Hashiguchi Shuhei 橋口周平

… Alternative Names

Researcher Number	40295275
Other IDs
External Links
Affiliation (Current)	2019: 鹿児島大学, 理工学域工学系, 助教
Affiliation (based on the past Project Information) *help	2015 – 2019: 鹿児島大学, 理工学域工学系, 助教 2015: 鹿児島大学, 工学部, 助教 2013 – 2015: 鹿児島大学, 理工学研究科, 助教 2011: 鹿児島大学, 大学院・理工学研究科(工学系), 助教 2011: 鹿児島大学, 大学院・理工学研究科, 助教 … More
Review Section/Research Field	Principal Investigator 生物・生体工学 / Virology / Veterinary medical science / 食の安全 / 獣医学 / Basic Section 42020:Veterinary medical science-related Except Principal Investigator Biological Sciences / Living organism molecular science / Veterinary medical science / Kansei informatics / 広領域 / Drug development chemistry / 生物機能・バイオプロセス
Keywords	Principal Investigator バクテリオファージ / ファージディスプレイ / ワクチン / ヒト抗体 / 抗体エンジニアリング / プリオン / 抗体 / アジュバント / M13 / ミモトープ … More Except Principal Investigator ファージライブラリー / MCP-1 / 分子設計 / IL-6 / ヒト抗体 / ワクチン / ペプチドミミック / scFv / ペプチドミメティックス / CCR5 / エイズ / インヒビター / IL-5 / 感染防御 / ファージライブラリ / 細菌感染症 / バクテリオファージ / 緑膿菌 / 黄色ブドウ球菌 / ファージセラピー / 薬剤耐性菌 / 乳房炎 / メラノプシン / 抗体医薬 / ペプチド / HMGB-1 / THP-1 / IL-8 / CTLA4 / 免疫応答 / コスティムユラ / T細胞 / ケモカイン / HIV-1 / エントリーインフビター / 感染 / サイトカイン / エントリーインヒビター / 免疫制御 / アルツハイマー認知症 / M13ファージ / 自然免疫 / ミミックペプチド / アミロイドベーター / MyD88 / TLR9 / Aβ42 / 受動免疫 / J20 / オリゴマー / ウマ細菌性角膜炎 / 角膜炎 / メラノプシン神経節細胞 / 錐体 / 桿体 / 照明 / 視知覚経路 / モノクロナル抗体 / TNFα / IgE / Phage library / Peptide mimic / Human antibody / Inhibitor / Molecular design / 分子標的医療 / 抗体エンジニアリング / ペプチドアンタゴニスト / ScFv / ヒト / 抗体 / ミミック / HUMAN ANTIBODY / ANTIBODY DRUG / MOLECULAR TARGETING / ANTIBODY ENGINEERING / PEPTIDE ANTAGONIST / PHAGE LIBRARY / ヒト抗体ファージライブラリ / 敗血症 / 炎症 / 阻害剤 / human antibody phage library / sepsis / inflammation / タンパク質のライブラリ化 / ライブラリ構築法 / モジュール構造を有するライブラリ / 非免疫グロブリンのライブラリ化 / ライブラリの性能評価 / ライブラリ構築 / ライブラリ構築手法 / １段階導入 / モジュール構造に適した構築法 / 立体構造保持の確認 / 抗体提示の条件検討 / ライブラリ構築戦略の変更 / ベクターの改変 / 抗体提示の確認 / 構造保持の確認 / 明るさ / 概日リズム / 光受容器 / メラノプシン細胞 / 錐体細胞 / 抗生物質 / エンドライシン / 獣医学 / ファージ Less

ファージワクチンの免疫応答誘導メカニズムの解明とB細胞移入療法への応用の試みPrincipal InvestigatorOngoing
- Principal Investigator
  
  橋口周平
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
Irradiance encoding process in the nonimage-forming pathwayOngoing
- Principal Investigator
  
  辻村誠一
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kansei informatics
- Research Institution
  Nagoya City University
  Kagoshima University
次世代型ファージ療法の開発と臨床応用Ongoing
- Principal Investigator
  
  岩野英知
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Veterinary medical science
- Research Institution
  Rakuno Gakuen University
Immunological mechanism for M13-phage-based vaccine immunogenicity and its application.Principal Investigator
- Principal Investigator
  
