KAWAI Yasuyuki 河合康幸

… Alternative Names

河合康幸カワイヤスユキ

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Researcher Number	40324157
Other IDs
External Links
Affiliation (Current)	2025: 金沢医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 金沢医科大学, 医学部, 教授 2015 – 2018: 金沢医科大学, 医学部, 准教授 2010 – 2013: 金沢医科大学, 医学部, 准教授 2007 – 2009: 金沢医科大学, 医学部, 講師 2006: Kanazawa Medical University, Assistant, 医学部, 助手 2003 – 2005: 福井大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Legal medicine / Cardiovascular medicine / Laboratory medicine
Keywords	Principal Investigator アポトーシス / 酸化ストレス / DNase I / 急性心筋梗塞 / 左房リモデリング / 心房細動 / 左室リモデリング / 急性心不全 / 血漿遊離DNA / apoptosis … More / acute heart failure / cell-free DNA / 冠動脈疾患 / 食後高血糖 / 抗酸化作用 / 冠攣縮性狭心症 / 抗酸化ストレス / 内皮機能障害 / シスチン / グルタミン酸 / 冠攣縮 / 心不全 / リモデリング / 心筋梗塞 / 心筋症 / 冠れん縮性狭心症 / デオキシリボ核酸分解酵素I / ニトロチロシン / 一過性心筋虚血 / 冠れん縮 / 迅速診断 / 酵素 / 不安定狭心症 / 循環器内科 / 心臓病態学 … More Except Principal Investigator 診断マーカー / deoxyribonuclease I / 心筋虚血 / SNP / 心筋梗塞 / DNase I / 法医学 / 酸化ストレス / 不安定狭心症 / DNase family / 自己免疫疾患 / 内因性急死 / 多型 / 虚血 / 血清 / 急性心筋梗塞 / 遺伝的多型 / 疾患感受性遺伝子 / 転写因子 / NMDA-R / グルタミン酸受容体 / グルタミン酸 / 心房細動 / 臨床心臓学 / TAGE / TNFα / ニトロチロシン / Glycer-AGEs / 糖尿病性心筋症 / Deoxyribonuclease I / Biomarkers / Gene expression / Age-related alterations / Proteomics / Genomics / Age-estimation / Forensic Science / 活性酸素 / ペルオキシゾーム / deoxyribonuclease / ミトコンドリアDNA / 法医学的応用 / ペルオキシソーム / 一次構造 / 年齢依存性生体分子 / フィブロネクチン / バイオマーカー / 遺伝子発現 / 年齢依存性変動 / プロテオミクス / ゲノミクス / 年齢推定 / 遺伝子型―活性相関 / SLE / 遺伝的危険因子 / DNase 1L2 / DNase II / リスクファクター / 消化器がん / 低酸素応答 / 急性冠症候群 / 集団調査 / deoxyribonuclease II / deoxyribonuclease I-like 3 / 一過性心筋虚血 / 非ST上昇型急性心筋梗塞 / 遺伝子型-活性相関 / 冠攣縮性狭心症 / 心室リモデリング / 虚血性心疾患 / 集団遺伝学 / ELISA / プロモーター / DNase I遺伝子 / 鑑別診断 / KNaseI遺伝子 / 分子進化 / proteolysis / 経皮的冠動脈形成術 / 遺伝解析 / ケースコントロール解析 / 低酸素ストレス Less

Clinical applications of plasma cell-free DNA as a predictor of prognosis after acute heart failure and myocardial infarctionPrincipal Investigator
- Principal Investigator
  
  KAWAI Yasuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kanazawa Medical University
Relationship between the mechanism of atrial fibrillation and glutamic acid
- Principal Investigator
  
  TAKANO Shintaro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa Medical University
Glycer-AGEs is associated with the severity of cardiac function of diabetic cardiomyopathy
- Principal Investigator
  
  AOKI hirofumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa Medical University
Identification of a new risk factor related to oxidative stress of vasospastic angina pectorisPrincipal Investigator
- Principal Investigator
  
  KAWAI Yasuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa Medical University
A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseasesPrincipal Investigator
- Principal Investigator
  
  KAWAI Yasuyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kanazawa Medical University
Utilization of DNase I as a risk factor and/or useful diagnostic biomarker for myocardial infarction and gastroenterological cancer
- Principal Investigator
  
  YASUDA Toshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  University of Fukui
Serum DNase I activity can be a useful biomarker for the early diagnosis of transient myocardial ischemia
- Principal Investigator
  
  UEKI Misuzu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Fukui
Diagnosis of unstable angina pectoris by serum deoxyribonuclease I as a new diagnostic maker of myocardial ischemiaPrincipal Investigator
- Principal Investigator
  
  KAWAI Yasuyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kanazawa Medical University
Forensic study on serum DNase I used as a sensitive marker for diagnosis of acute myocardial infarction
- Principal Investigator
  
  YASUDA Toshihiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  University of Fukui
急性心筋梗塞の超急性期における血液生化学的診断マーカーの開発
- Principal Investigator
  
  YASUDA Toshihiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Fukui
血中DNase Iを利用した心筋梗塞死の鑑別診断法の開発
- Principal Investigator
  
