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KOMAI KOICHIRO  駒井 浩一郎

… Alternative Names

Komai Koichiro  駒井 浩一郎

KOMAI Koichiro  駒井 浩一郎

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Researcher Number 40304117
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0015-5283
External Links
Affiliation (Current) 2025: 神戸大学, 保健学研究科, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 神戸大学, 保健学研究科, 准教授
2016 – 2018: 神戸大学, 保健学研究科, 准教授
2000 – 2005: 神戸大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Laboratory medicine / 膠原病・アレルギー・感染症内科学 / 内科学一般
Except Principal Investigator
Biological Sciences / 膠原病・アレルギー・感染症内科学
Keywords
Principal Investigator
スプライスバリアント / 自己炎症性疾患 / インフラマソーム / Db1プロトオンコジーン / 疾患遺伝子 / Dblプロトオンコジーン / 新型コロナウイルス感染症 / ASC / 炎症性疾患 / 回帰性リウマチ … More / PYCARD/ASC / 生活習慣病 / 認知症 / 自己炎症症候群 / IL-1 / スプライシング / 自然免疫 / ASC/PYCARD / 関節リウマチ / 慢性関節リウマチ (RA) / 関節リウマチ(RA) … More
Except Principal Investigator
Dbl / disease gene / 関節リウマチ / DR3 / 疾患遺伝子 / 慢性関節リウマチ / Rheumatoid arthritis / 遺伝子除去マウス / death receptor 3 (DR3) / rheumatoid arthritis (RA) / 遺伝解析 / Ang-1 / 関節破壊 / DR3,death receptor 3 / genetic predisposition / 遺伝素因 / rheumatoid arthritis / 内科 / テクノバイオロジー / 免疫学 / 遺伝子 / 遺伝学 / 関節リウマチ rheumatoid arthritis(RA) / death receptor 3(DR3) / アポトーシス apoptosis Less
  • Research Projects

    (7 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (7 People)
  •  Common Pathogenesis Mechanisms of Autoinflammatory Diseases by Inflammasome Adaptor ASC AnalysisPrincipal Investigator

    • Principal Investigator
      Komai Koichiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kobe University
  •  The development of a novel general-purpose biomarker for autoinflammatory syndromesPrincipal Investigator

    • Principal Investigator
      KOMAI Koichiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kobe University
  •  関節リウマチ疾患遺伝子Dblプロトオンコジーンによる分子病態メカニズム解明Principal Investigator

    • Principal Investigator
      駒井 浩一郎
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kobe University
  •  Research of rheumatoid arthritis using Dbl knock-out mice

    • Principal Investigator
      HASHIRAMOTO Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kobe University
  •  慢性関節リウマチ疾患遺伝子の同定及び病態発症メカニズム解明Principal Investigator

    • Principal Investigator
      駒井 浩一郎
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      内科学一般
    • Research Institution
      Kobe University
  •  慢性関節リウマチの多因子遺伝に関わる疾患遺伝子の同定

    • Principal Investigator
      SHIOZAWA Shunichi
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University
  •  Studies on the causative disease gene in autoimmunity and rheumatoid arthritis

    • Principal Investigator
      SHIOZAWA Shunichi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University

All 2023 2022 2021 2018 2017 2005 2004 2003 2002 2001 2000 Other

All Journal Article Presentation

  • [Journal Article] Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion2022

    • Author(s)
      Yumi Suganuma , Hayate Tanaka , Aya Kawase , Aoi Kishida , Moeko Yamaguchi , Atsuko Yabuuchi , Koji Inoue , Shunichi Shiozawa, Koichiro Komai
    • Journal Title

      Asian Pacific Journal of Allergy and Immunology

      Volume: 40(1) Pages: 81-86

    • DOI

      10.12932/ap-040319-0509

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Journal Article] Expression of ASC splice variant found in Japanese patients with palindromic rheumatism is regulated by rs8056505 single nucleotide polymorphism and interleukin-1 beta2022

    • Author(s)
      Masaya Hattori, Atsuko Yabuuchi, Hayate Tanaka, Taketo Kawara, Hongyan Wang, Koji Inoue, Shunichi Shiozawa, and Koichiro Komai
    • Journal Title

