Kasahara Koji 笠原浩司

… Alternative Names

笠原浩司カサハラコウジ

KASAHARA Koji 笠原浩司

KASAHARA Kouji 笠原浩司

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Researcher Number	40304159
Other IDs
Affiliation (Current)	2025: 東京農業大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京農業大学, 生命科学部, 教授 2020: 東京農業大学, 生命科学部, 准教授 2016 – 2017: 東京農業大学, 生命科学部, 准教授 2011 – 2015: 東京農業大学, 応用生物科学部, 准教授 2011: 横浜市立大学, 生命ナノシステム科学研究科, 客員研究員 … More 2010: 横浜市立大学, 生命ナノシステム科学研究科, 客員准教授 2009: Yokohama City University, 生命ナノシステム科学研究科, 助教 1998: Nara Institute of Science and Technology, Graduate School of Biological Sciences, バイオサイエンス研究科, 助手 Less
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 38060:Applied molecular and cellular biology-related Except Principal Investigator Molecular biology
Keywords	Principal Investigator 出芽酵母 / 転写 / リボソーム / リボソームタンパク質遺伝子 / 転写制御 / FKBP / HMGBタンパク質 / ヌクレオソーム / 酵母 / 真核生物 … More / TORC1 / ラパマイシン/FK506 / FKBP12 / カンジダグラブラータ / リボソームタンパク質 / エピジェネシス / 染色体構造 / ペプチジルプロリルイソメラーゼ / PPIase / リボソームRNA遺伝子 / 遺伝子発現 / RNAポリメラーゼ / PIC (転写開始前複合体) / リボソームRNA質遺伝子 / 転写・転写調節 / HMO1 / PIC(転写開始前複合体) / RNAポリメラーゼII / Hmo1 / PTC(転写開始前複合体) / RNAポリメラーゼTT … More Except Principal Investigator TAF / TFIID / 転写調節機構 / 転写 / 転写制御 / 基本転写因子 / 転写因子 / transcriptional regulation / activation / TAND / general transcription factor / transcription Less

真核生物のリボソーム合成制御の新規機構：ラパマイシン結合タンパク質の真の役割Principal Investigator
- Principal Investigator
  
  笠原浩司
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Tokyo University of Agriculture
真核生物のリボソーム合成制御の新規機構：ラパマイシン結合タンパク質の真の役割Principal Investigator
- Principal Investigator
  
  笠原浩司
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Tokyo University of Agriculture
A novel regulatory mechanism for transcription of ribosomal RNA in budding yeastPrincipal Investigator
- Principal Investigator
  
  Kasahara Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo University of Agriculture
Nobel regulatory mechanism for transcription of genes encoding ribosomal components in S. cerevisiaePrincipal Investigator
- Principal Investigator
  
  KASAHARA Koji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo University of Agriculture
Molecular mechanism of transcriptional regulation of ribosomal protein genes in budding yeastPrincipal Investigator
- Principal Investigator
  
  KASAHARA Koji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
酵母を用いた基本転写因子TFIIDサブユニット(TAFs)の機能解析
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology
Functional analysis of TAND (TAF N-terminal domain) that inhibits TBP : DNA interactions
- Principal Investigator
  
  KOKUBO Tetsuro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology

All 2023 2022 2021 2020 2016 2015 2013 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent2023
- Author(s)
  Iwami R, Takai N, Matsutani M, Shiwa Y, Kokubo H, Kasahara K, Kokubo T.
- Journal Title
  
  PLoS One
  
  Volume: 18 Issue: 2 Pages: e0281233-e0281233
- DOI
  10.1371/journal.pone.0281233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05965, KAKENHI-PROJECT-23K05642
[Journal Article] Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast2021
- Author(s)
  Koji Kasahara
- Journal Title
  
  Current Genetics
  
  Volume: － Issue: 3 Pages: 383-388
- DOI
  10.1007/s00294-020-01142-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05965
[Journal Article] Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.2020
- Author(s)
  Koji Kasahara, Risa Nakayama, Yuh Shiwa, Yu Kanesaki, Taichiro Ishige, Hirofumi Yoshikawa, Tetsuro Kokubo
- Journal Title
  
