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IGARASHI HIDEYA  五十嵐 英哉

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… Alternative Names

IGARASHI Hideya  五十嵐 英哉

五十嵐 英哉  イガラシ ヒデヤ

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Researcher Number 40291538
Affiliation (based on the past Project Information) *help 2013 – 2016: 川崎医科大学, 医学部, 准教授
2008 – 2011: Kawasaki Medical School, 医学部, 准教授
2008: 川崎医科大学, 免疫学, 准教授
2007: Kawasaki Medical School, 医学部, 講師
2006: 熊本大学, 大学院医学薬学研究部, 助手 … More
2005: 熊本大学, 大学院・医学薬学研究部, 助手
2003: School of Medicine Kumamoto University, Department of Immunology, Graduate School of Medical Sciences, Instructor, 大学院・医学薬学研究部, 助手
2002: 熊本大学, 医学部, 助手
2000: 熊本大, 医学部, 助手
1999: 熊本大学, 医学部, 助手
1997: 熊本大, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Immunology / Orthopaedic surgery / Immunology / Pathological medical chemistry
Except Principal Investigator
Experimental pathology
Keywords
Principal Investigator
B cell activation / B cell development / アポトーシス / B細胞 / glucocorticoid / GANP / PP5 / PP2A / フォスファターゼ / G5PR … More / GR / グルココルチコイド / Glucocorticoid / DNAチップ / TNFα / TNFR2 / E3ユビキチンリガーゼ / ユビキチン / ABIN / ユビキチンリガーゼ / NEDD4L / ABIN-3 / NF-kappaB / 滑膜線維芽細胞 / 関節リウマチ / 免疫寛容 / Bim / Caspase / BTK / 脱リン酸化酵素 / AICD / p38 MAPK / JNK / 脱リン酸化酵素結合制御ユニット / Double nositive(DN)細胞 / Double positive(DP)細胞 / 胸腺細胞分化 / T細胞 / 免疫学 / 発現制御 / シグナル伝達 / 抗原受容体 / IL-7 / IL-4 / CD40 / TRAP / T細胞依存性抗原 / 胚中心(GC) / テロメラーセ゜ … More
Except Principal Investigator
gp130 / 関節リウマチ / 疾患モデル動物 / ノックアウトマウス / 腸内常在細菌叢 / BST-1/CD157 / 無菌化(germ free) / 1型胸腺非依存性抗原 / メタボローム解析 / 腸管内常在細菌叢 / ADPリボシルシクラーゼ / 無菌マウス / 腸内細菌叢 / IL-17 / IL-6 / ノックインマウス / マウスモデル / サイトカイン / 自己免疫疾患 / 滑膜繊維芽細胞 / 免疫学 / 滑膜線維芽細胞 Less
  • Research Projects

    (8 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (3 People)
  •  Function of extracellular ADP-ribosyl cyclase BST-1/CD157 in the intestine

    • Principal Investigator
      Katsuhiko Ishihara
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kawasaki Medical School
  •  NF-kB inhibitory molecule mediated TNF responsiveness of rheumatoid arthritis delivered fibroblast-like synoviocytePrincipal Investigator

    • Principal Investigator
      IGARASHI HIDEYA
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kawasaki Medical School
  •  Spatiotemporal pathophysiology of systemic immunological disorders and autoimmune arthritis caused by aberrant cytokine signaling

    • Principal Investigator
      ISHIHARA Katsuhiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kawasaki Medical School
  •  Abnormality of synovial mesenchymal cells in autoimmune arthritis

    • Principal Investigator
      ISHIHARA Katsuhiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kawasaki Medical School
  •  The properties of B cell antigen receptor mediated induction signalsPrincipal Investigator

    • Principal Investigator
      IGARASHI Hideya
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kawasaki Medical School
      Kumamoto University
  •  Regulatory mechanism of glucocorticoid for B lymphocyte activation and developmentPrincipal Investigator