  植木美鈴
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  University of Fukui
Forensic Age-Estimation Using Proteomics-and Genomics-Approaches
- Principal Investigator
  
  YASUDA Toshihiko
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Legal medicine
- Research Institution
  University of Fukui
  福井医科大学

All 2018 2017 2014 2013 2012 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products2017
- Author(s)
  Watanabe M. Kawai Y, Kitayama M, Akao H, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Tsuchiya T, Nakanishi H, Saito K, Takeuchi M, Kajinami K.
- Journal Title
  
  Journal of Cardiology
  
  Volume: 69 Issue: 6 Pages: 625-631
- DOI
  10.1016/j.dmpk.2016.09.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09105, KAKENHI-PROJECT-15K15009
[Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm2014
- Author(s)
  Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K
- Journal Title
  
  Journal of Cardiology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591067
[Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm.2014
- Author(s)
  Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K.
- Journal Title
  
  Journal of Cardiology
  
  Volume: 印刷中 Issue: 2 Pages: 86-90
- DOI
  10.1016/j.jjcc.2013.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591067, KAKENHI-PROJECT-25460661
[Journal Article] Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction2012
- Author(s)
  K. Fujibayashi, Y. Kawai, T. Yasuda ら
- Journal Title
  
  J. Cardiol
  
  Volume: 59 Pages: 258-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659367
[Journal Article] Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction2012
- Author(s)
  Fujibayashi K, Kawai Y, Yasuda T, et al
- Journal Title
  
  Journal of Cardiology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590845
[Journal Article] Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction2012
- Author(s)
  K. Fujibayashi, Y. Kawai, M. Ueki
- Journal Title
  
  J. Cardiol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659146
[Journal Article] Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling2009
- Author(s)
  J. Kuribara, Y. Kawai, T. Yasuda.
- Journal Title
  
  J. Cardiol. 53
  
  Pages: 196-203
- NAID
  10025183040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390184
[Journal Article] Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischemia: results in vasospastic angina pectoris induced by provocation test2007
- Author(s)
  N. Morikawa, Y. Kawai, T. Yasuda.
- Journal Title
  
  Eur. Heart J 28
  
  Pages: 2992-2997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390184
[Journal Article] Association of Gln222Arg polymorphism in the deoxyribonuclease I (DNase I) gene with myocardial infarction in Japanese patients.2006
- Author(s)
  T.Kumamoto, Y.Kawai, K.Arakawa, N.Morikawa, H.Tada, K.Taniguchi, R.Tatami, I.Miyamori, Y.Kominato, K.Kishi, T.Yasuda
- Journal Title
  
  Eur. Heart J. 27(17)
  
  Pages: 2081-2087
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Spl in its transcriptional regulation.2006
- Author(s)
  Y.Kominato, M.Ueki, R.Iida, Y.Kawai, T.Nakajima, C.Makita, M.Itoi, Y.Tajima, K.Kishi, T.Yasuda
- Journal Title
  
  FEBS J. 273(13)
  
  Pages: 3094-3105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Molecular multiplicity of human DNase I and cardiovascular diseases.2006
- Author(s)
  T.Yasuda, M.Ueki, R.Iida, Y.Kawai, Y.Kominato, T.Nakajima, K.Kishi
- Journal Title
  
  DNA Polymorphism 14
  
  Pages: 11-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Novel VNTR polymorphism in human deoxyribonuclease I gene.2005
- Author(s)
  T.Yasuda, M.Ueki, R.Iida, Y.Kawai, T.Nakajima, Y.Kominato, K.Kishi
- Journal Title
  
  DNA Polymorphism 13
  
  Pages: 38-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Clinical applications of DNase I, a genetic marker already used for forensic identification.2005
- Author(s)
  T.Yasuda, Y.Kawai, M.Ueki, K.Kishi
- Journal Title
  
  Legal Med. 7(4)
  
  Pages: 274-277
- NAID
  10027261513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Serum deoxyribonuclease I activity can be use as a sensitive marker for detection of transient myocardial ischemia induced by percutaneous coronary intervention.2005
- Author(s)
  K.Arakawa, K.Kawai, T.Kumamoto, N.Morikawa, M.Yoshida, H.Tada, R.Kawaguchi, K.Taniguchi, I.Miyamori, Y.Kominato, K.Kishi, T.Yasuda
- Journal Title
  
  Eur. Heart J. 26(22)
  
  Pages: 2375-2380
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction2004
- Author(s)
  Y.Kawai
- Journal Title
  
  Circulation 109・2
  
  Pages: 2398-2400
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] The diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction2004
- Author(s)
  Yasuyuki Kawai
- Journal Title
  
  Circulation 109・20
  
  Pages: 2398-2400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] Aurvey on association of SNP in human DNase I gene with diseases.2004
- Author(s)
  T.Yasuda, M.Ueki, R.Iida, Y.Kawai, H.Takeshita, Y.Kaneko, T.Nakajima, K.Kishi
- Journal Title
  
