Seya Kazuhiko 瀬谷和彦

… Alternative Names

SEYA Kazuhiko 瀬谷和彦

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Researcher Number	40281919
Other IDs	https://orcid.org/0000-0001-5866-7148
Affiliation (Current)	2025: 弘前大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 弘前大学, 医学研究科, 助教 2015: 弘前大学, 大学院医学研究科, 助教 2013 – 2015: 弘前大学, 医学(系)研究科(研究院), 助教 2008 – 2010: 弘前大学, 大学院・医学研究科, 助教 2004 – 2005: 弘前大学, 医学部, 助手 1997 – 2002: 弘前大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Basic Section 55030:Cardiovascular surgery-related / General pharmacology / General pharmacology / Cardiovascular surgery / General physiology
Keywords	Principal Investigator 異所性石灰化 / 大動脈弁狭窄症 / テネイシンX / マトリックスGlaタンパク質 / 大動脈弁間質細胞 / calcification / aortic valve / 核内受容体 / 大動脈弁 / 大動脈弁異所性石灰化 / 薬理学 / 外科 … More Except Principal Investigator … More 大動脈弁石灰化 / 大動脈弁狭窄症 / 大動脈弁間質細胞 / Cbfa1 / siRNA / メカニカルストレス / BMP2 / 薬物治療 / 異所性骨化 / valve calcification / 異所性石灰化 / 血管内皮増殖因子受容体2 / 動脈硬化 / Valve calcification / VEGFR2 / 薬物療法 / 大動脈弁異所性石灰化 / CD34陰性細胞 / Wnt5a / メノキナン-4 / 重症大動脈弁狭窄症 / 症候性大動脈弁狭窄症 / 黄連解毒湯 / マトリックスGlaタンパク / テネイシンX / プレグナンX受容体 / 異物受容体 / 臨床 / CD34細胞 / ビタミンK依存性蛋白 / マトリックスGlaタンパク質 / 薬物送達 / 分子標的薬 / 石灰化大動脈弁 / 大動脈弁狭窄 / endochondral ossification / nucleotide receptor / gene expression / microarray / mechanical stress / ectopic bone formation / 内軟骨性骨化 / ヌクレオチド受容体 / 遺伝子発現 / マイクロアレイ / bioactive natural products / calcium release / muscle contraction / intracellular calcium / L6細胞 / 機械的刺激 / Ca遊離 / リアノジン受容体 / 天然生理活性物質 / カルシウム遊離 / 筋収縮 / 細胞内カルシウムイオン / Tell II phosphodiasterase / M2-muscarinic receptors / Nitric Oxide / Microdialysis / Canine isolated blood-perfused heart preparation / CGMP / Aging / Cardiac conduction system / イヌ血液潅流房室結節標本 / イヌ血液環流房室結節標本 / cAMP / イヌ血液還流房室結節標本 / II型ホスホジエステラーぜ / M2ムスカリン受容体 / 一酸化窒素 / マイクロダイアリシス / イヌ摘出心交叉環流標本 / cGMP / 加齢 / 心臓刺激伝導系 / phosphorylation / ECG / チャネル / 遺伝子 / マウス / カルシウム / sympathetic nerve / mouse / channel / calcium / ATP / 遺伝子導入 / 細胞外ヌクレオチド受容体 / アルカリフォスファターゼ / 形質転換 / TSG-6 / 骨化様式 / 過剰発現 / P2Y1 / gremlin / 幹細胞 / 細胞外ATP受容体 / 脊柱靱帯骨化症 / 機械的ストレス / 脊柱靱帯 Less

the transformation of aortic valve endothelial cells induced acceleration of aortic valve calcification and its mechanism
- Principal Investigator
  
  于在強
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
大動脈弁異所性石灰化に関わる核内受容体ファミリーの解析と新規治療の構築についてPrincipal Investigator
- Principal Investigator
  
  瀬谷和彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hirosaki University
The role and mechanism of VEGFR2 on aortic valve calcification
- Principal Investigator
  
  Yu Zaiqiang
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
Elucidation of the mechanism of pregnane X receptor-mediated aortic valve ectopic calcification and demonstration of its pathophysiological significance
- Principal Investigator
  
  Daitoku Kazuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
Demonstration and mechanism elucidation of the inhibition of aortic valve calcification by controlling expression of extracellular matrix proteinPrincipal Investigator
- Principal Investigator
  
