Itano Naoki 板野直樹

… Alternative Names

ITANO Naoki 板野直樹

板野直樹イタノナオキ

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Researcher Number	40257712
External Links
Affiliation (Current)	2025: 京都産業大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 京都産業大学, 生命科学部, 教授 2013 – 2018: 京都産業大学, 総合生命科学部, 教授 2012: 京都産業大学, 公私立大学の部局等, 教授 2011: 京都産業大学, 総合生命科学部, 教授 2008 – 2009: Shinshu University, 医学系研究科, 准教授 … More 2008: Shinshu University, 大学院・医学研究科, 准教授 2007: Shinshu University, 大学院・医学系研究科, 准教授 2006: Shinshu University, Graduate School of Medicine, Associate professor 2006: 信州大学, 大学院医学研究科, 助教授 2005: 信州大学, 大学院・医学研究科, 助教授 2002 – 2003: 愛知医科大学, 分子医科学研究所, 講師 1997 – 1998: 愛知医科大学, 分子医科学研究所, 助手 1995: 愛知医科大学, 分子医科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Experimental pathology / Structural biochemistry / Tumor biology / Biological Sciences Except Principal Investigator Experimental pathology
Keywords	Principal Investigator ヒアルロン酸 / がん幹細胞 / ストレス耐性 / ニッチ / マトリックス / 糖 / 細胞外マトリックス / 炎症 / 糖鎖 / 幹細胞 … More / 癌 / 合成酵素 / がん / ストレス応答 / 糖代謝 / ヘキソサミン / シグナル伝達 / ヘキソサミン合成経路 / ヘキソサミンシグナル / O-GlcNAc修飾 / 薬剤耐性 / Interaction / Structure / Extracellular matrix / Hyaluronan / Polysaccharide / 受容体 / 相互作用 / 高次構造 / ビアルロン酸 / 微小環境 / マクロファージ / 淘汰圧 / がん微小環境 / ケモカイン / リンパ管 / 腫瘍 / 遺伝子改変 / ヒアルロン酸合成酵素 / 糖鎖情報 / ノックアウトマウス / 糖転移酵素 / 遺伝子 … More Except Principal Investigator 細胞死 / ピロリ菌 / 感染 / 炎症 / ASC / 自然免疫 / 腫瘍 Less

がん細胞集団のレジリエンスを鍛える低容量ストレス応答の作動原理解明Principal Investigator
- Principal Investigator
  
  板野直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kyoto Sangyo University
Re-sensitization of drug-resistant cancer cells by targeting hexosamine signaling pathwaysPrincipal Investigator
- Principal Investigator
  
  Itano Naoki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kyoto Sangyo University
Fundamental study of niche modification for reducing cancer stem cell propertiesPrincipal Investigator
- Principal Investigator
  
  ITANO Naoki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto Sangyo University
Selective pressure driving cancer cell fate decisions: the mechanism of the creationPrincipal Investigator
- Principal Investigator
  
  ITANO Naoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto Sangyo University
ヒアルロン酸ーケモカインを基軸とした幹細胞ニッチ統合支配の分子機構Principal Investigator
- Principal Investigator
  
  板野直樹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
Molecular and pathological examination of lymphangiogenic tumor stromaPrincipal Investigator
- Principal Investigator
  
  ITANO Naoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
Role of ASC, which regulates inflammation and cell death, in Helicobacter pylori infection
- Principal Investigator
  
  TANIGUCHI Shun-ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
Molecular mechanism for structure-dependent ligand recognition of the hyaluronan receptorPrincipal Investigator
- Principal Investigator
  
  ITANO Naoki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Shinshu University
糖鎖長の改変によるヒアルロン酸糖鎖情報の解読Principal Investigator
- Principal Investigator
  
  板野直樹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Aichi Medical University
ヒアルロン酸合成酵素遺伝子の改変とマウス個体におけるヒアルロン酸の機能解析Principal Investigator
- Principal Investigator
  
