SHIMIZU Takahiko 清水孝彦

Researcher Number	40301791
Other IDs
Affiliation *help	2017 – 2018 : 千葉大学, 大学院医学研究院, 講師 2015 – 2017 : 千葉大学, 大学院医学研究院, 特任准教授 2015 – 2016 : 千葉大学, 医学(系)研究科(研究院), 准教授 2015 – 2016 : 千葉大学, 医学(系)研究科(研究院), 特任准教授 2015 : 千葉大学, 医学科研究院, 准教授 … More
Review Section/Research Field	Principal Investigator General medical chemistry / Orthopaedic surgery / 老化(加齢) / Neurology / Applied health science Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Orthopaedic surgery / General medical chemistry / General internal medicine(including psychosomatic medicine) / Bioproduction chemistry/Bioorganic chemistry … More
Keywords	Principal Investigator 酸化ストレス / ミトコンドリア / 神経変性 / イソアスパラギン酸 / 骨格筋 / SOD / 遺伝子治療 / イソアスパラギン酸メチル転移酵素 / MnSOD / 活性酸素 … More Except Principal Investigator 酸化ストレス / Aβ42 / 凝集 / 老化 / アルツハイマー病 / アルツハイマー / βアミロイド / DARR / オリゴマー / アミロイドβ / β-sheet / ミトコンドリア / 骨粗鬆症 / Mn-SOD / ターン / 加齢 / タキシフォリン / Alzheimer's disease / 活性酸素 / ベータシート / 核酸アプタマー / amyloid / turn / β-シート / iPS細胞 / 抗体 / 老年医学 / 毒性ターン / ラジカル / Cre-loxP / 固体NMR / 遺伝子 / モデルマウス / 活性酵素 / 急性肝障害 / アプリシアトキシン / βシート / アミロイド β / 遺伝子発現 / 骨格筋 / シリマリン / コエンザイムQ / Apoptosis / 肥満 / プロドラッグ / アプタマー / トランスジェニックマウス / 寿命 / ＳＯＤ２ / フイスゲン反応 / R2 / フラボノイド / DJ-1 / 肝細胞癌 / Huisgen反応 / aggregation / 酸素消費 / 骨代謝 / Respiratory complex / 酸素消費量 / MnSOD / CuZn-SOD / プロテインキナーゼC / 光親和性標識 / 脳脊髄液 / 骨細胞 / マウス / 凝集抑制 / Aβ抗体 / 内科 / 抗酸化 / 骨芽細胞 / アルキン / セメント芽細胞 / スーパーオキシドラジカル / 電子スピン共鳴法 / キャリア / 光アフィニティーラベリング / ジアミノピペリン酸 / familial Alzheimer's disease / 早老症候群 / インスリン抵抗性 / 肝再生 / 脳神経疾患 / ウェルナー / 破骨細胞 / パーキンソン病 / 白金 / RNA / セメント質 / クルクミン / 代謝 / NASH / 脂肪肝炎 / カテコール / 脂肪肝 / アポトーシス / 早老症 / 有機化学 / ATP合成 / 糖尿病 / 毒性コンホマー / ビタミンC / 酵素 / コエンザイムＱ / ターン形成 / Mitochondria / 間葉系幹細胞 / シグナル伝達 / 家族性アルツハイマー病 / solid-state NMR / 抗ターン抗体 / レプチン / 毒性オリゴマー / アミロイド / 老化機構 / インスリン受容体 / スーパーオキサイドディスムターゼ(SOD) / 神経細胞毒性 / Aging / 家族性アルツハイマー / シナプス毒性 / 分化 / ウェルナー症候群 / 歯周組織 / SOD2 / スピンラベル / 細胞質SOD / 呼吸鎖複合体 / 脳 / Superoxide / セメント質肥大 / Aβ1-42 / ESR / クロック-1遺伝子 / アジド / ATP synthesis / Werner症候群 / SOD / ミトコンドリア機能低下 / アルツハイマ-病 / β-シ-ト / β-turn Less

早老遺伝子の多角的解析に基づく老化と疾患の分子病態解明Ongoing
- Principal Investigator
  
  横手幸太郎
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Chiba University
Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaOngoing
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
Pathological elucidation of age-related diseases by integrative analyses of senescence genes
- Principal Investigator
  
  Yokote Koutaro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Chiba University
Oxidative stress in bone regulates skeletal homeostasis in micePrincipal Investigator
- Principal Investigator
  
  Shimizu Takahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Chiba University
The functional analysis of SOD2, antioxidantdefense in periodontal tissue
- Principal Investigator
  
  USUI MICHIHIKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Kyushu Dental College
To generate and analyze new Parkinson's disease mice model with increased oxidative stress
- Principal Investigator
  
  YAMAGUCHI Hiroo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Establishment of disease iPS cells and molecular analysis of age-related changes in progeroid syndrome
- Principal Investigator
  
  YOKOTE Koutaro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Chiba University
The role of oxidative stress in the maintenance of bone metabolism
- Principal Investigator
  
  SAITA Yoshitomo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Juntendo University
Effects of coenzyme Q on aging in mammls
- Principal Investigator
  
  TAKAHASHI Mayumi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Mitochondria Treatment by Antioxidant with Multi-enzyme Activity
- Principal Investigator
  
  KAWAKAMI Hiroyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Metropolitan University
Development of RNA aptamer against toxic Aβ oligomer
- Principal Investigator
  
  MURAKAMI Kazuma
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  ケミカルバイオロジー
- Research Institution
  Kyoto University
Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
The development and analyses of the mouse model of age-related osteoporosis.
- Principal Investigator
  
  SAITA Yoshitomo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Juntendo University
Molecular mechanism for aging control
- Principal Investigator
  
  SHIRASAWA Takuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Juntendo University
Oxidative stress in skeletal muscle causes severe disturbance of exercise activityPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takahiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Analysis of the paradoxical correlation between hepatic insulin resistance and oxidative stress in the pathogenesis of steatohepatitis
- Principal Investigator
  
  TOMITA Kengo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
- Principal Investigator
  
  SHIRASAWA Takuji
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
酸化ストレスによる神経変性の分子メカニズム解明Principal Investigator
- Principal Investigator
  
  清水孝彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Analysis of heart/muscle-specific Mn-SOD-deficient mice.
- Principal Investigator
  
