Kitagawa Motoo 北川元生

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KITAGAWA Motoo 北川元生

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Researcher Number	40262026
Other IDs
External Links
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 国際医療福祉大学, 医学部, 教授 2016: 千葉大学, 大学院医学研究院, 准教授 2012 – 2013: 千葉大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 千葉大学, 大学院・医学研究院, 准教授 2007: Chiba University, Graduate School of Medicine, Department of Molecular and Tumor Pathology, Associate Professor … More 2006: 千葉大学, 大学院医学研究院, 助教授 2001 – 2005: 千葉大学, 大学院・医学研究院, 助教授 1999 – 2000: 千葉大学, 医学部, 助教授 1999: 千葉大, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Molecular biology / Basic Section 48040:Medical biochemistry-related / Pathological medical chemistry Except Principal Investigator Experimental pathology / Biological Sciences / Science and Engineering / Human pathology / Experimental pathology
Keywords	Principal Investigator Mastermind / Notch / シグナル伝達 / Fucose / Notchシグナル / 遺伝子欠失マウス / 発生・分化 / EBウイルス / TM2D3 / Nucleotide sugar transporter … More / Signal Transduction / Glycoprotein / Delta / 糖タンパク質 / 細胞内シグナル伝達 / EGF / STAT / 造血 / 発現制御 / Notchシグナル伝達系 / 細胞表面受容体 / アルツハイマー病 / ノックアウトマウス / TM2D2 / TM2D1 / almondex / Knockout Mouse / Abnormal Sex Differentiation / Hematopoiesis / Development / Regulation of Transcription / がん / 性分化異常 / Genetic disease / Knockout mouse / Transcription factor / 遺伝性疾患 / 転写因子複合体 / Ligand-Receptor Interaction / Transcription Factor / Notch Signaling / Fringe / リガンドー受容体相互作用 / Neurotic / リガンド-受容体相互作用 / フコース / 転写因子 / Tumor suppressor / Tumor progression / Esophageal Cancer / Signal transduction / tumor suppressor / tumor suppresspr / 腫瘍進展 / 食道癌 / 統合失調症 / 造血器腫瘍 / LCL / バーキットリンパ腫 / RBP-J / EBNA2 … More Except Principal Investigator CD44 / hMena / RanBPM / NFkB / CD44 knockout mice / cell motility / yeast-two hybrid / CD44E / VEGF / 蛋白質 / 生体分子 / 癌 / 遺伝子 / 浸潤 / 腫瘍 / 実験病理 / 創傷治癒 / 止血 / プラズマ医療 / マウスモデル / タンパク凝固 / 血液凝固 / 低侵襲性医療 / プラズマ計測 / 血液タンパク凝固 / プラズマ / 低侵襲止血 / タンパク凝集 / プラズマ解析 / 病理解析 / RhoA / CD44シグナリング / Toll-like receptor / TUMOR PROGRESSION / MICROVESSEL FORMATION / TUMOR METASTASIS / TUMOR INVASION / TUMOR NECROSIS / バリアント / 転移 / 腫瘍のプログレッション / 腫瘍浸潤転移 / 腫瘍プログレッション / 腫瘍血管増生 / 腫瘍転移 / 腫瘍浸潤 / 腫瘍壊死 / EGFR / RTK / 腫瘍浸潤・転移 / がん治療 / 癌幹細胞 / CD44核内移行 / EMT / ヒアルロン酸 / ヒアルロン酸、がん治療 / 上皮-間葉転換(EMT) / 癌浸潤・転移、CD44 / チロシンリン酸化 / FAK / Rho / マトリックスメタロプロテイアーゼ / 細胞運動 / 細胞増殖 / jagged1 / notch遺伝子 / ヒト肺上皮細胞株 Less

Regulatory mechanisms of Notch receptor activation at the cell surfacePrincipal Investigator
- Principal Investigator
  
  Kitagawa Motoo
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  International University of Health and Welfare
Functions of regulators for Notch signaling, almondex/TM2D3Principal Investigator
- Principal Investigator
  
  Motoo Kitagawa
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  International University of Health and Welfare
  Chiba University
Involvement of a co-factor of Notch signaling, Mastermind, into SchizophreniaPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment
- Principal Investigator
  