  板野直樹
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Aichi Medical University
グリコサミノグリカン糖転移酵素遺伝子の単離に関する研究Principal Investigator
- Principal Investigator
  
  板野直樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Aichi Medical University

[Book] ヒアルロン酸合成酵素未来を拓く糖鎖科学(永井克孝監修)2005
- Author(s)
  板野直樹, 木全弘治
- Total Pages
  2
- Publisher
  金芳堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Book] プロテオグリカン分子群の合成と構造異常がもたらす細胞機能の変化-癌浸潤・転移の理解と克服に向けた解析-未来を拓く糖鎖科学(永井克孝監修)2005
- Author(s)
  板野直樹
- Total Pages
  6
- Publisher
  金芳堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Journal Article] Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation2024
- Author(s)
  Iwamoto Shungo、Kobayashi Takashi、Hanamatsu Hisatoshi、Yokota Ikuko、Teranishi Yukiko、Iwamoto Akiho、Kitagawa Miyu、Ashida Sawako、Sakurai Ayane、Matsuo Suguru、Myokan Yuma、Sugimoto Aiyu、Ushioda Ryo、Nagata Kazuhiro、Gotoh Noriko、Nakajima Kazuki、Nishikaze Takashi、Furukawa Jun-ichi、Itano Naoki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 15 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41419-024-06432-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18237, KAKENHI-PROJECT-22K06605, KAKENHI-PROJECT-21K08266, KAKENHI-PROJECT-21H02761, KAKENHI-PROJECT-23K24759
[Journal Article] Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin2023
- Author(s)
  Iwamoto Shungo、Mori Yugo、Yamashita Tomoko、Ojima Kazuki、Akita Kaoru、Togano Shingo、Kushiyama Shuhei、Yashiro Masakazu、Yatera Yuki、Yamaguchi Tomoko、Komiyama Akane、Sago Yuki、Itano Naoki、Nakada Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 8 Pages: 104971-104971
- DOI
  10.1016/j.jbc.2023.104971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06605, KAKENHI-PROJECT-21H03008
[Journal Article] Dysregulation of hexosamine biosynthetic pathway wiring metabolic signaling circuits in cancer2023
- Author(s)
  Itano Naoki、Iwamoto Shungo
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1867 Issue: 1 Pages: 130250-130250
- DOI
  10.1016/j.bbagen.2022.130250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06605, KAKENHI-PROJECT-18K06671
[Journal Article] Hyaluronan: Metabolism and Function.2020
- Author(s)
  Takashi Kobayashi, Theerawut Chanmee, Naoki Itano
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 11 Pages: 1525-1525
- DOI
  10.3390/biom10111525
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06671
[Journal Article] Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer2019
- Author(s)
  Chokchaitaweesuk Chatchadawalai、Kobayashi Takashi、Izumikawa Tomomi、Itano Naoki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 10 Issue: 11 Pages: 803-803
- DOI
  10.1038/s41419-019-2034-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06671
[Journal Article] Implications of altered O-glycosylation in tumour immune evasion2019
- Author(s)
  Itano Naoki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 165 Issue: 5 Pages: 387-390
- DOI
  10.1093/jb/mvz003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06671
[Journal Article] Metabolic Reprogramming and Hyaluronan Production in Cancer Stem Cells2018
- Author(s)
  Tomomi Izumikawa, Naoki Itano
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 30 Issue: 176 Pages: E147-E154
- DOI
  10.4052/tigg.1713.1E
- NAID
  130007486010
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2018-09-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06671
[Journal Article] Hyaluronan: A modulator of the tumor microenvironment.2016
- Author(s)
  Chanmee T, Ontong P, Itano N.
- Journal Title
  