  SHIRASAWA Takuji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Structural analysis of β-amyloid fibrils using solid-state NMR
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
脳酸化ストレス蓄積マウスの作製と解析Principal Investigator
- Principal Investigator
  
  清水孝彦
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
神経変性モデルマウスに蓄積した変性タンパク質の同定Principal Investigator
- Principal Investigator
  
  清水孝彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitors
- Principal Investigator
  
  IRIE Kazuhiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kyoto University
Identification of isoaspartic acid containing proteins in aged brainPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takahiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

[Book] 新老年学「第3版」2010
- Author(s)
  清水孝彦, ら
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20390085
[Book] 老化遺伝子,新老年学「第3版」編集代表:大内尉義、秋山弘子2010
- Author(s)
  清水孝彦、白澤卓二
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20500641
[Book] 臓器老化モデルマウスを用いた抗老化食品の探索49巻1号2010
- Author(s)
  清水孝彦
- Publisher
  化学と生物化学と生物編集部
- Data Source
  KAKENHI-PROJECT-20500641
[Book] Mn-SODコンディショナルノックアウトマウスを用いた抗老化研究130巻1号2010
- Author(s)
  清水孝彦、白澤卓二
- Publisher
  薬学雑誌日本薬学会
- Data Source
  KAKENHI-PROJECT-20500641
[Book] 新老年学「第3版」2010
- Author(s)
  清水孝彦, ら
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20500641
[Book] 酸化ストレスモデルマウス,老化・老年病研究のための動物実験ガイドブック2008
- Author(s)
  清水孝彦、川上哲、白澤卓二
- Publisher
  日本基礎老化学会編アドスリー社
- Data Source
  KAKENHI-PROJECT-20500641
[Book] 老化・老年病のための動物実験ガイドブック2008
- Author(s)
  清水孝彦ら
- Publisher
  アドスリー
- Data Source
  KAKENHI-PROJECT-20390085
[Book] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006
- Author(s)
  Takahiko Shimizu
- Publisher
  Nova Biomedical Books
- Data Source
  KAKENHI-PROJECT-17790201
[Book] Detection of amyloid beta peptides with L-isoaspartate in Alzhemier's disease2006
- Author(s)
  Takahiko Shimizu
- Publisher
  Nova Biomedical Books
- Data Source
  KAKENHI-PROJECT-17390085
[Book] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006
- Author(s)
  Takahiko Shimizu
- Publisher
  Nova Biomedical Books
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390085
[Book] 'Malignant' conformation of Alzheimer's β peptide (Aβ42) through radical formation (H. Ishida and H. Mihara (Eds.))2006
- Author(s)
  K. Murakami, *K. Irie, 他3名, T. Shimizu, T. Shirasawa
- Publisher
  The Japanese Peptide Society
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice2017
- Author(s)
  Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
- Journal Title
  
  Neurosci Lett.
  
  Volume : 642 Pages : 123-128
- DOI
  10.1016/j.neulet.2017.02.003
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111506, KAKENHI-PROJECT-26253081, KAKENHI-PROJECT-15H06174, KAKENHI-PROJECT-25293347, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K10743, KAKENHI-PROJECT-15K15616
[Journal Article] MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.2017
- Author(s)
  Gwo-Tzer Ho, Rhona E Aird, Bo Liu, Nicholas A Kennedy, David A Dorward, Colin L Noble, Takahiko Shimizu, Nicholas M Morton, Adriano G Rossi, R. Balfour Sartor, John P Iredale, Jack Satsangi.
- Journal Title
  
  Mucosal Immunology
  
  Volume : -
- DOI
  10.1038/mi.2017.31
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283
[Journal Article] EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice.2017
- Author(s)
  Oyama, J.*, Shirakihara, A., Nishikido, T., Maeda, T., Komoda, H., Shimizu, T., Makino, N., Node, K.
- Journal Title
  
  J Cardiol
  
  Volume : 69 Pages : 417-427
- DOI
  10.1016/j.jjcc.2016.05.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K08919
[Journal Article] Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation.2017
- Author(s)
  Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Shimizu, T., Jae Youl Cho, Dae Bang Seo*, Song Seok Shin
- Journal Title
  
  J. Ginseng Res.
  
  Volume : 印刷中
- DOI
  10.1016/j.jgr.2016.05.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26293165
[Journal Article] A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease2017
- Author(s)
  Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
- Journal Title
  
  Sci. Rep.
  
  Volume : 7 Pages : 11811-11811
- Publisher
  Springer Nature
- DOI
  10.1038/s41598-017-11671-6
- ISSN
  2045-2322
- Year and Date
  2017-09-18
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965
[Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016
- Author(s)
  Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
- Journal Title
  
  Sci. Rep.
  
  Volume : 6 Pages : 29038-29038
- Publisher
  Springer Nature
- DOI
  10.1038/srep29038
- PMID
  27374357
- Year and Date
  2016-07-04
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322
[Journal Article] Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice.2015
- Author(s)
  Izuo, N., Nojiri, H., Uchiyama, S., Noda, Y., Kawakami, S., Kojima, S., Sasaki, T., Shirasawa, T., Shimizu, T.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume : 2015 Pages : 238914-238914
- DOI
  10.1155/2015/238914
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-15K19279
[Journal Article] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.2015
- Author(s)
  Koike, M., Nojiri, H., Ozawa, Y., Watanabe, K., Muramatsu, Y., Kaneko, H., Morikawa, D., Kobayashi, K., Saita, Y., Sasho, T., Shirasawa, T., Yokote, K., Kaneko, K., Shimizu, T.
- Journal Title
  
  Sci Rep.
  
  Volume : 5 Pages : 11722-11722
- DOI
  10.1038/srep11722
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] The effects of 2% rebapimide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (Sod1) knockout mice.2015
- Author(s)
  Kojima, T., Dogru, M.*, Ibrahim, O. M., Wakamatsu, T. H., Ito, M., Igarashi, A., Inaba, T., Shimizu, T., Shirasawa, T. Shimazaki, J., Tsubota, K.
- Journal Title
  
  Invest. Ophthalmol. Vis. Sci.
  
