YAGISAWA Hitoshi 八木澤仁

… Alternative Names

HITOSHI Yagisawa 八木澤仁

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Researcher Number	40192380
Other IDs
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Affiliation (based on the past Project Information) *help	2012: 兵庫県立大学, 生命理学研究科, 准教授 2010 – 2012: 兵庫県立大学, 大学院・生命理学研究科, 准教授 2007 – 2008: University of Hyogo, Department of Life Science, Associate Professor 2007: 兵庫県立大学, 大学院・生命理学研究, 准教授 2007: University of Hyogo, 大学院・目・生命理学研究科, 准教授 … More 2006: 兵庫県立大学, 大学院生命理学研究科, 助教授 2005: 兵庫県立大学, 助教授 2002: 姫路工業大学, 大学院・理学研究科, 助教授 1998 – 2001: 姫路工業大学, 理学部, 助教授 1992 – 1996: 姫路工業大学, 理学部, 助教授 1990: 自治医科学大学, 医学部, 講師 1989 – 1990: 自治医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Biological Sciences / 広領域 / 血管生物学 / Tumor biology / Cell biology / Functional biochemistry Except Principal Investigator Cell biology / Biological Sciences / General medical chemistry / Functional biochemistry / Immunology
Keywords	Principal Investigator ホスホリパーゼC / PHドメイン / 癌 / シグナル伝達 / 細胞・組織 / 酵素 / 細胞骨格 / アメーバ運動 / マイクロインジェクション / 高血圧自然発症ラット(SHR) … More / 遺伝子発現 / 遺伝子連鎖解析 / 高血圧 / pleckstrin homology(PH) / phophoinositide / cytoskeleton / ameba movement / osmotic stress / nuclear import / nuclear export / phospholipase C / 緑色けい光タンパク(GFP) / 浸透圧 / 細胞内局在 / プレクストリン相同性領域(ph領域 / 脂質・タンパク相互作用 / トランスロケーション / 核外移行シグナル / 浸透圧ショック / プレクストリン相同性領域 / 細胞運動 / 緑色蛍光タンパク(GFP) / 核外移行シグナル(NES) / 核移行シグナル(NLS) / プレクストリンホモロジー(PH)ドメイン / イノシトールリン脂質 / 浸透圧ストレス / 核移行 / 核外移行 / PH domain / Linkage analysis / Gene expression / Spontaneously Hypertensive Rat / Phospholipase / Calcium ion / Vascular cells / Hypertension / 遺伝子クローニング / 血管内皮・平滑筋細胞 / 高血圧自然発症ラット / 連鎖解析 / ホスホリパーゼ / カルシウムイオン / 血管細胞 / アクチン骨格 / 細胞接着斑 / がん抑制 / 細胞組織 / 生体分子 / START-GAP / START -GAP / phopsholipase C / 細胞形態 / RhoGAP / 接着斑 / アクチン細胞骨格 / 細胞内シグナル伝達 / 抗がん遺伝子 / 細胞骨格・運動 / Ca^<2+> / 細胞核 / 細胞ストレス応答 / 細胞周期 / 脂質シグナル伝達 / イノシトールリン脂質結合タンパク / 原子間力顕微鏡 / 単離膜モデル / アクチン線維 / 自由生活アメーバ / 固体高分解能NMR / イノシトールシグナリング / カベオラ / 膜ターゲティング / Ca^<2+>結合 / C2領域 / プレクストリンホモロジー領域 / IP_3結合 / 細胞内カルシウム / アミノ酸置換 … More Except Principal Investigator PHドメイン / PIP3 / シグナル伝達 / 脂質二重膜 / 膜表在性蛋白質 / 固体NMR / イノシトール1,4,5-三リン酸 / cAMP / 分光法 / ホスホリパーゼC / 細胞内情報伝達系 / ホスホリパーゼC-δ1 / spectroscopy / molecular recognitior / lipid / cellular signal transduction / シグナル伝逹 / 分子認識 / 脂質 / protein phosphatase / anti-anxiety drug / central nervous system / gamma-aminobutyric acid / inositol 1, 4, 5-trisphospahte / calcium ion / 細胞機能 / Ins(1,4,5)P_3 / GABA受容体 / カルシウムイオン / 抗不安薬 / 抑制性神経伝達 / 蛋白質脱リン酸化 / 中枢神経系 / イノシトール三リン酸 / カルシウム / Phosphoinositides / Inositol 1,4,5-trisphosphate / Phospholipase / Pleckstrin homology domain / Inositol phosphates / イノシトールリン脂質 / ホスホリパーゼ / イノシトールリン酸 / homologous recombination / membrane protein / hyperthermophile / amino acid transporter / 融合タンパク質 / 大量発現 / 好熱菌 / 相同組み替え / 膜タンパク質 / 超好熱菌 / アミノ酸トランスポーター / signal transduction / astrocytes / IL-8 / IL-6 / IL-1 / コレラトキシン / IL6 / IL1 / 情報伝達機構 / アストロサイト / ILー8 / ILー6 / ILー1 / 二次構造 / 膜結合性蛋白質 / SWAP-70 / 生物物理 / PH ドメイン / 固体NMR 分光法 / 細胞内情報伝達 / 個体NMR / 脂質二十膜 Less

