Sahara Naruhiko 佐原成彦

… Alternative Names

SAHARA Naruhiko 佐原成彦

SAHARA Nobuhiko 佐原成彦

SAHARA N 佐原成彦

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Researcher Number	40261185
Other IDs
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Affiliation (Current)	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 上席研究員 2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 上席研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 上席研究員 2021 – 2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 上席研究員 2021 – 2022: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, グループリーダー 2018 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, グループリーダー(定常) 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, チームリーダー(定常) … More 2016: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主幹研究員(定常) 2016: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主幹研究員(定常)(定常) 2014 – 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, サブリーダー 2009: 理研, 研究員 2006 – 2008: 独立行政法人理化学研究所, アルツハイマー病研究チーム, 副チームリーダー 2003 – 2005: 独立行政法人理化学研究所, アルツハイマー病研究チーム, 研究員 2000: 大阪市大, 医学部, 助手 1998 – 2000: Medical School, Osaka City University, Research Associate, 医学部, 助手 1997: (財)東京都精神医学総合研究所, 技術部, 研究員 1995: 東京都精神医学総合研究所, 技術部, 研究員 1994: (財)東京都精神医学総合研究所, 分子生物学研究部門, 技術員 1994: Tokyo Institute of Psychiatry, Mol.Biol.Researcher, 分子生物学研究部門, 技術員 Less
Review Section/Research Field	Principal Investigator Complex systems / Neurochemistry/Neuropharmacology / Basic Section 49030:Experimental pathology-related / Basic Section 46010:Neuroscience-general-related / Biological Sciences / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology Except Principal Investigator Biological Sciences / Basic Section 52020:Neurology-related / Basic Section 52040:Radiological sciences-related … More / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / 老化(加齢) / Neurochemistry/Neuropharmacology Less
Keywords	Principal Investigator タウ / タウオパチー / 神経変性疾患 / 生体イメージング / 蛋白質相転移 / タウ蛋白質 / 動物モデル / タンパク質老化 / PETイメージング / マウスモデル … More / 脳イメージング / 神経炎症 / 神経細胞死 / 伝播 / 線維状凝集体 / ミクログリア / タンパク質相転移 / タウ蛋白 / 恒常性ミクログリア / 凝集性タウ蛋白質 / 凝集タンパク質伝播 / プリオン様伝播 / 脳萎縮 / 細胞毒性 / 毒性伝播 / モデル動物 / マルチモーダルイメージング / タウPETイメージング / 老化 / 蛋白質構造化学 / タンパク質構造化学 / トランスレーショナルリサーチ / 脳神経疾患 / 脳老化 / 脳老化イメージング / タウタンパク質毒性 / タウイメージング / 神経毒性 / in vivo imaging / 神経原線維変化 / 蛋白質凝集中間体 / アルツハイマー病 / アミロイドβペプチド / アポトーシス / FTDP-17 / プレセニリン1 / 家族性アルツハイマー病 … More Except Principal Investigator アルツハイマー病 / 老化 / アミロイド / Alzheimer's disease / タウ / 神経原線維 / 神経変性 / 老人斑 / 家族性アルツハイマー病 / 突然変異 / JNK / プレセニリン / APP / mutation / amyloid / ELISA / プレセニリン1 / アポトーシス / カスパーゼ / アミロイド蛋白 / プレセニリン-1 / PET / TMEM106B / ライソゾーム / 加齢 / 認知症 / ガンマナイフ / マイクロサージェリー / 脳機能性疾患 / 炭素イオン線治療 / ウイルスベクター / 点鼻ワクチン / タウオパチー / シングルセル解析 / ナノ粒子 / 脳内免疫応答 / タウワクチン / Presenilin / Aβ / Aging / Tau / Neurofibrillary tangles / GSK-3 / 行動異常 / マウスモデル / FTDP17 / GSK-3β / FTDP-17 / 痴呆 / 細胞骨格 / 神経原線維変化 / β-アミロイド / presenilin / neurotoxicity / model / transgenic mouse / Abeta, senile plaque / マルツハイマー病 / 神経毒性 / モデル / トランスジェニックマウス / senile plague / presenilin-1 / familial Alzheimer's disease / カルボキシルメチルトラニスフェラーゼ / ラセミ体 / 神経原繊維 / 細胞死 / 培養 / 栄養因子 / 神経変性死 / 抑制因子 / 成長因子 / 細胞培養 / 神経細胞 / 変性細胞 Less

タウオパチー病態形成を標的とした疾患修飾薬の開発Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Institutes for Quantum Science and Technology
Development of carbon-ion beam microsurgery technique for functional brain diseases and its clinical application
- Principal Investigator
  
  若月優
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Elucidation of the mechanisms of age-related alternations in the brain environment
- Principal Investigator
  
  島田斉
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
点鼻タウワクチンによる脳内免疫応答の解明とナノ粒子のベクター利用
- Principal Investigator
  
  井上治久
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto University
ニューロン－ミクログリア連関の破綻を起因としたタウ蛋白質相転移メカニズムの解明Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Institutes for Quantum Science and Technology
Investigating mechanisms of tau-induced neurotxicityPrincipal Investigator
- Principal Investigator
  
  Sahara Naruhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  National Institutes for Quantum Science and Technology
マルチモーダル生体イメージングシステムを活用したタウ蛋白質相転移メカニズムの解明Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Investigation for understanding the mechanisms of tau-induced neurotoxicity by using multimodal in vivo imaging techniquesPrincipal Investigator
- Principal Investigator
  
  Sahara Naruhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of imaging-based diagnostic procedures for brain protein agingPrincipal Investigator
- Principal Investigator
  
  Sahara Naruhiko
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
タウオパチーの病態解明とタウ凝集中間体を標的とした治療戦略Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
神経原線維変化形成機構
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経原線維変化形成機構
- Principal Investigator
  
  TAKASHIMA Akihiko
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Mechanism of NFT formation
- Principal Investigator
  
  TAKASHIMA Akihiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  RIKEN
タウを介したプレセニリンの神経変性調節機構の解明Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka City University
Neuropathological study on Abeta toxicity using transgenic mice with human APP
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka City University
プレセニリン断片の細胞生物学的解析
- Principal Investigator
  
  森啓
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka City University
プレセニリン1蛋白質と神経細胞死を結びつける情報伝達経路の同定Principal Investigator
- Principal Investigator
  
  佐原成彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka City University
プレセニリン断片の細胞生物学的解析
- Principal Investigator
  
  森啓
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Psychiatry
The effect of presenilin-1 on cerebral amyloid protein
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Osaka City University Medical School
  Tokyo Institute of Psychiatry
脳由来の新神経細胞生存維持因子の単離
- Principal Investigator
  
