SHIMIZU Tominaga 清水富永

Researcher Number	40283270
External Links
Affiliation (based on the past Project Information) *help	2003 – 2006: 信州大学, 医学部, 講師 2003: 信州大学, 医学部・整形外科学教室, 講師 2002: 信州大学, 医学部附属病院, 助手 2001: 信州大学, 医学部・付属病院, 助手 2000 – 2001: 信州大学, 医学部・附属病院・整形外科, 助手 … More 1999 – 2001: School of Medicine, Shinshu University, Assistant, 医学部・附属病院, 助手 1999: 信州大学, 医学部・附属病院整形外科, 助手 1997 – 1999: 信州大学, 医学部, 助手 1998: Shinshu Univ., Dept. of Orthopaedic Surgery, Assistant Professor, 医学部・整形外科学, 助手 1998: 信州大学, 医学部整形外科学, 助手 1998: 信州大学, 医学部附属病院, 助手 1997: 信州大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Biomedical engineering/Biological material science / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Orthopaedic surgery
Keywords	Principal Investigator drug delivery system / sonoporation / anti cancer drug / 抗腫瘍剤 / electrochemotherapy / 電極 / 電気化学療法 / nano-particle / ドラッグデリバリー / 電気刺激 … More / 抗癌剤 / ドラックデリバリー / 超音波刺激 / ナノパーティクル / methotrexate / arthritis / electrolode / drug delivety system / メトトレキサート / 関節炎 / bone morphogenetic protein / reconstruction / bone defect / malignant bone tumor / 手術 / 骨形成因子 / 再建 / 骨欠損 / 悪性骨腫瘍 / 骨軟部腫瘍 / 動脈内投与 … More Except Principal Investigator 骨形成 / 生体分解性ポリマー / ドラッグデリバリーシステム / 担体 / 骨形成因子 / KLF9 / サイトカイン / 人工関節 / Pentoxifylline / TNF-α / biodegradable polymer / bone morphogenetic protein / 骨形成タンパク / Bone / Biodegradable polymer / Drug delivery system / Carrier / Bone morphogenetic protein / 骨 / gene expression / 遺伝子 / 骨吸収 / 骨粗鬆症 / articular cartilage repair / chondrocyte differentiation factor / undifferentiated mesenchymal cells / 超音波遺伝子導入 / 遺伝子発現 / 軟骨分化 / 遺伝子解析 / 転写因子 / 軟骨分化促進 / 関節軟骨修復 / 軟骨分化促進因子 / 未分化間葉系細胞 / mononuclear cell / cytokine / biomaterial / drug delivery system / bone tissue repair / prosthesis for arthroplasty / 組織工学 / デリバリーシステム / 組織再生 / 再生医療 / 骨組織再生 / 骨欠損 / 骨髄単核球細胞 / 生体材料 / DDS / 骨組織修復 / orthopedics / sarcoma / gene / 整形外科 / 発現解析 / 骨軟部肉腫 / Hip prosthesis / Noggin / BMP / Bone marrow cells / Bone formation / Autograft / 骨形成因子(BMP-4) / noggin / 骨形成因子(BMP) / 骨髄細胞 / 自家骨移植 / synthetic carrier material / less invasive surgery / osteogenesis / 被吸収性ポリマー / 人工担体 / 低侵襲手術 / Poly-D,L-lactic acid-polyethylene glycol block copolymer / ポリ乳酸-ポリエチレングリコールブロック共重 / ポリ乳酸-ポリエチレングリコールブロック共重合体 / bone formation / proteins / genes / osteoblast / 骨基質タンパク / 骨芽細胞 / ヌードマウス / BMP-レセプター / 炎症性サイトカイン / 骨髄 / BMP(骨形成因子) / 海綿骨 / 副甲状腺ホルモン / ビスフォスフォネート / エストロゲン / 骨形態計測 Less

Nano-particles which Contained Drug Induction into Tumor Cell by Electrochemotherapy and SonoporationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Jun, 清水富永
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Comprehensive gene expression analysis during chondrogenesis from progenitor cells, ,and application of this technique to tissue repair
- Principal Investigator
  