抗がん遺伝子産物ＳＴＡＲＴ－ＧＡＰ／ＤＬＣファミリータンパク質の細胞内局在化機構Principal Investigator
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  University of Hyogo
MembraneinducedalterationsofstructureandsignaltransductionmechanisminthePIP3-bindingdomains
- Principal Investigator
  
  TUZI Satoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  University of Hyogo
固体NMR分光法による生体膜表面に局在する細胞内情報伝達システムの分子機構の解析
- Principal Investigator
  
  辻暁
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Hyogo
細胞核イノシトールリン脂質シグナル系の調節機構と細胞制御Principal Investigator
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Hyogo
Structure and function relationships of the anti -oncogenic START-GAP family gene productsPrincipal Investigator
- Principal Investigator
  
  HITOSHI Yagisawa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  University of Hyogo
Spectroscopic study of molecular mechanisms of the PIP3-dependent cellular signal transduction pathway located at the membrane surface
- Principal Investigator
  
  SATOU Tuzi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  University of Hyogo
固体NMR分光法による生体膜表面における細胞内情報伝達系蛋白質の動的構造の解析
- Principal Investigator
  
  TUZI Satoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Hyogo
膜と細胞骨格の制御因子としてのホスホイノシチド特異的ホスホリパーゼCのマシナリーPrincipal Investigator
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Himeji Institute of Technology
Studies on the functions of a novel inositol 1, 4, 5-trisphosphate binding protein
- Principal Investigator
  
  HIRATA Masato
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  KYUSHU UNIVERSITY
REGULATION AND INTRACELLULAR LOCALISATION OF PHOSPHOIN OSITIDE-BINDING PROTEINS.Principal Investigator
- Principal Investigator
  
  YAGISAWA Hitoshi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  広領域
- Research Institution
  Himeji Institute of Technology
δ型ホスホリパーゼCの構造と細胞内ターゲッティングPrincipal Investigator
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Himeji Institute of Technology
Studies on ANovel Ins (1,4,5)P_3 Binding Protein Function
- Principal Investigator
  
  HIRATA Masato
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyushu University
Structure and Function Relatioship of Amino Acid Transporter from Hyperthermophilic Bacterium.
- Principal Investigator
  
  HIRATA Hajime
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HIMEJI INSTITUTE OF TECHNOLOGY
Blood Pressure Control by Intracellular Ca2_+-Modulatory Factors in Vascular Endothelial and Smooth Muscle CellsPrincipal Investigator
- Principal Investigator
  
  YAGISAWA Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Himeji Institute of Technology(HIT)
高血圧自然発症ラット(SHR)における高血圧発症機構の分子生物学解析Principal Investigator
- Principal Investigator
  