  Cancer Letter
  
  Volume: 375 Issue: 1 Pages: 20-30
- DOI
  10.1016/j.canlet.2016.02.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430125
[Journal Article] Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling.2016
- Author(s)
  Chanmee T, Ontong P, Izumikawa T, Higashide M, Mochizuki N, Chokchaitaweesuk C, Khansai M, Nakajima K, Taniguchi N, Itano N.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 46 Pages: 24105-24120
- DOI
  10.1074/jbc.m116.751263
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-26430125
[Journal Article] Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the TGF-β-Snail signaling axis.2014
- Author(s)
  T. Chanmee, P. Ontong, N. Mochizuki, P. Kongtawelert, K. Konno, N. Itano
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 38 Pages: 26038-26056
- DOI
  10.1074/jbc.m114.564120
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430125
[Journal Article] －糖鎖と疾患－　癌進展におけるヒアルロン酸腫瘍微小環境の役割2013
- Author(s)
  望月信利，板野直樹
- Journal Title
  
  病理と臨床
  
  Volume: 31 Pages: 875-882
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Crucial role of hyaluronan in neointimal formation after vascular injury2013
- Author(s)
  Kashima, Y., Takahashi, M., Shiba, Y., Itano, N., Izawa, A., Koyama, J., Nakayama, J., Taniguchi, S., Kimata, K., and Ikeda, U.
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] -糖鎖と疾患‐癌進展におけるヒアルロン酸腫瘍微小環境の役割2013
- Author(s)
  望月信利,板野直樹
- Journal Title
  
  病理と臨床
  
  Volume: 31 Pages: 875-882
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts2012
- Author(s)
  Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., and Tanaka, S.
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35(3) Pages: 408-412
- NAID
  130001872324
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis2012
- Author(s)
  Goncharova, V., Serobyan, N., Iizuka, S., Schraufstatter, I., de Ridder, A., Povaliy, T., Wacker, V., Itano, N., Kimata, K., Orlovskaja, I.A., Yamaguchi, Y., and Khaldoyanidi, S.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287(30) Pages: 25419-25433
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.2012
- Author(s)
  Mack JA, Feldman RJ, Itano N, Kimata K, Lauer M, Hascall VC, Maytin EV.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 132 Issue: 1 Pages: 198-207
- DOI
  10.1038/jid.2011.248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570148, KAKENHI-PROJECT-23590478
[Journal Article] Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has32012
- Author(s)
  Mack, J.A., Feldman, R.J., Itano, N., Kimata, K., Lauer, M., Hascall, V.C., and Maytin, E.V.
- Journal Title
  
  J. Invest. Dermatol
  
  Volume: 132(1) Pages: 198-207
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Inflammatory alterations of the extracellular matrix in the tumor microenvironment.2011
- Author(s)
  J. Iijima, K. Konno, and N. Itano
- Journal Title
  
  Cancers
  
  Volume: 3 Pages: 3189-3205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590478
[Journal Article] Involvement of CD44 in mast cell proliferation during terminal differentiation.2009
- Author(s)
  Takani, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., Tanaka, S.
- Journal Title
  
  Lab.Invest. 89
  
  Pages: 446-455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057008
[Journal Article] Simple primary structure, complex turnover regulation and multiple roles of hyaluronan2008
- Author(s)
  Itano, N.
- Journal Title
  
  Journal of Biochemistry 144
  
  Pages: 131-137
- NAID
  10024911221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057008
[Journal Article] Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression2008
- Author(s)
  Itano, N, Zhuo, L, and Kimata, K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 1720-1725
- NAID
  10024010481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Altered hyaluronan biosynthesis in cancer progression2008
- Author(s)
  Itano, N., Kimata, K.
- Journal Title
  
  Seminar in Cancer Biology 18
  
  Pages: 268-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression2008
- Author(s)
  Itano, N., Zhuo, L., Kimata, K.
- Journal Title
  
  Cancer Science 99
  
  Pages: 1720-1725
- NAID
  10024010481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Altered hyaluronan biosynthesis in cancer progression.2008
- Author(s)
  Itano, N., ^*Kimata, K.
- Journal Title
  
