GOMI Fujiya 五味不二也

… Alternative Names

五味不二也ゴミフジヤ

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Researcher Number	40205620
Affiliation (based on the past Project Information) *help	2021 – 2023: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2012: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2008: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 2006 – 2007: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human, Research Scientist 2005 – 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 … More 2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 研究員 2000: (財)東京都老人総合研究所, 神経病理部門, 研究員 2000: TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY, DEPARTMENT OF ULTRASTRUCTURE RESEARCH ASSOCIATE, 神経病理部門, 研究員 1998 – 1999: 財団法人東京都老人総合研究所, 超微形態部門, 助手 1997: 東京都老人総合研究所, 超微形態部門, 助手 1995: (財)東京都老人総合研究所, 超微形態部門, 助手 1994: (財)東京都老人総合研究所, 超微形態, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Nerve anatomy/Neuropathology / 老化(加齢) / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Neuroscience in general
Keywords	Principal Investigator 癌幹細胞 / 多様性 / geneticin / 発現細胞 / 表面糖鎖 / 細胞表面糖鎖 / nestin / 膵癌細胞 Except Principal Investigator MAP1B / βアミロイド … More / AICD / microarray / β-amyloid / 神経細胞死 / β-アミロイド / 胎児性抗原 / 神経毒性 / アルツハイマー病 / neuronal death / intracellular Aβ / 細胞死関連遺伝子 / 細胞内Ass / 細胞内Aβ / fetal antigens / neurotoxicity / 胎児性遺伝子 / 神経新生 / B-アミロイド / トランスジェニックマウス / 転写因子 / ss-アミロイド / 神経再生 / 神経幹細胞 / 遺伝子発現 / 神経栄養因子 / 成長抑制因子 / ニューロン死 / 変性疾患 / 成長抑制因子(GIF) Less

幹細胞表面特異的糖鎖を標的とした膵癌の新規治療法の開発Principal Investigator
- Principal Investigator
  
  五味不二也
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Mechanism of accelerating death of newborn neurons by ss-amyloid
- Principal Investigator
  
  UCHIDA Yoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Molecular mechanism of neurogenesis in Alzheimer's disease
- Principal Investigator
  
  UCHIDA Yoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Profiling of gene expression related neuronal death by intracellular Aβ1-42
- Principal Investigator
  
  UCHIDA Yoko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
FETAL GENE EXPRESSION IN β-AMYLOID TREATED CORTICAL NEURONS AND ITS TOXIC OR PROTECTIVE EFFECTS ON NEURONS
- Principal Investigator
  
  UCHIDA Yoko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY
βアミロイド神経毒性の分子機構
- Principal Investigator
  
  内田洋子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
成長抑制因子の標的となる神経栄養因子の同定
- Principal Investigator
  
  内田洋子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
ニューロン死における成長抑制因子の役割
- Principal Investigator
  
  UCHIDA Yoko
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2023 2022 2021 2013 2012 2011 2010 2007