  八木澤仁
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Study on the IL-1-Mediated Signal Transduction System
- Principal Investigator
  
  KASAHARO Tadashi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Jichi Medical School

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Chapter: START-GAP/DLC family proteins are novel antioncogene products. In “Future aspects of tumor suppressor genes” ISBN 978-953-51-1063-72013
- Author(s)
  Yagisawa H.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22501016
[Book] Phosphoinositide-specific phospholipase C : Isoforms and related molecules2009
- Author(s)
  Yagisawa, H.
- Publisher
  Berlin Heidelberg(In "Handbook of Neurochemistry and Molecular Neurobiology (3^<rd> Edition), Neural Signal Mechanism Vol. 1b (ed. Mikoshiba K.), Chapter 14 : Phospholipid signaling and cell function, Springer-Verlag)
- Data Source
  KAKENHI-PROJECT-19570184
[Book] Handbook of Neurochemistry and Molecular Neurobiology (3^<rd> Edition), Neural Signal Mechanism Vol. 1b (ed. Mikoshiba K. ), Chapter 14 : Phospholipid signaling and cell function. Springer, New York.2009
- Author(s)
  Yagisawa H., et al.
- Publisher
  Phosphoinositide-Specific phospholipase C : Isoforms and related molecules.
- Data Source
  KAKENHI-PROJECT-19570184
[Book] Handbook of Neurochemistry and Molecular Neurobiology (3^<rd> Edition), Neural Signal Mechanism Vol. 1b (ed. Mikoshiba K.), Chapter 14 : Phospholipid signaling and cell function. Springer, New York2009
- Author(s)
  Yagisawa H., et.al.
- Publisher
  Phosphoinositide-specific phospholipase C : Isoforms and related molecules
- Data Source
  KAKENHI-PROJECT-19038020
[Book] Handbook of Neurochemistry and Molecular Neurobiology (3rd Edition), Neural Signal Mechanism Vol.lb (ed.Mikoshiba K.), Chapter 20: Phosphlipid signaling and cell function.Springer, New York2008
- Author(s)
  Yagisawa H., et. al.
- Publisher
  Phosphoinositide-specific phospholipase C: Isoforms and related mo lecules
- Data Source
  KAKENHI-PROJECT-19038020
[Book] Handbook of Neurochemistry and Molecular Neurobiology(3^<rd> Edition), Neural Signal Mechanism Vol.1b(ed.Mikoshiba K.), Chapter 20:Phospholipid signaling and cell function.Springer, New York.2008
- Author(s)
  Yagisawa H, et. al.
- Total Pages
  28
- Publisher
  Phosphoinositide-specific phospholipase C:Isoforms and related molecules.
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] DGKzeta is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway2012
- Author(s)
  Okada, M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Issue: 2 Pages: 479-84
- DOI
  10.1016/j.bbrc.2012.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227006, KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24592323
[Journal Article] DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry2012
- Author(s)
  Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Topham MK, Martelli AM, Goto K.
- Journal Title
  
  Cell Signal
  
  Volume: 24 Issue: 8 Pages: 1573-82
- DOI
  10.1016/j.cellsig.2012.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24390044
[Journal Article] Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain2012
- Author(s)
  Tokuda N, Kawai K, Lee YH, Ikegami T, Yamaguchi S, Yagisawa H, Fukui Y, Tuzi S
- Journal Title
  
  J Biochem
  
  Volume: 151 Issue: 4 Pages: 391-401
- DOI
  10.1093/jb/mvr146
- NAID
  10031166078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22570191
[Journal Article] Membrane-induced alteration of thesecondary structure in the SWAP-70pleckstrin homology domain2012
- Author(s)
  N. Tokuda, K. Kawai, Y. H. Lee (OsakaUniversity), T. Ikegami (OsakaUniversity), S. Yamaguchi, H. Yagisawa,Y. Fukui (National Health Research Institutes, Taiwan), and S. Tuzi
- Journal Title
  
  J.Biochem.
  