  森啓
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Psychiatry
脳神経細胞死誘因物質の分子生物学的研究
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Psychiatry
Study on the mechanism of amyloid betaprotein deposition in Alzheimer's disease brain
- Principal Investigator
  
  MORI Hiroshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Institute of Psychiatry

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2008 2007 2005

All Journal Article Presentation

[Journal Article] Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model.2023
- Author(s)
  Kudo T, Takuwa H, Takahashi M, Urushihata T, Shimojo M, Sampei K, Yamanaka M, Tomita Y, Sahara N, Suhara T, Higuchi M
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106342-106342
- DOI
  10.1016/j.isci.2023.106342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06929, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-23K21399
[Journal Article] PET-based classification of corticobasal syndrome.2022
- Author(s)
  Nakano Y, Shimada H, Shinotoh H, Hirano S, Tagai K, Sano Y, Yamamoto Y, Endo H, Matsuoka K, Takahata K, Kubota M, Takado Y, Kimura Y, Ichise M, Ono M, Sahara N, Kawamura K, Zhang MR, Kuwabara S, Suhara T, Higuchi M.
- Journal Title
  
  Parkinsonism & related disorders
  
  Volume: 98 Pages: 92-98
- DOI
  10.1016/j.parkreldis.2022.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07935, KAKENHI-PUBLICLY-21H00446
[Journal Article] Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology2022
- Author(s)
  Tsujikawa K,Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y,Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M, et al.
- Journal Title
  
  Sci Adv
  
  Volume: - Issue: 21
- DOI
  10.1126/sciadv.abm5029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00527, KAKENHI-PROJECT-22K19506, KAKENHI-PUBLICLY-21H05624, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-21K15330, KAKENHI-PROJECT-21H03537, KAKENHI-PUBLICLY-21H00446
[Journal Article] A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model2022
- Author(s)
  Kimura Taeko、Ono Maiko、Seki Chie、Sampei Kazuaki、Shimojo Masafumi、Kawamura Kazunori、Zhang Ming-Rong、Sahara Naruhiko、Takado Yuhei、Higuchi Makoto
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 49 Issue: 13 Pages: 4298-4311
- DOI
  10.1007/s00259-022-05898-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446
[Journal Article] 構造をもとにしたタウPETプローブ開発2022
- Author(s)
  佐原　成彦, 山口　芳樹, 樋口　真人
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 1144-1149
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022
- Author(s)
  Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
- Journal Title
  
  Aging Cell
  
  Volume: 21 Issue: 7
- DOI
  10.1111/acel.13615
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PLANNED-18H05414, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-23K24214
[Journal Article] Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice2022
- Author(s)
  Tachida Yuriko、Miura Saori、Muto Yui、Takuwa Hiroyuki、Sahara Naruhiko、Shindo Akihiro、Matsuba Yukio、Saito Takashi、Taniguchi Naoyuki、Kawaguchi Yasushi、Tomimoto Hidekazu、Saido Takaomi、Kitazume Shinobu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Issue: 6 Pages: 101880-101880
- DOI
  10.1016/j.jbc.2022.101880
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-23K21399
[Journal Article] タウオパチーにおけるミクログリアの役割―モデルマウスからの考察―2022
- Author(s)
  佐原成彦
- Journal Title
  
  日本認知症学会誌
  
  Volume: 36 Pages: 224-230
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies2021
- Author(s)
  Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, (24人省略), Shimada H.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 1 Pages: 42-58
- DOI
  10.1016/j.neuron.2020.09.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H03362, KAKENHI-PROJECT-19H03583
[Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease2021
- Author(s)
  Sobue Akira、Komine Okiru、Hara Yuichiro、Endo Fumito、Mizoguchi Hiroyuki、Watanabe Seiji、Murayama Shigeo、Saito Takashi、Saido Takaomi C.、Sahara Naruhiko、Higuchi Makoto、Ogi Tomoo、Yamanaka Koji
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 9 Issue: 1 Pages: 111111-111111
- DOI
  10.1186/s40478-020-01099-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03532, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H04986
[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021
- Author(s)
  Takado Yuhei、Takuwa Hiroyuki、Sampei Kazuaki、Urushihata Takuya、Takahashi Manami、Shimojo Masafumi、Uchida Shoko、Nitta Nobuhiro、Shibata Sayaka、Nagashima Keisuke、Ochi Yoshihiro、Ono Maiko、Maeda Jun、Tomita Yutaka、Sahara Naruhiko、Near Jamie、Aoki Ichio、Shibata Kazuhisa、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 42 Issue: 1 Pages: 197-212
- DOI
  10.1177/0271678x211045449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-19H01041, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-16072021
- Author(s)
  Shi Yang、Murzin Alexey G.、Falcon Benjamin、Epstein Alexander、Machin Jonathan、Tempest Paul、Newell Kathy L.、Vidal Ruben、Garringer Holly J.、Sahara Naruhiko、Higuchi Makoto、Ghetti Bernardino、Jang Ming-Kuei、Scheres Sjors H. W.、Goedert Michel
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 141 Issue: 5 Pages: 697-708
- DOI
  10.1007/s00401-021-02294-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03583
[Journal Article] Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor2021
- Author(s)
  93.Maeda J. Sahara N.（他１９名）
- Journal Title
  
  Brain Communications
  
  Volume: 3 Issue: 1 Pages: 1-19
- DOI
  10.1093/braincomms/fcab011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K16274, KAKENHI-PROJECT-16H06277
[Journal Article] Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy2021
- Author(s)
  Fairley Lauren H.、Sahara Naruhiko、Aoki Ichio、Ji Bin、Suhara Tetsuya、Higuchi Makoto、Barron Anna M.
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 18 Issue: 1
- DOI
  10.1186/s12974-021-02122-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021
- Author(s)
  Sato H、Takado Y、Toyoda S、Tsukamoto-Yasui M、Minatohara K、Takuwa H、Urushihata T、Takahashi M、Shimojo M、Ono M、Maeda J、Orihara A、Sahara N、Aoki I、Karakawa S、Isokawa M、Kawasaki N、Kawasaki M、Ueno S、Kanda M、Nishimura M、Suzuki K、Mitsui A、Nagao K、Kitamura A、Higuchi M
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 43 Pages: 1-11
- DOI
  10.1126/sciadv.abd5046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein2021
- Author(s)
  Ji Bin、Ono Maiko、Yamasaki Tomoteru、Fujinaga Masayuki、Zhang Ming-Rong、Seki Chie、Aoki Ichio、Kito Seiji、Sawada Makoto、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: - Issue: 8 Pages: 1-14
- DOI
  10.1177/0271678x21992457
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PLANNED-18H05429, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19K08137
[Journal Article] A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains2021
- Author(s)
  Shimojo M、Ono M、Takuwa H、Mimura K、Nagai Y、Fujinaga M、Kikuchi T、Okada M、Seki C、Tokunaga M、Maeda J、Takado Y、Takahashi M、Minamihisamatsu T、Zhang M‐R、Tomita Y、Suzuki N、Maximov A、Suhara T、Minamimoto T、Sahara N、Higuchi M
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 22
- DOI
  10.15252/embj.2021107757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580
[Journal Article] Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice2020
- Author(s)
  Takeuchi Hiroki、Imamura Keiko、Ji Bin、Tsukita Kayoko、Enami Takako、Takao Keizo、Miyakawa Tsuyoshi、Hasegawa Masato、Sahara Naruhiko、Iwata Nobuhisa、Inoue Makoto、Hara Hideo、Tabira Takeshi、Ono Maiko、Trojanowski John Q.、Lee Virginia M.-Y.、Takahashi Ryosuke、Suhara Tetsuya、Higuchi Makoto、Inoue Haruhisa
- Journal Title
  