  Ikehara Yuzuru
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
発がん促進、防御の二面性を示すNotchシグナル伝達系の調節因子群の機能Principal Investigator
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Biochemical and Cell Biological Study for Regulators of Notch SignalingPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University
腫瘍原性ヘルペスウイルスと宿主Notchシグナル伝達系との相互作用Principal Investigator
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Functions of Intracellular Regulators of Notch SignalingPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University
EBウイルスの発がんタンパク質EBNA2と宿主タンパク質との相互作用の研究Principal Investigator
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Molecular cloning and function of CD44 cytoplasmic domain associated molecules
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
Study of Intracellular Regulators of Notch SignalingPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Chiba University
Molecular Analysis on Tumor Invasion and Metastasis of CD44 Variant Forms
- Principal Investigator
  
  HARIGAYA Kenichi, 岸宏久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Chiba University
CD44の細胞運動・転移関連遺伝子発現における役割
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ヒト肺上皮細胞株に対するnotch遺伝子発現の影響に関する研究
- Principal Investigator
  
  湯本典夫
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
Physiological significance of EGF/STAT1 pathwayPrincipal Investigator
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Chiba University

All 2022 2021 2020 2019 2018 2017 2016 2013 2011 2010 2008 2007 2006

All Journal Article Presentation

[Journal Article] マウスTm2d3遺伝子は劣性致死性遺伝子である2022
- Author(s)
  板橋匠美、北川元生、増田渉、安島理恵子、相賀裕美子、梅宮敏文
- Journal Title
  
  医学検査
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07374
[Journal Article] マウスTm2d3遺伝子は劣性致死遺伝子である2022
- Author(s)
  板橋匠美、北川元生、増田渉、安島理恵子、相賀裕美子、梅宮敏文
- Journal Title
  
  医学検査
  
  Volume: 17 Pages: 412-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07374
[Journal Article] TM2D群（TM2D1、TM2D2、TM2D3）のNotchシグナルにおける機能2021
- Author(s)
  北川元生、板橋匠美、梅宮敏文、三宅克也、増田渉、安島理恵子、相賀裕美子
- Journal Title
  
  国際医療福祉大学学会誌
  
  Volume: 26 Pages: 196-196
- Data Source
  KAKENHI-PROJECT-19K07374
[Journal Article] Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice2020
- Author(s)
  Hirano Ken-ichi、Suganami Akiko、Tamura Yutaka、Yagita Hideo、Habu Sonoko、Kitagawa Motoo、Sato Takehito、Hozumi Katsuto
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.50979
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07315, KAKENHI-PROJECT-19K07374, KAKENHI-PROJECT-16K08577
[Journal Article] Notchシグナルの調節因子TM2D3の機能2020
- Author(s)
  北川元生、板橋匠美、梅宮敏文、増田渉、安島理恵子、相賀裕美子
- Journal Title
  
  国際医療福祉大学学会誌
  
  Volume: 25 Pages: 165-165
- Data Source
  KAKENHI-PROJECT-19K07374
[Journal Article] Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.2020
- Author(s)
  Das P., Salazar J. L., Li-Kroeger D., Yamamoto S., Nakamura M., Sasamura T., Inaki M., Masuda W., Kitagawa M., Yamakawa T., Matsuno K.
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 62 Issue: 1 Pages: 80-93
- DOI
  10.1111/dgd.12639
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07374, KAKENHI-INTERNATIONAL-15K21726, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16K08577
[Journal Article] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Journal Title
  
  国際医療福祉大学学会誌
  
  Volume: 24 Pages: 171-171
- Data Source
  KAKENHI-PROJECT-16K08577
[Journal Article] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Journal Title
  
  国際医療福祉大学学会誌
  
  Volume: 24 Pages: 171-171
- Data Source
  KAKENHI-PROJECT-19K07374
[Journal Article] TM2 domain containing 3（TM2D3）によるNotch1 の活性化2018
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Journal Title
  
  国際医療福祉大学学会誌
  
  Volume: 23 Pages: 151-151
- Data Source
  KAKENHI-PROJECT-16K08577
[Journal Article] Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling.2017
- Author(s)
  Toritsuka M, Kimoto S, Muraki K, Kitagawa M, Kishimoto T, Sawa A, Tanigaki K.
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 7 Issue: 3 Pages: e1049-e1049
- DOI
  10.1038/tp.2017.21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-26460381, KAKENHI-PROJECT-16K08577
[Journal Article] Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling.2016
- Author(s)
  Yuko Muroyama, Atsushi Baba, Motoo Kitagawa, Tetsuichiro Saito
- Journal Title
  
  PLOS Genetics
  
  Volume: 12(12) Issue: 12 Pages: e1006514-e1006514
- DOI
  10.1371/journal.pgen.1006514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07072, KAKENHI-PROJECT-26460269, KAKENHI-PROJECT-16K08577, KAKENHI-PROJECT-16K15166
[Journal Article] Lipoid Pneumonia with Partial Anomalous Pulmonary Venous Return2016
- Author(s)
  Fujita T., Terada J., Kitagawa M., Tatsumi K.
- Journal Title
  
  Intern. Med.
  