  Seminar in Cancer Biology 18
  
  Pages: 268-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Simple primary structure, complex turnover regulation and multiple roles of hvaluronan Journal of Biochemistry2008
- Author(s)
  Itano, N.
- Journal Title
  
  144
  
  Pages: 131-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Role of ASC in the Mouse Model of Helicobacter pylori Infection2008
- Author(s)
  Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Fukuda M, Nakayama J, Taniguchi S
- Journal Title
  
  J.Histochem & Cytochem 271
  
  Pages: 9-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Role of ASC in the Mouse Model of Helicobacter pylori. Infection2008
- Author(s)
  Benoit BN, Kobavashi M. Kawakubo M, Takeoka M, Sano K, Zou J, Itano N. Tsutsui H, Noda T, Fukuda M, Nakayama J, Tanjguchi S
- Journal Title
  
  J. Histochem & Cytochem. 271
  
  Pages: 9-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression.2008
- Author(s)
  ^*Itano. N., Zhuo, L., Kimata, K.
- Journal Title
  
  Cancer Science 99
  
  Pages: 1720-1725
- NAID
  10024010481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] 臨床糖鎖バイオマーカーの開発-糖鎖機能の解明とその応用(進行癌モニタリングのおけるヒアルロン酸リッチ腫瘍内微小環境の重要性)2008
- Author(s)
  三好征司, 小林宣隆, ^*板野直樹
- Journal Title
  
  メディカルドゥ遺伝子医学MOOK 11
  
  Pages: 234-239
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis : Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment2008
- Author(s)
  Koyama, H, Kobayashi, N, Harada, M, Takeoka, M, Kawai, Y, Sano, K, Fujimori, M, Amano, J, Ohhashi, T, Kannagi, R., Kimata, K, Taniguchi, S, and Itano, N
- Journal Title
  
  Am. J. Pathol 172
  
  Pages: 179-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenviromment.2008
- Author(s)
  Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano, J., Ohhashi, T., Kannagi, R., Kimata, K., Taniguchi, S., Itano, N.
- Journal Title
  
  Am. J. Pathol. 172
  
  Pages: 179-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Altered hyaluronan biosynthesis in cancer progression2008
- Author(s)
  Itano, N, and Kimata, K
- Journal Title
  
  Semin. Cancer Biol 18
  
  Pages: 268-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] 進行癌モニタリングのおけるヒアルロン酸リッチ腫瘍内微小環境の重要性2008
- Author(s)
  三好征司、小林宣隆、板野直樹
- Journal Title
  
  臨床糖鎖バイオマーカーの開発-糖鎖機能の解明とその応用(成松久監修)遺伝子医学MOOK
  
  Pages: 234-239
- Data Source
  KAKENHI-PROJECT-19590384
[Journal Article] Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Accelerates Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican/PG-M.2007
- Author(s)
  Koyama, H., Hibi, T., Isogai, Z., Yoneda, M., Fujimori, M., Amano, J., Kawakubo, M., Kannagi, R., Kimata, K., Taniguchi, S., and Itano, N.
- Journal Title
  
  American Journal of Pathology 170(3)
  
  Pages: 1086-1099
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Journal Article] Hyperproduction of Hyaluronan in Neu-Induced Mammary Thmor Accelerates Angiogenesis through Stromal Cell Recruitment : Possible Involvement of Versican /PG-M.2007
- Author(s)
  Koyama, H., Hibi, T., Isogai, Z., Yoneda, M. Fujimori, M., Amano, J., Kawakubo, M. Kannagi, R., Kimata, K., Taniguchi, S., Itano, N.
- Journal Title
  
  American Journal of Pathology 170(3)
  
  Pages: 1086-1099
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Journal Article] SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum2006
- Author(s)
  Zhuo, L., Kanamori, A. Kannagi, R., Itano. N. Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K.
- Journal Title
  
  Journal of Biological Chemistry 281(29)
  
  Pages: 20303-20314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Journal Article] SHAP potentiates the CD44-mediated leukocyte adhesionto the hyaluronan substratum2006
- Author(s)
  Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, N., Kimata, K.
- Journal Title
  