  Hashiguchi Shuhei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  獣医学
- Research Institution
  Kagoshima University
Design and basic reserch of novel antibody using Leucine Rich Repeat scaffold.
- Principal Investigator
  
  Yoshinaga Keisuke
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物機能・バイオプロセス
- Research Institution
  National Institute of Technology, Kumamoto College
Contribution of melanopsin ganglion cells to visual pathway
- Principal Investigator
  
  TSUJIMURA Sei-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kansei informatics
- Research Institution
  Kagoshima University
Research of phage therapy and phage vaccine for bacterial infectious diseases.
- Principal Investigator
  
  IWANO Hidetomo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Rakuno Gakuen University
M13 phage as a vaccine vehclePrincipal Investigator
- Principal Investigator
  
  Hashiguchi Shuhei
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kagoshima University
M13 bacteriophage-based vaccine design for prion.Principal Investigator
- Principal Investigator
  
  HASHIGUCHI Shuhei
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kagoshima University
Amyloid beta-42-mimotope displaying M13 bacteriophage for vaccine vehicle of Alzheimer's disease
- Principal Investigator
  
  SUGIMURA Kazuhisa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
Basic studies for development of inhibitor to target nuclear inflammatory cytokine related with sepsis
- Principal Investigator
  
  ITO Yuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kagoshima University
Prion-conformation-specific human antibodies established from phage display library.Principal Investigator
- Principal Investigator
  
  HASHIGUCHI Shuhei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食の安全
- Research Institution
  Kagoshima University
Study on molecular targeting using phage dispky library
- Principal Investigator
  
  SUGIMURA Kazuhisa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
抗体エンジニアリングによる免疫制御分子の開発Principal Investigator
- Principal Investigator
  
  橋口周平
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Kagoshima University
エイズ感染阻子分子の分子設計法の基礎研究
- Principal Investigator
  
  杉村和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
ファージディスプレイライブラリーを用いた感染防御と免疫制御法の開発
- Principal Investigator
  
  杉村和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
エイズ感染阻止分子の分子設計法の基礎研究
- Principal Investigator
  
  杉村和久
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
免疫制御分子の機能性ドメインミミックの分子設計と免疫制御
- Principal Investigator
  
  杉村和久
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
エイズワクチンの活性強化分子の分子設計法の基礎研究
- Principal Investigator
  
  杉村和久
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
Molecular design of functional domain-mimics of receptors and ligands
- Principal Investigator
  
  SUGIMURA Kazuhisa
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Kagoshima University
エイズワクチンの活性強化分子の分子設計法の基礎研究
- Principal Investigator
  
  SUGIMURA Kazuhisa
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University

All 2018 2017 2016 2015 2013 2012 2011 2010 2009 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] 生化学:ファージディスプレイとBeyond antibody:-抗体様分子による分子標的-2010
- Author(s)
  橋口周平、伊東祐二、田中孝一、松木園美穂、村岡賢、杉村和久
- Publisher
  社団法人日本生化学会
- Data Source
  KAKENHI-PROJECT-22790435
[Book] 生化学:ファージディスプレイとBeyond antibody :～抗体様分子による分子標的～2010
- Author(s)
  橋口周平, 伊東祐二, 田中孝一, 松木園美穂, 村岡賢, 杉村和久
- Publisher
  社団法人日本生化学会
- Data Source
  KAKENHI-PROJECT-22790435
[Book] Prions : Food and Drug Safety (Ed.T.Kitamoto)2005
- Author(s)
  Shuhei Hashiguchi et al.
- Total Pages
  2
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16613008
[Book] Prions : Food and Drug Safety(Ed T.Kitamoto)2005
- Author(s)
  Shuhei Hashiguchi et al.
- Total Pages
  2
- Publisher
  Springer
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16613008
[Book] 検査と技術2004
- Author(s)
  橋口周平
- Total Pages
  4
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16613008
[Journal Article] Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis.2015
- Author(s)
  Gondaira, S., Higuchi, H., Iwano, H., Nakajima, K., Kawai, K., Hashiguchi, S., Konnai, S., and Nagahata, H.
- Journal Title
  
  Vet Immunol Immunopathol.
  