  npj Vaccines
  
  Volume: 5 Issue: 1 Pages: 28-28
- DOI
  10.1038/s41541-020-0172-y
- NAID
  120006817588
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05213, KAKENHI-PUBLICLY-19H05010, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-17K10297, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-20K07890
[Journal Article] In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy2020
- Author(s)
  Barron Anna M.、Ji Bin、Fujinaga Masayuki、Zhang Ming-Rong、Suhara Tetsuya、Sahara Naruhiko、Aoki Ichio、Tsukada Hideo、Higuchi Makoto
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 94 Pages: 140-148
- DOI
  10.1016/j.neurobiolaging.2020.05.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
[Journal Article] Pick’s Tau Fibril Shows Multiple Distinct PET Probe Binding Sites: Insights from Computational Modelling2020
- Author(s)
  Mishra Sushil、Yamaguchi Yoshiki、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 349-349
- DOI
  10.3390/ijms22010349
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03362
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Journal Article] Tau binding protein CAPON induces tau aggregation and neurodegeneration2019
- Author(s)
  Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu S, Saido TC, Saito T
- Journal Title
  
  Nature Communications
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] In vivo binding of a tau imaging probe, [ 11 C]PBB3, in patients with progressive supranuclear palsy2019
- Author(s)
  Endo Hironobu、Shimada Hitoshi、Sahara Naruhiko、Ono Maiko、Koga Shunsuke、Kitamura Soichiro、Niwa Fumitoshi、Hirano Shigeki、Kimura Yasuyuki、Ichise Masanori、Shinotoh Hitoshi、Zhang Ming Rong、Kuwabara Satoshi、Dickson Dennis W.、Toda Tatsushi、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Movement Disorders
  
  Volume: 34 Issue: 5 Pages: 744-754
- DOI
  10.1002/mds.27643
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
[Journal Article] Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features2019
- Author(s)
  Ikeda Aya、Shimada Hitoshi、Nishioka Kenya、Takanashi Masashi、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Funayama Manabu、Ueno Yuji、Hatano Taku、Sahara Naruhiko、Suhara Tetsuya、Higuchi Makoto、Hattori Nobutaka
- Journal Title
  
  Movement Disorders
  
  Volume: 34 Issue: 4 Pages: 568-574
- DOI
  10.1002/mds.27623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-19K08003, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18H04043
[Journal Article] Association between brain and plasma glutamine levels in healthy young subjects investigated by MRS and LC/MS2019
- Author(s)
  Takado Yuhei、Sato Naoto、Kanbe Yuta、Tomiyasu Moyoko、Xin Lijing、Near Jamie、Yoshikawa Kohki、Sahara Naruhiko、Higashi Tatsuya、Suhara Tetsuya、Higuchi Makoto、Obata Takayuki
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 7 Pages: 1649-1649
- DOI
  10.3390/nu11071649
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08213, KAKENHI-PUBLICLY-19H05437
[Journal Article] Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs2019
- Author(s)
  Nakamura Mari、Shiozawa Seiji、Tsuboi Daisuke、Amano Mutsuki、Watanabe Hirotaka、Maeda Sumihiro、Kimura Taeko、Yoshimatsu Sho、Kisa Fumihiko、Karch Celeste M.、Miyasaka Tomohiro、Takashima Akihiko、Sahara Naruhiko、Hisanaga Shin-ichi、Ikeuchi Takeshi、Kaibuchi Kozo、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 4 Pages: 684-699
- DOI
  10.1016/j.stemcr.2019.08.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06472, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19J12871, KAKENHI-PROJECT-17K08668, KAKENHI-PROJECT-17K07383, KAKENHI-PLANNED-18H05414
[Journal Article] Tau binding protein CAPON induces tau aggregation and neurodegeneration2019
- Author(s)
  Hashimoto Shoko、Matsuba Yukio、Kamano Naoko、Mihira Naomi、Sahara Naruhiko、Takano Jiro、Muramatsu Shin-ichi、Saido Takaomi C.、Saito Takashi
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41467-019-10278-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
[Journal Article] Tau isoform expression and phosphorylation in marmoset brains2019
- Author(s)
  Sharma Govinda、Huo Anni、Kimura Taeko、Shiozawa Seiji、Kobayashi Reona、Sahara Naruhiko、Ishibashi Minaka、Ishigaki Shinsuke、Saito Taro、Ando Kanae、Murayama Shigeo、Hasegawa Masato、Sobue Gen、Okano Hideyuki、Hisanaga Shin-ichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 30 Pages: 11433-11444
- DOI
  10.1074/jbc.ra119.008415
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-19K06472, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K06942, KAKENHI-PUBLICLY-19H05437, KAKENHI-WRAPUP-19H05447, KAKENHI-PROJECT-16H06277
[Journal Article] PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury2019
- Author(s)
  Takahata K、Kimura Yi、Sahara N、Koga S、Shimada H、Ichise M、Saito F、Moriguchi S、Kitamura S、Kubota M、Umeda S、Niwa F、Mizushima J、Morimoto Y、Funayama M、Tabuchi H、Bieniek K. F、Kawamura K、Zhang Ming-Rong、Dickson D. W、Mimura M、Kato M、Suhara T、Higuchi M
- Journal Title
  
  Brain
  
  Volume: 142 Issue: 10 Pages: 3265-3279
- DOI
  10.1093/brain/awz238
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-19H03583
[Journal Article] Tau fibril formation in cultured cells compatible with a mouse model of tauopathy2018
- Author(s)
  Matsumoto G*, Matsumoto K, Kimura T, Suhara T, Higuchi M, Sahara N*, Mori N
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: in press
- NAID
  120006988072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] タウオパチーマウスモデルと生体脳イメージング2018
- Author(s)
  佐原　成彦
- Journal Title
  
  月刊細胞
  
  Volume: 50 Pages: 17-20
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.2018
- Author(s)
  Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: s1 Pages: S353-S359
- DOI
  10.3233/jad-179933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324
[Journal Article] Biochemical properties of pathology-related tau species in tauopathy brains: an extraction protocol for tau oligomers and aggregates2018
- Author(s)
  Sahara N* and Kimura T.
- Journal Title
  
  Amyloid proteins: methods and protocols, third edition.
  
