konaka hiroyuki 小中弘之

… Alternative Names

KONAKA Hiroyuki 小中弘之

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Researcher Number	40334768
Other IDs	https://orcid.org/0000-0002-6193-0274
Affiliation (Current)	2024: 金沢大学, 医学系, 協力研究員
Affiliation (based on the past Project Information) *help	2017 – 2019: 金沢大学, 医学系, 協力研究員 2016: 金沢大学, 附属病院, 講師 2013 – 2015: 金沢大学, 大学病院, 講師 2012 – 2013: 金沢大学, 附属病院, 講師 2011: 金沢大学, 大学病院, 講師 … More 2008 – 2010: Kanazawa University, 附属病院, 講師 2005 – 2007: Kanazawa University, Hospital, Lecturer, 医学部附属病院, 講師 2006: 金沢大学, 医学部付属病院, 講師 2004: 金沢大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Urology Except Principal Investigator Urology
Keywords	Principal Investigator NF-κB / 再燃メカニズム / クロストーク / 去勢抵抗性前立腺癌 / シグナル伝達 / LNCaP / PSA / シグナル伝達系 / AR / 転写活性 … More / ER / 遺伝子治療 / エストロゲン受容体 / 前立腺癌 / 免疫チェックポイント / 複合がん免疫療法 / 腫瘍免疫 / 免疫チェックポイント分子 / dominant negative / p65 / IκBa / androgen-dependent / androgen-independent / prostate cancer / 分子標的創薬 / 転写制御因子 / アンドロゲン非依存性前立腺癌 / 分子標的薬 / ドミナントネガティブ / デコイ / アンドロゲン / ホルモン不応性前立腺癌 / glucocorticoid receptor / androgen receptor / dexamethasone / promoter / gene therapy / 自殺遺伝子 / アデノウイルスベクター / グルココルチコイドレセプター / アンドロゲンレセプター / デキサメサゾン / プロモーター / UPR / 小胞体ストレス / ユビキチン-プロテアソーム系 / NF-kB / GR / グルココルチコイド受容体 / アンドロゲン受容体 / 核内受容体 / ERE / リガンド / エストロゲン / SCIDマウス … More Except Principal Investigator 前立腺癌 / 泌尿器癌 / 蛋白質 / 遺伝子 / 癌 / 泌尿器科癌 / 去勢抵抗性前立腺癌 / エクソソーム / DHEA / アンドロゲン受容体 / 2'-hydroxyflavanone / AR-V7 / 誘導体 / 2’-hydroxyflavanone / テロメアーゼ / 血管内浮遊癌細胞 / テロメラーゼ / 腎癌 / ドセタキセル耐性 / 植物フラボノイド / パクリタキセル耐性 / ノスカピン / docetaxel / flavonoids / prostate cancer / renal cell cancer / Noscapine / テストステロン / 酸性ホスファターゼ / トランスポゾン / アロマターゼ / 内因性レトロウイルス / 前立腺がん / LOH症候群 / 男性更年期障害 / 加齢男性性腺機能低下症候群 / アンチエイジング / セルフスクリーニング / バイオ診断チップ / イムノクロマトテストストリップ / ナノテクノロジー / PSA / マイクロビース / pro-PSA / Total-PSA / 金コロイド / テストストリップ / イムノチップ / イムノクロマトセンサー / スクリーニング Less

Depelopment of novel biokarker in metastasis of urological cancer using a novel circulating tumor cell detector system
- Principal Investigator
  
  KITAGAWA Yasuhide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Development of combined immune-oncology therapy targeting immune checkpoint for castration-resistant prostate cancerPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Establishment of a novel therapeutic strategy for castration-refractory prostate cancer targeting ubiquitin-proteasome systemPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Prevention of CRPC and application for docetaxel treatment using flavonoids
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Treatment strategy for circulating tumor cell using telomerase activity with epithelial-mesenchymal transition
- Principal Investigator
  
  KITAGAWA Yasuhide
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Effect of Noscapine and its derivative, EM101, on renal cell cancer and their mechanisms
- Principal Investigator
  
