血漿分析 / 薬物分析 / 蛍光標識 / 生体成分分析 / 毛髪分析 / Biologically important metals / Chelete formation / Transition metal cations / Fluorescence probes / Fluorescence resonance energy transfer / 亜鉛 / キレート形成 / 重金属 / 生体内金属 / 金属蛍光プローブ / 蛍光共鳴エネルギー移動 / Bioactive thiols / D,L-Amino acids / Ar laser He-Cd laser / Functional group analysis / Laser-induced fluorescence detection / HPCE / 生理活性物質 / ダイオードレーザー / チオール / アミノ酸 / ヘリウム-カドミウムレーザー / キャピラリ電気泳動 / アルゴンレーザー / 生理活性チオール / DL-アミノ酸 / ヘリウムーカドミウムレーザー / 官能基分析 / レーザー蛍光検出 / Fluorescence analysis / Diastereomer / Peptide / Chiral Edman degradation / L-Amino Acid / Chiral derivatization reagent / D,L-アミノ酸配列分析 / キラルエドマン法 / ジアステレオマ- / L-アミノ酸分析 / 光学活性蛍光標識化試薬 / 光学活性アミン / 光学活性カルボン酸 / 光学活性アミノ酸 / キラルメタボロミクス / 誘導体化 / 高感度特異的分析 / キラル誘導体化 / 光学異性体分析 / 違法ドラッグ / 電気化学分析 / 指定薬物 … More Except Principal Investigator ポリアミン / 乳癌 / labeling reagent / dehydrogenase / bacteria / oxidase / racemase / biosynthesis / mammals / D-amino acid / 標識試薬 / 脱水素酵素 / 細菌 / 酸化酵素 / ラセマーゼ / 生合成 / 哺乳類 / D-アミノ酸 Less

Diagnostic approach of diseases using non-invasive biosamples (saliva, hair and nail)Principal Investigator
- Principal Investigator
  
  Toyo'oka Toshimasa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Diagnostic approach to breast cancer patients based on target metabolomics in saliva
- Principal Investigator
  
  Toyama Tatsuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagoya City University
Synthesis of interigent derivatization reagents and discovery of disease-related biomarkers based on chiral metabolome analysisPrincipal Investigator
- Principal Investigator
  
  TOYO'OKA Toshimasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Scientific research of evidence-based prevention of illegal drug of abusePrincipal Investigator
- Principal Investigator
  
  TOYOOKA Toshimasa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Study of highly sensitive determination of oligosaccharides by enzymic transglycosylation reactionPrincipal Investigator
- Principal Investigator
  
  TOYO'OKA Toshimasa
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Separation and resolution of bioactive compounds, such as drug, utilizing hair roots as a specimenPrincipal Investigator
- Principal Investigator
  
  TOYO'OKA Toshimasa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of Fluorescence Probes for Transition Metal Cations, based upon Fluorescence Resonance Energy TransferPrincipal Investigator
- Principal Investigator
  
  TOYOOKA Toshimasa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Extensive research on D-amino acids present in mammals
- Principal Investigator
  
  IMAI Kazuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  The Universityof Tokyo
Development of Selective Analysis for Individual Functional Groups by High-performance Capillary Electrophoresis (HPCE) with Laser-induced Fluorescence (LIF) DetectionPrincipal Investigator
- Principal Investigator
  
  TOYO'OKA Toshimasa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of Chiral Edman Degradation Method and Sequential Analysis of D/L-Amino Acid (s) in PeptidePrincipal Investigator
- Principal Investigator
  
  TOYO-OKA Toshimasa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka

All 2017 2016 2015 2014 2013 2012 2010 2009 2008 2007 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Chapter 14, Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC. Chiral Separations: Methods and Protocols, 2nd Ed. Methods in Molecular Biology, Vol. 9702013
- Author(s)
  Toshimasa Toyo'oka
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-24590055
[Book] Amino Acid Analysis, Methods and Protocols, Methods in Molecular Biology2012
- Author(s)
  Shinsuke Inagaki, Toshimasa Toyo'oka
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-24590055
[Journal Article] The great importance of normalization of LC-MS data for highly-accurate non-targeted metabolomics.2017
- Author(s)
  Mizuno H, Ueda K, Kobayashi Y, Tsuyama N, Todoroki K, Min JZ, Toyo'oka T.
- Journal Title
  
  Biomed Chromatogr.
  