      Asian Pacific Journal of Allergy and Immunology

      Volume: -

    • DOI

      10.12932/ap-010322-1339

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Journal Article] Whole genome association study of rheumatoid arthritis using 27039 microsatellites.2005

    • Author(s)
      Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Yoshikawa Y, Fujimoto K, Oka A, Chiku S, Linsen SEV, Giphart MJ, Hoshina Y, Suzuki Y, Hotta T, Mochida J, Minezaki, Komai K, Shiozawa S, et al.
    • Journal Title

      Human Mol Genet 14

      Pages: 2305-2321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Identification of New Effector Proteins of Cdc42 That Was Specifically Down-Regulated by Exon-Skipped Phenotype of Db1 Proto-Oncogene with Genetic Association with Rheumatoid Arthritis (RA)2004

    • Author(s)
      Koichiro Komai et al.
    • Journal Title

      Arthritis & Rheumatism 第50巻・9号

      Pages: 152-152

    • Data Source
      KAKENHI-PROJECT-16790553
  • [Journal Article] 分子遺伝学アプローチによる関節リウマチ(RA)遺伝素因探索2004

    • Author(s)
      駒井 浩一郎(共著)
    • Journal Title

      臨床免疫 第41巻・3号

      Pages: 291-296

    • Data Source
      KAKENHI-PROJECT-16790553
  • [Journal Article] 関節リウマチの遺伝素因探索2004

    • Author(s)
      駒井 浩一郎(共著)
    • Journal Title

      現代医療 第36巻・3号

      Pages: 651-655

    • Data Source
      KAKENHI-PROJECT-16790553
  • [Journal Article] Human wee 1 kinase is directly transactivated by and increased in association with c-Fos/AP-1 : Rheumatoid synovial cells overexpressing these genes go into aberrant mitosis.2003

    • Author(s)
      Kawasaki H, Komai K, Nakamura M, Yamamoto E, OuYang Z, Nakashima T, Hashiramoto A, Shiozawa K, Ishikawa H, Kurosaka M, Shiozawa S.
    • Journal Title

      Oncogene 22

      Pages: 6839-6844

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Characterization of novel alternative splicing variants of the mouse MCF-2 (DBL) proto-oncogene.2003

    • Author(s)
      Komai K
    • Journal Title

      Biochem Biophys Res Commun 309巻

      Pages: 906-909

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Characterization of novel alternative splicing variants of the mouse MCF-2 (DBL) proto-oncogene.2003

    • Author(s)
      Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S.
    • Journal Title

      Biochem Biophys Res Commun 309

      Pages: 906-909

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Metabolism of 26, 26, 26, 27, 27, 27-F6-1a, 25-dihydroxyvitamin D3 by CYP24 : Species-based difference between humans and rats.2003

    • Author(s)
      Sakaki T, Sawada N, Abe D, Komai K, Shiozawa S, Nonaka Y, Nakagawa K, Okano T, Ohta M, Inouye K.
    • Journal Title

      Biochem Pharmacol 65

      Pages: 1957-1965

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] p21 is down-regulated in conjunction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients.2003

    • Author(s)
      Hikasa M, Yamamoto E, Kawasaki H, Komai K, Shiozawa K, Hashiramoto A, Miura Y, Shiozawa S.
    • Journal Title

      Biochem Biophys Res Commun 304

      Pages: 143-147

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.2002

    • Author(s)
      Komai K
    • Journal Title

      Biochem Biophys Res Commun 299巻

      Pages: 455-458

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.2002

    • Author(s)
      Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S.
    • Journal Title

      Biochem Biophys Res Commun 299

      Pages: 455-458

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] c-Fos/ activator protein-1 transactivates wee 1 kinase at G1/S to inhibit premature mitosis in antigen-specific Th1 cell.2001

    • Author(s)
      Kawasaki H, Komai K, Ouyang Z, Murata M, Hikasa M, Ohgiri M, Shiozawa S.
    • Journal Title

      EMBO J 20(16)

      Pages: 4618-4627

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.2000

    • Author(s)
      Sakai T, Sawada N, Komai K, Shiozawa S, Yamada S, Yamamoto K, Ohyama Y, Inouye K.
    • Journal Title

      Eur J Biochem 267(20)

      Pages: 6158-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Journal Article] The promoter region of death receptor 3 (DR3) is specifically hypermethylated in rheumatoid synovial cells.