All Journal Article Presentation

[Journal Article] Artificial intelligence-based analysis of time-lapse images of sphere formation and process of plate adhesion and spread of pancreatic cancer cells2023
- Author(s)
  Shichi Yuuki、Gomi Fujiya、Hasegawa Yasuko、Nonaka Keisuke、Shinji Seiichi、Takahashi Kimimasa、Ishiwata Toshiyuki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11 Pages: 1290753-1290753
- DOI
  10.3389/fcell.2023.1290753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08744, KAKENHI-PROJECT-21K08764, KAKENHI-PROJECT-22K08882
[Journal Article] Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression2022
- Author(s)
  Sasaki Norihiko、Hirano Kazumi、Shichi Yuuki、Gomi Fujiya、Yoshimura Hisashi、Matsushita Akira、Toyoda Masashi、Ishiwata Toshiyuki
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 9 Pages: 2055-2055
- DOI
  10.3390/cancers14092055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09207, KAKENHI-PROJECT-21K08744, KAKENHI-PROJECT-21K08764, KAKENHI-PROJECT-22K06013, KAKENHI-PROJECT-18K14597
[Journal Article] Multiple cystic sphere formation from PK-8 cells in three-dimensional culture2022
- Author(s)
  Yuuki Shichi, Fujiya Gomi, Yoshibumi Ueda, Keisuke Nonaka, Fumio Hasegawa, Yasuko Hasegawa, Nae Hinata, Hisashi Yoshimura, Masami Yamamoto, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 32 Pages: 101339-101339
- DOI
  10.1016/j.bbrep.2022.101339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06408, KAKENHI-PROJECT-21K08744, KAKENHI-PROJECT-21K08764, KAKENHI-PROJECT-22K08882
[Journal Article] Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures2022
- Author(s)
  Shichi Yuuki、Gomi Fujiya、Sasaki Norihiko、Nonaka Keisuke、Arai Tomio、Ishiwata Toshiyuki
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 12 Issue: 5 Pages: 746-746
- DOI
  10.3390/jpm12050746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09207, KAKENHI-PROJECT-21K08744, KAKENHI-PROJECT-21K08764
[Journal Article] Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures2021
- Author(s)
  Minami Fuuka, Sasaki Norihiko, Shichi Yuuki, Gomi Fujiya, Michishita Masaki, Ohkusu-Tsukada Kozo, Toyoda Masashi, Takahashi Kimimasa, Ishiwata Toshiyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 6775-6775
- DOI
  10.1038/s41598-021-86028-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09207, KAKENHI-PROJECT-19K11759, KAKENHI-PROJECT-19H03132, KAKENHI-PROJECT-21K08764
[Journal Article] Polyvinyl alcohol increased growth, migration, invasion, and sphere size in the PK-8 pancreatic ductal adenocarcinoma cell line2021
- Author(s)
  Fujiya Gomi, Norihiko Sasaki, Yuuki Shichi, Fuuka Minami, Seiichi Shinji, Masashi Toyoda, Toshiyuki Ishiwata
- Journal Title
  
  Heliyon
  
  Volume: 7 Issue: 2 Pages: e06182-e06182
- DOI
  10.1016/j.heliyon.2021.e06182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09207, KAKENHI-PROJECT-19K11759, KAKENHI-PROJECT-21K08764
[Journal Article] Calsyntenin-3 C-terminal fragment Accumulates in dystrophic neuritis surrounding abeta plaques in Tg2576 mouse and Alzheimer disease brains : its neurotoxic role in mediating dystrophic neurite formation.2013
- Author(s)
  Uchida Y, Gomi F, Murayama S, Takahashi H.
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 1718-1726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500347
[Journal Article] MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons.2012
- Author(s)
  Gomi F, Uchida Y.
- Journal Title
  
  Brain Res
  
  Volume: 1433 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500347
[Journal Article] MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons2012
- Author(s)
  Gomi F, Uchida Y
- Journal Title
  
  Brain Res
  
  Volume: 1,433 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500347
[Journal Article] Up-regulation of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons.2011
- Author(s)
  Uchida Y, Nakano S, Gomi F, Takahashi H.
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 651-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500347
[Journal Article] Up-regulatioll of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons.2011
- Author(s)
  Uchida Y, Nakano S, Gomi F, Takahashi H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Pages: 651-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500347
[Journal Article] Differential regulation of bHLH factors, Mash1 and Olig2, by ss-amyloid accelerates both differentiation and the death of cultured neural stem cells2007
- Author(s)
  Uchida Y, Nakano S, Gomi F, Hakahashi H
- Journal Title
  
  J Biol Chem 282
  
  Pages: 19700-19709
- Data Source
  KAKENHI-PROJECT-19500316
[Journal Article] Differential regulation of bHLH factors,Mash1 and Olig2,by β-amyloid accelerates both differentiation and the death of cultured neural stem cells.2007
- Author(s)
  Uchida Y, Nakano S, Gomi F, Takahashi H
- Journal Title
  