  Volume: 55 Issue: 10 Pages: 1399-1400
- DOI
  10.2169/internalmedicine.55.6392
- NAID
  130005151163
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08577
[Journal Article] MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development2013
- Author(s)
  Watanabe T, Komori T, Asahara H (他10名)
- Journal Title
  
  PLos Genet
  
  Volume: 9(1) Issue: 1 Pages: 1003132-1003132
- DOI
  10.1371/journal.pgen.1003132
- NAID
  120006985752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249062, KAKENHI-PROJECT-23249071, KAKENHI-PROJECT-24659143, KAKENHI-PROJECT-24659829
[Journal Article] Mastermind-like 1 (MamL1) andmastermind-like 3 (MamL3) are essential forNotch signaling in vivo2011
- Author(s)
  Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M
- Journal Title
  
  Development
  
  Volume: 138 Pages: 5235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by theHAS2-HYAL2/CD44 system on the plasma membrane2011
- Author(s)
  Saito T, Kawana H, Azuma K,Toyoda,A,Fujita H, Kitagawa M, Harigaya K
- Journal Title
  
  Int J Oncol
  
  Volume: 39(5) Pages: 1311-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers2011
- Author(s)
  Toyoda A, Yokota A, Saito T, Kawana H, Higashi M, Suzuki Y, Tanaka T, Kitagawa M, Harigaya K
- Journal Title
  
  Int J Oncol
  
  Volume: 38(1) Pages: 89-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Visualization of the Activity of Rac1Small GTPase in a Cell2010
- Author(s)
  Higashi M, Yu J, Tsuchiya H, Saito T, Oyama T, Kawana H, Kitagawa M, Tamaru J, Harigaya K
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 43(6) Pages: 163-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex2010
- Author(s)
  Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
- Journal Title
  
  Nat Cell Biol
  
  Volume: 12(3) Pages: 278-85
- NAID
  120005293254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Mastermind-like domain containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence2008
- Author(s)
  Fukami M., Wada Y., Okada M., Kato F., Katsumata N., Baba T., Morohashi K.-i., Laporte J., Kitagawa M., and Ogata T.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 5525-5532
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] CD44 suppresses Toll-like receptor-mediated inflammation2008
- Author(s)
  Kawana H., Karaki H., Higashi M., Miyazaki M., Hilberg F., Kitagawa M., and Harigaya K.
- Journal Title
  
  J. Immunol 180
  
  Pages: 4235-4245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A. 104
  
  Pages: 9764-9769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] Enhancement of chemosensitivity toward peplomycin by calpastatin -stabilized NF-kB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism2006
- Author(s)
  Liu T.-L., Shimada H., Ochiai T., Shiratori T., Lin S.-E., Kitagawa, M., Harigaya K., Maki M., Oka M., Abe T., Takiguchi M., and Hiwasa T.
- Journal Title
  