  Volume : 54 Pages : 7793-7802
- DOI
  10.1167/iovs.13-13128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462283
[Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015
- Author(s)
  泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
- Journal Title
  
  基礎老化研究
  
  Volume : 39 Pages : 29-34
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221202
[Journal Article] Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in cortex, hypothalamus and cerebellum.2015
- Author(s)
  Munetomo A, Hojo Y, Higo S, Kato A, Yoshida K, Shirasawa T, Shimizu T, Barron A, Kimoto T and Kawato S
- Journal Title
  
  J Physiol Sci
  
  Volume : 65 Pages : 253-263
- DOI
  10.1007/s12576-015-0363-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430006, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15H06154
[Journal Article] Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy.2015
- Author(s)
  Rowley, S., Liang, LP., Fulton, R., Shimizu, T., Day, B., Patel, M.
- Journal Title
  
  Neurobiol. Dis.
  
  Volume : 75 Pages : 151-158
- DOI
  10.1016/j.nbd.2014.12.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Journal Article] Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice.2015
- Author(s)
  Watanabe, K., Shibuya, S., Ozawa, Y., Izuo, N., Shimizu, T.
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume : 2015 Pages : 391075-391075
- DOI
  10.1155/2015/391075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K19279
[Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns.2015
- Author(s)
  Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
- Journal Title
  
  Journal of Eating Disorders
  
  Volume : 3 Pages : 14-14
- DOI
  10.1186/s40337-015-0050-6
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461749, KAKENHI-PROJECT-25461750, KAKENHI-PROJECT-15K01703, KAKENHI-PROJECT-26293165
[Journal Article] Brain-specific superoxide dismutase 2 deficiency causes perinatal death with spongiform encephalopathy in mice.2015
- Author(s)
  Izuo, N., Nojiri, H., Uchiyama, S., Noda, Y., Kawakami, S., Kojima, S., Sasaki, T., Shirasawa, T., Shimizu, T.
- Journal Title
  
  Oxid. Med. Cell. Longev
  
  Volume : 2015 Pages : 238914-238914
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462283
[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
- Author(s)
  Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
- Journal Title
  
  Leukemia and Lymphoma
  
  Volume : 印刷中 Pages : 1-4
- DOI
  10.3109/10428194.2015.1016930
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis2015
- Author(s)
  Kobayashi K1, Nojiri H2, Saita Y2, Morikawa D1, Ozawa Y3, Watanabe K3, Koike M1, Asou Y4, Shirasawa T5, Yokote K6, Kaneko K2, Shimizu T3.
- Journal Title
  
  SCIENTIFIC REPORTS
  
  Volume : Mar 16;5 Pages : 9148-9148
- DOI
  10.1038/srep09148
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791568, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes.2014
- Author(s)
  Watanabe, K., Shibuya, S., Ozawa, Y., Nojiri, H., Izuo, N., Yokote, K., and Shimizu, T.
- Journal Title
  
  BioMed. Res. Int.
  
  Volume : 2014 Pages : 140165-140165
- DOI
  10.1155/2014/140165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462283
[Journal Article] Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading.2013
- Author(s)
  Morikawa D, Nojiri H, Saita Y, Kobayashi K, Watanabe K, Ozawa Y, Koike M, Asou Y, Takaku T, Kaneko K, Shimizu T.
- Journal Title
  
  J Bone Miner Res.
  
  Volume : november 28(11) Pages : 2368-80
- DOI
  10.1002/jbmr.1981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791568
[Journal Article] Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis2013
- Author(s)
  Watanabe K, Shibuya S, Koyama H, Ozawa Y, Toda T, Yokote K, Shimizu T.
- Journal Title
  
  Int J Mol Sci
  
  Volume : 14(6) Pages : 10998-11010
- DOI
  10.3390/ijms140610998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-24659346
[Journal Article] 骨細胞における抗酸化酵素Sod2の骨リモデリング制御機構2013
- Author(s)
  小林慶司, 野尻英俊, 齋田良知, 森川大智, 小池正人, 麻生義則, 金子和夫, 清水孝彦
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume : 87巻8号
- Data Source
  KAKENHI-PROJECT-24791568
[Journal Article] 骨細胞特異的Sod2欠損マウスにおける骨リモデリング制御機構の解析2013
- Author(s)
  小林慶司, 野尻英俊, 齋田良知, 森川大智, 小池正人, 麻生義則, 金子和夫, 清水孝彦
- Journal Title
  
  日本骨代謝学会学術集会プログラム抄録集
  
  Volume : 31 Pages : 77-77
- Data Source
  KAKENHI-PROJECT-24791568
[Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons: implications for the novel therapeutic strategy of Alzheimer’s disease2013
- Author(s)
  Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 438 Pages : 1-5
- DOI
  10.1016/j.bbrc.2013.05.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
[Journal Article] LR11: a novel biomarker identified in follicular lymphoma2013
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
- Journal Title
  
  British Journal of Haematology
  
  Volume : 163(2) Pages : 277-280
- DOI
  10.1111/bjh.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
[Journal Article] Factors associated with the efficiency of PBSC collection in POEMS syndrome patients undergoing autologous PBSC transplantation.2012
- Author(s)
  Shimizu N
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume : 47 Pages : 1010-1012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659346
[Journal Article] Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous CoQ10.2012
- Author(s)
  Takahashi, M., Ogawara, M., Shimizu, T., Shirasawa, T.
- Journal Title
  
  Exp. Gerontol
  
  Volume : 47 Pages : 276-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] CuZn-SOD 欠損は低骨代謝回転型骨量減少と加齢性コラーゲン架橋変化を引き起こし骨脆弱化する2012
- Author(s)
  清水孝彦, 野尻英俊
- Journal Title
  
  Biomedical Research on Trace Elements
  
  Volume : 23巻1号 Pages : 1-5
- Data Source
  KAKENHI-PROJECT-24791568
[Journal Article] Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor.2012
- Author(s)
  Shimizu N
- Journal Title
  
  Bone Marrow Transplant
  
  Volume : 47(12) Pages : 1587-1588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659346
[Journal Article] Reversal of slow growth and heartbeat through restoration of mitochondrial functions in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.2012
- Author(s)
  1. Takahashi, M., Shimizu, T., Shirasawa, T.
- Journal Title
  
  Exp. Gerontol.
  