  Volume: 31 Issue: 1 Pages: 1-7
- DOI
  10.1002/bmc.3864
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00543, KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-16K21276, KAKENHI-PROJECT-16K08200
[Journal Article] Derivatization-based High-throughput Bioanalysis by LC-MS2017
- Author(s)
  Toyo'oka Toshimasa
- Journal Title
  
  Anal. Sci.
  
  Volume: 33 Issue: 5 Pages: 555-564
- DOI
  10.2116/analsci.33.555
- NAID
  130006777385
- ISSN
  0910-6340, 1348-2246
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07895
[Journal Article] Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.2016
- Author(s)
  Takayama T, Tsutsui H, Shimizu I, Toyama T, Yoshimoto N, Endo Y, Inoue K, Todoroki K, Min JZ, Mizuno H, Toyo'oka T.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 452 Pages: 18-26
- DOI
  10.1016/j.cca.2015.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10060, KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-16K08200
[Journal Article] Diagnostic Approach to Disease Using Non-invasive Samples Based on Derivatization and LC-ESI-MS/MS2016
- Author(s)
  Toshimasa Toyo'oka
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 9 Pages: 1397-1411
- DOI
  10.1248/bpb.b16-00453
- NAID
  130005262298
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895
[Journal Article] Dried saliva spot (DSS) as a convenient and reliable sampling for bioanalysis: An application for the diagnosis of diabetes mellitus2016
- Author(s)
  Masahiro Numako, Takahiro Takayama, Ichiro Noge, Yutaka Kitagawa, Kenichiro Todoroki, Hajime Mizuno, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytical Chemistry
  
  Volume: 88 Issue: 1 Pages: 635-639
- DOI
  10.1021/acs.analchem.5b04059
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-16K08200
[Journal Article] Determination of creatinine-related molecules in saliva by reversed-phase liquid chromatography with tandem mass spectrometry and the evaluation of hemodialysis in chronic kidney disease patients2016
- Author(s)
  Mayu Suzuki, Mitsuyoshi Furuhashi, Shogo Sesoko, Kazuhiro Kosuge, Toshio Maeda, Kenichiro Todoroki, Koichi Inoue, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 911 Pages: 92-99
- DOI
  10.1016/j.aca.2016.01.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-16K08200
[Journal Article] First observation of N-acetyl leucine and N-acetyl isoleucine in diabetic patient hair and quantitative analysis by UPLC-ESI-MS/MS2015
- Author(s)
  Jun Zhe Min, Yuki Tomiyasu, Takashi Morotomi, Ying-Zi Jiang, Gao Li, Qing Shi, Hai-fu Yu, Koichi Inoue, Kenichiro Todoroki, Toshimasa Toyo'oka
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 444 Pages: 143-148
- DOI
  10.1016/j.cca.2015.02.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-25460040, KAKENHI-PROJECT-26713021
[Journal Article] Profiling of chiral and achiral carboxylic acid metabolomics: Synthesis and evaluation of triazine-type chiral derivatization reagents for carboxylic acids by LC-ESI-MS/MS and the application to saliva of healthy volunteers and diabetic patients2015
- Author(s)
  Takahiro Takayama, Tomohiro Kuwabara, Toshio Maeda, Ichiro Noge, Yutaka Kitagawa, Koichi Inoue, Kenichiro Todoroki, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 407 Issue: 3 Pages: 1003-1014
- DOI
  10.1007/s00216-014-8275-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-25460040
[Journal Article] Human nails metabolite analysis: A rapid and simple method for quantification of uric acid in human fingernail by high-performanceliquid chromatography with UV-detection2015
- Author(s)
  Xi-Ling Li, Gao Li, Ying-Zi Jiang, Dongzhou Kang, Cheng Hua Jin, Qing Shi,Toufeng Jin, Koichi Inoue, Kenichiro Todoroki, Toshimasa Toyo'oka, Jun Zhe Min
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 1002 Pages: 394-398
- DOI
  10.1016/j.jchromb.2015.08.044
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-25460040, KAKENHI-PROJECT-26713021
[Journal Article] A novel approach for LC-MS/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents2015
- Author(s)
  Takahiro Takayama, Toshiki Mochizuki, Kenichiro Todoroki, Jun Zhe Min,Hajime Mizuno, Koichi Inoue, Hiroyasu Akatsu, Ichiro Noge, Toshimasa Toyo'oka
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 898 Pages: 73-84
- DOI
  10.1016/j.aca.2015.10.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-25460040, KAKENHI-PROJECT-25461777
[Journal Article] Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis2015
- Author(s)
  Koichi Inoue, Hirofumi Tsuchiya, Takahiro Takayama, Hiroyasu Akatsu,Yoshio Hashizume, Takayuki Yamamoto, Noriyuki Matsukawa, Toshimasa Toyo'oka
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 974 Pages: 24-34
- DOI
  10.1016/j.jchromb.2014.10.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-24590061, KAKENHI-PROJECT-25461777
[Journal Article] Towards the chiral metabolomics: Liquid chromatography-mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers2015
- Author(s)
  Toshiki Mochizuki, Takahiro Takayama, Kenichiro Todoroki, Koichi Inoue, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 875 Pages: 73-82
- DOI
  10.1016/j.aca.2015.02.054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-25460040
[Journal Article] Evaluation of a series of prolylamidepyridine as the chiral derivatization reagents for enantioseparation of carboxylic acids by LC-ESI-MS/MS and the application to human saliva2014
- Author(s)
  Tomohiro Kuwabara, Takahiro Takayama, Kenichiro Todoroki, Koichi Inoue, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 406 Issue: 11 Pages: 2641-2649
- DOI
  10.1007/s00216-014-7637-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-25460040
[Journal Article] Isotopic variants of light and heavy L-pyroglutamic acid succinimidyl esters as the derivatization reagents for DL-amino acid chiral metabolomics identification by liquid chromatography and electrospray ionization mass spectrometry2014
- Author(s)
  Toshiki Mochizuki, Kenichiro Todoroki, Koichi Inoue, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 811 Pages: 51-59
- DOI
  10.1016/j.aca.2013.12.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-25460040
[Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.2014
- Author(s)
  Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T.
- Journal Title
  