  Apoptosis 11
  
  Pages: 1025-1037
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Transmembrane 2 domain containing 3 (TM2D3) のin vitroおよびin vivoにおけるNotchシグナルへの関与2022
- Author(s)
  増田渉、板橋匠美、梅宮敏文、岩間厚志、安島理恵子、三宅克也、ジャミヤンスレンジャンバルドルジ、湯澤聡、東和彦、田丸淳、木曽誠、松野健治、相賀裕美子、北川元生
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Involvement of Transmembrane 2 domain containing 3 (TM2D3) into Notch signaling in vitro and in vivo2022
- Author(s)
  Motoo Kitagawa
- Organizer
  Institute for Protein Research (IPR) International Seminar “Towards controlling the Notch signaling pathway”
- Invited
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] TM2D群（TM2D1、TM2D2、TM2D3）のNotchシグナルにおける機能2022
- Author(s)
  北川元生、Jambaldorj Jamiyansuren、湯澤聡、板橋匠美、梅宮敏文、岩間厚志、増田渉、三宅克也、相賀裕美子、安島理恵子
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Involvement of Transmembrane 2 domain containing 3 (TM2D3) into Notch signaling in vitro and in vivo.2021
- Author(s)
  Wataru Masuda, Takumi Itabashi, Toshifumi Umemiya, Rieko Ajima, Katsuya Miyake, Kazuhiko Azuma, Jun-ichi Tamaru, Makoto Kiso, Tomoko Yamakawa, Puspa Das, Kenji Matsuno, Yumiko Saga, Motoo Kitagawa
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] TM2D群（TM2D1、TM2D2、TM2D3）のNotchシグナルにおける機能2021
- Author(s)
  北川元生、板橋匠美、梅宮敏文、三宅克也、増田渉、安島理恵子、相賀裕美子
- Organizer
  第11回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Transmembrane 2 domain containing 3 (TM2D3) regulates presentation of Notch receptors on the cell surface2020
- Author(s)
  Wataru Masuda, Tomoko Yamakawa, Rieko Ajima, Katsuya Miyake, Takumi Itabashi, Toshifumi Umemiya, Kazuhiko Azuma, Jun-ichi Tamaru, Makoto Kiso, Puspa Das, Yumiko Saga, Kenji Matsuno, Motoo Kitagawa
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Notchシグナルの調節因子TM2D3の機能2020
- Author(s)
  北川元生、板橋匠美、梅宮敏文、増田渉、安島理恵子、相賀裕美子
- Organizer
  第9回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] TM2 domain containing 3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors.2019
- Author(s)
  Masuda W., Yamakawa T., Ajima R., Miyake K., Umemiya T., Azuma K., Tamaru J.-i., Kiso M., Saga Y., Matsuno K., Kitagawa M.
- Organizer
  The Notch Meeting XI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] Transmembrane 2 domain-containing 3（TM2D3）はNotch受容体の細胞表面における発現を制御する2019
- Author(s)
  北川元生
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Transmembrane 2 domain-containing 3（TM2D3）はNotch受容体の細胞表面における発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Organizer
  第9回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Organizer
  第9回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] TM2 domain containing 3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors2019
- Author(s)
  Masuda W., Yamakawa T., Ajima R., Miyake K., Umemiya T., Azuma K., Tamaru J.-i., Kiso M., Saga Y., Matsuno K., Kitagawa M.
- Organizer
  The Notch Meeting XI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07374
[Presentation] Transmembrane 2 domain-containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] Transmembrane 2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019
- Author(s)
  北川元生、増田渉、山川智子、安島理恵子、三宅克也、梅宮敏文、東和彦、田丸淳一、相賀裕美子、松野健治
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] TM2 domain containing 3（TM2D3）によるNotch1 の活性化2018
- Author(s)
  北川元生
- Organizer
  第8回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] TM2 domain containing 3, a mammalian homologue of Drosophila neurogenic gene product Almondex, activates Notch1.2017
- Author(s)
  Motoo Kitagawa
- Organizer
  The Notch Meeting X
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08577
[Presentation] Switching of CD44 and hMena mRNA splice variants between the intramucosal lesion and invasive front of early stage human colorectal carcinoma (pT1) : and their relationship to the expression of cancer stem cell markers and clinicopathological features.2013
- Author(s)
  Hiroshi Yoshida^<1,2>, Akihiro Toyoda^<1>, Wataru Masuda^<1>, Noriyuki Tanaka^<1,2>, Motoo Kitagawa^<1>, Yoshio Suzuki^<2>, Kenichi Harigaya^<1>
- Organizer
  AACR 2013
- Place of Presentation
  Washington, DC、USA
- Year and Date
  2013-04-07
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Switching of CD44 and hMena mRNA splice variants between the intramucosal lesion and invasive front of early stage human colorectal carcinoma (pT1), and their relationship to the expression of cancer stem cell markers and clinico- pathological features2013
- Author(s)
  Yoshida H, Toyoda A, Tanaka N, Masuda W,Kitagawa M, Suzuki Y, Harigaya K
- Organizer
  Proceedings of the 104th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr 280
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] HAS2-Hyal2/CD44 system supports spontaneous random cell movement of human cancer cells in an autocrine mechanism2011
- Author(s)
  Saito T, Kawana H, Azuma K, Toyoda A, Fujita H, Kitagawa M, HarigayaK
- Organizer
  Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-01-23
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Functions of Mastermind in Notch-dependent and Notch-independent transcriptional activation2011
- Author(s)
  Motoo Kitagawa, Kenichi Harigaya
- Organizer
  第6回Notch研究会
- Place of Presentation
  千葉県野田市
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The Notch Meeting
- Place of Presentation
  Athens, Greece
- Year and Date
  2007-09-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] The novel hypospadias gene CXorf6 transactivates the promoter of a Notch target gene2007
- Author(s)
  Fukami M., Wada Y., Okada M., Hasegawa T., Miyabayashi K., Yamada G. Morohashi K.-i, Kitagawa M., and Ogata T.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastemind-1 is required for Notch signal-dependent steps in Iymphocyte development in vivo2007
- Author(s)
  Kitagawa M., et. al.
- Organizer
  第66回目本癌学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] The Notch coactivators Mastermind-1 and -2 are essential for embryonic vascular development in mice2007
- Author(s)
  Oyama T., Harigaya K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007
- Author(s)
  Kitagawa M. et. al.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 5th Stem Cell Research symposium
- Place of Presentation
  Awaji
- Year and Date
  2007-05-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Functions of a neurogenicgene, pecanex, in Notch signaling2007
- Author(s)
  Yamakawa T., Sasamura T., Oyama T., Kanai M., Kitagawa M., Harigaya K., and Matsuno K.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is fequired for Notch signal-dependent steps in lymphocyte development in vivo.2007
- Author(s)
  Kitagawa M., et. al.
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18012011
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Kitagawa M., Oyama T., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Sakamoto R., Sato M., Yoshida N., and Harigaya K.
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] hMena works as a negative regulator of Rac 1 GTPase at the tip of lamellipodia2006
- Author(s)
  Ishikawa C., Higashi M., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  46th Annual Meeting of American Society for Cell Biology
- Place of Presentation
  San Diego, USA
- Year and Date
  2006-12-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] hMena works as a negative regulator of Racl GTPase at the tip of lamellipodia2006
- Author(s)
  Higashi M., Ishikawa C., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hozumi K., Habu S., Iwama A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  MSBA Forum 2006
- Place of Presentation
  Nagoya
- Year and Date
  2006-12-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 4th Stem Cell Research symposium
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Roles of hMena in cell morphology and motility2006
- Author(s)
  Higashi M., Mimura C., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Cloning of a novel short form variant of hMena (Mena-d)2006
- Author(s)
  Azuhata K., Higashi M., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  65th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Analysis of effects on Toll-like receptor signaling caused by CD44-deficiency2006
- Author(s)
  Kawana H., Karaki H., Higashi M., Kitagawa M., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257

