LEE Sannamu 李相男

Researcher Number	40248472
Other IDs
Affiliation (based on the past Project Information) *help	2007: 福岡大学, 理学部, 研究員 2000 – 2006: 福岡大学, 理学部, 助手 1993 – 1998: 福岡大学, 理学部, 助手
Review Section/Research Field	Principal Investigator Biophysics / Biophysics Except Principal Investigator Cerebral neurosurgery / Science and Engineering
Keywords	Principal Investigator 構造生物学 / ペプチド / 生体膜 / ペプチド合成 / 膜蛋白質 / 人工蛋白質 / リポソーム / Energy transfer / 膜貫通ペプチド / エネルギー移動 … More / 膜タンパク質 / membrane protein / 脂質蛋白質相互作用 / イオンチャンネル / 分子生物学 / 蛋白質-脂質相互作用 / デノボ合成 / 両親媒性α-ヘリックス / 蛋白質のフォールディング / 構造生化学 / Structural biolog / Lipid helix / Neutron scattering in solution / Lipisome / Phospholipid / Gold nanowire / Amphuphilic peptide / Nanotube / 両親媒性モデルペプチド / 細胞内小胞輸送 / 両親媒性ベプチド / 脂質ヘリックス / 中性子溶液散乱 / リン脂質 / 金ワイヤー / 両親媒性ペプチド / ナノチューブ / Structural biology / Cholesterol / Sphingomyelin / Raft / Membrane dynamics / Transmembrane peptide / 生体膜の流動性 / 脂質タンパク質相互作用 / 蛍光のエネルギー移動 / 生体膜膜貫通α-ヘリックスペプチド / コレステロール / スフィンゴミエリン / ラフト / 膜の流動性 / Peptide-lipid interaction / Pyrene / alpha-helical structure / Biomembrane / Lipid bilayer / Peptide / Membrane protein / 蛍光アミノ酸 / 脂質-ペプチド相互作用 / 膜貫通α-ヘリックス / ペプチド-脂質相互作用 / ピレン / α-ヘリシクス / 脂質二分子膜 / molten globule / biomembrane / ion channel / artificial protein / structural biology / モルテングローブル / Lipid-protein interaction / Isk protein / Potassium Channel / Peptide synthesis / Membrane Protein / Ion Channel / Molecular biology / 生体膜貫通構造 / 生物物理学 / 立体構造解析 / Isk蛋白質 / カリウムチャンネル / アポトーシス / チャンネル / 脂質-タンパク質相互作用 / 膜作用タンパク質 / 蛋白質の折れ畳み / 球状タンパク質 / 蛋白質のデノボ・デザイン / 会合体蛋白質 … More Except Principal Investigator lipid bilayer / pore-forming / necrosis / apoptosis / cytotoxic / U87-MG / SGP / U87MG / 膜作用性球状人工蛋白質(SGP) / ジメチルスルホキシド-水混合溶液 / アルコール-水混合溶液 / シミュレーション / X線・中性子散乱 / タンパク質 / アミロイド形成 / β-ラクトグロブリン / フルオロアルコール / 溶媒クラスター / X線・中性子回折 / アミロイド線維 / 疎水性-親水性バランス / 溶媒効果 / タンパク質のフォールディング Less

生体関連分子の機能発現に対する溶媒効果の分子論的研究
- Principal Investigator
  
  山口敏男
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Fukuoka University
Phospholipid-nanotube containing a peptide, Hel 13-5, as a model of transport vesicles in cell.Principal Investigator
- Principal Investigator
  
  LEE Sannamu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Fukuoka University
Study of the New Therapeutic Strategy for the Malignant Brain Tumor by using of Artificially Designed Pore-Forming Small Globular Protein
- Principal Investigator
  
  IWASA Mitsutoshi, TSUGU Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Fukuoka University
Effect of membrane dynamics on affecting molecular behavior of trans-membrane a -helical peptidesPrincipal Investigator
- Principal Investigator
  
  LEE Sannamu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Fukuoka University
球状ミニ蛋白質のデノボデザインによる蛋白質の構造安定化要因及び折れ畳み機構の解明Principal Investigator
- Principal Investigator
  