  J Biol Chem 282
  
  Pages: 19700-19709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500316
[Presentation] 膵癌培養細胞株におけるスフェアの形成過程および接着遊走過程のタイムラプス解析.2023
- Author(s)
  志智優樹、五味不二也、長谷川康子、進士誠一、高橋公正、石渡俊行.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08764
[Presentation] FGFR4 阻害剤 BLU554 は膵癌細胞の増殖、浸潤を抑制し細胞老化を誘導する.2023
- Author(s)
  五味不二也、志智優樹、進士誠一、石渡俊行.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08764
[Presentation] Enhanced morphofunctional characteristics of pancreatic ductal adenocarcinoma cell lines in three-dimensional culture.2023
- Author(s)
  Yuuki Shichi, Fujiya Gomi, Yasuko Hasegawa, Seiichi Shinji, Kimimasa Takahashi, Toshiyuki Ishiwata.
- Organizer
  Second JCA/AACR Precision Cancer Medicine International Conference.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08764
[Presentation] FGFR4 inhibitors reduced cell proliferation and migration, and induced cellular senescence in pancreatic cancer.2023
- Author(s)
  Toshiyuki Ishiwata, Norihiko Sasaki, Fujiya Gomi, Yuuki Shichi, Seiichi Shinji, Masashi Toyoda.
- Organizer
  AGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08764
[Presentation] Chat過剰発現による神経細胞死に関与する分子の検討2012
- Author(s)
  五味不二也、内田洋子
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] Chatによる神経細胞死におけるNEDD9とp130Casの効果2011
- Author(s)
  五味不二也、内田洋子
- Organizer
  第34回に本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] Assにより誘導されるCas/HEF1 associated signal transducer の細胞死への効果2010
- Author(s)
  五味不二也、内田洋子
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] ABにより誘導されるCas/HEFI associated signal transducerの細胞死への効果2010
- Author(s)
  五味不二也、内田洋子
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] Cas/HEF1 associated signal transducerによる神経細胞死2010
- Author(s)
  五味不二也、内田洋子
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] Cas/HEFI associated signal transducerによる神経細胞死2010
- Author(s)
  五味不二也、内田洋子
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22500347
[Presentation] アルツハイマー病モデルマウスにおけるbHLH因子の発現変化とその意味2007
- Author(s)
  内田洋子, 中野俊一郎, 五味不二也
- Organizer
  日本基礎老化学会
- Place of Presentation
  札幌市
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-19500316
[Presentation] アルツハイマー病モデルマウスにおけるBhlh因子の発現変化とその意味2007
- Author(s)
  内田洋子, 中野俊一郎, 五味不二也
- Organizer
  日本基礎老化学会
- Place of Presentation
  札幌市
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-19500316
[Presentation] ADモデルマウス脳におけるOlig2遺伝子の発現変化とその意味2007
- Author(s)
  内田洋子, 五味不二也
- Organizer
  Neuro2007
- Place of Presentation
  横浜市
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19500316
[Presentation] ADマウスモデル脳における Olig2 遺伝子の発現変化とその意味2007
- Author(s)
  内田洋子, 五味不二也
- Organizer
  Neuro 2007
- Place of Presentation
  横浜市
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19500316

1. UCHIDA Yoko (60133633)

# of Collaborated Projects: 7 results

# of Collaborated Products: 17 results
2. 進士誠一 (80409193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 佐々木紀彦 (80639063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 石渡俊行 (90203041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. YAMAMOTO Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 志智優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

GOMI Fujiya 五味 不二也

五味 不二也 ゴミ フジヤ

Research Projects

Research Products

Co-Researchers

幹細胞表面特異的糖鎖を標的とした膵癌の新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of accelerating death of newborn neurons by ss-amyloid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of neurogenesis in Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Profiling of gene expression related neuronal death by intracellular Aβ1-42

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FETAL GENE EXPRESSION IN β-AMYLOID TREATED CORTICAL NEURONS AND ITS TOXIC OR PROTECTIVE EFFECTS ON NEURONS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

βアミロイド神経毒性の分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成長抑制因子の標的となる神経栄養因子の同定

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ニューロン死における成長抑制因子の役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Artificial intelligence-based analysis of time-lapse images of sphere formation and process of plate adhesion and spread of pancreatic cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple cystic sphere formation from PK-8 cells in three-dimensional culture2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyvinyl alcohol increased growth, migration, invasion, and sphere size in the PK-8 pancreatic ductal adenocarcinoma cell line2021

Author(s)

GOMI Fujiya 五味不二也

五味不二也ゴミフジヤ

[Presentation] 膵癌培養細胞株におけるスフェアの形成過程および接着遊走過程のタイムラプス解析.2023

[Presentation] FGFR4 阻害剤 BLU554 は膵癌細胞の増殖、浸潤を抑制し細胞老化を誘導する.2023