  Volume: 165 Pages: 45-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292182
[Journal Article] Development of Universal Phage Vaccine Displaying Extracellular Domains of M2e Derived from Human Influenza A Viruses2015
- Author(s)
  Ryohei Shioya, Ryuji Miyahara, Yoshitsugu Shoji, Kazuhisa Sugimura, Shuhei Hashiguchi
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 265-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450427
[Journal Article] Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis2015
- Author(s)
  Gondaira S, Higuchi H, Iwano H, Nakajima K, Kawai K, Hashiguchi S, Konnai S, Nagahata H.
- Journal Title
  
  Vet. Immunol. Immunopathol.
  
  Volume: 165 Pages: 45-53
- DOI
  10.1016/j.vetimm.2015.03.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25292182, KAKENHI-PROJECT-26450432, KAKENHI-PROJECT-25257415
[Journal Article] 分子標的素子デザインにおけるファージライブラリー法2015
- Author(s)
  橋口周平、宮原隆二、岸本聡、伊東祐二
- Journal Title
  
  日本生物工学会誌
  
  Volume: 93 Pages: 289-292
- Data Source
  KAKENHI-PROJECT-25450427
[Journal Article] Direct evidence of generation and accumulation ofβ-sheet-rich prion protein in scrapie-infected neuroblastoma cells with a human IgG1 antibody specific for the b-form prion protein2012
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, and Kazuhisa Sugimura
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 14023-14039
- URL
  http://www.jbc.org/content/287/17/14023.full
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Direct evidence of generation and accumulation of β-sheet-rich prion protein in scrapie-infected neuroblastoma cells with a human IgG1 antibody specific for the b-form prion protein2012
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287 Pages: 14023-14039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Desensitization vaccine strategy using M13 phage whose g8p displays a B cell IgG epitope of Cry j 1 as a major allergen of Japanese cedar pollen2012
- Author(s)
  Kai Satomi, Shuhei Hashiguchi, Kazuhisa Sugimura
- Journal Title
  
  Peptide Science 2011
  
  Pages: 269-270
- Data Source
  KAKENHI-PROJECT-22790435
[Journal Article] Direct evidence of generation and accumulation of β-sheet-rich prion protein in ScN2a cells de novo illuminated by human IgG1 antibody recognizing β-form but not α-form of prion protein.2012
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura.
- Journal Title
  
  The journal of biological chemistry.
  
  Volume: 287巻 Pages: 14023-14039
- DOI
  10.1074/jbc.m111.318352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790435, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482
[Journal Article] Desensitization vaccine strategy using M13 phage whose g8p displays a B cell IgG epitope of Cry j 1 as a major allergen of Japanese cedar pollen2012
- Author(s)
  Kai S, Hashiguchi S, et al
- Journal Title
  
  Peptide Science 2011
  
  Pages: 269-270
- Data Source
  KAKENHI-PROJECT-22790435
[Journal Article] A mimotope peptide of Aβ42 fibril-specific antibodies with Aβ42 fibrillation inhibitory activity induces anti-Aβ42 conformer antibody response by a displayed form on an M13 phage in mice2011
- Author(s)
  Koichi Tanaka, Masaaki Nishimura, Yuya Yamaguchi, Shuhei Hashiguchi, Sho Takiguchi, Makoto Yamaguchi, Haruna Tahara, Takuma Gotanda, Risa Abe, Yuji Ito, Kazuhisa Sugimura
- Journal Title
  
  J.Neuroimmunology
  
  Volume: 236 Pages: 27-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] A mimotope peptide of Aβ42 fibril-specific antibodies with Aβ42 fibrillation inhibitory activity induces anti-Aβ42 conformer antibody response by a displayed form on an M13 phage in mice2011
- Author(s)
  Koichi Tanaka, Masaaki Nishimura, Yuya Yamaguchi, Shuhei Hashiguchi, Sho Takiguchi, Makoto Yamaguchi, Haruna Tahara, Takuma Gotanda, Risa Abe, Yuji Ito, Kazuhisa Sugimura
- Journal Title
  
  J. Neuroimmunology
  
  Volume: 236 Pages: 27-38
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21641049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Immunological basis of M13 phage vaccine : Regulation under MyD88 and TLR9 signaling2011
- Author(s)
  Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 402巻 Pages: 19-22
- DOI
  10.1016/j.bbrc.2010.09.094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790435
[Journal Article] Characterization of Human Single-Chain Antibodies Against Highly Pathogenic Avian Influenza H5N1 Viruses : Mimotope and Neutralizing Activity.2010
- Author(s)
  JiuPian Yang, Reiko Yoshida, Yuji Ito, Yuki Kariya, Xu Zhang, Shuhei Hashiguchi, Toshihiro Nakashima, Yasuo Suda, Ayato Takada, Kazuhisa Sugimura.
- Journal Title
  
  J.Biochem.
  