  PLoS Genetics
  
  Volume: 16(6) Issue: 6 Pages: e1008865-e1008865
- DOI
  10.1371/journal.pgen.1008865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05965, KAKENHI-PROJECT-18K06063
[Journal Article] Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo.2016
- Author(s)
  K. Kasahara, A. Higashino, S. Unzai, H. Yoshikawa, T. Kokubo
- Journal Title
  
  Genes Cells
  
  Volume: 21(12) Issue: 12 Pages: 1333-1352
- DOI
  10.1111/gtc.12449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06953, KAKENHI-PROJECT-15K06980, KAKENHI-PROJECT-26440009
[Journal Article] Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo.2015
- Author(s)
  A. Higashino, Y. Shiwa, H. Yoshikawa, T. Kokubo, K. Kasahara
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 79(3) Issue: 3 Pages: 384-393
- DOI
  10.1080/09168451.2014.978258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24657119, KAKENHI-PUBLICLY-25118520, KAKENHI-PROJECT-26440009
[Journal Article] A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 Promoter of Saccharomyces cerevisiae.2015
- Author(s)
  K. Watanabe, M. Yabe, K. Kasahara, T. Kokubo
- Journal Title
  
  PLoS One
  
  Volume: 10(6) Issue: 6 Pages: e0129357-e0129357
- DOI
  10.1371/journal.pone.0129357
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06953, KAKENHI-PROJECT-26440009
[Journal Article] A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 promoter of Saccharomyces cerevisiae2015
- Author(s)
  Kiyoshi Watanabe, Makoto Yabe, Koji Kasahara, and Tetsuro Kokubo
- Journal Title
  
  PLOS ONE
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440009
[Journal Article] Hmo1 directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region2011
- Author(s)
  Kasahara K., Ohyama Y., Kokubo T.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 39 Pages: 4136-4150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Hmo1 directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region2011
- Author(s)
  Kasahara K., Ohyama Y., and Kokubo T.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 39 Pages: 4136-4150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570215
[Journal Article] Hmo1 directs preinitiation complex assembly to an appropriate site on its target gene ptomoters by masking a nucleosome-free region.2011
- Author(s)
  Kasahara K., Ohyama Y., and Kokubo T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 39(10) Pages: 4136-4150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Hmo1 directs preinitiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region2011
- Author(s)
  Kasahara K., Ohyama Y., and Kokubo T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 39(10) Pages: 4136-4150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570215
[Journal Article] 出芽酵母におけるリボソームタンパク質遺伝子の新規転写開始制御機構2011
- Author(s)
  笠原浩司
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 736-742
- NAID
  10029575105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Novel regulatory mechanisms for transcriptional initiation of ribosomal protein genes in S. cerevisiae2011
- Author(s)
  Kasahara K.
- Journal Title
  
  Seikagaku
  
  Volume: 83(8) Pages: 736-42
- NAID
  10029575105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570215
[Journal Article] 出芽酵母におけるリボソームタンパク質遺伝子の新規転写開始制御機構(ミニレビュー)2011
- Author(s)
  笠原浩司
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 736-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for diffferent TFIID conformations at different promoters.2010
- Author(s)
  0htsuki K., Kasahara K., Shirahige K., Kokubo T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38(6) Pages: 1805-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Genome-wide localization analysis of a complete set of Tafs reveals a specificeffect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.2010
- Author(s)
  Ohtsuki K., Kasahara K., Shimhige K., Kokubo T.
- Journal Title
  
  Nucleic Acids Research 38(6)
  
  Pages: 1805-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA2010
- Author(s)
  Ohyama Y., Kasahara K., Kokubo T.
- Journal Title
  
  Genes to Cells 15(12)
  
  Volume: 15 Pages: 1169-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae2010
- Author(s)
  Sugihara F., Kasahara K., Kokubo T.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 39 Pages: 59-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Saccharomyces cerevisiae Ssdlp promotesCLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA2010
- Author(s)
  0hyama Y., Kasahara K., and Kokubo T.
- Journal Title
  
  Genes to Cells
  
  Volume: 15(12) Pages: 1169-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Journal Article] Saccharomyces Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation.2009
- Author(s)
  Takahashi H., Kasahara K., Kokubo T.
- Journal Title
  