  Volume: 3 Pages: 435-445
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018
- Author(s)
  Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 61 Issue: 3 Pages: 1037-1052
- DOI
  10.3233/jad-170509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
[Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018
- Author(s)
  Matsumoto Gen、Matsumoto Kazuki、Kimura Taeko、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko、Mori Nozomu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 5 Pages: 1497-1497
- DOI
  10.3390/ijms19051497
- NAID
  120006988072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06398
[Journal Article] Microglial activation during pathogenesis of tauopathy in rTg4510 mice: implications for the early diagnosis of tauopathy2018
- Author(s)
  Sahara N*, Maeda J, Ishikawa I, Tokunaga M, Suhara T, Higuchi M
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] タウオパチーマウスモデルを用いた脳タンパク質老化モデル評価系の確立2018
- Author(s)
  佐原　成彦
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 152 Pages: 4-9
- NAID
  130007403948
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Comparative in-vitro quantification of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models2018
- Author(s)
  Ni R, Ji B, Ono M, Sahara N, Zhang M-R, Aoki I, Nordberg A, Suhara T, Higuchi M
- Journal Title
  
  J. Nuclear Medicine
  
  Volume: 117 Issue: 6 Pages: 960-966
- DOI
  10.2967/jnumed.117.201632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K19872
[Journal Article] Tau filaments and development of positron emission tomography (PET) tracers2018
- Author(s)
  Goedert M*, Yamaguchi Y, Mishra S, Higuchi M, Sahara N
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 9 Pages: 70-70
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Tau filaments and development of positron emission tomography (PET) tracers2018
- Author(s)
  Goedert M*, Yamaguchi Y, Mishra S, Higuchi M, Sahara N
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 9 Pages: 70-70
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula2018
- Author(s)
  Shinotoh Hitoshi、Shimada Hitoshi、Kokubo Yasumasa、Tagai Kenji、Niwa Fumitoshi、Kitamura Soichiro、Endo Hironobu、Ono Maiko、Kimura Yasuyuki、Hirano Shigeki、Mimuro Maya、Ichise Masanori、Sahara Naruhiko、Zhang Ming-Rong、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Neurology
  
  Volume: 92 Issue: 2
- DOI
  10.1212/wnl.0000000000006736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-18K06575
[Journal Article] Microglial activation during pathogenesis of tauopathy in rTg4510 mice: implications for the early diagnosis of tauopathy2018
- Author(s)
  Sahara N*, Maeda J, Ishikawa I, Tokunaga M, Suhara T, Higuchi M
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line2017
- Author(s)
  Sahara N*, Shimojo M, Ono M, Takuwa H, Febo M, Higuchi M, Suhara T
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 8 Pages: 663-663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to a-synuclein pathology.2017
- Author(s)
  Koga S, Ono M, Sahara N, Higuchi M, Dickson DW.
- Journal Title
  
  Movement Disorder
  
  Volume: - Issue: 6 Pages: 884-892
- DOI
  10.1002/mds.27013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-16H05324
[Journal Article] Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders.2017
- Author(s)
  71.Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M.
- Journal Title
  
  Brain
  
  Volume: 1403 Pages: 764-780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes2017
- Author(s)
  Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 5 Pages: 1118-1131
- DOI
  10.1016/j.celrep.2017.01.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K15480, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-17K09753, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-15H04278, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09310
[Journal Article] タウオリゴマーの実態とその遺伝学的因果関係2017
- Author(s)
  佐原成彦
- Journal Title
  
  実験医学　認知症　発症前治療のために改名すべき分子病態は何か？
  
  Volume: 35 Pages: 90-96
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] タウオリゴマーの実態とその遺伝学的因果関係2017
- Author(s)
  佐原成彦
- Journal Title
  
  実験医学　認知症　発症前治療のために解明すべき分子病態は何か？
  
  Volume: 35 Pages: 90-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] 認知症診断ツールとしてのPETイメージング2017
- Author(s)
  佐原成彦
- Journal Title
  
  メディカルドゥ・最新精神・神経遺伝医学研究と遺伝カウンセリング
  
  Volume: 2 Pages: 80-87
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line2017
- Author(s)
  Sahara N*, Shimojo M, Ono M, Takuwa H, Febo M, Higuchi M, Suhara T
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 8 Pages: 663-663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders.2017
- Author(s)
  71.Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M.
- Journal Title
  
  Brain
  
  Volume: 140 Pages: 764-780
- DOI
  10.1093/brain/aww339
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979
[Journal Article] In vivo imaging of inflammation in Alzheimer’s disease.2016
- Author(s)
  69.Huguchi M, Ji B, Sahara N, and Suhara T.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Pages: 139-144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons2016
- Author(s)
  Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., Yawata, S., Watanabe, D., Hasegawa, M., Trojanowski, J. Q., Lee, V. M.-Y., Suhara, T., Higuchi, M., and Inoue, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 34904-34904
- DOI
  10.1038/srep34904
- NAID
  120005850272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26112007, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K14315, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-16K06993, KAKENHI-PROJECT-15H02370
[Journal Article] タウイメージング：PBB32016
- Author(s)
  佐原　成彦, 木村　泰之
- Journal Title
  
  最新医学社・認知症：診断・バイオマーカー
  
  Volume: 3 Pages: 110-116
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] In vivo imaging of neuroinflammation in Alzheimer’s disease.2016
- Author(s)
  Higuchi H, Ji B, Maeda J, Sahara N, Suhara T.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: in press Pages: 1-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Alzheimer病マウスモデルを用いた生体脳イメージング研究2016
- Author(s)
  佐原成彦
- Journal Title
  
  BIOClinica, 脳タンパク質老化と認知症制御
  
  Volume: 31 Pages: 33-37
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] In vivo imaging of neuroinflammation in Alzheimer’s disease.2016
- Author(s)
  Higuchi H, Ji B, Maeda J, Sahara N, Suhara T.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: in press Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] In vivo imaging of neuroinflammation in Alzheimer's disease2016
- Author(s)
  Makoto Higuchi, Bin Ji, Jun Maeda, Naruhiko Sahara and Tetsuya Suhara
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: unsettled Issue: 2 Pages: 139-144
- DOI
  10.1111/cen3.12308
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-15K06793
[Journal Article] Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging.2015
- Author(s)
  Masafumi Shimojo, Makoto Higuchi, Tetsuya Suhara, Naruhiko Sahara
- Journal Title
  