  Volume: 148 Pages: 504-515
- NAID
  10027879101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Essential role of MyD88 in humoral response to M13 bacteriophage in mice and negative role of TLR9 in IgG1 response.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Takeuchi O, Akira S, Sugimura K.
- Journal Title
  
  International Immunology
  
  Volume: 22 : Supplement Number 1
- Data Source
  KAKENHI-PROJECT-22790435
[Journal Article] ファージディスプレイとBeyond antibody :～抗体様分子による分子標的～2010
- Author(s)
  橋口周平、伊東祐二、田中孝一、松木園美穂、村岡賢、杉村和久
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 710-726
- NAID
  10027502225
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Immunological basis of M13 phage vaccine : Regulation under MyD88 and TLR9 signaling.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Takeuchi O, Akira S, Sugimura K
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 19-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790435
[Journal Article] Immunological basis of M13 phage vaccine : Regulation under MyD88 and TLR9 signaling.2010
- Author(s)
  Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura
- Journal Title
  
  BBRC
  
  Volume: 402 Pages: 19-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310144
[Journal Article] Prion-conformation-specific human antibodies established from phage display library.2005
- Author(s)
  Shuhei Hashiguchi, Mayumi Yamamoto, Sho Kitamoto, Toshihiro Nakashima, Hitoki Yamanaka, Daisuke Ishibashi, Suehiro Sakaguchi, Shigeru Katamine, Yyji Ito, Kazuhisa Sugimura
- Journal Title
  
  Prions : Food and Drug Safety (Ed.T.Kitamoto)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16613008
[Journal Article] Binding Epitope of Human Anti-FcεRI α-chain Receptor Antibody, RE51,with the Blocking Activity on IgE-mediated Histamine Release2004
- Author(s)
  橋口周平(他, 3名)
- Journal Title
  
  Immunology2004(Ed : Medimond S.r.l.)
  
  Pages: 541-544
- Data Source
  KAKENHI-PROJECT-15310152
[Journal Article] Binding Epitope of Human Anti-FcεRI α-chain Receptor Antibody, RE51, with the Blocking Activity on IgE-mediated Histamine Release2004
- Author(s)
  橋口周平(他、3名)
- Journal Title
  
  Immunology2004(Ed : Medimond S.r.l.)
  
  Pages: 541-544
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310152
[Journal Article] 抗体エンジニアリングと診断技術2004
- Author(s)
  橋口周平(他、1名)
- Journal Title
  
  検査と技術(医学書院) 32(11)
  
  Pages: 1319-1322
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310152
[Journal Article] 抗体エンジニアリングと診断技術2004
- Author(s)
  橋口周平(他, 1名)
- Journal Title
  
  検査と技術(医学書院) 32(11)
  
  Pages: 1319-1322
- Data Source
  KAKENHI-PROJECT-15310152
[Journal Article] Human Anti-FcεRI α-specific human single-chain Fv (scFv) antibody with antagonistic activity toward IgE/FceRIα-binding2003
- Author(s)
  橋口周平(他, 7名)
- Journal Title
  
  J.Biochem. 133(1)
  
  Pages: 43-49
- Data Source
  KAKENHI-PROJECT-15310152
[Journal Article] Human FcεRIα-specific human single-chain Fv (scFv) antibody with antagonistic activity toward IgE/FceRIα-binding2003
- Author(s)
  橋口周平(他、7名)
- Journal Title
  
  J.Biochem. 133(1)
  