  Seya Kazuhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hirosaki University
Calcific aortic stenosis: Identification of calcification-inducing cell, clarifying calcification signalingPrincipal Investigator
- Principal Investigator
  
  Seya Kazuhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hirosaki University
To investigate mechanism of aortic valve calcification and to establish medical agents for aortic valve stenosis
- Principal Investigator
  
  Daitoku Kazuyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Hirosaki University
Sympathetic nerve control with the voltage-dependent calcium channel beta subunits.
- Principal Investigator
  
  murakami manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Hirosaki University
Exploring molecular targets for the establishment of drug therapy for the ossification of the posterior longitudinal ligament of the spine
- Principal Investigator
  
  FURUKAWA Kenichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hirosaki University
Analysis of genes related to the ectopic bone formation induced by mechanical stress and search for drugs targeting the genes.
- Principal Investigator
  
  FURUKAWA Ken-Ichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hirosaki University
Screening and characterization of new regulation factor of Ca^<2+> release channels
- Principal Investigator
 
 FURUKAWA Ken-ichi
- Project Period (FY)
 2000 – 2002
- Research Category
 
 Grant-in-Aid for Scientific Research (B)
- Research Field
 
 General pharmacology
- Research Institution
 Hirosaki University
Aging of cardiac conduction system
- Principal Investigator
  
  MOTOMURA Shigeru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  HIROSAKI UNIVERSITY

[Book] 大動脈弁はなぜ石灰化するのか2021
- Author(s)
  福田幾夫、大徳和之、瀬谷和彦、于　在強
- Total Pages
  74
- Publisher
  やまと印刷株式会社
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells2024
- Author(s)
  Kaizuka Masatoshi、Kawaguchi Shogo、Tatsuta Tetsuya、Tachizaki Mayuki、Kobori Yuri、Tanaka Yusuke、Seya Kazuhiko、Matsumiya Tomoh、Imaizumi Tadaatsu、Sakuraba Hirotake
- Journal Title
  
  NeuroMolecular Medicine
  
  Volume: 26 Issue: 1 Pages: 16-16
- DOI
  10.1007/s12017-024-08782-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08064
[Journal Article] Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling2024
- Author(s)
  Nakamura Yuzuru、Ishibashi Hikaru Kristi、Saruga Tatsuro、Imaizumi Tadaatsu、Kurose Akira、Tachizaki Mayuki、Kawaguchi Shogo、Seya Kazuhiko、Sasaki Eiji、Ishibashi Yasuyuki
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 51 Issue: 1 Pages: 131-131
- DOI
  10.1007/s11033-023-09063-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09393, KAKENHI-PROJECT-23K08064
[Journal Article] The inhibitory effect of DIF-3 on polyinosinic?polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2024
- Author(s)
  Araya Ryusei、Men Shihu、Uekusa Yoshinori、Yu Zaiqiang、Kikuchi Haruhisa、Daitoku Kazuyuki、Minakawa Masahito、Kawaguchi Shogo、Furukawa Ken-Ichi、Oshima Yoshiteru、Imaizumi Tadaatsu、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 157-165
- DOI
  10.1016/j.jphs.2024.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0099, KAKENHI-PROJECT-23K08064
[Journal Article] Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis2023
- Author(s)
  Karasawa Takao、Sato Riko、Imaizumi Tadaatsu、Fujita Masashi、Aizawa Tomomi、Tsugawa Koji、Mattinzoli Deborah、Kawaguchi Shogo、Seya Kazuhiko、Terui Kiminori、Joh Kensuke、Tanaka Hiroshi
- Journal Title
  