    • Principal Investigator
      IGARASHI Hideya
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kumamoto University
  •  胚中心B細胞におけるテロメラーゼ活性誘導機構の解析Principal Investigator

    • Principal Investigator
      五十嵐 英哉
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Kumamoto University
  •  ヒト正常リンパ球におけるテロメラーゼ活性の誘導機序とそのシグナル伝達の解析Principal Investigator

    • Principal Investigator
      五十嵐 英哉
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University

All 2015 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

  • [Book] Molecular mechanisms of rheumatoid arthritis revealed by categorizing subtypes of fibroblast-like synoviocytes. in Rheumatoid Arthritis-Etiology, and Consequences and Co-morbidities2012

    • Author(s)
      Ishihara K, Igarashi H
    • Publisher
      InTech
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Book] Molecular mechanisms of rheumatoid arthritis revealed by categorizing subtypes of fibroblast-like synoviocytes. in Rheumatoid Arthritis-Etiology, and Consequences and Co-morbidities2012

    • Author(s)
      Ishihara K & Igarashi H
    • Publisher
      InTech
    • URL

      http://www.intechopen.com/articles/show/title/molecular-mechanisms-of-rheumatoid-arthritis-revealed-by-categorizing-subtypes-of-fibroblast-like-sy

    • Data Source
      KAKENHI-PROJECT-21590448
  • [Journal Article] TNF receptor type 2 transmits caspase-dependent apoptotic signals in fibroblast-like synoviocytes derived from rheumatoid arthritis.2015

    • Author(s)
      Hiroyasu HIRANO, Hideya IGARASHI, Yoshitaka MORITA, Katsuhiko ISHIHARA
    • Journal Title

      Kawasaki Medical Journal

      Volume: 41(2) Pages: 29-40

    • NAID

      110009986978

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Journal Article] TNF receptor type 2 transmits caspase-dependent apoptotic signals in fibroblast-like synoviocytes derived from rheumatoid arthritis.2015

    • Author(s)
      Hirano H, Igarashi H, Morita Y, Ishihara K.
    • Journal Title

      Kawasaki Medical Journal

      Volume: 41 Pages: 29-40

    • DOI

      10.11482/KMJ-E41(2)29

    • NAID

      110009986978

    • ISSN
      0385-0234, 2434-3404
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462390
  • [Journal Article] A pro-inflammatoty role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis2011

    • Author(s)
      Igarashi H, Ishihara K, et al
    • Journal Title

      Immunol.Lett.

      Volume: 141 Issue: 2 Pages: 246-253

    • DOI

      10.1016/j.imlet.2011.10.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590448, KAKENHI-PROJECT-22591685
  • [Journal Article] A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis2011

    • Author(s)
      Igarashi H, Yahagi A, Saika T, Hashimoto J, Tomita T, Yoshikawa H, Ishihara K.
    • Journal Title

      Immunol. Lett

      Volume: 141 Pages: 246-253

    • URL

      http://dx.doi.org/10.1016/j.imlet.2011.10.011

    • Data Source
      KAKENHI-PROJECT-21590448
  • [Journal Article] TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis.2010

    • Author(s)
      Hideya Igarashi, Katsuhiko Ishihara, et al.
    • Journal Title

      Clin Exp Immunol

      Volume: 161 Pages: 71-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Journal Article] TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derivedfrom a fraction of patients with rheumatoid arthritis2010

    • Author(s)
      Igarashi H, Hashimoto J, Tomita T, Yoshikawa H, Ishihara K.
    • Journal Title

      Clin Exp Immunol

      Volume: 161 Issue: 1 Pages: 71-80

    • DOI

      10.1111/j.1365-2249.2010.04163.x

    • Data Source
      KAKENHI-PROJECT-21590448
  • [Journal Article] The immature B-cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse.2009

    • Author(s)
      Teppei Toda, Masahiro Kitabatake, Hideya Igarashi, Nobuo Sakaguchi.
    • Journal Title

      European Journal of Immunology 39

      Pages: 600-611

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Journal Article] GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells.2009