  Pages: 43-49
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310152
[Presentation] Preferential uptake of M13 phage vaccine by murine macrophages without the production of proinflammatory cytokines.2018
- Author(s)
  Kei Nakagawaji, Shuhei Hashiguchi, Akikazu Murakami, Masahito Hashimoto
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] M13ファージペプチドワクチンの設計法：抗原提示方法の改良による抗原性の増強2017
- Author(s)
  宮原隆二、樋口雄介、橋本雅仁、橋口周平
- Organizer
  平成29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] Diurnal variations in humoral immune response against bacteriophage in mice2017
- Author(s)
  橋口周平、辻村誠一
- Organizer
  第24回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] M13ファージを担体としたワクチンによる自己抗体誘導の可能性2017
- Author(s)
  中川路けい、宮原隆二、橋本雅仁、橋口周平
- Organizer
  平成29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] 抗原エピトープ特異的IgG抗体を誘導するファージワクチンの分子設計法2017
- Author(s)
  宮原隆二、篠崎太亮、中西美加、中川路けい、橋本雅仁、橋口周平
- Organizer
  第160回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] Immunogenicity of M13 phage vaccine displaying N-terminal region of amyloid beta peptide: comparison of M13 phage vaccine expressed as g3p fusion and g8p fusion2016
- Author(s)
  Ryuji Miyahara, Akiko Shimotsu, Yui Matsushita, Mai Tsukada, Masahito Hashimoto, Kazuhisa Sugimura, Shuhei Hashiguchi
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] M13ファージペプチドワクチンの設計法：抗原分子の提示方法の違いと抗原性2016
- Author(s)
  宮原隆二、下津尭子、松下由依、篠崎太亮、橋本雅仁、橋口周平
- Organizer
  ファージ・環境ウイルス研究合同シンポジウム
- Place of Presentation
  JAMSTEC横浜本部（神奈川県横須賀市）
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] M13 phage vaccine for Alzheimer’s disease that induce T-cell independent IgG response against Aβ peptide2016
- Author(s)
  Ryuji Miyahara, Yui Matsushita, Akiko Shimotsu, Taisuke Shinozaki, Masahito Hashimoto, Kazuhisa Sugimura, Shuhei Hashiguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08024
[Presentation] Immunogenicity of M13 phage vaccine displaying the extracellular domain of matrix protein 2 (M2e) of human influenza A virus.2015
- Author(s)
  Shuhei Hashiguchi, Ryuji Miyahara, Ryohei Shioya, Yui Matsushita, Akiko Shimotsu, Kazuhisa Sugimura
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道・札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] M13ファージを担体とした抗Aβ抗体を誘導するワクチン開発2015
- Author(s)
  宮原隆二、庄司恵二、塩屋亮平、下津尭子、松下由依、杉村和久、橋口周平
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森・ホテル青森 (青森県・青森市)
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] アジュバントの添加を必要としない繊維状ファージ (M13) を担体としたファージワクチンの開発2015
- Author(s)
  橋口周平
- Organizer
  第158回日本獣医学会学術集会
- Place of Presentation
  北里大学獣医学部 (青森県・十和田市)
- Year and Date
  2015-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] スギ花粉アレルゲンCry j 1のIgE結合エピトープを提示したファージワクチンによる脱感作効果の検討2015
- Author(s)
  橋口周平、泊大介、宮原隆二、塩屋亮平、杉村和久
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール (東京都・港区高輪)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] Characterization of antibody responses to M13 phage vaccine: MyD88-dependent and T-cell independent IgG subclass responses.2013
- Author(s)
  Shuhei Hashiguchi, Masaya Toyonaga, Yoshitsugu Shoji, Takuma Gotanda, Kazuhisa Sugimura.
- Organizer
  International Congress of Immunology 2013
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] Medical application of peptide-displaying M13 phage for vaccine vehicle.2013
- Author(s)
  Masaya Toyonaga, Shoji Yoshitsugu, Shuhei Hashiguchi, Kazuhisa Sugimura.
- Organizer
  4th Asia-Pacific International Peptide Symposium and 50th Japanese Peptide Symposium (APIPS2013)
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] Immunological characterization of M13 phage vaccine.2013
- Author(s)
  Sugimura K, Osako T, Kawabata S, Miyahara R, Tsurumaru T, Oda R, Tomari D, Shioya R, Hashiguchi S.
- Organizer
  International Congress of Immunology 2013
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] Immunological characterization of M13 phage vaccine: Possible involvement of Marginal Zone B cells to generate IgG response and germinal centers in response to M13 phage.2013
- Author(s)
  Shuhei Hashiguchi, Masaya Toyonaga, Yoshitsugu Shoji, Kazuhisa Sugimura.
- Organizer
  Annual Meeting of The Japanese Society for Immunology, 2013
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] M13 bacteriophage for a vaccine vehicle.2013
- Author(s)
  Shuhei Hashiguchi
- Organizer
  Phage2013