  Frontiers in neuroscience
  
  Volume: 9 Pages: 482-482
- DOI
  10.3389/fnins.2015.00482
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06793, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-26117008
[Journal Article] Alzheimer病マウスモデルを用いた生体脳イメージング研究2015
- Author(s)
  佐原　成彦
- Journal Title
  
  BIOClinica, 脳タンパク質老化と認知症制御
  
  Volume: 31 Pages: 33-37
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] PET Quantification of Tau Pathology in Human Brain with 11C-PBB32015
- Author(s)
  Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of nuclear medicine
  
  Volume: 56 Issue: 9 Pages: 1359-1365
- DOI
  10.2967/jnumed.115.160127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06793, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25461862, KAKENHI-PROJECT-26713031, KAKENHI-PLANNED-26117008
[Journal Article] タウPETイメージングによる認知症研究の新展開2015
- Author(s)
  佐原　成彦, 樋口　真人
- Journal Title
  
  認知症の脳画像診断：早期検出と鑑別を目指して
  
  Volume: 9 Pages: 162-167
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] Tau PET2015
- Author(s)
  遠藤　浩信, 佐原　成彦, 島田　斉
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 10 Pages: 1156-1158
- Data Source
  KAKENHI-PROJECT-15K06793
[Journal Article] TOC1:A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy.2014
- Author(s)
  Ward SM, Himmelstein DS, Ren Y, Fu Y, Yu X-W, Roberts K, Binder LI, Sahara N
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 67 Pages: 37-48
- DOI
  10.1016/j.nbd.2014.03.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Age-related decline on white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study.2014
- Author(s)
  Sahara N*, Perez PD, Lin W-L, Dickson DW, Ren Y, Zeng H, Lewis J, Febo M
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 35 Issue: 6 Pages: 1364-1374
- DOI
  10.1016/j.neurobiolaging.2013.12.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Tau oligomers as potential targets for early diagnosis of tauopathy.2014
- Author(s)
  Sahara N*, Ren Y, Ward S, Binder L.I., Suhara T, Higuchi M
- Journal Title
  
  J. Alzheimer’s Disease
  
  Volume: 40 Issue: s1 Pages: S91-S96
- DOI
  10.3233/jad-132429
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau2014
- Author(s)
  Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A.
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 5 Pages: 26-26
- DOI
  10.3389/fneur.2014.00026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PUBLICLY-24111562, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008
[Journal Article] Effects of the C57BL/6 strain background on tauopathy progression in the tTg4510 mouse model.2014
- Author(s)
  Bailey RM, Howard J, Knight J, Sahara N, Dickson DW, and Lewis J.
- Journal Title
  
  Mol Neurodegener
  
  Volume: 15 Issue: 1 Pages: 8-8
- DOI
  10.1186/1750-1326-9-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Journal Article] Tau oligomerization : a role of tau aggregation intermediates linked to neurodegeneration2008
- Author(s)
  Sahara N
- Journal Title
  
  Current Alzheimer Research (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500328
[Journal Article] Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3β is required for tau aggregation2008
- Author(s)
  Sahara N
- Journal Title
  
  Eur. J. Neurosci. 27(11)
  
  Pages: 2897-2906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500328
[Journal Article] Assembly of two distinct dimers and oligomers from full-length tau2007
- Author(s)
  Sahara N, Maeda S, Murayama M, Suzuki T, Dohmae N, Yen S-H, Takashima A
- Journal Title
  
  Eur. J. Neurosci. 25
  
  Pages: 3020-3029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Novel conformation-sensitive antibodies specific to three-and four-rep eat tau2007
- Author(s)
  Ueno H, Murayama O, Maeda S, Sahara N, Park JM, Murayama M, Sanda A, Iwahashi K, Matsuda M, Takashima A
- Journal Title
  
  Biochem. Biophys. Res. Commun. 358(2)
  
  Pages: 602-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Molecular Chaperone-Mediated Tau Protein Metabolism Counteracts the Formation of Granular Tau Oligomers in Human Brain2007
- Author(s)
  Sahara N, Maeda S, Yoshiike Y, Miroroki T, Yamashita S, Murayama M, Park J.-M, Saito Y, Murayama S, Takashima A
- Journal Title
  
  J. Neurosci. Res 85
  
  Pages: 3098-3108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Granular tau oligomers as intermediates of tau filaments2007
- Author(s)
  Maeda S, Sahara N, Kim H, Saito Y, Akagi T, Miyasaka T, Hashikawa T, Murayama S, Ikai A, Takashima A
- Journal Title
  
  Biochemistry 46(12)
  
  Pages: 3856-3861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Hyperphosphorylated tau in parahippocampal cortex impairs place lear ning in aged mice expressing wild-type human tau2007
- Author(s)
  Kimura T, Yamashita S, Fukuda T, Park J-M, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, and Takashima A
- Journal Title
  
  The EMBO Journal 26(24)
  
  Pages: 5143-5152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Aluminum induces tau aggregation in vitro but not in vivo2007
- Author(s)
  Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A
- Journal Title
  
  J. Alzheimer's Disease 11(4)
  
  Pages: 419-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Decrease Aβs secretion in Familial Alzheimer's disease-linked mutant Presenilin 12007
- Author(s)
  Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A
- Journal Title
  
  Neurosci. Res. 57(3)
  
  Pages: 446-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] In vivo evidence of CHIP up-regulation attenuating tau aggregation2005
- Author(s)
  Sahara N
- Journal Title
  