  Renal Failure
  
  Volume: 45 Issue: 1 Pages: 2224890-2224890
- DOI
  10.1080/0886022x.2023.2224890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07862, KAKENHI-PROJECT-23K08064
[Journal Article] Wnt5a pathway was not involved in the progression of valve calcification in calcific aortic valve stenosis2023
- Author(s)
  Zaiqiang Yu、Kazuyuki Daitoku、Ikuo Fukuda、Tadaatsu Imaizumi、Masahito Minakawa、Ken-Ichi Furukawa、Kazuhiko Seya
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 73 Pages: 20-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08064
[Journal Article] Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022
- Author(s)
  Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minagawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, Kazuhiko Seya, and Tadaatsu Imaizumi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Elucidation of the inhibitory effect of hopeaphenol on polynosinic- polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022
- Author(s)
  Xu L, Yu Z, Uesaka Y, Kawaguchi S, Kikuchi H, Daitoku K, MInakawa M, MOtomura S, Furukawa KI, Oshima Y, Seya K, Imaizumi T
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149 Issue: 3 Pages: 147-157
- DOI
  10.1016/j.jphs.2022.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09117
[Journal Article] Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.2021
- Author(s)
  Liu Xu、Yu Zaiqiang、Daitoku Kazuyuki、Fukuda Ikuo、Motomura Shigeru、Matsumiya Tomoh、Imaizumi Tadaatsu、Furukawa Ken-Ichi、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 145 Issue: 2 Pages: 213-221
- DOI
  10.1016/j.jphs.2020.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-18K16381, KAKENHI-PROJECT-20K09117
[Journal Article] Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells2021
- Author(s)
  Kawaguchi Shogo、Sakuraba Hirotake、Kikuchi Hidezumi、Numao Noriyuki、Asari Taka、Hiraga Hiroto、Ding Jiangli、Matsumiya Tomoh、Seya Kazuhiko、Fukuda Shinsaku、Imaizumi Tadaatsu
- Journal Title
  
  Molecular Immunology
  
  Volume: 129 Pages: 32-38
- DOI
  10.1016/j.molimm.2020.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089
[Journal Article] Daily Brazilian green propolis intake elevates blood artepillin C levels in humans2021
- Author(s)
  Ding Jiangli、Matsumiya Tomoh、Hayakari Ryo、Shiba Yuko、Kawaguchi Shogo、Seya Kazuhiko、Ueno Kayo、Imaizumi Tadaatsu
- Journal Title
  
  Journal of the Science of Food and Agriculture
  
  Volume: － Issue: 11 Pages: 4855-4861
- DOI
  10.1002/jsfa.11132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089
[Journal Article] Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat2021
- Author(s)
  Zaiqiang Yu, Xu Liu, Kazuyuki Daitoku, Ken-Ichi Furukawa, Ikuo Fukuda, Shigeru Motomura, Kazuhiko Seya
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 71 Issue: 2-4 Pages: 101-107
- DOI
  10.32216/hirosakiigaku.71.2-4_101
- NAID
  130007998247
- ISSN
  0439-1721, 2434-4656
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR2019
- Author(s)
  Yang Wei、Yu Zaiqiang、Chiyoya Mari、Liu Xu、Daitoku Kazuyuki、Motomura Shigeru、Imaizumi Tadaatsu、Fukuda Ikuo、Furukawa Ken-Ichi、Tsuji Motonori、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 372 Issue: 3 Pages: 277-284
- DOI
  10.1124/jpet.119.263160
- NAID
  130007811872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-16K10619
[Journal Article] Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells2019
- Author(s)
  Imaizumi Tadaatsu、Satake Urara、Miyashita Ruri、Kawaguchi Shogo、Matsumiya Tomoh、Seya Kazuhiko、Ding Jiangli、Tanaka Hiroshi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 337 Pages: 577047-577047
- DOI
  10.1016/j.jneuroim.2019.577047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089
[Journal Article] Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells2019
- Author(s)
  Hirono Koji、Imaizumi Tadaatsu、Aizawa Tomomi、Watanabe Shojiro、Tsugawa Koji、Shiratori Toshihiro、Kawaguchi Shogo、Seya Kazuhiko、Matsumiya Tomoh、Ito Etsuro、Tanaka Hiroshi
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 6 Pages: 1-8
- DOI
  10.1080/14397595.2019.1682768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-17K09681
[Journal Article] Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor2019
- Author(s)
  Yu Zaiqiang、Seya Kazuhiko、Chiyoya Mari、Daitoku Kazuyuki、Motomura Shigeru、Imaizumi Tadaatsu、Fukuda Ikuo、Furukawa Ken-Ichi
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: in oress Issue: 6 Pages: 944-956
- DOI
  10.1007/s00774-019-01001-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10449, KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-18K16381, KAKENHI-PROJECT-16K10619, KAKENHI-PROJECT-17K10916
[Journal Article] Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.2019
- Author(s)
  Shogo Kawaguchi、 Hirotake Sakuraba、 Toshihiro Haga、 Tomoh Matsumiya、 Kazuhiko Seya、 Tetsu Endo、 Naoya Sawada、 Chikara Iino、 Hidezumi Kikuchi、 Hiroto Hiraga、 Shinsaku Fukuda、 Tadaatsu Imaizumi
- Journal Title
  