    • Author(s)
      Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, Sato K, Iguchi T, Shiozawa K, Hashiramoto A, Shiozawa S.
    • Journal Title

      Arthritis Rheum (in press.)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13204059
  • [Presentation] 抗菌ペプチドdermcidinはNLRP3 インフラマソームに結合し、IL-1β産生を抑制する2023

    • Author(s)
      片岡直紀、駒井浩一郎
    • Organizer
      第67回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] インフラマソーム構成因子ASCの選択的スプライシングを制御するIL-1β下流因子の解明2023

    • Author(s)
      有吉薫香、川良毅人、駒井浩一郎
    • Organizer
      第67回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] SARS-CoV由来ORF3aはexon2欠損型ASCスプライスバリアントと共役的にNLRP3インフラマソーム機能を活性化する2023

    • Author(s)
      竹松蒔絵、駒井浩一郎
    • Organizer
      第67回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] SARS-CoV由来ORF3aがASCバリアント依存性インフラマソーム機能に与える影響2022

    • Author(s)
      竹松蒔絵、片岡直紀、駒井浩一郎
    • Organizer
      第66回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] 回帰性リウマチ患者におけるCaspase-1遺伝子解析2022

    • Author(s)
      有吉薫香、川良毅人、井上康二、塩沢俊一、 駒井浩一郎
    • Organizer
      第66回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] インフラマソーム結合性新規タンパク質の同定2022

    • Author(s)
      小林奈々子、片岡直紀、王紅彦、服部将也、駒井浩一郎
    • Organizer
      第66回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] 日本人回帰性リウマチ患者に見出したASCバリアントのスプライシング変動機構2021

    • Author(s)
      服部将也、王紅彦、籔内温子、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第65回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07339
  • [Presentation] NLRC4インフラマソームにおけるexon2欠損型PYCARD/ASCの機能解析2018

    • Author(s)
      岸田あおい、菅沼佑美、籔内温子、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第62回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] 日本人回帰性リウマチ患者におけるPYCARD / ASCスプライスバリアント産生機序の解明2018

    • Author(s)
      籔内温子、岸田あおい、菅沼佑美、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第62回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] exon2 欠損型PYCARD/ASCはNLRP3インフラマソーム機能を亢進する2018

    • Author(s)
      菅沼佑美、岸田あおい、籔内温子、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第62回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] Exon2欠損型PYCARD/ASCバリアントのNLRC4インフラマソーム機能への関与2017

    • Author(s)
      岸田あおい、河瀬絢、菅沼佑美、田中颯、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第61回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] PYCARD/ASC スプライスバリアントのインフラマソームに与える機能変調およびバリアント産生機序の解明2017

    • Author(s)
      菅沼佑美、岸田あおい、籔内温子、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] Identification and functional analysis of a splice variant of inflammasome adaptor PYCARD/ASC in Japanese patients with palindromic rheumatism.2017

    • Author(s)
      Aoi Kishida, Yumi Suganuma, Aya Kawase, Hayate Tanaka, Atsuko Yabuuchi, Koji Inoue, Shunichi Shiozawa, Koichiro Komai
    • Organizer
      The 7th East Asian Group of Rheumatology Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08934
  • [Presentation] Exon2 欠損型PYCARD/ASC バリアント発現に伴うNLRP3インフラマソーム機能の解析2017

    • Author(s)
      菅沼佑美、河瀬絢、岸田あおい、田中颯、井上康二、塩沢俊一、駒井浩一郎
    • Organizer
      第61回日本リウマチ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08934
  • 1.  ISHIKAWA Hitoshi (30107958)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  SHIOZAWA Shunichi (40154166)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  MIURA Yasushi (60346244)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  HASHIRAMOTO Akira (80346246)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 5.  塚本 康夫 (30031149)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  村田 美紀 (70346245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  塩澤 俊一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results

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