  Anal Chem.
  
  Volume: ８６ Issue: 1 Pages: 797-804
- DOI
  10.1021/ac403315h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24590055
[Journal Article] HPLC enantioseparation of α,α-diphenyl-2- pyrrolidinemethanol and methylphenidate using a chiral fluorescent derivatization reagent and its application to the analysis of rat plasma.2010
- Author(s)
  Shinsuke Inagaki, Sayuri Taniguchi, Haruo Hirashima, Tatsuya Higashi, Jun Zhe Min, Ruri Kikura-Hanajiri, Yukihiro Goda, Toshimasa Toyo'oka
- Journal Title
  
  J.Sep.Sci. 33
  
  Pages: 3137-3143
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Simultaneous and group determination methods for designated substances by HPLC with multi-channel electrochemical detection and their application to real samples.2010
- Author(s)
  Jun Zhe Min, Kazuhide Yamashita, Toshimasa Toyo'oka, Shinsuke Inagaki, Tatsuya Higashi, Ruri Kikura-Hanajiri, Yukihiro Goda
- Journal Title
  
  Biomed.Chromatogr. 24
  
  Pages: 1287-1299
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Rapid, sensitive and simultaneous determination of fluorescence-labeled designated substances controlled by the Pharmaceutical Affairs Law in Japan by ultra-performance liquid chromatography coupled with electrospray-ionization time of flight mass spectrometry.2009
- Author(s)
  Jun Zhe Min, Suguru Hatanaka, Toshimasa Toyo'oka, Shinsuke Inagaki, Ruri Kikura-Hanajiri, Yukihiro Goda
- Journal Title
  
  Anal.Bioanal.Chem. 395(5)
  
  Pages: 1411-1422
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Rapid detection of ketamine and norketamine in rat hair using micropulverized extraction and ultra-performance liquid chromatography. electrospray ionization mass spectrometry.2009
- Author(s)
  Shinsuke Inagaki, Hatsune Makino, Takeshi Fukushima, Jun Zhe Min, Toshimasa Toyo'oka
- Journal Title
  
  Biomed.Chromatogr. 23(12)
  
  Pages: 1245-1250
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Simultaneous determination of 11 designated hallucinogenic phenethylamines by ultra-fast liquid chromatography with fluorescence detection.2008
- Author(s)
  Jun Zhe Min, Yoshiha Shimizu, Toshimasa Toyo'oka, Shinsuke Inagaki, Ruri Kikura-Hanajiri, Yukihiko Goda
- Journal Title
  