    • Author(s)
      Hideya Igarashi, Kazuhiko Kuwahara, Mikoto Yoshida, Yan Xing, Kazuhiko Maeda, Kouichi Nakajima, Nobuo Sakaguchi.
    • Journal Title

      Molecular Immunology 46

      Pages: 1031-1041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Journal Article] Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes2008

    • Author(s)
      Xing Y, Wang X, Igarashi H, Kawamoto H, Sakaguchi N.
    • Journal Title

      Molecular Immunology 45

      Pages: 2028-2037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Journal Article] NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha.2006

    • Author(s)
      Hideya Igarashi et al.
    • Journal Title

      International Immunology 18

      Pages: 653-669

    • Data Source
      KAKENHI-PROJECT-17590440
  • [Journal Article] Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids.2005

    • Author(s)
      Hideya Igarashi et al.
    • Journal Title

      International Immunology 17

      Pages: 501-511

    • NAID

      10019359022

    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] ABIN(A20-Binding Inhibitors of NF-kB)-3は関節リウマチ由来滑膜線維芽細胞(RA-FLS)株でAktのユビキチン化を制御する2015

    • Author(s)
      五十嵐英哉、石原克彦
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-22
    • Data Source
      KAKENHI-PROJECT-25462390
  • [Presentation] 関節リウマチ由来滑膜線維芽細胞において2型TNF受容体(TNFR2)はカスパーゼを介するアポトーシスシグナルを伝達する2015

    • Author(s)
      平野紘康、五十嵐英哉、矢作綾野、守田吉孝、石原克彦
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-22
    • Data Source
      KAKENHI-PROJECT-25462390
  • [Presentation] NF-κB抑制因子ABIN-3はRA治療の標的分子となりうるか2015

    • Author(s)
      五十嵐英哉
    • Organizer
      第26回日本リウマチ学会中国・四国支部学術集会シンポジウム リウマチ性疾患の基礎研究
    • Place of Presentation
      岡山
    • Year and Date
      2015-12-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25462390
  • [Presentation] Critical roles of neutrophils for development of arthritis in the knock-in mouse gp130F759 induced by systemic infection of Mycoplasma fermentans2015

    • Author(s)
      Ayano YAHAGI, Hiroyasu HIRANO, Hideya IGARASHI, Katsuhiko ISHIHARA
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] The classification of rheumatoid arthritis based on the response to TNFα by the fibroblast-like synoviocytes2011

    • Author(s)
      Igarashi H
    • Organizer
      13th International TNF Conference
    • Place of Presentation
      淡路島(兵庫)
    • Year and Date
      2011-05-16
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] The pro-inflammatory function of A20 and ABINs in a subtype of fibro blast-like synoviocytes derived from rheumatoid arthritis2011

    • Author(s)
      Igarashi H, Ishihara K, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] 線維芽細胞様滑膜細胞株亜型に発現するRA関連遺伝子の探索2011

    • Author(s)
      五十嵐英哉、石原克彦, ら
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2011-04-23
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] RA滑膜線維芽細胞株においてABIN1は炎症促進性に機能する2011

    • Author(s)
      五十嵐英哉、石原克彦
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] A subtype of fibroblast-like synoviocytes derived from rheumatoid arthritis exhibits a pro-inflammatory phenotype by A20 and ABINs2011

    • Author(s)
      Igarashi H
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] The pro-inflammatory function of A20 and ABINs in a subtype of fibroblast-like synoviocytes derived from rheumatoid arthritis2011

    • Author(s)
      Igarashi H
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] gp130F759マウスの関節における網羅的発現遺伝子解析2011

    • Author(s)
      石原克彦、五十嵐英哉, ら
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2011-07-20
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] RA滑膜線維芽細胞株においてABIN1は炎症促進性に機能する2011

    • Author(s)
      五十嵐英哉
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] Heterogeneity of gene expression profiles in fibroblast-like synoviocytes of rheumatoid arthritis and osteoarthritis2010