  Volume: 151 Pages: 391-401
- Data Source
  KAKENHI-PROJECT-22570191
[Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011
- Author(s)
  Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K.
- Journal Title
  
  Exp Cell Res
  
  Volume: 317 Issue: 20 Pages: 2853-63
- DOI
  10.1016/j.yexcr.2011.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-21570213, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745
[Journal Article] Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology2009
- Author(s)
  Kawai, K., Iwamae, Y., Yamaga, M., Ishii, H., Hirata, H., Homma, Y. and Yagisawa, H.
- Journal Title
  
  Genes Cells 14
  
  Pages: 227-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells2009
- Author(s)
  Otsuka, A., Abe, T., Watanabe, M., Yagisawa, H., Takei, K. and Yamada, H.
- Journal Title
  
  Biochem Biophys Res Commun 378
  
  Pages: 478-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region2009
- Author(s)
  Kawai, K., Seike, J., Iino, T., Kiyota, M., Iwamae, Y. and Yagisawa, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun 380
  
  Pages: 736-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] Recruitment and activation of phospholipase C (PLC)-δ_1 in lipid rafts by muscarinic stimulation of PC12 cells : contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCδ_1 binding protein2008
- Author(s)
  Yamaga, M., Kawai, K., Kiyota, M., Homma Y. and Yagisawa, H.
- Journal Title
  
  Adv. Enzyme Regul 48
  
  Pages: 41-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology2007
- Author(s)
  Kawai, K., Kiyota, M., Seike J., Deki, Y. and Yagisawa H.
- Journal Title
  
  Biochem. Biophys. Res. Commun 364
  
  Pages: 783-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] Phosphatidylserine induces functional and structural alterations of the membrane-associated PH domain of phospholipase C-δ12007
- Author(s)
  Uekama, N., Sugita, T., Okada, M., Yagisawa, H. and Tuzi, S.
- Journal Title
  
  FEBS J. 274
  
  Pages: 177-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] Lipid components in the detergent-resistant membrane microdomain (DRM) obtained from the synaptic plasma membrane of rat brain2007
- Author(s)
  Matsuura, D., Taguchi, K., Yagisawa, H. and Maekawa S.
- Journal Title
  
  Neurosci. Lett. 423
  
  Pages: 158-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570184
[Journal Article] Phosphatidylserine induces functional and structural alterations of the membrane-associated pleckstrin homology domain of phospholipase C-&12007
- Author(s)
  Naoko, Uekama, Takio, Sugita, Masashi, Okada, Hitoshi, Yagisawa, Satoru, Tuzi
- Journal Title
  