  李相男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fukuoka University
球状ミニ蛋白質のデノボ合成による蛋白質の構造安定化要因及び折れ畳み機構の解明Principal Investigator
- Principal Investigator
  
  李相男
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka University
The evolution of oligomerization factors of membrane-spanning alpha-helical segments into lipid bilayersPrincipal Investigator
- Principal Investigator
  
  LEE Sannamu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Fukuoka University
球状ミニ蛋白質のデノボ合成による蛋白質の構造安定化要因および折れ畳み機構の解明Principal Investigator
- Principal Investigator
  
  李相男
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka University
De novo synthesis of a small globular protein SGP and its insertion into lipid bilayPrincipal Investigator
- Principal Investigator
  
  LEE Sannamu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Fukuoka University
Synthesis of Transmembrane Segment of A Single Spanning Protein, Isk, Forming Potassium Channel and Its Interaction with Phospholipid BilayrPrincipal Investigator
- Principal Investigator
  
  LEE Sannamu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Fukuoka University

All 2007 2006 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] モデル小ペプチドのアルコール誘起α-ヘリックス形成における溶媒環境の役割2007
- Author(s)
  藤永丈晴、中村智、Krishtal Sergey, 吉田亨次、李相男、金澤健治、根本直、山口敏男、
- Journal Title
  
  福岡大学理学集報 37・1
  
  Pages: 23-31
- Data Source
  KAKENHI-PROJECT-15076211
[Journal Article] Amyloid formation and cytotoxicity of a de novo designed protein, amyloidgenesin, and its analogs2006
- Author(s)
  Okada, T., Lee, S., Yoshida, K., Yamaguchi, T., Nakashima, M., Takahashi, M.
- Journal Title
  
  Peptide Science
  
  Pages: 217-220
- NAID
  10017675682
- Data Source
  KAKENHI-PROJECT-15076211
[Journal Article] Mode of Interaction of amphiphilic α-helical peptide with phosphatidylcholines at the air-water interface2006
- Author(s)
  Nakahara, H., Nakamura, S., Hiranita, T., Kawasaki, H., Lee, S., Sugihara, G., Shibata.O.
- Journal Title
  
  Langmuir 22(3)
  
  Pages: 1182-1192
- Data Source
  KAKENHI-PROJECT-15076211
[Journal Article] A monolayer study on three binary mixed systems of dipalmitol phosphatidyl choline with choresterol, cholestanol and stigmasterol.2004
- Author(s)
  M.Kodama, O.Shibata, S.Lee.
- Journal Title
  
  Colloids Surface B, Biointerfaces 30
  
  Pages: 211-226
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] The effect of cholesterol and monosialoganglioside (GMI) on the release and aggregation of Amyloid beta-peptide from liposomes prepared from brain membrane-like lipids2004
- Author(s)
  Y.Tashima, R.Oe, S.Lee, G.Sugihara, E.J.Chambers, M.Takahashi, T.Yamada
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 17587-17595
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] A monolayer study on three binary mixed systems of dipalmitol phosphatidylcholine with choresterol, cholestanol and stigmasterol2004
- Author(s)
  M.Kodama, O.Shibata, S.Nakamura, S.Lee, G.Sugihara
- Journal Title
  
  Colloids Surface B, Biointerfaces 33
  
  Pages: 211-226
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of Amyloid beta-peptide from liposomes prepared from brain membrane-like lipids2004
- Author(s)
  Y.Tashima, R.Oe, S.Lee, G.Sugihara.
- Journal Title
  
  Journal of the Biological Chemistry 279
  
  Pages: 17587-17595
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] A monolayer study on three binary mixed systems of dipalmitol phosphatidyl choline with choresterol, cholesterol and stigmasterol2004
- Author(s)
  M.Kodama, O.Shibata, S.Lee, G.Sugihara
- Journal Title
  
  Colloids Surface B, Biointerfaces 30
  
  Pages: 211-226
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of Amyloid beta-peptide from liposomes prepared from brain membrane-like lipids2004
- Author(s)
  Y.Tashima, R.Oe, S.Lee, G.Sugihara, E.J.Chambers, M.Takahashi, T.Yamada
- Journal Title
  