  J.Neurochmistry 94
  
  Pages: 1254-1263
- Data Source
  KAKENHI-PROJECT-17025045
[Presentation] タウオパチーに対する核酸医薬・mRNA医薬開発に向けて：タウ病態の標的分子2022
- Author(s)
  佐原　成彦
- Organizer
  第41回日本認知症学会学術集会　第37回日本老年精神医学会　合同開催
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] イメージングに基づく認知症医生物学2022
- Author(s)
  佐原　成彦
- Organizer
  第11回認知症予防学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] Investigating phase transition of tau protein as a singularity point of neurodegenerative diseases2022
- Author(s)
  佐原　成彦
- Organizer
  Neuro2022, 日本神経化学会、日本神経科学会
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] 認知症早期診断を目指した生体イメージングバイオマーカーの探索2021
- Author(s)
  佐原　成彦
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] 認知症における恒常性ミクログリア動態2021
- Author(s)
  佐原　成彦
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] 認知症早期診断を目指した生体イメージングバイオマーカーの探索2021
- Author(s)
  佐原　成彦
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] Crosstalk between neurodegeneration and neuroinflammation in mouse models of tauopathy2021
- Author(s)
  佐原　成彦
- Organizer
  IUBMB Focused Meeting on Neurodegenerative Diseases, International Union of Biochemistry and Molecular biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] Crosstalk between neurodegeneration and neuroinflammation in mouse models of tauopathy2021
- Author(s)
  佐原　成彦
- Organizer
  IUBMB Focused Meeting on Neurodegenerative Diseases, International Union of Biochemistry and Molecular biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] 認知症における恒常性ミクログリア動態2021
- Author(s)
  佐原　成彦
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00446
[Presentation] Microglial contributions to neurodegeneration in tauopathy2020
- Author(s)
  佐原　成彦
- Organizer
  第39回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] Microglial contributions to tau-induced neurodegeneration in a mouse model of tauopathy2020
- Author(s)
  Sahara Naruhiko
- Organizer
  Tau 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] Microglial contributions to neurodegeneration in tauopathy2020
- Author(s)
  佐原　成彦
- Organizer
  第39回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] タウオパチーの多様性を考慮した診断・治療薬開発について－現状および今後の展望－2020
- Author(s)
  佐原　成彦
- Organizer
  第38回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] タウオパチーの多様性を考慮した診断・治療薬開発について－現状および今後の展望－2020
- Author(s)
  佐原　成彦
- Organizer
  第38回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] Microglial contributions to tau-induced neurodegeneration in a mouse model of tauopathy2020
- Author(s)
  Sahara Naruhiko
- Organizer
  Tau2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] 生体イメージング技術を基盤としたタウオパチー創薬プラットフォームの開発2019
- Author(s)
  佐原　成彦
- Organizer
  第 38 回日本認知症学会学術集会
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] 生体イメージング技術を基盤としたタウオパチー創薬プラットフォームの開発2019
- Author(s)
  佐原　成彦
- Organizer
  第 38 回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] マルチモーダルイメージングによる認知症発症メカニズムの探索2019
- Author(s)
  佐原　成彦
- Organizer
  第37回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] Dissecting neurofibrillary tangle formation in cellular and mouse models of tauopathy2019
- Author(s)
  Sahara Naruhiko
- Organizer
  APPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] Dissecting neurofibrillary tangle formation in cellular and mouse models of tauopathy2019
- Author(s)
  Sahara Naruhiko
- Organizer
  APPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] Distinct microglial response against Alzheimer’s pathologies characterized by P2Y12 receptor2019
- Author(s)
  Naruhiko Sahara, Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Maiko Ono, Keiichiro Minatohara, Hiroyuki Takuwa, Yuhei Takado, Bin Ji, Ming-Rong Zhang, Makoto Higuchi
- Organizer
  SFN 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] Distinct microglial response against Alzheimer’s pathologies characterized by P2Y12 receptor2019
- Author(s)
  Naruhiko Sahara, Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Maiko Ono, Keiichiro Minatohara, Hiroyuki Takuwa, Yuhei Takado, Bin Ji, Ming-Rong Zhang, Makoto Higuchi
- Organizer
  SFN2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896
[Presentation] マルチモーダルイメージングによる認知症発症メカニズムの探索2019
- Author(s)
  佐原　成彦
- Organizer
  第37回日本神経治療学会学術集会
- Data Source
  KAKENHI-PUBLICLY-19H05437
[Presentation] タウオパチーモデルにおける線維状タウ凝集体の構築2018
- Author(s)
  佐原　成彦, 松本　弦
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Neuroinflammatory process during pathogenesis of tauopathy in rTg4510 mice2018
- Author(s)
  Sahara N, Maeda J, Minamihisamatsu T, Ono M, Shimojo M, Takuwa H, Takado Y, Kimura T, Ji B, Suhara T, Higuchi M.
- Organizer
  Advances in Neurodegenerative Disease Research and Therapy, Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Microglia engulfment of tangle-bearing neurons in a living tauopathy model2018
- Author(s)
  Sahara N, Takuwa H, Takado Y, UrushihataT, Shimojo M, Takahashi M, Ono N, Kimura T, Seki C, Maeda J, Ji B, Tomita Y, Zhang M-R, Suhara T, Higuchi M.
- Organizer
  Neuroscience 2018, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Visualization of microglial response to tau-induced neurodegeneration in a model of tauopathy2017
- Author(s)
  Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Maiko Ono, Hiroyuki Takuwa, Masafumi Shimojo, Takeharu Minamihisamatsu, Masaki Tokunaga, Shoko Uchida, Izumi Matsumoto, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウオパチーマウスモデルを用いた脳タンパク質老化モデル評価系の確立2017
- Author(s)
  佐原成彦
- Organizer
  日本薬理学会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Development of novel tau PET tracer, [18F]AM-PBB3 and [18F]PM-PBB32017
- Author(s)
  Ono M, Kitamura S, Shimada H, Sahara N, Takuwa H, Yoshiyama Y, Trojanowski JQ, Lee VWY, Suhara T, Jang M-K, Tamagnan G, Marek K, Higuchi M
- Organizer
  Human Amyloid Imaging Conference Secretariat
- Place of Presentation
  米国、マイアミ
- Year and Date
  2017-01-11
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Investigating combinatory phosphorylation of tau in a propagation model of tauopathy2017
- Author(s)
  Naruhiko Sahara, Taeko Kimura, Gen Matsumoto
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] In vivo visualization of tau pathology, neurodegeneration and neuroinflammation for developing a diagnostic platform of tauopathy2017
- Author(s)
  佐原成彦
- Organizer
  脳タンパク質老化と認知症制御第2回国際シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] タウを標的とした診断・治療薬開発の現状2017
- Author(s)
  佐原成彦
- Organizer
  第３９回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウを標的とした診断・治療薬開発の現状2017
- Author(s)
  佐原成彦
- Organizer