  Volume : 47 Pages : 425-431
- DOI
  10.1016/j.exger.2012.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model2012
- Author(s)
  Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemsitry
  
  Volume : 76 Pages : 1098-1103
- DOI
  10.1271/bbb.110934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
[Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012
- Author(s)
  Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
- Journal Title
  
  Transl. Psychiatry
  
  Volume : 2
- DOI
  10.1038/tp.2012.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Pharmaceutical Effect of Manganese Porphyrins on Manganese Superoxide Dismutase Deficient Mice2012
- Author(s)
  N. Hayakawa, S. Asayama, Y. Noda, ShimizuT. ShimizuT., H. Kawakami
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume : 9 Pages : 2956-2959
- DOI
  10.1021/mp300147v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300166, KAKENHI-PROJECT-24650281
[Journal Article] SOD1 (Copper/Zinc Superoxide Dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease.2011
- Author(s)
  Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
- Journal Title
  
  J Biol Chem.
  
  Volume : 286 Pages : 44557-44568
- DOI
  10.1074/jbc.m111.279208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
[Journal Article] Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation.2011
- Author(s)
  Sasaki T., Shimizu T., Koyama T., Sakai M., Uchiyama S., Kawakami S., Noda Y., Shirasawa T., Kojima S.
- Journal Title
  
  J Neurosci Res 89
  
  Pages : 601-610
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.2011
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Biochem Biophys Res Commun (in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease.2011
- Author(s)
  Murakami, K., Shimizu, T. Irie, K.
- Journal Title
  
  J Amino Acid 2011
  
  Pages : 654207-654207
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation.2011
- Author(s)
  Sasaki, T., Shimizu, T., Koyama, T., Sakai, M., Uchiyama, S., Kawakami, S., Noda, Y., Shirasawa, T., Kojima, S.
- Journal Title
  
  J Neurosci Res 89
  
  Pages : 601-610
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.2011
- Author(s)
  Lustgarten, M.S., Jang, Y.C., Liu, Y., Qi, W., Qin, Y., Dahia, P.L., Shi, Y., Bhattacharya, A., Muller, F.L., Shimizu, T., Shirasawa, T., Richardson, A. Van Remmen, H.
- Journal Title
  
  Aging Cell 10
  
  Pages : 493-505
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice.2011
- Author(s)
  Makino, N., Maeda, T., Oyama, J.I., Sasaki, M., Higuchi, Y., Mimori, K. Shimizu, T.
- Journal Title
  
  J Mol Cell Cardiol 50
  
  Pages : 670-677
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article]2010
- Author(s)
  清水孝彦, 他
- Journal Title
  
  新老年学「第3版」(東京大学出版会)
  
  Pages : 213-236
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010
- Author(s)
  Murakami, K., (他8名), Shimizu, T., Irie, K
- Journal Title
  
  ACS Chem. Neurosci
  
  Volume : 1 Pages : 747-756
- DOI
  10.1021/cn100072e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010
- Author(s)
  Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
- Journal Title
  
  Geriatr. Gerontol. Int
  
  Volume : 10
- DOI
  10.1111/j.1447-0594.2010.00598.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article] Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model2010
- Author(s)
  Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
- Journal Title
  
  Biosci. Biotechnol. Biochem
  
  Volume : 74 Pages : 2299-2306
- DOI
  10.1271/bbb.100524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248015
[Journal Article]2010
- Author(s)
  清水孝彦, ら
- Journal Title
  
  新老年学「第3版」(東京大学出版社)
  
  Pages : 213-236
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase (Mn-SOD) gene.2010
- Author(s)
  Shimizu T., Kawakami S., Nojiri N., Shirasawa T.
- Journal Title
  
  Geriatr Gerontol Int 10
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010
- Author(s)
  Kuwahara H., Horie T. Ishikawa S. Tsuda C., Kawakami S., Noda Y., Kaneko T., Tahara S., Tachibana T., Okabe M., Melki J., Takano R., Toda T., Morikawa D., Nojiri H., Kurosawa H., Shirasawa T., Shimizu T.
- Journal Title
  
  Free Rad Biol Med 48
  
  Pages : 1252-1262
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Free Radic Biol Med 48
  
  Pages : 1252-1262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010
- Author(s)
  Kuwahara, H., Horie, T. Ishikawa, S. Tsuda, C., Kawakami, S., Noda, Y., Kaneko, T., Tahara, S., Tachibana, T., Okabe, M., Melki, J., Takano, R., Toda, T., Morikawa, D., Nojiri, H., Kurosawa, H., Shirasawa, T., Shimizu, T.
- Journal Title
  
  Free Rad Biol Med 48
  
  Pages : 1252-1262
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase (Mn-SOD) gene.2010
- Author(s)
  Shimizu, T., Kawakami, S., Nojiri, N., Shirasawa, T.
- Journal Title
  
  Geriatr Gerontol Int 10
  
  Pages : 70-79
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Conditional knockout of MnSOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009
- Author(s)
  Lustgarten M., Jang Y., Liu Y., Muller F., Qi W., Steinhelper M., Brooks S., Larkin L. M., Shimizu T., Shirasawa T., McManus L., Bhattacharya A., Richardson A., Van Remmen H.
- Journal Title
  
  Am J Physiol 297
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.2009
- Author(s)
  Murakami K., Inagaki J., Saito M., Ikeda Y., Tsuda C., Noda Y., Kawakami S., Shirasawa T., Shimizu T.
- Journal Title
  
  Biochem Biophys Res Commun 382
  
  Pages : 457-61
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Physiol Cell Physiol 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.2009
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 382
  
  Pages : 457-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Identification of Physiological and Toxic Conformations in Aβ42 Aggregates2009
- Author(s)
  Y. Masuda,(他3名) K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages : 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Identification of physiological and toxic conformations in Aβ42 aggregates2009
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  ChemBioChem 10
  
  Pages : 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2009
- Author(s)
  Kawakami, S., Matsuda, A., Sunagawa, T., Noda, Y., Kaneko, T., Tahara, S., Hiraumi, Y., Adachi, S., Matsui, H., Ando, K., Fujita, T., Maruyama, N., Shirasawa, T., Shimizu, T.
- Journal Title
  
  Cir J 73
  
  Pages : 2125-2134
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Conditional knockout of MnSOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009
- Author(s)
  Lustgarten, M., Jang, Y., Liu, Y., Muller, F., Qi, W., Steinhelper, M., Brooks, S., Larkin, L. M., Shimizu, T., Shirasawa, T., McManus, L., Bhattacharya, A., Richardson, A., Van Remmen, H.
- Journal Title
  
  Am J Physiol 297
  
  Pages : 1520-1532
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin Cderivative.2009
- Author(s)
  Murakami, K., Inagaki, J., Saito, M., Ikeda, Y., Tsuda, C., Noda, Y., Kawakami, S., Shirasawa, T., Shimizu, T.
- Journal Title
  