  J.Chromatogr.B 873
  
  Pages: 187-194
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Determination methods for biologically active compounds by ultra-performance liquid chromatography coupled . . .2008
- Author(s)
  Toshimasa Toyo'oka
- Journal Title
  
  Journal of Chromatographic Science 46
  
  Pages: 233-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590038
[Journal Article] Fully automated two-dimensional high-performance liquid chromatography with time-of-fight mass spectrometry for …2007
- Author(s)
  J.Z.Min, T.Toyo'oka, T.Kurihara, M.Kato, T.Fukushima, S.Inagaki
- Journal Title
  
  Journal of Chromatography A (In press)
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Determination of oligosaccharides in glycopeptides using immobilized Endo-M and ultra-performance liquid chromatography with ……2007
- Author(s)
  J.Z.Min, T.Toyo'oka, T.Kurihara, M.Kato, T.Fukushima, S.Inagaki
- Journal Title
  
  Biomedical Chromatography (In press)
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Determination of oligosaccharides in glycopeptides using immobilized Endo-M and ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry.2007
- Author(s)
  J.Z.Min, T.Toyo'oka, T.Kurihara, M.Kato, T.Fukushima.
- Journal Title
  
  Biomedical Chromatography (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Fully automated two-dimensional high-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry for the determination of oligosaccharides in glycopeptides after enzymic fluorescence labeling.2007
- Author(s)
  J.Z.Min, T.Toyo'oka, T.Kurihara, T.Fukushima, S.Inagaki.
- Journal Title
  
  Journal of Chromatography A (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Novel fluorescent asparaginyl-N-acetyl-D-glucosamines (Asn-GlcNAc) for the resolution of oligosaccharides in glycopeptides, based on enzyme transglycosylation reaction.2005
- Author(s)
  J.Z.Min, T.Toyo'oka, H.Kawanishi, T.Fukushima, M.Kato.
- Journal Title
  
  Analytica Chimica Acta 550
  
  Pages: 173-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Fluorescent chiral derivatization reagents possessing benzofurazan structure for the resolution of optical isomers in HPLC: The synthesis, characteristics and application2005
- Author(s)
  Toyo'oka, Toshimasa
- Journal Title
  
  Current Pharmaceutical Analysis 1
  
  Pages: 57-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590047
[Journal Article] Resolution of N-linked oligosaccharides in glycoproteins based upon transglycosylation reaction by CE-TOF-MS.2005
- Author(s)
  J.Z.Min, T.Toyo'oka, M.Kato, T.Fukushima.
- Journal Title
  
  Chemical Communication
  
  Pages: 3484-3486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Novel fluorescent asparaginyl-N-acetyl-D-glucosamines (Asn-G1uNAc) for the resolution of oligosaccharides in glycopeptides, ・・・・・・.2005
- Author(s)
  J.Z.Min, T.Toyo'oka, H.Kawanishi, T.Fukushima, M.Kato
- Journal Title
  
  Analytica Chimica Acta 550
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Resolution of N-linked oligosaccharides in glycoproteins based upon transglycosylation reaction by CE-TOF-MS2005
- Author(s)
  J.Z.Min, T.Toyo'oka, M.Kato, T.Fukushima
- Journal Title
  
  Chemical Communication
  
  Pages: 3484-3486
- Data Source
  KAKENHI-PROJECT-17590037
[Journal Article] Hair analysis of histamine after fluorescence labeling by column-switching reversed-phase liquid chromatography with electrospray ionization mass spectrometry.2004
- Author(s)
  Toyo'oka Toshimasa, et al.
- Journal Title
  
  Analytical Biochemistry 333
  
  Pages: 236-245
- Data Source
  KAKENHI-PROJECT-15590047
[Journal Article] Hair analysis of histamine after fluorescence labeling by column-switching reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair.2004
- Author(s)
  Toyo'oka Toshimasa, et al.
- Journal Title
  
  Analytical Biochemistry 333
  
  Pages: 236-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590047
[Journal Article] Hair analysis of histamine after fluorescence labeling by column-switching reversed-phase liquid chromatography with electrospray ionization mass spectrometry and application to human hair2004
- Author(s)
  Toyo'oka, Toshimasa et al.
- Journal Title
  
  Analytical Biochemistry 333
  
  Pages: 236-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590047
[Journal Article] Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma, by reversed-phase liquid-chromatography with electrospray ionization mass spectrometry.2003
- Author(s)
  Toyo'oka Toshimasa, et al.
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 30
  