  第３９回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Visualization of microglial response to tau-induced neurodegeneration in a model of tauopathy2017
- Author(s)
  Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Maiko Ono, Hiroyuki Takuwa, Masafumi Shimojo, Takeharu Minamihisamatsu, Masaki Tokunaga, Shoko Uchida, Izumi Matsumoto, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Comparative study of tau PET ligands for detecting distinct tau pathologies2017
- Author(s)
  佐原成彦
- Organizer
  脳タンパク質老化と認知症制御国際タウシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Comparative study of tau PET ligands for detecting distinct tau pathologies2017
- Author(s)
  佐原成彦
- Organizer
  脳タンパク質老化と認知症制御国際タウシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Investigating combinatory phosphorylation of tau in a propagation model of tauopathy2017
- Author(s)
  Naruhiko Sahara, Taeko Kimura, Gen Matsumoto
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Development of novel tau PET tracers, [18F]AM-PBB3 and [18F]PM-PBB32017
- Author(s)
  Ono M, Kitamura S, Shimada H, Sahara N, Takuwa H, Yoshiyama Y, Trojanowski JQ, Lee VMY, Suhara T, Jang, M-K, Tamagnan G, Marek K, Higuchi M
- Organizer
  Human Amyloid Imaging Conference Secretariat
- Place of Presentation
  米国、マイアミ
- Year and Date
  2017-01-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウオパチーマウスモデルを用いた脳タンパク質老化モデル評価系の確立2017
- Author(s)
  佐原成彦
- Organizer
  日本薬理学会
- Place of Presentation
  長崎ブリックホール（長崎市）
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] In vivo visualization of tau pathology, neurodegeneration and neuroinflammation for developing a diagnostic platform of tauopathy2017
- Author(s)
  佐原成彦
- Organizer
  脳タンパク質老化と認知症制御第2回国際シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] The Association Between Aβ and Tau Accumulation And Its Influence On Clinical Features In Aging And Alzheimer's Disease Spectrum Brains: [11C]PBB3 PET Study2016
- Author(s)
  Shimada H, Suhara T, Shinoto H, Endo H, Niwa F, Kitamura S, Hirano S, Kimura Y, Yamada M, Sahara N, Zhang M-R, Kuwabara S, Higuchi M
- Organizer
  Alzheimer's Association
- Place of Presentation
  カナダ、トロント
- Year and Date
  2016-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] マルチモーダルイメージングによる脳タンパク質老化モデル病態評価系の確立2016
- Author(s)
  佐原成彦
- Organizer
  新学術研究領域「脳タンパク質老化と認知症制御」
- Place of Presentation
  サンルートプラザ東京（千葉県浦安市）
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Investigating the link between pathological tau accumulation, neuroinflammation and brain atrophy in a model of tauopathy2016
- Author(s)
  Sahara N, Ishikawa A, Tokunaga M, Minamihisamatsu T, Ono M, Uchida S, Matsumoto I, matsumoto, Takuwa H, Zhang M-R, Suhara T, Higuchi M
- Organizer
  Alzheimer's association international conference
- Place of Presentation
  カナダ、トロント
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Investigating the link between pathological tau accumulation, neuroinflammation and brain atrophy in a model of tauopathy2016
- Author(s)
  Sahara N, Ishikawa A, Tokunaga M, Minamihisamatsu T, Ono M, Uchida S, Matsumoto I, Takuwa H, Zhang M-R, Suhara T, Higuchi T
- Organizer
  Alzheimer's Association
- Place of Presentation
  カナダ、トロント
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Quantification and reference optimization of tau PET imaging with [11C] PBB3 in PSP patients2016
- Author(s)
  Hitoshi Shimada, Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hironobu Endo, Keisuke Takahata, Fumitoshi Niwa, Soichiro Kitamura, Shigeki Hirano, Hitoshi Shinotoh, Naruhiko Sahara, Makiko Yamada, Ming-Rong Zhang, Makoto Higuchi, Tetsuya Suhara
- Organizer
  10th Human Amyloid Imaging, World Events Forum
- Place of Presentation
  米国・マイアミ
- Year and Date
  2016-01-13
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] The Association Between Aβ and Tau Accumulation And Its Influence On Clinical Features In Aging And Alzheimer's Disease Spectrum Brains: [11C]PBB3 PET Study2016
- Author(s)
  Shimada H, Suhara T, Shinoto H, Endo H, Niwa F, Kitamura S, Hirano S, Kimura Y, Yamada M, Sahara N, Zhang M-R, Kuwabara S, Higuchi M
- Organizer
  Alzheimer's association international conference 2014,
- Place of Presentation
  カナダ、トロント
- Year and Date
  2016-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] In vivo assessment of synaptic properties in rTg4510 tauopathy transgenic mouse model by positron emission tomography2016
- Author(s)
  Shimojo M, Tokunaga M, Takuwa H, Takado Y, Minamihisamatsu T, Zhang M-R, Suhara T, Higuchi M, Sahara N
- Organizer
  Society for Neuroscience
- Place of Presentation
  米国、サンディエゴ
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] in vivo multimodal imaging of tauopathy revealed a rapid turnover of pathological tau inclusions in a tauopathy mouse model2016
- Author(s)
  Sahara N, Takuwa H, Ishikawa I, Urushihata T, Minamihisamatsu T, Tokunaga M, Shimojo M, Uchida S, Matsumoto I, Zhang M-R, Suhara T, Higuchi M
- Organizer
  Society for Neuroscience
- Place of Presentation
  米国、サンディエゴ
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウタンパク質にとって正常と異常の違いは何か？2015
- Author(s)
  佐原　成彦
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] タウPETイメージングが認知症研究にもたらしたもの2015
- Author(s)
  佐原　成彦
- Organizer
  第２２３回つくばブレインサイエンスセミナー, つくばブレインサイエンス協会
- Place of Presentation
  つくば
- Year and Date
  2015-11-10
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Utility of tau imaging probe PBB3 in human and mouse brains2015
- Author(s)
  佐原　成彦
- Organizer
  脳タンパク質老化と認知症制御第1回国際シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] タウ蛋白質を標的とした治療薬開発の現状2015
- Author(s)
  佐原　成彦
- Organizer
  創薬薬理フォーラム第２３回シンポジウム, 創薬薬理フォーラム
- Place of Presentation
  東京
- Year and Date
  2015-09-16
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Utility of Tau Imaging Probe PBB3 on a Mouse Model of Tauopathy2015
- Author(s)
  Naruhiko Sahara, Ai Ishikawa, Masaki Tokunaga, Takeharu Minamihisamatsu, Jun Maeda, Maiko Ono, Shoko Uchida, Izumi Matsumoto, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
- Organizer
  Alzheimer”s Association International Conference 2015
- Place of Presentation
  米国・ワシントンD.C.
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] タウオリゴマー研究の総括と今後の展望2015
- Author(s)
  佐原　成彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Longitudinal in vivo imaging of tau pathology, microglial activation and neuronal loss in a mouse model of tauopathy2015
- Author(s)
  佐原　成彦, 石川　愛, 徳永　正希, 南久松　丈晴, 前田　純, 下條　雅文, 小野　麻衣子, 内田　翔子, 松本　いづみ, 田桑　弘之, 張　明栄, 須原　哲也, 樋口　真人
- Organizer