  Journal of Biologicla Chemistry 281(29)
  
  Pages: 20303-20314
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570098
[Presentation] ヒアルロン酸過剰産生がん細胞で特徴的に変化するN-型糖鎖のグライコミクス解析2023
- Author(s)
  板野直樹、岩本駿吾、花松久寿、古川潤一
- Organizer
  第32回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K06605
[Presentation] がん幹細胞性の制御におけるヒアルロン酸産生の意義の解明2023
- Author(s)
  蘆田紗和子、岩本駿吾、板野直樹
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-22K06605
[Presentation] ヒアルロン酸産生はヘキソサミン合成経路を介してがん幹細胞性を制御する2022
- Author(s)
  板野直樹、岩本駿吾、小林孝
- Organizer
  第8回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] ヘキソサミン代謝によるがん幹細胞性の制御：ヒアルロン酸と糖鎖修飾を介したシグナルの意義2022
- Author(s)
  岩本駿吾、板野直樹
- Organizer
  第31回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] ヘキソサミン代謝によるがん幹細胞性の制御：ヒアルロン酸とO-GlcNacシグナルの意義2020
- Author(s)
  小林孝、Chatchadawalai Chokchaitaweesuk、泉川友美、板野直樹
- Organizer
  第52回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] Enhanced hexosamine metabolism drives metabolic and signaling circuit involving hyaluronan production and O-GlcNAcylation to promote cancer stem-like properties.2019
- Author(s)
  Naoki Itano
- Organizer
  Hyaluronan 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] ヒアルロン酸産生はヘキソサミン合成経路を介してがん幹細胞性を制御する2019
- Author(s)
  2.小林孝、Chatchadawalai Chokchaitaweesuk、泉川友美、板野直樹
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] ヒアルロン酸合成に伴うがんの悪性化とヘキソサミン合成経路の代謝流束およびO-GlcNAc修飾の亢進2019
- Author(s)
  3.Chatchadawalai Chokchaitaweesuk、小林孝、泉川友美、板野直樹
- Organizer
  第9２回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] Role of Hyaluronan in Metabolic Reprogramming of Cancer Stem Cells2018
- Author(s)
  Naoki Itano
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06671
[Presentation] ヘキソサミン合成経路を介したがん幹細胞の代謝リプログラミング2017
- Author(s)
  泉川友美、チャンミー　シーラウット、東出実歩、ショーチャイタウィスゥ　チャッチャダワライ、中嶋和紀、柿崎育子、谷口直之、板野直樹
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] ヒアルロン酸生合成を起点とした代謝リプログラミングとがん幹細胞性の発現調節2017
- Author(s)
  泉川友美、板野直樹
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] ヘキソサミン合成経路を介したがん幹細胞様細胞の代謝リプログラミング2017
- Author(s)
  板野直樹
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling2017
- Author(s)
  Itano, N., Chanmee, T., Ontong, P., Izumikawa, T., Higashide, M., Mochizuki, N., Chokchaitaweesuk, C., Khansai, M., Nakajima, K., Kakizaki, I., Kongtawelert, P., Taniguchi, N.
- Organizer
  International Society for Hyaluronan Sciences 11th International Conference (Hyaluronan 2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] 乳がん細胞の上皮-間葉転換を制御するヘキソサミン合成経路の役割2017
- Author(s)
  東出実歩、泉川友美、Chokchaitaweesuk Chatchadawarai、板野直樹
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] ヘキソサミン合成経路による上皮‐間葉転換制御機構2016
- Author(s)
  東出実歩、望月信利、チャンミー　シーラウット、板野直樹
- Organizer
  第63回日本生化学会近畿支部例会
- Place of Presentation
  神戸薬科大学（兵庫県・神戸市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling2016
- Author(s)
  Tomomi Izumikawa, Theerawut Chanmee, Pawared Ontong, Miho Higashide, Nobutoshi Mochizuki, Chatchadawalai Chokchaitaweesuk, Manatsanan Khansai, Kazuki Nakajima, Ikuko Kakizaki, Prachya Kongtawelert, Naoyuki Taniguchi, Naoki Itano
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] Excessive hyaluronan production promotes acquisition of cancer stem signatures2015
- Author(s)
  Itano, N. Chanmee, T., Ontong, P., Mochizuki, N., Kongtawelert, P., Konno, K.
- Organizer
  International Society for Hyaluronan Sciences 10th International Conference
- Place of Presentation
  Florence, Italy
- Year and Date
  2015-07-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] がん幹細胞制御因子としてのヒアルロン酸2015
- Author(s)
  板野直樹