  WAKITANI Shigeyuki
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
  Shinshu University
Organization of Electrolodes for the Electrochemotherapy for Deep-seated Malignant Musculoskeletal TumorPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Tominaga
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Development of new prostheses for arthroplasty with an added ability to promote bone repair using bone morphogenetic protein (BMP)
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
悪性骨軟部腫瘍に対する抗腫瘍剤動脈内投与による電気化学療法Principal Investigator
- Principal Investigator
  
  清水富永
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
New type of prosthesis combined with rhBMP-2 delivery system
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Gene Expresion of Soft Tissue Sarcoma
- Principal Investigator
  
  GOMYO Hiroki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinsyu University
Basic research to develop technology for practical use of BMP in less invasive orthopaedic surgery
- Principal Investigator
  
  TAKAOKA Kunio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Analysis concerning the mechanisms of differentiation in the bone marrow stromal cells after bone implantatio
- Principal Investigator
  
  TAKAOKA Kunio, 吉村康夫
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
骨髄内での骨形成制御メカニズムの解明-新しい骨粗鬆症の病態と治療の解明-
- Principal Investigator
  
  江原宗平
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Synthetic biodegradable polymers as injectable delivery systems for BMPs
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Application of BMP for reconstruction of bone defect after the removable of malignant bone tumorPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Tominaga
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shinshu University
骨粗鬆症における骨再形成の誘導
- Principal Investigator
  
  TAKAOKA Kunio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Identification of novel protein molecules produced by osteoblasts
- Principal Investigator
  
  TAKAOKA Kunio
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University

All 2005 2004 2003

All Journal Article

[Journal Article] Recurrence potential of diffuse-type giant cell tumor in the foot -radiological and pathological features2005
- Author(s)
  Tominaga Shimizu, Tsutomu Akahane, et al.
- Journal Title
  
  Foot and ankle international 26
  
  Pages: 474-478
- Data Source
  KAKENHI-PROJECT-17591559
[Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced anti-inflammatory effects in rabbit antigen-induced arthritic knees2005
- Author(s)
  Hiroyuki Nakaya, Tominaga Shimizu, et al.
- Journal Title
  
  Arthritis and Rheumatism (In press)
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Recurrence potential of diffuse-type giant cell tumor in the foot : radiologic and pathologic features2005
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  Foot Ankle Int 28(6)(In press)
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced antiinflammatory effects in the knees of rabbits with antigen-induced arthritis.2005
- Author(s)
  Hiroyuki Nakaya, Tominaga Shimizu, Kenichi Isobe, et al.
- Journal Title
  
  Arthritis Rheum 52
  
  Pages: 2559-2566
- Data Source
  KAKENHI-PROJECT-17591559
[Journal Article] Meningioma arising in Werner syndrome confirmed by mutation analysis.2005
- Author(s)
  Nakamura Y, Shimizu T, et al.
- Journal Title
  
  Journal of Clinical Neuroscience 12
  
  Pages: 503-506
- Data Source
  KAKENHI-PROJECT-17591559
[Journal Article] Recurrence potential of diffuse-type giant cell tumor in the foot radiologic and pathologic features2005
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  Foot Ankle Int. 26(6)
  
  Pages: 474-478
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Serum total acid phosphatase is a useful criterion for monitoring the clinical course of giant cell tumor of bone2005
- Author(s)
  Tsutomu Akahane, Tominaga Shimizu, Kenichi Isobe
- Journal Title
  
  Acta Orthop Scad 76
  
  Pages: 651-653
- Data Source
  KAKENHI-PROJECT-17591559
[Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced anti-inflammatory effects in rabbit antigen-induced arthritic knees2005
- Author(s)
  Hiroyuki Nakaya, Tominaga Shimizu, et al.
- Journal Title
  
  Arthritis and Rheumatism. 52(8)
  
  Pages: 2559-2566
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Effective treatment for mice osteosarcoma by low voltage electrochemotherapy with low-dose MTX2004
- Author(s)
  Kenichi Isobe, Tominaga Shimizu, et al.
- Journal Title
  