  Neuroscience 2015, Society for Neuroscience
- Place of Presentation
  米国・シカゴ
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウオパチーマウスによるタウイメージング薬剤の開発 Development of tau imaging probes using the mouse model of tauopathy2015
- Author(s)
  石川　愛, 佐原　成彦, 徳永　正希, 南久松　丈晴, 内田　翔子, 松本　いづみ, 島田　斉, 平野　成樹, 篠遠　仁, 桑原　聡, 須原　哲也, 樋口　真人
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] ヒトならびに動物モデルを用いたタウPETイメージング：創薬ツールとしての可能性2015
- Author(s)
  佐原　成彦
- Organizer
  北陸認プロFD講演会, 北陸認知症プロフェッショナル医養成プランプロジェクト
- Place of Presentation
  福井
- Year and Date
  2015-12-15
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] [11C]PBB3 PETによるMAPT遺伝子変異症例のタウイメージング2015
- Author(s)
  篠遠　仁, 佐原　成彦, 島田　斉, Wszorek, Z., 池内　健, 羽生　春夫, 石井　賢二, 樋口　真人, 須原　哲也
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウタンパク質にとって正常と異常の違いは何か？2015
- Author(s)
  佐原　成彦
- Organizer
  第15回日本蛋白質科学会年会, 日本蛋白質科学会
- Place of Presentation
  徳島
- Year and Date
  2015-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Longitudinal in vivo imaging of tau pathology, microglial activation and neuronal loss in a mouse model of tauopathy2015
- Author(s)
  佐原　成彦, 石川　愛, 徳永　正希, 南久松　丈晴, 前田　純, 下條　雅文, 小野　麻衣子, 内田　翔子, 松本　いづみ, 田桑　弘之, 張　明栄, 須原　哲也, 樋口　真人
- Organizer
  Neuroscience 2015, Society for Neuroscience
- Place of Presentation
  米国・シカゴ
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] タウオパチーマウスによるタウイメージング薬剤の開発 Development of tau imaging probes using the mouse model of tauopathy2015
- Author(s)
  石川　愛, 佐原　成彦, 徳永　正希, 南久松　丈晴, 内田　翔子, 松本　いづみ, 島田　斉, 平野　成樹, 篠遠　仁, 桑原　聡, 須原　哲也, 樋口　真人
- Organizer
  第56回日本神経学会学術大会, 日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] タウオリゴマー研究の総括と今後の展望2015
- Author(s)
  佐原　成彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Utility of tau imaging probe PBB3 in human and mouse brains2015
- Author(s)
  佐原　成彦
- Organizer
  脳タンパク質老化と認知症制御第1回国際シンポジウム, 新学術領域脳タンパク質老化と認知症制御
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Utility of Tau Imaging Probe PBB3 on a Mouse Model of Tauopathy2015
- Author(s)
  Naruhiko Sahara, Ai Ishikawa, Masaki Tokunaga, Takeharu Minamihisamatsu, Jun Maeda, Maiko Ono, Shoko Uchida, Izumi Matsumoto, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
- Organizer
  Alzheimer”s Association International Conference 2015
- Place of Presentation
  米国・ワシントンD.C.
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] [11C]PBB3 PETによるMAPT遺伝子変異症例のタウイメージング2015
- Author(s)
  篠遠　仁, 佐原　成彦, 島田　斉, Wszorek, Z., 池内　健, 羽生　春夫, 石井　賢二, 樋口　真人, 須原　哲也
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] マウスモデルを用いた、神経障害に関与するタウ病変の生体内評価系の確立2015
- Author(s)
  石川　愛, 佐原　成彦, 徳永　正希, 田桑　弘之, 島田　斉, 平野　成樹, 篠遠　仁, 桑原　聡, 須原　哲也, 樋口　真人
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] マウスモデルを用いた、神経障害に関与するタウ病変の生体内評価系の確立2015
- Author(s)
  石川　愛, 佐原　成彦, 徳永　正希, 田桑　弘之, 島田　斉, 平野　成樹, 篠遠　仁, 桑原　聡, 須原　哲也, 樋口　真人
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K06793
[Presentation] Visualization of tau lesions in brains of tauopathy patients and model mice using tau ligand PBB32014
- Author(s)
  佐原　成彦, Maiko Ono, Shunsuke Koga, Jun Maeda, Izumi Matsumoto, Dennis W. Dickson, Zbigniew K. Wszolek, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
- Organizer
  2014北米神経科学学会
- Place of Presentation
  ワシントンD.C.
- Year and Date
  2014-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Tau PET imaging: New insight into early diagnosis of tauopathy2014
- Author(s)
  佐原　成彦
- Organizer
  2nd International Conference on Alzheimer”s Disease & Dementian
- Place of Presentation
  スペイン・バレンシア
- Year and Date
  2014-09-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Age-related white matter pathogenesis in a mouse model of tauopathy2014
- Author(s)
  佐原　成彦, Wen-Lang Lin, Perez Pablo, Makoto Higuchi, Tetsuya Suhara, Marcelo Febo
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  デンマーク・コペンハーゲン
- Year and Date
  2014-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Tau imaging: the frontier of neuroimaging in neurodegenerative disease2014
- Author(s)
  佐原　成彦
- Organizer
  Autonomous University of Madrid セミナー, マドリッド自治大学
- Place of Presentation
  スペイン・マドリッド
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Imaging diverse tau fibril strains in tauopathies2014
- Author(s)
  Makoto Higuchi, Hitoshi Shimada, Naruhiko Sahara, Masahiro Maruyama, Hitoshi Shinotoh, Ming-Rong Zhang, Tetsuya Suhara
- Organizer
  9th International Conference on Frontotemporal Dementias,
- Place of Presentation
  カナダ・バンクーバー
- Year and Date
  2014-10-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Tau PET imaging in animal models and humans2014
- Author(s)
  Makoto Higuchi, Hitoshi Shimada, Naruhiko Sahara, Tetsuya Suhara
- Organizer
  Alzheimer's Association International Conference 2014,
- Place of Presentation
  デンマーク・コペンハーゲン
- Year and Date
  2014-07-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008
[Presentation] Linkage between spatial memory disturbance and tau protein in JNPL3 male mice2008
- Author(s)
  Sahara N
- Organizer
  International Conference on Alzheimer's Disease
- Place of Presentation
  Chigcago, IL, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20500328

1. MORI Hiroshi (10159189)

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Sahara Naruhiko 佐原 成彦

SAHARA Naruhiko 佐原 成彦

SAHARA Nobuhiko 佐原 成彦

SAHARA N 佐原 成彦

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タウオパチー病態形成を標的とした疾患修飾薬の開発Principal Investigator

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ニューロン－ミクログリア連関の破綻を起因としたタウ蛋白質相転移メカニズムの解明Principal Investigator

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Investigating mechanisms of tau-induced neurotxicityPrincipal Investigator

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マルチモーダル生体イメージングシステムを活用したタウ蛋白質相転移メカニズムの解明Principal Investigator

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Investigation for understanding the mechanisms of tau-induced neurotoxicity by using multimodal in vivo imaging techniquesPrincipal Investigator

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Development of imaging-based diagnostic procedures for brain protein agingPrincipal Investigator

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タウオパチーの病態解明とタウ凝集中間体を標的とした治療戦略Principal Investigator

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Principal Investigator

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Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タウを介したプレセニリンの神経変性調節機構の解明Principal Investigator

Sahara Naruhiko 佐原成彦

SAHARA Naruhiko 佐原成彦

SAHARA Nobuhiko 佐原成彦

SAHARA N 佐原成彦