  Inflammation
  
  Volume: 42 Issue: 6 Pages: 2095-2104
- DOI
  10.1007/s10753-019-01073-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-19K17449
[Journal Article] Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells2018
- Author(s)
  Imaizumi Tadaatsu、Sassa Naoko、Kawaguchi Shogo、Matsumiya Tomoh、Yoshida Hidemi、Seya Kazuhiko、Shiratori Toshihiro、Hirono Koji、Tanaka Hiroshi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 324 Pages: 16-21
- DOI
  10.1016/j.jneuroim.2018.08.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-16K10449
[Journal Article] Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway 2018
- Author(s)
 YOSHIDA Hidemi、IMAIZUMI Tadaatsu、MATSUMIYA Tomoh、SEYA Kazuhiko、KAWAGUCHI Shogo、TANAKA Hiroshi
- Journal Title
 
 Biomed. Res.
 
 Volume: 39 Issue: 5 Pages: 231-240
- DOI
 10.2220/biomedres.39.231
- NAID
 130007498531
- ISSN
 0388-6107, 1880-313X
- Year and Date
 2018-10-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-16K10449
[Journal Article] Gnetin C, a resveratrol dimer, reduces amyloid-β 1–42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells 2018
- Author(s)
 SEINO Syota、KIMOTO Takeru、YOSHIDA Hidemi、TANJI Kunikazu、MATSUMIYA Tomoh、HAYAKARI Ryo、SEYA Kazuhiko、KAWAGUCHI Shogo、TSURUGA Kazushi、TANAKA Hiroshi、IMAIZUMI Tadaatsu
- Journal Title
 
 Biomed. Res.
 
 Volume: 39 Issue: 3 Pages: 105-115
- DOI
 10.2220/biomedres.39.105
- NAID
 130007396412
- ISSN
 0388-6107, 1880-313X
- Year and Date
 2018-06-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-16K10449
[Journal Article] Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves2018
- Author(s)
  Chiyoya Mari、Seya Kazuhiko、Yu Zaiqiang、Daitoku Kazuyuki、Motomura Shigeru、Imaizumi Tadaatsu、Fukuda Ikuo、Furukawa Ken-Ichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 136 Issue: 4 Pages: 257-265
- DOI
  10.1016/j.jphs.2018.03.004
- NAID
  130007812658
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10449, KAKENHI-PROJECT-15K10231
[Journal Article] Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves2018
- Author(s)
  Chiyoya M, Seya K, Yu Z, Daitoku K, Motomura S, Imaizumi T, Fukuda I, Furukawa KI
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 136 Pages: 257-265
- NAID
  130007812658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10619
[Journal Article] Retinoic acid-inducible gene-I, melanoma differentiation-associated gene 5 and C-X-C motif chemokine ligand 10 are induced by a Toll-like receptor 3 agonist in human brain microvascular endothelial cells2018
- Author(s)
  Imaizumi Tadaatsu、Arai Akine、Kawaguchi Shogo、Hayakari Ryo、Matsumiya Tomoh、Seya Kazuhiko、Yoshida Hidemi、Tanaka Hiroshi
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 9 Issue: 3 Pages: 189-197
- DOI
  10.1111/cen3.12463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] Simultaneous measurement of adenosine 3’,5’-cyclic monophosphate and guanosine 3’,5’-cyclic monophosphate in biological samples.2017
- Author(s)
  Kazuhiko Seya, Shigeru Motomura, Tadaatsu Imaizumi, Ken-Ichi Furukawa.
- Journal Title
  
  Hirosaki Med J
  
  Volume: 68 Pages: 52-61
- NAID
  130008036645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] 新生仔マウス初代培養心筋細胞の単離培養法2017
- Author(s)
  韓沖、瀬谷和彦、小潟佳輝、野崎修平、米倉学、村上学
- Journal Title
  