    • Author(s)
      Katsuhiko Ishihara, Hideya Igarashi
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] 線維芽細胞様滑膜細胞株亜型に発現するRA関連遺伝子の探索2010

    • Author(s)
      五十嵐英哉
    • Organizer
      第54回日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] TNFα応答性とNF-κB経路関連分子の発現誘導に基づく関節リウマチ由来滑膜線維芽細胞の亜型分類2010

    • Author(s)
      五十嵐英哉
    • Organizer
      第33回日本分子生物学会総会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] Comparative analysis of gene expression in a subtype of fibrobtast-like synoviocytes between rheumatoid arthritis and osteoarthritis2010

    • Author(s)
      Hideya Igarashi, Katsuhiko Ishihara
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] gp130F759マウスの自己免疫性関節炎自然発症経過におけるIL-17の産生2010

    • Author(s)
      石原克彦、五十嵐英哉, ら
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] Comparative analysis of gene expression in a subtype of fibroblast-like synoviocytes between rheumatoid arthritis and osteoarthritis2010

    • Author(s)
      Hideya Igarashi
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] RA滑膜線維芽細胞様細胞におけるAIDの発現は癌抑制遺伝子TP53の突然変異と関連する2009

    • Author(s)
      五十嵐英哉
    • Organizer
      リウマチ学会
    • Place of Presentation
      国際館パミール(東京都)
    • Year and Date
      2009-04-25
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] 関節リウマチ患者由来滑膜線維芽細胞における異所性AID発現とp53遺伝子の体細胞突然変異との関連について2009

    • Author(s)
      五十嵐英哉
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] 関節リウマチ患者由来滑膜線維芽細胞における異所性AID発現とp53遺伝子の体細胞突然変異との関連について2009

    • Author(s)
      五十嵐英哉
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21590448
  • [Presentation] NZB-like autoimmunity was induced in the transgenic mice of B cell survival molecule G5PR.2008

    • Author(s)
      Masahiro Kitabatake, Hideya Igarashi, Teppei Toda, Mareki Oh tsuji, Hiromichi Tsurui, Sachiko Hirose, Nobuo Sakaguchi.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] Alteration of receptor editing activity in the B cell differentiation of NZB mouse.2008

    • Author(s)
      Teppei Toda, Masahiro Kitabatake, Hideya Igarashi, Nobuo Sakaguchi.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] Protein phosphatase subunit G5PR regulates the JNK-mediated apoptosis signal and is required for survival of CD4^+CD8^+double-positive thymocytes2007

    • Author(s)
      Xing Yan, Wang Xiaodan, Hideya Igarashi, Hiroshi Kawamoto, Nobuo Sakaguchi
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] Role of G5PR in the development of autoimmune disease2007

    • Author(s)
      Masahiro Kitabatake, Hideya Igarashi, Teppei Toda, Mareki Ohtsuji, Hiromichi Tsurui, Sachiko Hirose, Nobuo Sakaguchi
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] Search for cell-intrinsic abnormalities of synovial fibroblasts in rheumatoid arthritis2007

    • Author(s)
      Katsuhiko Ishihara, Hideya Igarashi, Toshiyuki Fukada, Masaaki Murakami and Toshio Hirano
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590390
  • [Presentation] Protein phosphatase subunit G5PR is required for survival of CD4+CD8+double-positive thymocytes2007

    • Author(s)
      刑 岩、王 暁丹、五十嵐 英哉、阪口 薫雄
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜国際会議場、横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17590440
  • [Presentation] Search for cell-intrinsic abnormalities of synovial fibroblasts in rheumatoid arthritis2007

    • Author(s)
      Katsuhiko Ishihara, Hideya Igarashi, Toshiyuki Fukada, Masaaki Murakami, Toshio Hirano
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-17590440
  • 1.  ISHIHARA Katsuhiko (10263245)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 2.  矢作 綾野 (10584873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  HIRANO Hiroyasu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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