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県・名古屋市
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] ヒアルロン酸産生によるがん幹細胞の代謝リプログラミング2015
- Author(s)
  板野直樹
- Organizer
  BMB2015
- Place of Presentation
  兵庫県・神戸市
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] 癌進展におけるヒアルロン酸微小環境の多面的な役割2014
- Author(s)
  板野直樹
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館、京都市
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] ヒアルロン酸誘導性上皮間葉転換によるがん幹細胞性の制御2014
- Author(s)
  チャンミー　シーラウット，板野直樹
- Organizer
  第23回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢市文化ホール、金沢市
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-26430125
[Presentation] Hyperproduction of hyaluronan generate cancer stem-like cells2013
- Author(s)
  Chanmee, T., Konno, K., Kongtawelert, P., Itano, N.
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference (Hyaluronan 2013)
- Place of Presentation
  Oklahoma City, OK, USA
- Year and Date
  2013-07-07
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] Impact of the hyaluronan-rich tumor microenvironment on cancer progression2013
- Author(s)
  Itano, N.
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference (Hyaluronan 2013)
- Place of Presentation
  Oklahoma City, OK, USA
- Year and Date
  2013-07-06
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] ヒアルロン酸合成異常と癌の進展2013
- Author(s)
  板野直樹
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪市(シンポジウム)
- Year and Date
  2013-08-06
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] ヒアルロン酸腫瘍微小環境の形成と癌の進展2012
- Author(s)
  板野直樹
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] ヒアルロン酸合成異常と癌の進展2011
- Author(s)
  板野直樹
- Organizer
  第8回日本病理学会カンファレンス(招待講演)
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] Impact of the hyaluronan-rich tumor microenvironment on cancer progression.2011
- Author(s)
  Naoki Itano
- Organizer
  Uppsala University Svedberg Seminar Series(招待講演)
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] 腫瘍関連マクロファージとヒアルロン酸リッチ腫瘍微小環境2011
- Author(s)
  板野直樹
- Organizer
  北海道大学遺伝子病制御研究所共同研究集会(招待講演)
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] 間質ヒアルロン酸の欠損は腫瘍関連マクロファージの動員と腫瘍血管新生を抑制する2009
- Author(s)
  板野直樹、竹岡みち子、谷口俊一郎
- Organizer
  第18回日本がん転移学会学術集会・総会
- Place of Presentation
  旭川グランドホテル(北海道)
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20057008
[Presentation] A deficiency in stromal hyaluronan impairs macrophage recruitment and tumor neovascularization.2009
- Author(s)
  Itano, N., Taniguchi, S.
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20057008
[Presentation] ヒアルロン酸を介したマクロファージ動員による腫瘍間質形成と血管成熟化機構の検討2008
- Author(s)
  小林宣隆、三好征司、鄒健、小山洋、竹岡みち子、吉田和夫、天野純、谷口俊一郎、板野直樹
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ASC regulates tumor immunity by IL-18/IFN-gamma axis.2008
- Author(s)
  鄒健, 二好征司, 小林宣隆, ベノイトベカレニュマ, 竹岡みち子, 板野直樹, 谷口俊一郎
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] 血管・リンパ管新生におけるヒアルロン酸リッチ腫瘍微小環境と腫瘍関連マクロファージの作用2008
- Author(s)
  三好征司、小林宣隆、板野直樹
- Organizer
  平成20年度糖鎖機能研究会
- Place of Presentation
  愛知(岡崎自然科学研究機構)
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ヒアルロン酸 : がん-間質細胞相互作用の微小環境メディエータ-2008
- Author(s)
  板野直樹, 谷口俊一郎
- Organizer
  第67回日本癌学会学術総会シンポジウム「がんの浸潤・転移の分子機構」
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] Chronic High-Intensity Walking Exercise Alters DNA Methylation in Normal Middle-Aged and Older Subjects to Younger State2008
- Author(s)
  Koki Nakajima, Michiko Takeoka, Masyuki Mori,Akihiro Sakurai,Hiroshi Nose, Keiichi Higuchi, Naoki Itano and Shun'ichiro Taniguchi
- Organizer
  7th World Congress on Aging and Physical Activity