  Biochem Biophys Res Commun 382
  
  Pages : 457-61
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2009
- Author(s)
  Kawakami S., Matsuda A., Sunagawa T., Noda Y., Kaneko T., Tahara S., Hiraumi Y., Adachi S., Matsui H., Ando K., Fujita T., Maruyama N., Shirasawa T., Shimizu T.
- Journal Title
  
  Cir J 73
  
  Pages : 2125-2134
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article]2008
- Author(s)
  清水孝彦, ら
- Journal Title
  
  老化・老年病のための動物実験ガイドブック(アドスリー)
  
  Pages : 115-122
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008
- Author(s)
  Hashizume K., Hirasawa M., Imamura Y., Noda S., Shimizu T., Shinoda K., Kurihara T., Noda K., Ozawa Y., Ishida S., Miyake Y., Shirasawa T., Tsubota K.
- Journal Title
  
  Am J Pathol 172
  
  Pages : 1325-1331
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos.2008
- Author(s)
  Takahashi M., Shimizu T., Moriizumi E., Shirasawa T.
- Journal Title
  
  Mech Ageing Dev 129
  
  Pages : 291-298
- Data Source
  KAKENHI-PROJECT-20390085
[Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Pathol 129
  
  Pages : 291-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Verification of the Intermolecular Parallel 13-sheet in E22K-Aβ42 Aggregates by Solid-state NMR Using Rotational Resonance : Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42. Biosci.2008
- Author(s)
  Y. Masuda,(他3名),K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
- Journal Title
  
  Biotechnol. Biochem 72
  
  Pages : 2170-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro2008
- Author(s)
  K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa, *K. Irie,
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages : 745-751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR2008
- Author(s)
  Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages : 3206-3210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] アミロイドβ (Aβ42) の毒性コンホメーションの提唱2008
- Author(s)
  *村上一馬, 清水孝彦, 白澤卓二, 入江一浩
- Journal Title
  
  基礎老化研究 32
  
  Pages : 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Aβ422008
- Author(s)
  Y. Masuda, 他2名, 2-3番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages : 2170-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008
- Author(s)
  Hashizume, K., Hirasawa, M., Imamura, Y., Noda, S., Shimizu, T., Shinoda, K., Kurihara, T., Noda, K., Ozawa, Y., Ishida, S., Miyake, Y., Shirasawa, T., Tsubota, K.
- Journal Title
  
  Am J Pathol 172
  
  Pages : 1325-1331
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos.2008
- Author(s)
  Takahashi, M., Shimizu, T., Moriizumi, E. Shirasawa, T.
- Journal Title
  
  Mech Ageing Dev 129
  
  Pages : 291-298
- Data Source
  KAKENHI-PROJECT-20500641
[Journal Article] The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimer's Disease.2007
- Author(s)
  K. Irie., K. Murakami,(他5名) K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem 7
  
  Pages : 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007
- Author(s)
  *K. Irie., K. Murakami, 他5名, 3-7番目, K. Takeoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
- Journal Title
  
  Mini-Rev. Med. Chem. 7
  
  Pages : 1001-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208011
[Journal Article] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006
- Author(s)
  Takahiko Shimizu
- Journal Title
  
  Nova Biomedical Books
  
  Pages : 369-374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390085
[Journal Article] Biological significance of isoasparate and its repair system2005
- Author(s)
  Takahiko Shimizu
- Journal Title
  
  Biol Pharm Bul 28・9
  
  Pages : 1590-1596
- Data Source
  KAKENHI-PROJECT-17790201
[Journal Article] Biological significance of isoaspartate and its repair system2005
- Author(s)
  Takahiko Shimizu
- Journal Title
  
  Biological and Pharmaceutical Bulletin 28・9
  
  Pages : 1590-1596
- Data Source
  KAKENHI-PROJECT-17025051
[Journal Article] Biological significance of isoaspartate and its repair system2005
- Author(s)
  Takahiko Shimizu
- Journal Title
  
  Biol Pharm Bul 28・9
  
  Pages : 1590-1596
- Data Source
  KAKENHI-PROJECT-17390085
[Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  K.Irie, K.Murakami, Y.Masuda, A.Morimoto, H.Ohigashi, R.Ohashi, K.Takegoshi, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biosci.Bioeng. 99(55)
  
  Pages : 437-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Verification of the turn at positions 22 and 23 of the β-amyloid fibrils using solid-state NMR : implication for the pathogenesis of Alzheimer's disease.2005
- Author(s)
  Y.Masuda, K.Irie, K.Murakami, H.Ohigashi, R.Ohashi, K.Takegoshi, T.Shimizu, T.Shirasawa
- Journal Title
  
  Bioorg.Med.Chem. 13(24)
  
  Pages : 6803-6809
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Formation and stabilization model of the 42-mer Aβ radical : implications for the long-lasting oxidative stress in Alzheimer's disease.2005
- Author(s)
  K.Murakami, K.Irie, H.Ohigashi, H.Hara, M.Nagao, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Am.Chem.Soc. 127(43)
  
  Pages : 15168-15174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] New aggregation model of amyloid β by the systematic proline replacement.2005
- Author(s)
  K.Murakami, K.Irie, A.Morimoto, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  In Peptide Science 2004, Shimohigashi, Y.(Ed.), The Japanese Peptide Society, Fukuoka, Japan
  
  Pages : 179-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Journal Article] Analysis of the secondary structure of β-amyloid (Aβ42) fibrils by systematic proline replacement.2004
- Author(s)
  A.Morimoto, K.Irie, K.Murakami, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
- Journal Title
  
  J.Biol.Chem. 279(50)
  