  Pages: 1773-1787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590047
[Journal Article] Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid chromatography with electrospray ionization mass spectrometry2003
- Author(s)
  Toyo'oka, Toshimasa et al.
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 30
  
  Pages: 1773-1787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590047
[Presentation] 簡易糖尿病診断を目的とした蛍光検出法による唾液中DL-乳酸の測定2017
- Author(s)
  沼子将大、高山卓大、轟木堅一郎、水野初、閔俊哲、豊岡利正
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 唾液中ポリアミン安定化法の開発と乳がん診断法への応用2017
- Author(s)
  鈴木安希子、高山卓大、清水逸平、轟木堅一郎、水野初、閔俊哲、豊岡利正
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 12C/13Cキラル誘導体化試薬を併用した高精度キラルメタボロミクスの開発2017
- Author(s)
  高山卓大、轟木堅一郎、水野初、閔俊哲、豊岡利正
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] アミノ酸キラル分析を指向した新規キラル誘導体化試薬の開発とその分離挙動解析2017
- Author(s)
  柳澤拓摩、高山卓大、轟木堅一郎、水野初、閔俊哲、豊岡利正
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 誘導体化法によるアミノ酸の光学異性体一斉分離法の開発2017
- Author(s)
  高山卓大、柳澤拓摩、水野　初、豊岡利正、轟木堅一郎
- Organizer
  第24回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 3種同位体標識誘導体化試薬を組み合わせた迅速かつ高精度なキラルメタボロミクスの開発2017
- Author(s)
  福井芹菜、高野大貴、高山卓大、水野　初、豊岡利正、轟木堅一郎
- Organizer
  第30回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 誘導体化法を基盤とするバイオアナリシス研究　―アミノ酸の光学異性体分析を中心に―2016
- Author(s)
  豊岡利正
- Organizer
  新アミノ酸分析研究会第6回学術講演会
- Place of Presentation
  東京大学
- Year and Date
  2016-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] Diagnostic approach for diabetes mellitus using Dried Saliva Spot (DSS) by UPLC-MS/MS2016
- Author(s)
  Toshimasa Toyo'oka, Masahiro Numako, Takahiro Takayama, Kenichiro Todoroki, Hajime Mizuno, Jun Zhe Min
- Organizer
  31st Internal Symposium on Chromatography (ISC 2016)
- Place of Presentation
  University College Cork, Ireland
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 非侵襲的試料を用いた疾病診断2016
- Author(s)
  豊岡利正
- Organizer
  第76回分析化学討論会
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2016-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 生体機能性分子の高感度・特異的分析法の開発とバイオアナリシスへの展開2016
- Author(s)
  豊岡利正
- Organizer
  日本分析化学会第65年会
- Place of Presentation
  北海道大学
- Year and Date
  2016-09-14
- Invited
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] カルボン酸分離分析用の安定同位体含有光学活性誘導体化試薬の合成と評価2015
- Author(s)
  宇野馨、高山卓大、轟木堅一郎、水野初、閔俊哲、豊岡利正
- Organizer
  第26回クロマトグラフィー科学会議
- Place of Presentation
  九州大学
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 誘導体化LC―MS/MS測定法による光学活性代謝物の網羅的エナンチオマー分別分析法の開発と応用2015
- Author(s)
  高山卓大、井之上浩一、轟木堅―郎、水野初、閔俊哲、豊岡利正
- Organizer
  第28回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎大学
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] LC-MS/MS用光学活性誘導体化試薬の創製とキラルメタボロミクスへの適用2015
- Author(s)
  豊岡利正
- Organizer
  第22回クロマトグラフィーシンポジウム
- Place of Presentation
  近畿大学
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] 唾液を用いた簡便な乳がん診断法の開発2015
- Author(s)
  高山卓大、遠山竜也、吉本信保、遠藤友美、水野初、井之上浩-、轟木堅一郎、閔俊哲、豊岡利正
- Organizer
  第26回クロマトグラフィー科学会議
- Place of Presentation
  九州大学
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-15K07895
[Presentation] LC-MS/MS分析を目的としたカルボン酸標識用キラル誘導体化試薬の開発2013
- Author(s)
  桑原朋大、森田真介、長尾竜治、閔　俊哲、轟木堅一郎、井之上浩一、豊岡利正
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性カルボキシル化合物のLC-MS/MS分析用光学活性誘導体化試薬の開発および生体試料への応用2013
- Author(s)
  高山卓大、桑原朋大、閔俊哲、井之上浩一、轟木堅一郎、豊岡利正
- Organizer
  第24回クロマトグラフィー科学会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性アミン・アミノ酸を標的とした L-Pyroglutamic acid 活性エステル型キラル誘導体化試薬の開発2013
- Author(s)
  望月俊樹、閔　俊哲、井之上浩一、轟木堅一郎、豊岡利正
- Organizer
  第26回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] トリアジン構造を有する光学活性誘導体化試薬の開発とLC-MS/MS分析2013