  FEBS J 274
  
  Pages: 177-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570184
[Presentation] Cloning and characterization of phosphoinositide-specific phospholipase C of a giant amoeba, Amoeba proteus.2012
- Author(s)
  Yagisawa, H
- Organizer
  45回日本発生生物学会・64回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Interaction between START-GAP/DLC ; a family of novel antioncogene products, and tensin, a component of a focal adhesion complex2012
- Author(s)
  H Yagisawa, et al.
- Organizer
  神戸大学先端融合科学シンポジウム
- Place of Presentation
  神戸大学理学部(兵庫県)
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] A new prospect of START-GAP1/DLC1 (deleted in liver cancer-1) as a pathogen for coronary spastic angina (CSA).2012
- Author(s)
  Yagisawa H.
- Organizer
  The 17th Japan-Korea Cancer Research Workshop
- Place of Presentation
  釜山（韓国）
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] The START-GAP/DLC family: antioncogene products that act as RhoGAPs and activators of phospholipase C2012
- Author(s)
  Yagisawa, H
- Organizer
  FASEB Science Research Conference “Lipid Signaling Pathways in Cancer”
- Place of Presentation
  コロラド、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Cloning of a gene encoding a novel type of phosphoinositide-specific phospholipase C from a giant amoeba, Amoeba proteus.2012
- Author(s)
  Yagisawa H.
- Organizer
  35回日本分子生物学会年会
- Place of Presentation
  福岡国際会館（福岡県）
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] START-GAP1 (DLC1), a novel antioncogene product, transiently delocalizes from focal adhesions under EGF stimulus2012
- Author(s)
  H Yagisawa
- Organizer
  The 7th Korea-Japan Conference on Cellular Signalling for Young Scientist
- Place of Presentation
  Ulsan National Institute of Science and Technology,(ウルサン、大韓民国)
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Amoeba proteusイノシトールリン脂質特異的ホスホリパーゼC (PI-PLC) の構造と性質2012
- Author(s)
  Yagisawa H.
- Organizer
  45回日本原生動物学会
- Place of Presentation
  兵庫県立大学（兵庫県）
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Changes in thesecondary structure of the SWAP-70 PHdomain induced at the lipid bilayersurface2011
- Author(s)
  Satoru Tuzi, Naomi Tokuda, KatsuhisaKawai, Young-Ho Lee (OsakaUniversity), Takahisa Ikegami (OsakaUniversity), Yasuhisa Fukui (NationalHealth Research Institutes, Taiwan) andHitoshi Yagisawa
- Organizer
  The 10th JBS BiofrontierSymposium: International SymposiumNew Aspects of Phospholipid Biology andMedicine 2011
- Place of Presentation
  福岡県
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-δ1 into the nucleus2011
- Author(s)
  H Yagisawa, M Okada
- Organizer
  Symposium : "The diversity of inositide signaling" The 54th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  山代温泉郷(石川県)(招待講演)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Conformational alteration of SWAP-70PH domain induced at the membranesurface2011
- Author(s)
  Naomi Tokuda, Katsuhisa Kawai,Young-Ho Lee (Osaka University),Takahisa Ikegami (Osaka University),Hitoshi, Yagisawa, Yasuhisa Fukui(National Health Research Institutes,Taiwan), and Satoru Tuzi
- Organizer
  The 49th annual meeting of thebiophysical society Japan
- Place of Presentation
  兵庫県
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] 抗がん遺伝子産物START-GAP1(DLC1)は接着斑構成因子vinculinのC末端領域を介して結合する2011
- Author(s)
  八木澤仁、四方佑斉、生田桃子
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] EGF regulates localization of START-GAP1 (DLC1), a novel antioncogene product, at focal adhesions2011
- Author(s)
  M Ikita, H Nishitani, H Yagisawa
- Organizer
  第34回分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Measurement of inositol polyphosphates by ion chromatography and their physiological status in higher plant2011
- Author(s)
  T Mimura, et al., H Yagisawa
- Organizer
  Symposium : "The diversity of inositide signaling" The 54th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  山代温泉郷(石川県)(招待講演)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] solid-stateNMR study of structural alteration andfunction of the PH domain induced at thelipid bilayer surface2011
- Author(s)
  Naomi Tokuda, Katsuhisa Kawai,Young-Ho Lee (Osaka University),Takahisa Ikegami, Hitoshi, Yagisawa(Osaka University), Yasuhisa Fukui(National Health Research Institutes,Taiwan), and Satoru Tuzi, A
- Organizer
  The internationalsymposium on nuclear magneticresonance 2011: the 50th memorialannual meeting of the nuclear magneticresonance society of Japan
- Place of Presentation
  神奈川県
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] Mechanisms of nucleocytoplasmic transport of phospholipase C-δ1 and its role in cellular function2011