  Pages : 52781-52788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380080
[Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018
- Author(s)
  坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
- Organizer
  2018年度日本農芸化学会大会（大会トピックス賞）（名城大学、名古屋市）
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Mitochondrial SOD in osteocytes plays a pivotal role in maintaining bone metabolism in mice.2017
- Author(s)
  Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri.
- Organizer
  Asian Society of Aging Research Symposium 2017
- Place of Presentation
  札幌グランドホテル（北海道札幌市）
- Year and Date
  2017-03-02
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017
- Author(s)
  泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Mitochondrial superoxide regulation in chondrocytes suppresses mechanical overloading-induced cartilage degeneration.2016
- Author(s)
  Masato Koike, Hidetoshi Nojiri, Haruka Kaneko, Daichi Morikawa, Keiji Kobayashi, Yoshitomo Saita, Kazuo Kaneko, Takahiko Shimizu.
- Organizer
  Orthopaedic Research Society (ORS) Annual Meeting 2016
- Place of Presentation
  Orlando (USA)
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.2016
- Author(s)
  Takahiko Shimizu, Masato Koike, Hidetoshi Nojiri.
- Organizer
  Cell symposia Aging & Metabolism
- Place of Presentation
  Melia Stiges（スペイン）
- Year and Date
  2016-07-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Apple polyphenols protect cartilage degeneration through modulating mitochondrial function in mice.2016
- Author(s)
  Isao Masuda, Masato Koike, Yusuke Ozawa, Kenji Watanabe, Shohei Nakashima, Hiroshi Sugiyama, Tomomasa Kanda Hidetoshi Nojiri, Takahiko Shimizu.
- Organizer
  2016 World Congress of Osteoarthritis Research Society International
- Place of Presentation
  Amsterdam（オランダ）
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016
- Author(s)
  Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
- Place of Presentation
  Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割2016
- Author(s)
  村上一馬、清水孝彦、入江一浩
- Organizer
  第11回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  お茶の水女子大学（東京都文京区）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016
- Author(s)
  村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016
- Author(s)
  泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Identification of the “Toxic Conformer” of Amyloid β and its Pathogenic Contribution of Alzheimer’s Disease.2016
- Author(s)
  Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
- Organizer
  The Japan-Korea Joint Aging Symposium
- Place of Presentation
  Daegu（韓国）
- Year and Date
  2016-06-15
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Pathological significance of telomere in a model mouse for Werner syndrome.2016
- Author(s)
  Shuichi Shibuya, Koutaro Yokote, Takahiko Shimizu.
- Organizer
  RecQ helicase symposium 2016
- Place of Presentation
  Seattle（米国）
- Year and Date
  2016-05-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016
- Author(s)
  泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  伊勢原市民文化会館（神奈川県伊勢原市）
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016
- Author(s)
  Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
- Organizer
  2016 Spring International Conference of the Korean Society for Gerontology
- Place of Presentation
  Convention Hall (Daegu, Korea)
- Year and Date
  2016-06-16
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015
- Author(s)
  泉尾直孝、久米利明、村上一馬、入江一浩、泉安彦、赤池昭紀、横手幸太郎、清水孝彦
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
- Organizer
  日本基礎老化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Mn-SOD loss in osteocytes causes age-related bone loss associated with impairment of bone remodeling.2015
- Author(s)
  Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri
- Organizer
  The 10th IAGG (International Association of Gerontology and Geriatrics) Asia/Oceania 2015 Congress
- Place of Presentation
  Chiang Mai (Thailand)
- Year and Date
  2015-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Contribution of mitochondrial superoxide and SOD2 imbalance to the locomotive syndrome.2015
- Author(s)
  Hidetoshi Nojiri, Daichi Morikawa, Keiji Kobayashi, Masato Koike, Yoshitomo Saita, Kazuo Kaneko, Takahiko Shimizu
- Organizer
  The 2nd International Academy of Sportology
- Place of Presentation
  順天堂大学（東京都文京区）
- Year and Date
  2015-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015
- Author(s)
  Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Hilton Hawaiian Villege (Honolulu, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015
- Author(s)
  村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015
- Author(s)
  泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26221202
[Presentation] SOD2 loss in osteocytes perturbs canalicular networks associated with impairment of bone remodeling in age-related osteoporosis.2015
- Author(s)
  Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri, Koutaro Yokote
- Organizer
  Biology of Ageing Conference
- Place of Presentation
  Singapore
- Year and Date
  2015-10-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeroid syndrome2013
- Author(s)
  Shimizu, T., Koyama, H., Shibuya, S., Shimamoto, A., Takemoto, M., Yokote, K.
- Organizer
  The 20^<th> IAGG World Congress of Gerontology and Geriatrics (IAGG 2013)
- Place of Presentation
  Seoul Korea
- Data Source
  KAKENHI-PROJECT-24659346
[Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013
- Author(s)
  Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, USA
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Osteocyte Specific Deletion of Superoxide Dismutase2 Induces Osteocyte Loss Resulting in Bone Loss Associated with Impairment of Bone Remodeling2013
- Author(s)
  Keiji Kobayashi, Hidetoshi Nojiri, Yoshitomo Saita, Daichi Morikawa, Masato Koike, Yusuke Ozawa, Yoshinori Asou, Kazuo Kaneko, Takahiko Shimizu,
- Organizer
  2013 ASBMR Annual Meeting Abstracts
- Place of Presentation
  Baltimore, USA
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 骨細胞特異的Sod2欠損マウスにおける骨リモデリング制御機構の解析2013
- Author(s)
  小林慶司, 野尻英俊, 齋田良知, 森川大智, 小池正人, 麻生義則, 金子和夫, 清水孝彦
- Organizer
  日本骨代謝学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 骨細胞における抗酸化酵素Sod2の骨リモデリング制御機構2013
- Author(s)
  小林慶司, 野尻英俊, 齋田良知, 森川大智, 小池正人, 麻生義則, 金子和夫, 清水孝彦
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 細胞質活性酸素とSOD1は機械的刺激応答に伴う骨量変化を制御する2013
- Author(s)
  清水孝彦, 森川大智, 野尻英俊, 斎田良知, 渡辺憲史, 麻生義則, 金子和夫
- Organizer
  日本基礎老化学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない2012
- Author(s)
  清水孝彦
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない2012
- Author(s)
  清水孝彦
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] メカニカルストレス応答における酸化ストレスと抗酸化酵素の解析2012
- Author(s)
  森川大智, 野尻英俊, 齋田良知, 小林慶司, 渡辺憲史, 麻生義則, 金子和夫, 清水孝彦
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  新宿
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 細胞質酸化ストレスは低代謝型骨量減少を引き起こす2012
- Author(s)
  森川大智, 野尻英俊, 斎田良知, 津田千鶴, 斎藤充, 宮崎剛, 金子和夫, 清水孝彦
- Organizer
  日本生化学会大会・日本分子生物学会年会合同大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] スーパーオキサイドディスムターゼ1(SOD1)欠損は低代謝回転型骨量減少と加齢性コラーゲン架橋変化を引き起こし骨脆弱化する2012
- Author(s)
  野尻英俊, 斎田良知, 森川大智, 小林慶司, 宮崎剛, 斎藤充, 丸毛啓史, 金子和夫, 清水孝彦
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  新宿
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012
- Author(s)
  Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
- Organizer
  Alzheimer's Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver, British Columbia, Canada
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Mn-SOD欠損細胞及びマウスに対するMnポルフィリンダイマー含有リポソームの抗酸化活性評価2012
- Author(s)
  米田祥浩, 山口翔平,清水孝彦, 朝山章一郎, 川上浩良
- Organizer
  第61回高分子学会年次大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-22300166
[Presentation] コエンザイムQの新たな機能：生体リズムと寿命の調節.2012
- Author(s)