  弘前医学
  
  Volume: 67 Pages: 147-152
- NAID
  130008038287
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] Effects of Enflurane on Cardiac Autonomic Nervous Activity in Mice2017
- Author(s)
  Yoshiki Ogata, Manabu Yonekura, Rouichi Yamaki, Chong Han, Tomonori Fujisawa, Kazuhiko Seya, Hidetoshi Niwa, Tetsuya Kushikata, Tadaatsu Imaizumi, Kazuyoshi Hirota, Hirofumi Tomita, Manabu Murakami
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 67 Pages: 153-157
- NAID
  130008038285
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] Expression of CCL5 is induced by polyinosinic : polycytidylic acid in cultured hCMEC/D3 human brain microvascular endothelial cells2017
- Author(s)
  Arai Akine、Yoshida Hidemi、Hayakari Ryo、Matsumiya Tomoh、Kawaguchi Shogo、Seya Kazuhiko、Tanaka Hiroshi、Imaizumi Tadaatsu
- Journal Title
  
  Clin Exp Neuroimmunol.
  
  Volume: 8 Issue: 4 Pages: 331-340
- DOI
  10.1111/cen3.12416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] Ketamine suppresses the proliferation of rat C6 glioma cells2017
- Author(s)
  Niwa Hidetomo、Furukawa Ken-Ichi、Seya Kazuhiko、Hirota Kazuyoshi
- Journal Title
  
  Oncology Lett.
  
  Volume: 14 Issue: 4 Pages: 4911-4917
- DOI
  10.3892/ol.2017.6806
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10449, KAKENHI-PROJECT-16K20078
[Journal Article] 1-Methyl-2-undecyl-4(1H)-quinidone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-12016
- Author(s)
  Kazuhiko Seya, Ken-Ichi Furukawa, Mari Chiyoya, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Shigeru Motomura, Manabu Murakami, Yoshiteru Oshima, and Ikuo Fukuda
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 131 Issue: 1 Pages: 51-57
- DOI
  10.1016/j.jphs.2016.04.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10449
[Journal Article] 8-Methyltryptanthrin-induced differentiation of P19CL6 embryonal carcinoma cells into spontaneously beating cardiomyocyte-like cells.2014
- Author(s)
  Seya K, Yamaya A, Kamachi S, Murakami M, Kitahara H, Kawakami J, Okumura K, Murakami M, Motomura S, Furukawa K.
- Journal Title
  
  8-Methyltryptanthrin-induced differentiation of P19CL6 embryonal carcinoma cells into spontaneously beating cardiomyocyte-like cells.
  
  Volume: 77 Issue: 6 Pages: 1413-9
- DOI
  10.1021/np500108r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460293, KAKENHI-PROJECT-26461120
[Journal Article] The role of CD34-negative mesenchymal stem-like cells as cellular origin on human aortic valve calcification.2013
- Author(s)
  Nomura A, Seya K, Yu Z, Daitoku K, Motomura S,Murakami M, Fukuda I, Furukawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440 Issue: 4 Pages: 780-785
- DOI
  10.1016/j.bbrc.2013.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460293
[Journal Article] Contribution of bone morphogenetic protein-2 to aortic valve calcification in aged rat.2011
- Author(s)
  Seya K, Yu Z, Kanemaru K, Daitoku K, Akemoto Y, Shibuya H, Fukuda I, Okumura K, Motomura S, Furukawa K-I
- Journal Title
  
  Journal of Pharmacological Sciences 115
  
  Pages: 8-14
- NAID
  10029891345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590245
[Journal Article] TNF-α accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway.2011
- Author(s)
  Yu Z, Seya K, Daitoku K, Motomura S, Fukuda I, Furukawa K-I
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 337
  
  Pages: 16-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590245
[Journal Article] Opposite effects of two resveratrol tetramers, vitisin A and hopeaphenol on apoptosis of myocytes isolated from adult rat heart.2009
- Author(s)
  Seya K, Furukawa K-I, 他11名
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 328
  
  Pages: 90-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590245
[Journal Article] Calcification of aortic smooth muscle cells isolated from spontaneously hypertensive rats.2008
- Author(s)
  Kanemaru K, Seya K, Miki I, Motomura S, Furukawa K-I
- Journal Title
  