- Author(s)
  YAGISAWA, Hiotoshi
- Organizer
  GORDON RESEARCH CONFERENCE : Signal Transduction in the Nucleus
- Place of Presentation
  Four Points Sheraton Ventura(U.S.A.)
- Year and Date
  2011-03-01
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Changes in the secondary structure of the SWAP-70 PH domain induced at the lipid bilayer surface2011
- Author(s)
  S Tuzi, et al., H Yagisawa
- Organizer
  The 10th JBS Biofrontier Symposium commemorating Kyushu University Centennial Anniversary International Symposium : New Aspects of Phospholipid Biology and Medicine 2011
- Place of Presentation
  ホテルルイガンス(福岡県)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] がん抑制遺伝子産物START-GAP1(DLC1)は接着斑構成分子vinculinとLDモチーフを介して結合する2010
- Author(s)
  生田桃子、四方佑斉, 他、八木澤仁
- Organizer
  BMB2010第33回日本生化学会・第83回日本分子生物学会合同大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Nuclear-cytoplasmic shuttling of PLCδ1 and its implication in cell proliferation2010
- Author(s)
  YAGISAWA, Hitoshi
- Organizer
  BMB2010第33回日本生化学会・第83回日本分子生物学会合同大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] 固体NMR による脂質膜表面において誘起されるSWAP-70 PHドメインの構造変化および機能の解析2010
- Author(s)
  徳田尚美・川合克久・八木澤仁・福井泰久(National Health Research Institutes,Taiwan)・辻暁
- Organizer
  第49回NMR 討論会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] 固体NMR 分光法によるPH ドメインの脂質膜表面における構造変化の解析2010
- Author(s)
  徳田尚美・八木澤仁・福井泰久(NationalHealth Research Institutes, Taiwan)・辻暁
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  兵庫県
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] Conformationalalterations of the pleckstrin homologydomains at the lipid bilayer surface2010
- Author(s)
  S. Tuzi, N. Tokuda, K. Kawai, Y. Fukui(National Health Research Institutes,Taiwan), H. Yagisawa
- Organizer
  2010International Chemical Congress ofPacific Basin Societies (Honolulu 2010)
- Place of Presentation
  アメリカ合衆国、ハワイ
- Data Source
  KAKENHI-PROJECT-22570191
[Presentation] Characterization of the START domain of p122RhoGAP/START-GAP/DLC-12010
- Author(s)
  YAGISAWA, H, BANIK, G, YAMAGA, M
- Organizer
  The 27th Naito Conference on Membrane Dyanmics and Lipid Biology[I]
- Place of Presentation
  シャトレーゼ・ガトーキングダム札幌(北海道)
- Data Source
  KAKENHI-PROJECT-22501016
[Presentation] Influence of membrane curvature on the structure of the phospholipase C (PLC)-δ1 PH domain : implication in intracellular localization2009
- Author(s)
  Uekama, N., Aoki, T., Muraoka, T., Yagisawa, H., Nishimura K. and Tuzi, S.
- Organizer
  Gordon Research Conference on "Signal Transduction Within the Nucleus."
- Place of Presentation
  California, USA
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] イノシトールリン脂質代謝酵素の核-細胞質間移行とその生理的意義2008
- Author(s)
  八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] イノシトールリン脂質代謝酵素の核-細胞質間移行とその生理的意義BMB20082008
- Author(s)
  八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会シンポジウム「核-細胞質間輸送と生命機能制御のインターフェイス」
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 脂質膜上における局所構造に基づくpleckstrin homology domain-脂質膜間相互作用の解析2008
- Author(s)
  徳田尚美、八木澤仁、福井泰久、辻暁
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波大学(筑波)
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19036031
[Presentation] Measurement of inositol polyphosphates by ion chromatography and their physiological status in higher plants2008
- Author(s)
  Mimura, T., Mitsuhashi, N., Richardso, A., Chung, S-K. and Yagisawa, H.
- Organizer
  第31回神経科学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Ca^<2->-dependent nuclear accumulation of phospholipase C-δ12008
- Author(s)
  Yagisawa, H. and Okada, M.
- Organizer
  第31回神経科学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] イノシトールリン脂質代謝酵素の核-細胞質問移行とその生理的意義2008
- Author(s)
  八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] 脂質膜上における局所構造の特徴に基づくpleckstrin homology domain-脂質膜間相互作用の解析2008
- Author(s)
  徳田尚美, 八木澤仁, 他
- Organizer
  NMR討論会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-δ 12008
- Author(s)
  Naoko Uekama, Takahiro Aoki, Toshihiro Maruoka, Seiji Kurisu, Akiko Hatakeyama, Masashi Okada, Hitoshi Yagisawa, Katsuyuki Nishimura, Satoru Tuzi
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19036031
[Presentation] START-GAP1の接着斑局在化におけるテンシン2との結合の役割2008
- Author(s)
  北村真也、前平航司、川合克久、西谷秀男、八木澤仁
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 脂質膜上における局所構造の特徴に基づくpleckstrin homology domain-脂質膜間相互作用の解析2008
- Author(s)
  徳田尚美、八木澤仁, 他
- Organizer
  NMR討論会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] START-GAP1は接着斑局在化領域のテンシン2に対するリン酸化依存的結合により接着斑に局在化する2008
- Author(s)