  2. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
- Organizer
  第35回日本分子生物学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] コエンザイムQ10はclk-1変異線虫の寿命延長と行動リズム遅延及びclk-1欠損マウスの生体リズム遅延を完全レスキューする.2012
- Author(s)
  1. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
- Organizer
  第35回日本基礎老化学会大会
- Place of Presentation
  東邦大学
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] Silymarin attenuated the amyloid βdeposition and behavioral abnormalities in a mouse model of Alzheimer's disease2011
- Author(s)
  Takahiko Shimizu
- Organizer
  41st Annual Meeting of Society for Neuroscience
- Place of Presentation
  Convention Center (Washington, USA)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Mnポルフィリンダイマーを用いたSOD欠損細胞に対する抗酸化評価2011
- Author(s)
  窪田陸,田端久志, 清水孝彦(都健康長寿医療センター研),朝山章一郎,川上浩良
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県立大学・静岡県コンベンションアーツセンター・ツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-22300166
[Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010
- Author(s)
  村上一馬, 堀越(櫻庭)優子, 村田央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
- Organizer
  2010年度日本農芸化学会大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Meet the Expert 1講演名:酸化ストレスと骨代謝-SOD欠損マウスを用いた解析-2010
- Author(s)
  清水孝彦
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  東京
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-21791416
[Presentation] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2010
- Author(s)
  Shirasawa T., Kawakami S., Shimizu T.
- Organizer
  Gordon Research Conferences
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-20390085
[Presentation] 細胞内SOD欠損による運動器障害の解析2010
- Author(s)
  清水孝彦、白澤卓二
- Organizer
  第33回日本分子生物学会年会・第83 回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 筋細胞におけるミトコンドリア内酸化ストレスは呼吸鎖を障害し著しい運動能力の低下をきたす2010
- Author(s)
  野尻英俊、桑原宏朋、森川大智、斎田良知、金子和夫、清水孝彦
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2010
- Author(s)
  Shirasawa, T., Kawakami, S., Shimizu, T.
- Organizer
  Gordon Research Conferences
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 細胞質酸化ストレスは低代謝型骨減少症を引き起こす2010
- Author(s)
  森川大智、野尻英俊、斎田良知、津田千鶴、斎藤充、宮崎剛、金子和夫、清水孝彦
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Intracellular superoxide dismutase deficiency decreased bone mass in vivo by impairment of cell viability and redox balance in osteoblasts.2010
- Author(s)
  Saita, Y.Nojiri, H.Tsuda, C.Miyazaki, T.Morikawa, D., Kaneko, K.Shimizu, T.
- Organizer
  The 32th Annual Meeting, The American Society for Bone and Mineral Research (ASBMR), Tronto
- Place of Presentation
  Canada
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Mn-SOD コンディショナルノックアウトマウスを用いた抗老化研究2009
- Author(s)
  清水孝彦、白澤卓二
- Organizer
  第123回日本薬学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] ミ活性酸素と臓器老化-SOD欠損マウスを用いた解析-2009
- Author(s)
  清水孝彦、白澤卓二
- Organizer
  第9回日本抗加齢医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Copper/zinc superoxide dismutase deficiency causes low turnover osteopenia via osteoblastic dysfunction.2009
- Author(s)
  Nojiri, H.Saita, Y.Tsuda, C.Morikawa, D., Kurosawa, H.Shimizu, T.
- Organizer
  The 31th Annual Meeting, The American Society for Bone and Mineral Research (ASBMR)
- Place of Presentation
  Denver, Colorado
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 骨格筋特異的Mn-SOD欠損マウスの酸化ストレスによる運動能不全の解析2009
- Author(s)
  堀江哲郎、津田千鶴、石川慎、野田義博、桑原宏朋、川上哲、小澤裕介、白澤卓二、清水孝彦
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 臓器特異的にMn-SODをノックアウトしたマウス・心筋組織のミトコンドリアの形態2009
- Author(s)
  立花利公、野尻英俊、清水孝彦、岡部正隆、白澤卓二
- Organizer
  日本顕微鏡学会第65回学術講演会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2009
- Author(s)
  Shimizu, T.Horie, T.Kuwahara, H.Ishikawa, S.Tsuda, C.Kaneko, T.Tahara, S.Nojiri, N.Shirasawa, T.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Copper/zinc superoxide dismutase deficiency causes low turnover osteopenia.2009
- Author(s)
  Tsuda, C.Nojiri, H.Saita, Y.Miyazaki, T.Ozawa, Y.Morikawa, D.Shimizu, T.
- Organizer
  第32回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 骨格筋特異的Mn-SOD欠損マウスを用いた筋機能と活性酸素過剰解析2008
- Author(s)
  堀江哲郎、津田千鶴、石川慎、野田義博、桑原宏朋、川上哲、小澤裕介、吉田朋恵、白澤卓二、清水孝彦
- Organizer
  第8回日本抗加齢医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] ミトコンドリアフリーラジカルと臓器障害2008
- Author(s)
  清水孝彦、白澤卓二
- Organizer
  第8回日本抗加齢医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] Analysis of heart/muscle-specific Mn-SOD-deficient mice.The Japan-Korea Joint Seminar : Toward the Establishment of Asian Aging Research and Education Center2008
- Author(s)
  Shimizu, T.
- Organizer
  Nagasaki
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 抗酸化剤投与によるMn-SOD欠損に起因する拡張型心筋症の予防と治療2008
- Author(s)
  川上哲、松田瑛奈、金子孝夫、田原正一、砂川忠広、白澤卓二、清水孝彦
- Organizer
  日本基礎老化学会第31回大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 骨格筋の運動機能におけるMn-SODの役割2008
- Author(s)
  清水孝彦、堀江哲郎、桑原宏朋、津田千鶴、石川慎、野田義博、川上哲、白澤卓二
- Organizer
  日本基礎老化学会第31回大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] CuZn-SOD欠損マウスは加齢性皮膚炎を発症する2008
- Author(s)
  稲垣潤、池田泰隆、川上哲、白澤卓二、清水孝彦
- Organizer
  第8回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] 抗酸化剤投与によるmitochondrial cardiomyopathyの予防と治療2008
- Author(s)
  川上哲、松田瑛奈、金子孝夫、田原正一、白澤卓二、清水孝彦
- Organizer
  第8回日本抗加齢医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20500641
[Presentation] アミロイドβペプチドのターン構造形成とアスパラギン酸残基修飾2007
- Author(s)
  清水孝彦
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18208011
[Presentation] SOD1の減少はアルツハイマー病様病態を早期に発症させる
- Author(s)
  清水孝彦
- Organizer
  第12回日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22603006
[Presentation] Mitochondrial superoxide in chondrocytes regulates age-related osteoarthritis.
- Author(s)
  Takahiko Shimizu
- Organizer
  The 4th International Symposium of Asian Association of Aging Research (AAAR) 2014
- Place of Presentation
  Beijing (China)
- Year and Date
  2014-11-07 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] SOD2 deficiency in chondrocytes accelerates age-related osteoarthritis in mice
- Author(s)
  M. Koike, H. Nojiri, Y. Ozawa, K. Watanabe, I. Masuda, Y. Muramatsu, H. Kaneko, D. Morikawa, K. Kobayashi, Y. Saita, T. Sasho, T. Shirasawa, K. Yokote, K. Kaneko, T. Shimizu
- Organizer
  Osteoarthritis and Cartilage 2014 World Congress
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 骨細胞における酸化ストレスは骨リモデリングバランスの破綻をもたらす
- Author(s)
  小林慶司, 野尻英俊, 齋田良知, 森川大智, 小池正人, 小澤裕介, 麻生義則, 金子和夫, 清水孝彦
- Organizer
  日本整形外科学会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2014-05-22 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-24791568
[Presentation] 細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する
- Author(s)
  清水　孝彦
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] Superoxide dismutase 2 deficiency in osteocytes causes age-related bone loss associated with impairment of bone remodeling.
- Author(s)
  Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri.
- Organizer
  The Japan-Korea Joint Symposium 2014
- Place of Presentation
  Jeju (Korea)
- Year and Date
  2014-06-20 – 2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-26462283
[Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeric syndrome.
- Author(s)
  Takahiko Shimizu, Hirofumi Koyama, Shuichi Shibuya, Akira Shimamoto, Minoru Takemoto, Koutaro Yokote.
- Organizer
  The 20th IAGG World Congress of Gerontology and Geriatrics
- Place of Presentation
  COEX(韓国、ソウル)
- Data Source
  KAKENHI-PROJECT-24659346
[Presentation] SOD1 insufficiency exacerbates Alzheimer’s-like phenotypes in mice
- Author(s)
  Shimizu, T. et al.
- Organizer
  The 20th IAGG World Congress of Gerontology and Geriatrics
- Place of Presentation
  Coex (Seoul, Korea)
- Data Source
  KAKENHI-PROJECT-21248015
[Presentation] 早老症の病態と幹細胞
- Author(s)
  横手幸太郎、清水孝彦、竹本稔
- Organizer
  第13回日本抗加齢医学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Invited
- Data Source
  KAKENHI-PROJECT-24659346