  Journal of Pharmacological 106
  
  Pages: 280-286
- NAID
  10024318473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] Orengetokuto inhibits aortic valve calcification: Confirming by animal model of SHR rat2023
- Author(s)
  Zaiqiang Yu, Shihu Men, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Kazuhiko Seya
- Organizer
  第53回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] Orengedokuto inhibits TNF-α-induced HAVIC calcification obtained from calcific aortic valve stenosis patients2023
- Author(s)
  Zaiqiang Yu, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Kazuhiko Seya
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] Inhibitory effect of CD34 on human aortic valve calcification2023
- Author(s)
  Shihu Men, Zaiqiang Yu, Liu Xu, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Ken-Ichi Furukawa, Kazuhiko Seya
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] 石灰化大動脈弁狭窄症患者より得た大動脈弁間質細胞はVEGFR2陽性であり、異所性石灰化に寄与する2021
- Author(s)
  劉　旭，○于　在強,　大徳和之,　福田幾夫，元村　成,　松宮朋穂, 今泉忠淳，古川賢一, 瀬谷和彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09089
[Presentation] Menaquinone-4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR2020
- Author(s)
  Kazuhiko Seya, Wei Yang, Zaiqiang Yu, Mari Chiyoya, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09089
[Presentation] 大動脈弁狭窄症患者から得た大動脈弁間質細胞の石灰化に対するマトリックスGlaタンパク質の抑制作用2019
- Author(s)
  瀬谷和彦 ,于　在強, 千代谷真理, 大徳和之, 元村　成, 今泉忠淳, 福田幾夫, 古川賢一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves2019
- Author(s)
  Kazuhiko Seya, Zaiqiang Yu, Mari Chiyoya, Wei Yang, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] 大動脈弁狭窄症患者から得た大動脈弁間質細胞の高リン酸による石灰化誘発に対する1-methyl-2-undecyl-4(1H)-quinoloneの抑制作用2019
- Author(s)
  瀬谷　和彦、古川　賢一、千代谷真理、于　在強、菊地晴久、大徳和之、元村　成、今泉忠淳、大島吉輝、福田幾夫
- Organizer
  第48回日本心脈管作動物質学会年会
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] TNF-α-induces calcification of cultured human aortic valve interstitial cells obtained from patients with calcific aortic stenosis: involvement of BMP22018
- Author(s)
  Kazuhiko Seya, Zaiqiang Yu, Mari Chiyoya, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] ワルファリンは大動脈弁異所性石灰化を促進するか？：大動脈弁間質細胞を用いた検討2018
- Author(s)
  于在強、瀬谷和彦、千代谷真理、大徳和之、今泉忠淳、古川賢一、福田幾夫
- Organizer
  第48回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10619
[Presentation] ヒト石灰化大動脈弁から得た間質細胞においてBMP2が誘発する石灰化に対するワルファリンの影響2018
- Author(s)
  瀬谷和彦、于在強、楊　微、大徳和之、元村成、今泉　忠淳、福田幾夫、古川賢一
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] 石灰化大動脈弁狭窄症患者由来の大動脈弁間質細胞におけるTNF-α誘発性異所性石灰化機序の解明2018
- Author(s)
  瀬谷　和彦、于　在強、千代谷真理、大徳　和之、元村　成、
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] Human aortic valve interstitial cells obtained from patients with calcific aortic stenosis have high sensitivity to TNF-α resulting in ectopic calcification.2017
- Author(s)
  Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
- Organizer
  2018 ISHR-JPN Section Meeting (Osaka)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] 大動脈弁間質細胞の石灰化におけるマトリックスグラタンパク質遺伝子発現の抑制効果2017
- Author(s)
  于在強、瀬谷和彦、千代谷真理、大徳和之、今泉忠淳、元村成、福田幾夫、古川賢一
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-16K10619
[Presentation] カルモジュリン依存性プロテインキナーゼIVと交感神経2017
- Author(s)
  韓沖、野崎修平、小潟佳輝、瀬谷和彦、米倉学、富田泰史、大場貴喜、柳澤輝行、坂上洋行、尾野恭一、村上学
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] 大動脈弁に局在する易石灰化性未分化細胞における遺伝的特徴の解析2017
- Author(s)
  瀬谷和彦、于在強、野村亜南、千代谷真理、大徳和之、今泉忠淳、元村成、福田幾夫、古川賢一
- Organizer
  第68回日本薬理学会北部会（山形）
- Data Source
  KAKENHI-PROJECT-16K10449
[Presentation] The role of CD34-negative mesenchymal stem-like cells as cellular origin on human aortic valve calcification.2014
- Author(s)
  Seya K, Nomura A, Yu Z, Daitoku K, Motomura S,Murakami M, Fukuda I, Furukawa K.
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460293
[Presentation] TNF-αは石灰化動脈弁狭窄症患者から得た動脈弁間質細胞の石灰化をBMP2-Dlx5経路を介して促進する2011
- Author(s)
  于在強,瀬谷和彦,大徳和之,元村成,福田幾夫,古川賢一
- Organizer
  日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] P2Y1の一過性過剰発現は脊柱靭帯骨化症患者由来の脊柱靭帯細胞の石灰化を誘発する2010
- Author(s)
  田中直,浅利享,小野睦,沼沢拓也,藤哲,瀬谷和彦,元村成,古川賢一
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] TNF-αはNF-kB経路を介して石灰化大動脈弁狭窄症患者由来の大動脈弁間質細胞の石灰化を促進する2010
- Author(s)
  于在強,瀬谷和彦,大徳和之,元村成,福田幾夫,古川賢一
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] 脊柱後縦靱帯骨化症患者におけるP2Y1受容体の病態生理学的役割-過剰発現による解析2010
- Author(s)
  田中直,古川賢一、浅利享,小野睦,沼沢拓也,瀬谷和彦,藤哲,元村成
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] 頚椎後縦靱帯骨化症分類に基づいた遺伝子発現の検討2009
- Author(s)
  工藤整、田中直、沼沢拓也、小野睦、和田簡一郎、浅利亨、瀬谷和彦、三木いづみ、籐哲、元村成、古川賢一
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] 脊椎後縦靱帯骨化症患者におけるP2Y1受容体の病態生理学的役割-過剰発現による解析2009
- Author(s)
  田中直、工藤整、小野睦、沼沢拓也、瀬谷和彦、三木いづみ、籐哲、元村成、古川賢一
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590245
[Presentation] 大動脈弁間質細胞の高リン酸誘発性異所性石灰化に対する1-methyl-2-undecyl-4(1H)-quinoloneの抑制作用
- Author(s)
  瀬谷和彦，于　在強，菊地　晴久，大徳　和之，福田　幾夫，村上　学，大島　吉輝，古川　賢一
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460293
[Presentation] Both warfarin and vitamin K stimulate the ectopic calcifi cation of human aortic valve interstitial cells through binding to pregnane X receptor
- Author(s)
  瀬谷和彦、于在強、野村亜南、大徳和之、元村成、村上学、福田幾夫、古川賢一
- Organizer
  第８８回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460293