- Place of Presentation
  Oxford, UK
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] M13ファージワクチンデザインのためのM13ファージのin vivo動態の解析2013
- Author(s)
  豊永将也、庄司恵二、末広一彦、中倉大彰、中島麻美、徳永麗雅、橋口周平、杉村和久
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] アルツハイマー病モデルマウス(J20)脳内での、繊維状アミロイドβ(Aβ)に特異的な抗体(B7)によるAβプラークの免疫組織学的解析2011
- Author(s)
  川畑壮大朗、安部梨沙、田中孝一、大迫哲平、橋口周平、鈴木賢太朗、山田源、中島敏博、中河史朗、杉村和久
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Amyloid beta42-mimotope-displaying M13 phage induce anti-amyloid beta42antibody without adjuvant2011
- Author(s)
  大迫哲平、安部梨沙、川畑壮大朗、田中孝一、五反田卓摩、橋口周平、中河志朗、杉村和久
- Organizer
  第40回日本免疫学会学術集会記録
- Place of Presentation
  千葉,幕張メッセ
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] M13 bacteriophage for vaccine vehicle of Alzheimer's disease2011
- Author(s)
  Kazuhisa Sugimura, Shuhei Hashiguchi, Teppei Osako, Kawabata Sotaro, Risa Abe
- Organizer
  1st Oxford International bacteriophage conference, Phage2011 : Bacteriophage Application
- Place of Presentation
  Oxford, UK
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Amyloid beta-42-mimotope displaying M13 bacteriophage for Vaccine vehicle of Alzheimer's disease2011
- Author(s)
  Kazuhisa Sugimura, Shuhei Hashiguchi, Teppei Osako, Sotaro Kawabata, Risa Abe, Shiro Nakagawa
- Organizer
  5th Vaccine and ISV Annual Global Congress
- Place of Presentation
  Seattle, USA
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Strong innate immunity to M13 bacteriophage : Implication for vaccine development2011
- Author(s)
  Shuhei Hashiguchi, Takuma Gotanda, Yuta Hamazoe, Kazuhisa Sugimura
- Organizer
  第40回日本免疫学会学術集会記録
- Place of Presentation
  千葉,幕張メッセ
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] アルツハイマー病モデルマウス(J20)脳内での、線維状アミロイドβ(Aβ)に特異的な抗体(B7)によるAβプラークの免疫組織学的解析2011
- Author(s)
  川畑壮大朗、安部梨沙、田中孝一、大迫哲平、橋口周平、鈴木賢太郎、山田源、中島敏博、中河志朗、杉村和久
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  兵庫,神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Monoclonal human IgG1 specific to Prion2011
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei, Hashiguchi, Daisuke Ishibashi, Noriyuki Nishida, Suehiro Sakaguchi, Kazuhisa Sugimura
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] M13 bacteriophage for vaccine vehicle of Alzheimer's disease2011
- Author(s)
  Kazuhisa Sugimura, Shuhei Hashiguchi, Teppei Osako, Sotaro Kawabata, Risa Abe
- Organizer
  1st Oxford International Bacteriophage Conference, Phage 2011
- Place of Presentation
  St Hilda's college Oxford University
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Amyloid beta 42-mimotope-displaying M13 phage induce anti-amyloid beta 42 antibody without adjuvant2011
- Author(s)
  Kazuhisa Sugimura, Risa Abe, Sotaro Kawabata, Teppei Osako, Takuma Gotanda, Shuhei Hashiguchi, Shiro Nakagawa
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2011
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Strong Innate Immunity to M13 Bacteriophage : Implication for Vaccine Development2011
- Author(s)
  Shuhei Hashiguchi, Takuma Gotanda, Yuta Hamazoe, Tsuyoshi Tsurumaru, Kazuhisa Sugimura
- Organizer
  5th Vaccine and ISV Annual Global Congress
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Amyloid beta-42-mimotope displaying M13 bacteriophage for vaccine vehicle of Alzheimer's disease2011
- Author(s)
  Kazuhisa Sugimura, Shuhei Hashiguchi, TEppei Osako, Sotaro Kawabata, Risa Abe, Shiro Nakagawa
- Organizer
  5th Vaccine and ISV Annual Global Congress
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Monoclonal human IgG1 specific to Prion2011
- Author(s)
  Kubota T, Hamazoe Y, Hashiguchi S, et al
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Strong innate immunity to M13 bacteriophage2011
- Author(s)
  Hashiguchi S, Gotannda T, et al
- Organizer
  第40回日本免疫学会総会・学術集会記録
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Strong Innate Immunity to M13 Bacteriophage : Implication for Vaccine Development2011
- Author(s)
  Shuhei Hashiguchi, Takuma Gotanda, Yuta Hamazoe, Tsuyoshi Tsurumaru, Kazuhisa Sugimura
- Organizer
  5th Vaccine and ISV Annual Global Congress
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Strong innate immunity to M13 bacteriophage : Implication for vaccine development2011
- Author(s)
  Shuhei Hashiguchi, Takuma Gotanda, Hamazoe Yuta, Kazuhisa Sugimura
- Organizer
  第40回日本免疫学会総会・学術集会記録
