KUNO Kouji 久野耕嗣

Researcher Number	40242565
Other IDs
External Links
Affiliation *help	2016 – 2018 : 金沢大学, がん進展制御研究所, 准教授 2007 : 金沢大, がん研究所, 助教授 2007 : Kanazawa University, Cancer Research Institute, Associate Professor 2001 – 2006 : 金沢大学, がん研究所, 助教授 2001 : 金沢大学, がん研究所, 講師 1992 – 2000 : 金沢大学, がん研究所, 助手 1999 : 金沢大, がん研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Experimental pathology / Experimental pathology / Biological Sciences Except Principal Investigator Immunology / Biological Sciences
Keywords	Principal Investigator ADAM / メタロプロテアーゼ / 細胞外マトリックス / metalloproteinase / シグナル伝達 / NFκB / ADAMTS / アグリカン / 関節炎 / 副腎 … More Except Principal Investigator 受容体 / NFkB / TNF / インターロイキン8 / Anti-inflammatory drug / 浸潤・転移 / 基質 / 細胞外マトリックス / 再潅流障害 / 癌細胞浸潤・転移 / Interferon gamma / 抗炎症剤 / IL-8遺伝子発現 / Treatment / 遺伝子発現 / プロテインキナーゼ / 疾患 / 病態生理作用 / 構造と機能 / インターロイキン1受容体タイプ1 / IL-1シグナル伝達 / Pathophysiology / 治療 / 細胞・組織 / ADAM / 遺伝子欠損マウス / 組織破壊 / IFNγ / 酵素 / IL-6受容体gp130 / インタ-ロイキン8遺伝子 / 転写因子 / インタ-ロイキン1受容体 / インターロイキン 8 / Receptor / Signal transduction / Disease / 好中球 / シグナル伝達機構 / シグナル伝達 / 抗体 / IL-8 gene activation / Gene / Antibody / 増殖因子 / 細胞外マトリックス代謝 / 転写 / MMP / 炎症 / マトリクライン / Interleukin 8 / ホルボールエステル / Transcriptional factors / Interleukin 1 / 形態形成 / クローニング / インターロイキン1 Less

Study of function of ADAMTS-1 in skin wound healingPrincipal Investigator
- Principal Investigator
  
  KUNO Kouji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanazawa University
Analyses of role of ADAMTS-1 in ovarian function by using ADAMTS-1 null micePrincipal Investigator
- Principal Investigator
  
  KUNO Kouji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanazawa University
Study of function of ADAMTS-1 in bone metabolismPrincipal Investigator
- Principal Investigator
  
  KUNO Kouji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  KANAZAWA UNIVERSITY
線虫C．elegansのADAMTS−1ホモログ遺伝子の破壊とその変異体の解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kanazawa University
細胞外マトリックス代謝研究の新展開の総括
- Principal Investigator
  
  岡田保典
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
TSPモチーフを有するADAMファミリー分子,ADAMTS-1の機能解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1999 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
Analysis of substrates for ADAMTS-1 metalloproteinasePrincipal Investigator
- Principal Investigator
  
  KUNO Kouji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
炎症時に発現されるADAMTS1遺伝子のトランスジェニックマウスの作製と解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kanazawa University
炎症時に発現される新しいADAMファミリー遺伝子ADAMTS-1の機能発現解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
IL-1シグナル伝達におけるIκBαキナーゼ群の役割の解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
IL-1非応答性突然変異株の分離とその変異を相補するcDNAのクローニングPrincipal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
インターロイキン1受容体を介するシグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
Establishment of pathophysiological role of interleukin 8 and development of its inhibitors
- Principal Investigator
  
  MATSUSHIMA Kouji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
インターロイキン1受容体の細胞内領域と会合するタンパク質因子の解析Principal Investigator
- Principal Investigator
  
  久野耕嗣
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
Analysis of the structure of interleukin 1 receptor and the mechanism of IL-1 signal transduction
- Principal Investigator
  