  DNA Polymorphism 12
  
  Pages: 276-279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] The diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction.2004
- Author(s)
  Y.Kawai, M.Yoshida, K.Arakawa, T.Kumamoto, N.Morikawa N.Tanaka, K.Masamura, H.Tada, S.Ito, H.Hoshizaki, S.Oshima, K.Taniguchi, H.Terasawa, I.Miyamori, K.Kishi, T.Yasuda
- Journal Title
  
  Circulation 109(20)
  
  Pages: 2398-2400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Journal Article] An abrupt elevation of the serum deoxyribonuclease I (DNase I ) activity in acute myocardial infarction.2003
- Author(s)
  M.Yoshida, Y.Kawai, K.Masamura, M.Katoh, N.Tanaka, M.Saga, I.Miyamori, T.Yasuda, H.Tada, S.Ito, H.Hoshizaki, S.Oshima, K.Taniguchi
- Journal Title
  
  Circulation J. 67(Suppl. 1)
  
  Pages: 300-300
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209023
[Presentation] Glutamic acid as a risk factor of vasospasm in non-smoker2018
- Author(s)
  Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Yasuyuki Kawai, Kouji Kajinami
- Organizer
  The 82th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-15K09105
[Presentation] Glycer-AGEs is associated with the severity of cardiac function of diabetic cardiomyopathy2017
- Author(s)
  Yuushi Yasuda, Wataru Fujita, Kousuke Fujibayashi, Minoru Wakasa, Yasuyuki Kawai, Katuaki Sato, Masayoshi Takeuchi, Hiroaki Nakanishi, Koji Kajinami
- Organizer
  ESC congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09105
[Presentation] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm2013
- Author(s)
  Tanabe K. Kawai Y. Kitayama M, Akao H, Ishida R, Motoyama A, Watanabe M, Kojima K, Kajinami K.
- Organizer
  The 73^<rd> annual scientific meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23591067
[Presentation] Doxyribonuclease I as a useful diagnostic marker of unstable angina or non-ST-segment elevation myocardial infarction2009
- Author(s)
  Kawai Y, et al
- Organizer
  The 73^<rd> annual scientific meeting of the Japanese Circulation Society
- Place of Presentation
  Osaka
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-20590845
[Presentation] Deoxyribonuclease I as a useful diagnostic marker of unstable angina or non-ST-segment elevation myocardial infarction2009
- Author(s)
  Y. Kawai, M. Kitayama, T. Yasuda.
- Organizer
  第73回日本循環器学会総会
- Place of Presentation
  大阪
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19390184
[Presentation] デオキシリボ核酸分解酵素I (DNase I) の臨床応用2009
- Author(s)
  河合康幸
- Organizer
  法医臨床社会医学セミナー
- Place of Presentation
  出雲市
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-19390184
[Presentation] Deoxyribonuclease I as a useful diagnostic marker of un-stable angina or non-ST-segment elevation myocardial i-nfarction.2009
- Author(s)
  Kawai Y, et al.
- Organizer
  The 73^<rd> Annual Scientific Meeting of the Japanese Circulation Socity
- Place of Presentation
  Osaka
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-20590845
[Presentation] Deoxyribonuclease I as a useful diagnostic marker of unstable angina or non-ST-segment elevation myocardial infarction2009
- Author(s)
  河合康幸
- Organizer
  第73回日本循環器学会総会
- Place of Presentation
  大阪市
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19390184
[Presentation] 一過性心筋虚血マーカーとしての血清DNase I:冠攣縮誘発試験の検討2008
- Author(s)
  安田年博、飯田礼子、河合康幸
- Organizer
  第92次日本法医学会総会
- Place of Presentation
  長崎
- Year and Date
  2008-04-24
- Data Source
  KAKENHI-PROJECT-19390184
[Presentation] Serum DNase I activity on arrival predicts TIM1 flow after coronary intervention in patients with acute myocardial infarction2008
- Author(s)
  嵯峨亮、河合康幸、安田年博
- Organizer
  第72回日本循環器学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19390184

1. YASUDA Toshihiro (80175645)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. IIDA Reiko (40139788)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
3. UEKI Misuzu (00165656)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
4. TAKESHITA Haruo (90292599)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. KOMINATO Yoshihiko (30205512)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
6. 藤林幸輔 (10633323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. 中西宏明 (90392274)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. 岸紘一郎 (30169841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. AOKI hirofumi (10639206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKANO Shintaro (80793421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤原純子 (20346381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 若狭稔 (50468980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKEUCHI masayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAWAI Yasuyuki 河合 康幸

河合 康幸 カワイ ヤスユキ

Research Projects

Research Products

Co-Researchers

Clinical applications of plasma cell-free DNA as a predictor of prognosis after acute heart failure and myocardial infarctionPrincipal Investigator

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Review Section

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Identification of a new risk factor related to oxidative stress of vasospastic angina pectorisPrincipal Investigator

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A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseasesPrincipal Investigator

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Diagnosis of unstable angina pectoris by serum deoxyribonuclease I as a new diagnostic maker of myocardial ischemiaPrincipal Investigator

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[Journal Article] Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm2014

Author(s)

Journal Title

Data Source

[Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm.2014

Author(s)

KAWAI Yasuyuki 河合康幸

河合康幸カワイヤスユキ