1. IRIE Kazuhiro (00168535)

# of Collaborated Projects : 6results

# of Collaborated Products : 43results
2. SHIRASAWA Takuji (80226323)

# of Collaborated Projects : 4results

# of Collaborated Products : 9results
3. TAKEGOSHI Kiyonori (10206964)

# of Collaborated Projects : 3results

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4. MURAKAMI Kazuma (80571281)

# of Collaborated Projects : 3results

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5. NOJIRI Hidetoshi (10317456)

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6. YOKOTE Koutaro (20312944)

# of Collaborated Projects : 3results

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7. SAITA Yoshitomo (00534885)

# of Collaborated Projects : 2results

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8. TOMITA Kengo (50317129)

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9. TAKAHASHI Mayumi (50133632)

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10. 竹本稔 (60447307)

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11. KAWAKAMI Hiroyoshi (10221897)

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12. ASAYAMA Shoichiro (90315755)

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13. USUI MICHIHIKO (10453630)

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14. YAMAGUCHI Hiroo (00701830)

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15. KIRA Jun-ichi (40183305)

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16. OGAWARA Midori (60100111)

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17. MORIIZUMI Eiko (20322711)

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18. 久米利明 (10303843)

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19. 徳田隆彦 (80242692)

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20. 喜田昭子 (70273430)

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21. 前澤善朗 (80436443)

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22. Iwasaki Shinichi

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23. SHIMIZU Eiji

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# of Collaborated Products : 1results
24. NAKAZATO Michiko

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# of Collaborated Products : 1results
25. MATSUZAWA Daisuke

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# of Collaborated Products : 1results
26. SHIMIZU Naomi

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27. NAKASEKO Chiaki

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# of Collaborated Products : 2results
28. OHWADA Chikako

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# of Collaborated Products : 2results
29. BUJO Hideaki

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# of Collaborated Products : 2results
30. TAKEUCHI Masahiro

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# of Collaborated Products : 2results
31. JIANG Meizi

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# of Collaborated Products : 2results
32. 麻生義則

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33. 村山繁雄

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34. 藤本千里

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35. 山岨達也

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36. 木下淳

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37. 川戸佳

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38. 棟朝亜理紗

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39. 平野好幸

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40. 前田豊樹

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41. 堺田恵美子

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42. 東守洋

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43. 田丸淳一

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44. 建部陽嗣

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45. 赤池昭紀

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46. 泉安彦

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SHIMIZU Takahiko 清水 孝彦

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早老遺伝子の多角的解析に基づく老化と疾患の分子病態解明Ongoing

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Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid betaOngoing

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Oxidative stress in bone regulates skeletal homeostasis in micePrincipal Investigator

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Oxidative stress in skeletal muscle causes severe disturbance of exercise activityPrincipal Investigator

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SHIMIZU Takahiko 清水孝彦