  Clin Orthop 426
  
  Pages: 226-231
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] E nhancement of recombinant human bone morphogenetic protein-2 (rhbmp-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline2004
- Author(s)
  Horiuchi H, Nawata M, Kamijo T, Saito N, Wakitani S, Kobayashi S, Shimizu T, Kato H
- Journal Title
  
  J Bone Miner Metab 22
  
  Pages: 329-334
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370459
[Journal Article] Radiological image study of ancient schwannoma2004
- Author(s)
  Kenichi Isobe, Tominaga Shimizu, et al.
- Journal Title
  
  AJR 183
  
  Pages: 331-336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Assesment of microinvasion with reverse transcriptase polymerase Reaction in a case of synovial sarcoma2004
- Author(s)
  Jun Nakasone, Tominaga Shimizu, et al.
- Journal Title
  
  J Orthop Sci. 9
  
  Pages: 162-165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Three-Dimensional Starch Model for Simulation of Corrective Osteotomy for a Complex Bone Deformity2004
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  Foot Ankle Int. 24(4)
  
  Pages: 364-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Effective treatment for mice osteosarcoma by low voltage electrochemotherapy with low-dose MTX2004
- Author(s)
  Kenichi Isobe, Tominaga Shimizu, et al.
- Journal Title
  
  Clin Orthop. 183
  
  Pages: 331-336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Electrocheniotherapy for digital chondrosarcoma2003
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  J Orthop Sci. 8(2)
  
  Pages: 238-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Massive calcification in pseudohypoparathyroidism2003
- Author(s)
  Tominaga shimizu, et al.
- Journal Title
  
  New Engl J Med 349
  
  Pages: 464-464
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Massive calcification in pseudohypoparathyroidism2003
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  New Engl J Med.
  
  Pages: 349-464
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Bilateral Solid Parameniscal Masses in the Knee.2003
- Author(s)
  Tsutomu Akahane, Tominaga Shimizu, et al.
- Journal Title
  
  The Journal of Arthroscopic & Related Surgery 19(10)
  
  Pages: 14-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Electrochemotherapy for digital chondrosarcoma2003
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  J Orthop Sci 8(2)
  
  Pages: 248-251
- NAID
  50000783982
- Data Source
  KAKENHI-PROJECT-15591572
[Journal Article] Three-Dimensional Starch Model for Simulation of Corrective Osteotomy for a Complex Bone Deformity2003
- Author(s)
  Tominaga Shimizu, et al.
- Journal Title
  
  Foot Ankle Int 24(4)
  
  Pages: 364-367
- Data Source
  KAKENHI-PROJECT-15591572

1. TAKAOKA Kunio (30112048)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
2. SAITO Naoto (80283258)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
3. NIKAIDO Toshio (50180568)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKAHASHI Jun (60345741)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. EBARA Sohei (40176780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. WAKITANI Shigeyuki (70243243)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. GOMYO Hiroki (70311694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YOSHIMURA Yasuo (10303439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KOBAYASHI Seneki (40205464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 上村幹男 (60273091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OKUBO Kousaku (40233069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SAITOH Satoru (20175350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MURAKAMI Narumichi (50334892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KADOYA Masumi (40115225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FURUTA Masakazu (40181458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISOBE Kenichi (80397314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 清水元彦 (70226257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 藤井信吾 (30135579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 橋本淳 (40237938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 谷川浩隆 (40262711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OKADA Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NOZAKI Kazutoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高橋浩一郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 谷上信

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Tominaga 清水 富永

Research Projects

Research Products

Co-Researchers

Nano-particles which Contained Drug Induction into Tumor Cell by Electrochemotherapy and SonoporationPrincipal Investigator

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Organization of Electrolodes for the Electrochemotherapy for Deep-seated Malignant Musculoskeletal TumorPrincipal Investigator

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悪性骨軟部腫瘍に対する抗腫瘍剤動脈内投与による電気化学療法Principal Investigator

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Application of BMP for reconstruction of bone defect after the removable of malignant bone tumorPrincipal Investigator

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[Journal Article] Recurrence potential of diffuse-type giant cell tumor in the foot -radiological and pathological features2005

Author(s)

SHIMIZU Tominaga 清水富永