1. Daitoku Kazuyuki (50374822)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. FURUKAWA Kenichi (20165468)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
3. Yu Zaiqiang (40624268)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
4. 今泉忠淳 (90232602)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
5. 福田幾夫 (50344594)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
6. murakami manabu (80302090)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
7. MOTOMURA Shigeru (40091756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NUMASAWA Takuya (80396407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. ONO Kyoichi (70185635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHBA Takayoshi (80431625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUGITA Chiharu (70632694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OSHIMA Yoshiteru (00111302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. INOUE Ituro (00192500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OKADA Akihiro (90312488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 柳田俊彦 (60295227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 根本隆行 (90506833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 皆川正仁 (50374830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. ISHIBASHI Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. SASAKI Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. TANAKA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 松宮朋穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
22. 石橋恭太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 津川浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 植草義徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seya Kazuhiko 瀬谷 和彦

SEYA Kazuhiko 瀬谷 和彦

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大動脈弁異所性石灰化に関わる核内受容体ファミリーの解析と新規治療の構築についてPrincipal Investigator

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Demonstration and mechanism elucidation of the inhibition of aortic valve calcification by controlling expression of extracellular matrix proteinPrincipal Investigator

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Calcific aortic stenosis: Identification of calcification-inducing cell, clarifying calcification signalingPrincipal Investigator

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[Book] 大動脈弁はなぜ石灰化するのか2021

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[Journal Article] Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells2024

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[Journal Article] Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling2024

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Seya Kazuhiko 瀬谷和彦

SEYA Kazuhiko 瀬谷和彦