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Amyloid Beta-42-Mimotope Displaying M13 Bacteriophage for Vaccine Vehicle of Arzheimer's Disease2011
- Author(s)
  Kazuhisa Sugimura, Shuhei Hashiguchi, Teppei Osako, Sotaro Kawabata, Risa Abe, Shiro Nakagawa
- Organizer
  5th Vaccine and ISV Annual Global Congress
- Place of Presentation
  Seattle
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Immunological basis of M13 phage vaccines : an effective vaccine design tested in a mouse model of Alzheimer's disease2010
- Author(s)
  Shuhei Hashiguchi, Yuya Yamaguchi, Haruna Tahara, Takashi Yamada, Satomi Kai, Risa Abe, Koichi Tanaka, Kazuhisa Sugimura
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] M13バクテリオファージが誘導するIgG抗体応答はMyD88に依存する2010
- Author(s)
  橋口周平、山口雄也、竹内理、審良静男、杉村和久
- Organizer
  日本生化学会九州支部例会
- Place of Presentation
  鹿児島県鹿児島市
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Amyloid beta42-mimotope-displaying M13 phage induce anti-amyloid beta42antibody without adjuvant2010
- Author(s)
  Kazuhisa Sugimura, Risa Abe, Sotaro Kawabata, Teppei Osako, Takuma Gotanda, Shuhei Hashiguchi, Shiro Nakagawa
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] M13バクテリオファージ免疫におけるTLRファミリー分子の役割について2010
- Author(s)
  田原春菜、橋口周平、山口雄也、竹内理、審良静男、杉村和久
- Organizer
  BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Immunological basis of M13 phage vaccines : an effective vaccine design tested in a mouse model of Alzheimer's disease.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Tahara H, Yamada T, Kai S, Abe R, Tanaka K, Sugimura K.
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都府京都市
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Essential role of MyD88 in humoral response to M13 bacteriophage in mice and negative role of TLR9 in IgG1 response2010
- Author(s)
  Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] M13バクテリオファージ免疫におけるTLRファミリー分子の役割について2010
- Author(s)
  田原春菜、橋口周平、山口雄也、竹内理、審良静男、杉村和久
- Organizer
  BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] Immunological basis of phage vaccine as an experimental model using Alzheimer's disease model mice, J20 immunized with a mimotope-phage clone selected by a fibrillar Abeta42-specific antibody.2010
- Author(s)
  Yuya Yamaguchi, Shuhei Hashiguchi, Koichi Tanaka, Risa Abe, Kazuhisa Sugimura.
- Organizer
  The Immunotherapeutics and vaccine summit
- Place of Presentation
  Cambridge, MA
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] M13バクテリオファージが誘導するIgG抗体応答はMyD88に依存する2010
- Author(s)
  橋口周平、山口雄也、竹内理, 審良静男、杉村和久
- Organizer
  日本生化学会九州支部例会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Essential role of MyD88 in humoral response to M13 bacteriophage in mice and negative role of TLR9 in IgG1 response.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Takeuchi O, Akira S, Sugimura K.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Immunological basis of M13 phage vaccines : an effective vaccine design tested in a mouse model of Alzheimer's disease.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Tahara H, Yamada T, Kai S, Abe R, Tanaka K, Sugimura K.
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都市
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] M13バクテリオファージ免疫におけるTLRファミリー分子の役割について2010
- Author(s)
  田原春菜, 橋口周平, 山口雄也, 竹内理, 審良静男、杉村和久
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790435
[Presentation] Essential role of MyD88 in humoral response to M13 bacteriophage in mice and negative role of TLR9 in IgG1 response.2010
- Author(s)
  Hashiguchi S, Yamaguchi Y, Takeuchi O, Akira S, Sugimura K.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸市
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] アミロイドベータ1-42ミモトープをディスプレイしたM13ファージが誘導する免疫応答の解析2009
- Author(s)
  山口雄也, 橋口周平, 永尾宏子, 山田昴, 杉村和久
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21310144
[Presentation] M13バクテリオファージが誘導する免疫応答の解析
- Author(s)
  庄司恵二、塩屋亮平、宮原隆二、杉村和久、橋口周平
- Organizer
  第5回ファージ研究会
- Place of Presentation
  三重大学生物資源学部大講義室（三重県・津市）
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25450427
[Presentation] ファージワクチンの基礎的研究：Ｍ１３ファージ蛋白を用いた特異的免疫応答の解析
- Author(s)
  庄司恵二、橋口周平、塩屋亮平、宮原隆二、杉村和久
- Organizer
  平成26年度日本生化学会九州支部例会
- Place of Presentation
  九州大学コラボステーションI（福岡県・福岡市）
- Year and Date
  2014-05-17 – 2014-05-18
- Data Source
  KAKENHI-PROJECT-25450427