1. HARIGAYA Kenichi (40101894)

# of Collaborated Projects: 13 results

# of Collaborated Products: 26 results
2. HIGASHI Morihiro (00323395)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KAWANA Hidetada (80359596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 岸宏久 (90323394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 増田渉 (00623464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
6. TANIGAKI Kenji (70362473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. HASHIMOTO Kenji (10189483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Ikehara Yuzuru (10311440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAGISHI Masahiro (00220252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMBE Kiyoyuki (90452474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGANO Tomio (50572228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITAGAKI Hirotomo (00793184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAGUCHI Takshi (60626563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 湯本典夫 (40203658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石井源一郎 (00270869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 榊田創 (90357088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 金載浩 (30376595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中西速夫 (20207830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 池原早苗 (50598779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 湯澤聡 (40515029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MAKINOUCHI Susumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. WATANABE Shunji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MIYAMOTO Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. FUJINO Shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MATSUMOTO Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YOSINO Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MURANAKA Toshiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KIYAMA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HASHIMOTO Mika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. FUJIWARA Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. FUJIWARA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. YAMADA Hiromasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YAMAGISHI Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. NAKANOMIYA akihisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. NONAKA Atushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. MINOWA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. HOTTA Tomonori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. Vanni Antoni

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. Matteo Zuin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. Shimizu Tetsuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. TAMURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. SUGANAMI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. YUZAWA Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
44. 室山優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 小守壽文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitagawa Motoo 北川 元生

KITAGAWA Motoo 北川 元生

Research Projects

Research Products

Co-Researchers

Regulatory mechanisms of Notch receptor activation at the cell surfacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functions of regulators for Notch signaling, almondex/TM2D3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of a co-factor of Notch signaling, Mastermind, into SchizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発がん促進、防御の二面性を示すNotchシグナル伝達系の調節因子群の機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biochemical and Cell Biological Study for Regulators of Notch SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍原性ヘルペスウイルスと宿主Notchシグナル伝達系との相互作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functions of Intracellular Regulators of Notch SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EBウイルスの発がんタンパク質EBNA2と宿主タンパク質との相互作用の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular cloning and function of CD44 cytoplasmic domain associated molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Intracellular Regulators of Notch SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Kitagawa Motoo 北川元生

KITAGAWA Motoo 北川元生

[Journal Article] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019

[Journal Article] TM2 domain containing 3（TM2D3）はNotch受容体の細胞表面の発現を制御する2019