- Place of Presentation
  Tsukuba
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] ヒアルロン酸 : がん-間質細胞相互作用の微小環境メデイェーター2008
- Author(s)
  板野直樹, 谷口俊一郎
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ウォーキング運動のエピジェネティック効果-ASC遺伝子のメチル化に着目して-(第3報)2008
- Author(s)
  中島弘毅, 竹岡みち子, 森政之, 櫻井晃洋, 能勢博, 樋口京一, 板野直樹, SUGRC, 谷口俊一郎
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] ヒアルロン酸:がん-間質細胞相互作用の微小環境メディエータ-2008
- Author(s)
  板野直樹, 谷口俊一郎
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ASC regulates tumor immunity byIL-18/IFN-gamma axis2008
- Author(s)
  鄒健、三好征司、小林宣隆、ベノイトベカレニュマ、竹岡みち子、板野直樹、谷口俊一郎
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] 血管・リンパ管新生におけるヒアルロン酸リッチ腫瘍微小環境と腫瘍関連マクロファージの作用2008
- Author(s)
  三好征司, 小林宣隆, 板野直樹
- Organizer
  2008年度糖鎖機能研究会
- Place of Presentation
  愛知(岡崎自然科学研究機構)
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] Jun Nakayama, Shun'ichiro Taniguchi Role of ASC protein in the mouse model of Helicobacter pyliro infection2008
- Author(s)
  BEKALE NGUEMA BENOIT, Michiko Takeoka, Naoki Itano
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] ヒアルロン酸細胞外マトリックスによる腫瘍関連マクロファージ(TAM)の動員機構2008
- Author(s)
  三好征司、小林宣隆、鄒健、竹岡みち子、谷口俊一郎、板野直樹
- Organizer
  第17回日本がん転移学会学術集会
- Place of Presentation
  鹿児島サンロイヤルホテル
- Year and Date
  2008-07-24
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ヒアルロン酸を介したマクロファージ動員による腫瘍間質形成と血管成熟化機構の検討2008
- Author(s)
  小林宣隆、三好征司、鄒健、小山洋、竹岡みち子、吉田和夫、天野純、谷口俊一郎、板野直樹
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] ウォーキング運動のエピジェネティツク効果-ASC遺伝子のメチル化に着目して-(第3報)2008
- Author(s)
  中島弘毅, 竹岡みち子, 森政之, 横井晃洋, 能勢博, 樋口京一, 板野直樹, SUGRC, 谷口俊一郎
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] Chronic High-Intensity Walking Exercise Alters DNA Methylation in Normal Middle-Aged and Older Subjects to Younger State.2008
- Author(s)
  Koki Nakajima, Michiko Takeoka, Masyuki Mori, Akihiro Sakurai, Hiroshi Nose, Keiichi Higuchi, Naoki Itano, Shun'ichiro Taniguchi
- Organizer
  7th World Congress on Aging and Physical Activity
- Place of Presentation
  Tsukuba
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] ヒアルロン酸細胞外マトリックスによる腫瘍関連マクロファージ(TAM)の動員機構2008
- Author(s)
  三好征司、小林宣隆、鄒健、竹岡みち子、谷口俊一郎、板野直樹
- Organizer
  第17回日本がん転移学会学術集会
- Place of Presentation
  鹿児島(鹿児島サンロイヤルホテル)
- Year and Date
  2008-07-24
- Data Source
  KAKENHI-PROJECT-19590384
[Presentation] Role of ASC protein in the mouse model of Helicobacter pyliro infection.2008
- Author(s)
  BEKALE NGUEMA BENOIT, Michiko Takeoka, Naoki Itano, JunNakayama, Shun'ichiro Taniguchi
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] ASC deficiency enhances autophagy for cell survival.2007
- Author(s)
  Takahashi Y, Takahashi M, Itano N, Sagara J, Taniguchi S.
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] Impact of the hyaluronan-rich tumor microenvironment on cancer progression
- Author(s)
  N. Itano
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference
- Place of Presentation
  Oklahoma City, OK, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] Hyaluronan production regulates self-renewal of cancer stem cells
- Author(s)
  T. Chanmee, N. Itano
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] ヒアルロン酸合成異常と癌の進展
- Author(s)
  板野直樹
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23590478
[Presentation] Hyperproduction of hyaluronan generate cancer stem-like cells
- Author(s)
  T. Chanmee, K. Konno, P. Kongtawelert, N. Itano
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference
- Place of Presentation
  Oklahoma City, OK, USA
- Data Source
  KAKENHI-PROJECT-23590478