1. SUGIMURA Kazuhisa (80127240)

# of Collaborated Projects: 11 results

# of Collaborated Products: 23 results
2. ITO Yuji (60223195)

# of Collaborated Projects: 11 results

# of Collaborated Products: 5 results
3. 古川純康 (10305154)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. IWANO Hidetomo (60382488)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. 中島秀喜 (20192669)

# of Collaborated Projects: 4 results

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6. NAKASHIMA Toshihiro

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HIGUCHI Hidetoshi (00305905)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. HAGIWARA Katsuro (50295896)

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9. MAEHARA Seiya (50438363)

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10. TSUJIMURA Sei-ichi (10381154)

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11. 森田健 (20326474)

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12. 山下和香代 (70580067)

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13. 太田英伸 (80422103)

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15. TAMURA Yutaka (50382487)

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16. BABA Masanori (70181039)

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17. YOSHIZAKI Kazuyuki (90144485)

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18. ABEYAMA Kazuhiro (30284897)

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19. Yoshinaga Keisuke (30513238)

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26. 岩崎智仁 (30305908)

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# of Collaborated Projects: 1 results

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31. 臼井優 (60639540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KONNAI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. ISHIBASHI Ishibashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 永幡肇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 赤坂一之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashiguchi Shuhei 橋口 周平

HASHIGUCHI Syuhei 橋口 周平

HASHIGUCHI Shuhei 橋口 周平

Research Projects

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ファージワクチンの免疫応答誘導メカニズムの解明とB細胞移入療法への応用の試みPrincipal InvestigatorOngoing

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Irradiance encoding process in the nonimage-forming pathwayOngoing

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次世代型ファージ療法の開発と臨床応用Ongoing

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Immunological mechanism for M13-phage-based vaccine immunogenicity and its application.Principal Investigator

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M13 phage as a vaccine vehclePrincipal Investigator

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M13 bacteriophage-based vaccine design for prion.Principal Investigator

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Prion-conformation-specific human antibodies established from phage display library.Principal Investigator

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抗体エンジニアリングによる免疫制御分子の開発Principal Investigator

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Hashiguchi Shuhei 橋口周平

HASHIGUCHI Syuhei 橋口周平

HASHIGUCHI Shuhei 橋口周平