  MATSUSHIMA Kouji
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University

All 2008 2007 2005 2004 Other

All Journal Article Presentation Book

[Book] ADAMTS-1.Handbook of Proteolytic Enzymes(Second Edition)(Barrett A.J., Rawlings N.D., and Woessner J.F., eds.)2004
- Author(s)
  Kuno K.
- Total Pages
  3
- Publisher
  London, Academic Press
- Data Source
  KAKENHI-PROJECT-16590305
[Book] ADAMTS-1. In Handbook of Proteolytic Enzymes (Second Edition) (Barrett A.J., Rawlings N.D., and Woessner J.F., eds.)2004
- Author(s)
  Kuno K.
- Total Pages
  3
- Publisher
  London, Academic Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590305
[Book] ADAMTS-1. in Handbook of Proteolytic Enzymes (Second edition)(Barrett, A.J., Rawlings, N.D.eds.)
- Author(s)
  Kuno K.
- Total Pages
  2
- Publisher
  Academic Press(印刷中)
- Data Source
  KAKENHI-PROJECT-11240204
[Book] ADAMTS-1. in Handbook of Proteolytic Enzymes (Second edition) (Barrett, A.J. and Rawlings, N.D.eds.)
- Author(s)
  Kuno K.
- Total Pages
  2
- Publisher
  Academic Press(印刷中)
- Data Source
  KAKENHI-PROJECT-14570182
[Journal Article] Protective roles of the fractalkine/CX3CL1-CX3CR1 interaction in alkali-induced corneal neovascularization thorough enhanced anti-angiogenic factor expression2008
- Author(s)
  Lu P., Li L., Kuno K., Wu Y., Baba T., Li Y, Zhang X., Mukaida N
- Journal Title
  
  Journal of Immunology 180(6)
  
  Pages : 4283-4291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590365
[Journal Article] ADAMTS-1 is involved in follicular development, ovulatory process and organization of the medullary vascular network in the ovary.2005
- Author(s)
  Shozu M, Minami N, Yokoyama H, Inoue M, Kurihara H, Matsushima K, Kuno K
- Journal Title
  
  Journal of Molecular Endocrinology 35
  
  Pages : 343-355
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590305
[Journal Article] ADAMTS-1.2004
- Author(s)
  Kuno K.
- Journal Title
  
  Handbook of Proteolytic Enzymes (Second edition) (Barrett, A.J. and Rawlings, N.D. eds.) (Academic Press)
  
  Pages : 735-737
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590305
[Journal Article] The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental metastatic potential.2004
- Author(s)
  Kuno K, et al.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 319
  
  Pages : 1327-1333
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590305
[Journal Article] The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental metastatic potential.2004
- Author(s)
  Kuno K., Bannai K., Hakozaki M., Matsushima K., Hirose K.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 319
  
  Pages : 1327-1333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590305
[Presentation] Abnormal caudal intervertebral disc formation in ADAMTS-1 null mice2007
- Author(s)
  Kunitaka Hirose, Atsuko Asaka, Hiroki Kurihara, Kouji Matsushima, Kouji Kuno
- Organizer
  The 28^<th> Annual Meetings of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590365
[Presentation] ADAMTS-1遺伝子欠損マウスにおける尾椎椎間板形成異常2007
- Author(s)
  久野耕嗣, ら
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590365

1. MATSUSHIMA Kouji (50222427)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
2. 岡田保典 (00115221)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. 佐藤博 (00115239)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. 梁幾勇 (70332583)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 大西淳之 (40261276)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 山本俊輔 (90040188)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 岡田明子 (00233320)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. AKIYAMA Mariko (60019867)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 郭哲輝 (50126570)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. MUKAIDA Naofumi (30182067)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KUNO Kouji 久野 耕嗣

Research Projects

Research Products

Co-Researchers

Study of function of ADAMTS-1 in skin wound healingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of role of ADAMTS-1 in ovarian function by using ADAMTS-1 null micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of function of ADAMTS-1 in bone metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

線虫C．elegansのADAMTS−1ホモログ遺伝子の破壊とその変異体の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

細胞外マトリックス代謝研究の新展開の総括

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TSPモチーフを有するADAMファミリー分子,ADAMTS-1の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of substrates for ADAMTS-1 metalloproteinasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

炎症時に発現されるADAMTS1遺伝子のトランスジェニックマウスの作製と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

炎症時に発現される新しいADAMファミリー遺伝子ADAMTS-1の機能発現解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-1シグナル伝達におけるIκBαキナーゼ群の役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-1非応答性突然変異株の分離とその変異を相補するcDNAのクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インターロイキン1受容体を介するシグナル伝達機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of pathophysiological role of interleukin 8 and development of its inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

KUNO Kouji 久野耕嗣