1. TSUTSUI Hiroko (40236914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TANIGUCHI Shun-ichiro (60117166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. KOBAYASHI Motohiro (00362137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. SAGARA Junji (10225831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IZUMIKAWA Tomomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. MOCHIZUKI Nobutoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. HIGASHIDE Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. Chanmee Theerawut

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. Ontong Pawared

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. Chokchaitaweesuk Chatchadawarai

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. NAKAJIMA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 木全弘治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 後藤典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Itano Naoki 板野 直樹

ITANO Naoki 板野 直樹

板野 直樹 イタノ ナオキ

Research Projects

Research Products

Co-Researchers

がん細胞集団のレジリエンスを鍛える低容量ストレス応答の作動原理解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Re-sensitization of drug-resistant cancer cells by targeting hexosamine signaling pathwaysPrincipal Investigator

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Fundamental study of niche modification for reducing cancer stem cell propertiesPrincipal Investigator

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Selective pressure driving cancer cell fate decisions: the mechanism of the creationPrincipal Investigator

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ヒアルロン酸ーケモカインを基軸とした幹細胞ニッチ統合支配の分子機構Principal Investigator

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Molecular and pathological examination of lymphangiogenic tumor stromaPrincipal Investigator

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Role of ASC, which regulates inflammation and cell death, in Helicobacter pylori infection

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Molecular mechanism for structure-dependent ligand recognition of the hyaluronan receptorPrincipal Investigator

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糖鎖長の改変によるヒアルロン酸糖鎖情報の解読Principal Investigator

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ヒアルロン酸合成酵素遺伝子の改変とマウス個体におけるヒアルロン酸の機能解析Principal Investigator

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グリコサミノグリカン糖転移酵素遺伝子の単離に関する研究Principal Investigator

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[Book] ヒアルロン酸合成酵素未来を拓く糖鎖科学(永井克孝監修)2005

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[Book] プロテオグリカン分子群の合成と構造異常がもたらす細胞機能の変化-癌浸潤・転移の理解と克服に向けた解析-未来を拓く糖鎖科学(永井克孝監修)2005

Author(s)

Itano Naoki 板野直樹

ITANO Naoki 板野直樹

板野直樹イタノナオキ

[Journal Article] －糖鎖と疾患－　癌進展におけるヒアルロン酸腫瘍微小環境の役割2013