  川合克久, 他, 八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] Ca^(2+)-dependent nuclear accumulation of phospholipase Cδ12008
- Author(s)
  八木澤仁, 岡田雅司
- Organizer
  第31回神経科学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAP1の接着斑局在化におけるテンシン2との結合の役割2008
- Author(s)
  北村真也, 他, 八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] START-GAP1の接着斑局在化におけるテンシン2との結合の役割2008
- Author(s)
  北村真也, 他八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAP1は接着斑局在化領域のテンシン2に対するリン酸化依存的結合により接着斑に局在化する.2008
- Author(s)
  川合克久, 他八木澤仁
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAP1は接着斑局在化領域のテンシン2に対するリン酸化依存的結合により接着斑に局在化する2008
- Author(s)
  川合克久、北村真也、川合由華、西谷秀男、八木澤仁
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Measurement of inositol polyphosphates by ion chromatography and their physiological status in higher plants2008
- Author(s)
  三村徹郎、八木澤仁, 他
- Organizer
  第31回神経科学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] 脂質膜上における局所構造の特徴に基づくpleckstrin homology domain-脂質膜間相互作用の解析2008
- Author(s)
  徳田尚美、八木澤仁、福井泰久、辻暁
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAP1, a PLCδ_1-binding RhoGAP, in focal adhesions regulates cell morphology and motility2007
- Author(s)
  Yagisawa, H., Seike, J., and Kawai, K.
- Organizer
  Howard Hughes Medical Institute, Janelia Conference on "Inositide Signalling"
- Place of Presentation
  Virginia USA
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 脂質二重膜表面におけるpleckstrin homology domain の動的構造の解析2007
- Author(s)
  徳田尚美、八木澤仁、福井泰久、辻暁
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 固体NMR分光法による膜表在性タンパク質PLC-δ1の局所運動性の解析2007
- Author(s)
  上釜奈緒子、八木澤仁、辻暁、西村勝之
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Regulation of intercellular lacalization of a dual functional PLCδ1-binding protein,p122 RhoGAP/DLC1,a member of the tumor-suppressing STA RT-GAP Family proteins.2007
- Author(s)
  Yagisawa H, et. al.
- Organizer
  48^<th> International Symposium on "Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues
- Place of Presentation
  University of Bologna, Italy.
- Year and Date
  2007-09-24
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Regulation of intracellular localization of a dual functional PLCδ1-binding protein, p122RhoGAP/DLC1, a member of the tumor suppressing START-GAP family proteins2007
- Author(s)
  Yagisawa, H., Kawai, K., Iwamae, Y., Kiyota, M. and Yamaga, M.
- Organizer
  48^<th> International Symposium on "Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues
- Place of Presentation
  Bologna, Italy
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAPI,a PLCdeltal-binding RhoGAP,in focal adhesions regul ates cell morphology and motility,2007
- Author(s)
  Yagisawa H, et. al.
- Organizer
  Howard Hughes Medical Institute, Janelia Conference"Inositide Signalling, "
- Place of Presentation
  Virginia USA
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 固体NMRによる膜表在性タンパク質PLC-δ1PHドメインの局所運動性解析2007
- Author(s)
  上釜奈緒子、八木澤仁、辻暁、西村勝之
- Organizer
  第46回NMR討論会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] START-GAP 1,a PLCdeltal-binding RhoGAP,in focal adhesions regulates cell morphology and motility2007
- Author(s)
  Yagisawa H, et. al.
- Organizer
  Howard hughes Medical Institute, Janelia Conference "Inositide Signalling, "
- Place of Presentation
  Virginia USA
- Data Source
  KAKENHI-PROJECT-19038020
[Presentation] ホスホリパーゼC-δ1PHドメインおよびEF-handドメインの脂質二重膜上における構造とダイナミクス2007
- Author(s)
  三宅健史、川合克久、八木澤仁、辻暁
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Phosphorylation of phospholipase C-δ_1 regulates its enzymatic activity2007
- Author(s)
  Fujii, M. and Yagisawa, H.
- Organizer
  Howard Hughes Medical Institute, Janelia Conference on "Inositide Signalling"
- Place of Presentation
  Virginia USA
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] p122RhoGAPによる細胞形態変化には接着斑への局在化が寄与する2007
- Author(s)
  川合克久、清田稔、清家淳一、岩前由衣、八木澤仁
- Organizer
  BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] 脂質二重膜表面の曲率とホスホリパーゼC-δ1 PH ドメインの立体構造変化 : 固体NMR分光法による解析2007
- Author(s)
  上釜奈緒子、青木隆広、丸岡俊宏、栗栖聖治、畠山明子、岡田雅司、八木澤仁、西村勝之、辻暁
- Organizer
  BMB2007(第30回日本分子生物学会年会・第80回日本生化学会合同大会)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570184
[Presentation] Regulation of intercellular lacalization of a dual functional PLCδ1-bindingprotein,pl22 RhoGAP/DLCl,a member of the tumor-suppressing START-GAP Family proteins2007
- Author(s)
  Yagisawa H, et. al.
- Organizer
  48th International Symposium on "Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues
- Place of Presentation
  University of Bologna,Italy.
- Year and Date
  2007-09-24
- Data Source
  KAKENHI-PROJECT-19038020