  Journal of the Biological Chemistry 279,17
  
  Pages: 17587-17595
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] Nanotubules formed by highly hydrophobic amphiphilic alpha-helical peptides and natural phospholipids2003
- Author(s)
  Furuya, T., Kiyota, T., Lee, S.
- Journal Title
  
  Biophysical Journal 84
  
  Pages: 1950-1959
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] An artificially designed pore-forming protein with anti-tumor effects2003
- Author(s)
  Ellerby, H.M, Lee, S., Ellerby, L.M., et al.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 35311-35316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] Nanotubules foamed by highly hydrophobic amphiphilic alpha-helical peptides and natural phospholipids2003
- Author(s)
  Fumya, T., Kiyota, T., Lee, S., et al.
- Journal Title
  
  Biophysical Journal 84
  
  Pages: 1950-1959
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Journal Article] An artificially designed pore-forming protein with anti-tumor effects2003
- Author(s)
  Ellerby, H.M, Lee, S., Ellerby, L.M.
- Journal Title
  
  Journal of the Biological Chemistry 278
  
  Pages: 35311-35316
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570141
[Patent] Artificial pulmonary surfactants
- Inventor(s)
  Lee, S., Yukitake K, Nakamura, Y
- Data Source
  KAKENHI-PROJECT-15076211
[Presentation] On the Role of Solvent Environment in Alcohol-induced a-Helix Formation of Model Peptides2007
- Author(s)
  T.Yamaguchi, T.Fujinaga, S.Nakamura, S.Krishtal, K.Yoshida, S.Lee, K.Kanazawa, T.Nemoto,
- Organizer
  30th International Conference on Solution CHemistry
- Place of Presentation
  Perth,Australia
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-15076211

1. SUGIHARA Gohsuke (50090915)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMASHITA Shoji (70089936)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. IWASA Mitsutoshi (40341416)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TSUGU Hitoshi (80279273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ANZAI Kazunori (70128643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAGADOME Shigemi (60180501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. INOUE Tohru (50078599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUSHIMA Takeo (10078735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAMI Noboru (80154904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口敏男 (70158111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 吉田亨次 (00309890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

LEE Sannamu 李 相男

Research Projects

Research Products

Co-Researchers

生体関連分子の機能発現に対する溶媒効果の分子論的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phospholipid-nanotube containing a peptide, Hel 13-5, as a model of transport vesicles in cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the New Therapeutic Strategy for the Malignant Brain Tumor by using of Artificially Designed Pore-Forming Small Globular Protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of membrane dynamics on affecting molecular behavior of trans-membrane a -helical peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

球状ミニ蛋白質のデノボデザインによる蛋白質の構造安定化要因及び折れ畳み機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

球状ミニ蛋白質のデノボ合成による蛋白質の構造安定化要因及び折れ畳み機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

The evolution of oligomerization factors of membrane-spanning alpha-helical segments into lipid bilayersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

球状ミニ蛋白質のデノボ合成による蛋白質の構造安定化要因および折れ畳み機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

De novo synthesis of a small globular protein SGP and its insertion into lipid bilayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of Transmembrane Segment of A Single Spanning Protein, Isk, Forming Potassium Channel and Its Interaction with Phospholipid BilayrPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] モデル小ペプチドのアルコール誘起α-ヘリックス形成における溶媒環境の役割2007

Author(s)

Journal Title

Data Source

[Journal Article] Amyloid formation and cytotoxicity of a de novo designed protein, amyloidgenesin, and its analogs2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mode of Interaction of amphiphilic α-helical peptide with phosphatidylcholines at the air-water interface2006

Author(s)

Journal Title

Data Source

[Journal Article] A monolayer study on three binary mixed systems of dipalmitol phosphatidyl choline with choresterol, cholestanol and stigmasterol.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] The effect of cholesterol and monosialoganglioside (GMI) on the release and aggregation of Amyloid beta-peptide from liposomes prepared from brain membrane-like lipids2004

LEE Sannamu 李相男