  Genes to Cells
  
  Volume: 14(1) Pages: 53-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770189
[Presentation] 出芽酵母におけるリボソームタンパク質遺伝子の転写制御の解明2022
- Author(s)
  島村直希、笠原浩司
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K05965
[Presentation] 新規単離極限環境紅藻のMn耐性関連遺伝子の探索2016
- Author(s)
  小田しおり、重信直人、兼崎友、渡辺智、千葉櫻拓、笠原浩司、三角修己、吉川博文
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26440009
[Presentation] 蜂蜜酵母Zygosaccharomyces mellisの高糖度耐性遺伝子の探索2016
- Author(s)
  田村倫子、笠原浩司、桑村麻由里、阿久澤さゆり、村清司
- Organizer
  2015年度日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26440009
[Presentation] 新規単離極限環境紅藻のMn耐性関連遺伝子の探索2015
- Author(s)
  小田しおり、重信直人、兼崎友、渡辺智、千葉櫻拓、笠原浩司、三角修己、吉川博文
- Organizer
  2015年日本植物学会第79回大会
- Place of Presentation
  新潟
- Year and Date
  2015-09-06
- Data Source
  KAKENHI-PROJECT-26440009
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA結合機構2013
- Author(s)
  東野綺子, 雲財悟, 中山理紗, 土屋奈穂, 吉川博文, 古久保哲朗, 笠原浩司
- Organizer
  2013年日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23570215
[Presentation] ラッカセイ種皮ポリフェノールのBacillus cereusに対する抗菌作用の検証2013
- Author(s)
  小澤恵実, 田村倫子, 田中尚人, 矢口行雄, 笠原浩司, 村清司, 荒井綜一
- Organizer
  2013年日本農芸化学会年次大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23570215
[Presentation] 出芽酵母リボソームタンパク質遺伝子の新規転写制御機構2011
- Author(s)
  笠原浩司, 大山良文, 古久保哲朗
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21770189
[Presentation] 出芽酵母リボソームタンパク質遺伝子の新規転写制御機構2011
- Author(s)
  笠原浩司, 大山良文, 古久保哲朗
- Organizer
  2011年日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570215
[Presentation] 出芽酵母リボソームタンパク質遺伝子の新規転写制御機構2011
- Author(s)
  笠原浩司、大山良文、古久保哲朗
- Organizer
  日本分子生物学会年会（2011年度）
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23570215
[Presentation] Deletion of the N-terminal domain of TAF1(Taf1-TAND) exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast2009
- Author(s)
  0hyama Y., Kasahara K., Kokubo T.
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21770189
[Presentation] Deletion of the N-terminal domain of TAF1 (taf1-TAND) exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast2009
- Author(s)
  Ohyama Y., Kasahara K., Kokubo T.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21770189
[Presentation] リボソーム構成因子の発現調節に関わる酵母Hmo1タンパク質のDNA結合機構
- Author(s)
  笠原浩司
- Organizer
  第36会日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Data Source
  KAKENHI-PROJECT-23570215

1. KOKUBO Tetsuro (10271587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 志波優 (00647753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 三宅剛司 (00283937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kasahara Koji 笠原 浩司

笠原 浩司 カサハラ コウジ

KASAHARA Koji 笠原 浩司

KASAHARA Kouji 笠原 浩司

Research Projects

Research Products

Co-Researchers

真核生物のリボソーム合成制御の新規機構：ラパマイシン結合タンパク質の真の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

真核生物のリボソーム合成制御の新規機構：ラパマイシン結合タンパク質の真の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel regulatory mechanism for transcription of ribosomal RNA in budding yeastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nobel regulatory mechanism for transcription of genes encoding ribosomal components in S. cerevisiaePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of transcriptional regulation of ribosomal protein genes in budding yeastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

酵母を用いた基本転写因子TFIIDサブユニット(TAFs)の機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Functional analysis of TAND (TAF N-terminal domain) that inhibits TBP : DNA interactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 Promoter of Saccharomyces cerevisiae.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 promoter of Saccharomyces cerevisiae2015

Author(s)

Kasahara Koji 笠原浩司

笠原浩司カサハラコウジ

KASAHARA Koji 笠原浩司

KASAHARA Kouji 笠原浩司