1. KAMATA Hideaki (10233925)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HIRATA Hajime (40049052)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TUZI Satoru (60227387)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. HIRATA Masato (60136471)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KATAN Matilda

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KASAHARO Tadashi (60049096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAGUCHI Yuji (00220286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ONOZAKI Kikuo (20101313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIGUCHI Yoshiki (90183574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKEUCHI Hiroshi (70304813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KANEMATSU Takashi (10264053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 野島博 (30156195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MATSUDA Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATILDA Kata

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KATAN Matild

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATILDA Katan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OKADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. TANAKA Toshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 八月朔日泰和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 後藤薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 伊関憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAGISAWA Hitoshi 八木澤 仁

HITOSHI Yagisawa 八木澤 仁

Research Projects

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Co-Researchers

抗がん遺伝子産物ＳＴＡＲＴ－ＧＡＰ／ＤＬＣファミリータンパク質の細胞内局在化機構Principal Investigator

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細胞核イノシトールリン脂質シグナル系の調節機構と細胞制御Principal Investigator

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Structure and function relationships of the anti -oncogenic START-GAP family gene productsPrincipal Investigator

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膜と細胞骨格の制御因子としてのホスホイノシチド特異的ホスホリパーゼCのマシナリーPrincipal Investigator

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REGULATION AND INTRACELLULAR LOCALISATION OF PHOSPHOIN OSITIDE-BINDING PROTEINS.Principal Investigator

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δ型ホスホリパーゼCの構造と細胞内ターゲッティングPrincipal Investigator

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Blood Pressure Control by Intracellular Ca2_+-Modulatory Factors in Vascular Endothelial and Smooth Muscle CellsPrincipal Investigator

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YAGISAWA Hitoshi 八木澤仁

HITOSHI Yagisawa 八木澤仁