- Author(s)
  高山卓大、桑原朋大、長尾竜治、閔俊哲、井之上浩一、轟木堅一郎、豊岡利正
- Organizer
  日本分析化学会第62年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 非侵襲的試料を用いた疾病診断2013
- Author(s)
  豊岡利正
- Organizer
  第44回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  浜松
- Invited
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] アルツハイマー病脳のLC-MSによるメタボローム解析2013
- Author(s)
  筒井陽仁、井之上浩一、赤津裕康、橋詰良夫、松川則之、山本孝之、豊岡利正
- Organizer
  第26回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性アミンを標的としたキラル誘導体化試薬の開発とキラルメタボロミクスへの展開2013
- Author(s)
  望月俊樹、谷口さゆり、筒井陽仁、閔　俊哲、轟木堅一郎、井之上浩一、豊岡利正
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性アミンを標的としたLC-MS/MS用キラル誘導体化試薬としてのL-Pyroglutamic acid2012
- Author(s)
  望月俊樹、谷口さゆり、閔　俊哲、轟木堅一郎、井之上浩一、豊岡利正
- Organizer
  日本分析化学会第61年会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 生体内光学活性カルボン酸の分離分析に応用可能なLC/ESI-MS/MS用誘導体化試薬の開発2012
- Author(s)
  桑原朋大、森田真介、長尾竜治、閔　俊哲、轟木堅一郎、井之上浩一、豊岡利正
- Organizer
  日本分析化学会第61年会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] チオウレア構造を有するLC/ESI-MS/MSキラル誘導体化試薬の開発2012
- Author(s)
  長尾竜治、閔　俊哲、井之上浩一、轟木堅一郎、豊岡利正
- Organizer
  第22回クロマトグラフィー科学会議
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 合田幸広:Diphenyl-2-pyrrolidine methanolおよびmethylphenidateの光学異性体分離2010
- Author(s)
  平島晴生、谷口さゆり、稲垣真輔、東達也、閔俊哲、豊岡利正、花尻瑠璃
- Organizer
  第17回クロマトグラフィーシンポジウム、講演要旨集、p.65-66
- Place of Presentation
  広島
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] 合田幸広:HPLC-蛍光検出による光学異性体を含む指定薬物の一斉分析法の開発2010
- Author(s)
  平島晴生、谷口さゆり、稲垣真輔、東達也、閔俊哲、豊岡利正、花尻瑠理
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010、講演要旨集、p.123
- Place of Presentation
  静岡
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] 合田幸広:HPLC-電気化学検出法を用いたデザイナードラッグの簡便かつ高感度な分析法の開発2009
- Author(s)
  山下和秀、閔俊哲、豊岡利正、稲垣真輔、東達也、花尻瑠理
- Organizer
  日本分析化学会第58年会、講演要旨集、p.86
- Place of Presentation
  札幌
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] 合田幸広:HPLC-クーロアレイ検出器(CAD)による指定薬物の高感度一斉分析法の開発2009
- Author(s)
  山下和秀、閔俊哲、豊岡利正、稲垣真輔、花尻瑠理
- Organizer
  日本薬学会第129年会、要旨集4、p.96
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] 合田幸広:UPLC-ESI-TOF-MSによる蛍光標識化指定薬物の高感度迅速一斉分析法の開発2008
- Author(s)
  閔俊哲、畠中俊、豊岡利正、稲垣真輔、花尻瑠理
- Organizer
  第19回クロマトグラフィー科学会議、講演要旨集、p.63-64
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] 合田幸広:UFLC-蛍光法によるフェネチルアミン系指定薬物の高感度一斉分離検出法の開発2008
- Author(s)
  閔俊哲、清水芳羽、豊岡利正、稲垣真輔、花尻瑠理
- Organizer
  第15回クロマトグラフィーシンポジウム、講演要旨集、p.135-136
- Place of Presentation
  静岡
- Year and Date
  2008-05-31
- Data Source
  KAKENHI-PROJECT-20590038
[Presentation] ノンターゲットキラルメタボロミクスの測定戦略
- Author(s)
  望月俊樹、高山卓大、井之上浩一、轟木堅一郎、閔俊哲、豊岡利正
- Organizer
  第25回クロマトグラフィー科学会議
- Place of Presentation
  京都
- Year and Date
  2014-12-11 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] UHPLC-MSを用いたアルツハイマー病の標的プロテオミクス/メタボロミクス統合解析
- Author(s)
  山本誠、井之上浩一、赤津裕康、松川則之、橋詰良夫、山本孝之、豊岡利正
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性誘導体化試薬light/heavy-DMT-3(S)-Apyを用いた唾液中キラルカルボン酸メタボロミクス
- Author(s)
  高山卓大、前田利男、野毛一郎、北川　裕、轟木堅一郎、井之上浩一、閔俊哲、豊岡利正
- Organizer
  日本分析化学会第63年会
- Place of Presentation
  広島
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] 光学活性誘導体化試薬DMT-3(S)-Apyを用いた唾液中カルボン酸メタボロミクスのLC-ESI-MS/MS分析
- Author(s)
  高山卓大、桑原朋大、前田利男、野毛一郎、北川裕、井之上浩一、轟木堅一郎、豊岡利正
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] LC-MSによるメタボロミクス測定技術の食品分析・病態解析への適用
- Author(s)
  豊岡利正
- Organizer
  日本食品科学工学会第61回大会
- Place of Presentation
  福岡
- Year and Date
  2014-08-28 – 2014-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-24590055
[Presentation] キラルメタボロミクスを指向したLC-ESI-MS/MS用新規キラル誘導体化試薬を用いた生体試料中DL-アミノ酸分析
- Author(s)
  望月俊樹、高山卓大、轟木堅一郎、井之上浩一、閔俊哲、豊岡利正
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590055

1. IMAI Kazuhiro (50012620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. ESAKI Nobuyosi (50135597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ASANO Yasuhisa (00222589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGATA Yoko (00164442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MISONO Haruo (30027073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Toyama Tatsuya (30315882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 金野柳一 (30129043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 香川靖雄 (30048962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岩坪威 (50223409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉本信保 (10551244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 遠藤友美 (20566228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. AKATSU Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 津山尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOYO'OKA Toshimasa 豊岡 利正

豊岡 利正 トヨオカ トシマサ

TOYOOKA Toshimasa 豊岡 利正

TOYO-OKA Toshimasa 豊岡 利正

Research Projects

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Co-Researchers

Diagnostic approach of diseases using non-invasive biosamples (saliva, hair and nail)Principal Investigator

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Diagnostic approach to breast cancer patients based on target metabolomics in saliva

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Synthesis of interigent derivatization reagents and discovery of disease-related biomarkers based on chiral metabolome analysisPrincipal Investigator

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Scientific research of evidence-based prevention of illegal drug of abusePrincipal Investigator

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Study of highly sensitive determination of oligosaccharides by enzymic transglycosylation reactionPrincipal Investigator

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Separation and resolution of bioactive compounds, such as drug, utilizing hair roots as a specimenPrincipal Investigator

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Development of Fluorescence Probes for Transition Metal Cations, based upon Fluorescence Resonance Energy TransferPrincipal Investigator

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Extensive research on D-amino acids present in mammals

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Development of Selective Analysis for Individual Functional Groups by High-performance Capillary Electrophoresis (HPCE) with Laser-induced Fluorescence (LIF) DetectionPrincipal Investigator

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Development of Chiral Edman Degradation Method and Sequential Analysis of D/L-Amino Acid (s) in PeptidePrincipal Investigator

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[Book] Chapter 14, Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC. Chiral Separations: Methods and Protocols, 2nd Ed. Methods in Molecular Biology, Vol. 9702013

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[Book] Amino Acid Analysis, Methods and Protocols, Methods in Molecular Biology2012

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[Journal Article] The great importance of normalization of LC-MS data for highly-accurate non-targeted metabolomics.2017

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TOYO'OKA Toshimasa 豊岡利正

豊岡利正トヨオカトシマサ

TOYOOKA Toshimasa 豊岡利正

TOYO-OKA Toshimasa 豊岡利正