  MIYAGI Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
A novel treatment strategy for castration-refractory prostate cancer targeting cross-talk between NF-kB and an intranuclear steroid receptor superfamilyPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Comprehensive elucidation of estrogen receptor mediated signal pathways in hormone refractory prostate cancerPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
ゲノム病としての前立腺がん-内因性レトロウイルスとアンドロゲン調節領域-
- Principal Investigator
  
  高栄哲 (高榮哲)
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
ナノバイオテクノロジーを応用した中高年男性の健康度診断チップシステムの開発
- Principal Investigator
  
  並木幹夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Significance of NE-κB activation and therapeutic strategies for targeting its pathway in androgen-independent prostate cancerPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
泌尿器悪性腫瘍に対するバイオ診断チップを用いたセルフスクリーニングシステム
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Novel integrative gene therapy for hormone refractory prostate cancerPrincipal Investigator
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University

All 2013 2012 2011 2010 2008 2007 2006

All Journal Article Presentation

[Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone2013
- Author(s)
  Ofude M, Mizokami A, Kumaki M, Izumi K, Konaka H, Kadono Y, Kitagawa Y, Shin M, Zhang J, Keller ET, Namiki M
- Journal Title
  
  Anticancer Res
  
  Volume: 33(10) Pages: 61-4453
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/24123015
- Data Source
  KAKENHI-PROJECT-23592328
[Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone2013
- Author(s)
  M. Ofude, A. Mizokami, M. Kumaki, K. Izumi, H. Konaka, Y. Kadono, Y. Kitagawa, M. Shin, J. Zhang, E. T. Keller and M. Namiki
- Journal Title
  
  Anticancer Research
  
  Volume: 10 Pages: 4453-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462472
[Journal Article] Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrinβ12013
- Author(s)
  Shin M, Mizokami A, Kim J, Ofude M, Konaka H, Kadono Y, Kitagawa Y, Miwa S, Kumaki M, Keller ET, Namiki M
- Journal Title
  
  Prostate
  
  Volume: 73(11) Pages: 70-1159
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23532895
- Data Source
  KAKENHI-PROJECT-23592328
[Journal Article] Increases in bone turnover marker levels at an early phase after starting zoledronic acid predicts skeletal-related events in patients with prostate cancer with bone metastasis2012
- Author(s)
  Izumi K, Mizokami A, Itai S, Shima T, Shigehara K, Miwa S, Maeda Y, Konaka H, Koh E, Namiki M
- Journal Title
  
  BJU Int
  
  Volume: 109(3) Pages: 394-400
- NAID
  120003141900
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21599822
- Data Source
  KAKENHI-PROJECT-23592328
[Journal Article] Tri-Modality therapy with I-125 brachytherapy, external beam radiation therapy, and short- or long-term hormone therapy for high-risk localized prostate cancer (TRIP): study protocol for a phase III, multicenter, randomized, controlled trial2012
- Author(s)
  Konaka H, Egawa S, Saito S, Yorozu A, Takahashi H, Miyakoda K, Fukushima M, Dokiya T, Yamanaka H, Stone NN, Namiki M
- Journal Title
  
  BMC Cancer
  
  Volume: 12 Pages: 110-110
- NAID
  120006580768
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22439742
- Data Source
  KAKENHI-PROJECT-23592328
[Journal Article] What is appropriate neoadjuvant/adjuvant androgen deprivation for high-risk/locally advanced prostate cancer?2011
- Author(s)
  Namiki M, Konaka H. Asian J
- Journal Title
  
  Androl
  
  Volume: 13(4) Pages: 5-624
- NAID
  120003221538
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21642996
- Data Source
  KAKENHI-PROJECT-23592328
[Journal Article] Ethinylestradiol improves prostate-specific antigen levels in pretreated castration-resistant prostate cancer patients.2010
- Author(s)
  Izumi K, Kadono Y, Shima T, Konaka H, Mizokami A, Koh E, Namiki M.
- Journal Title
  
  Anticancer Res. 30
  
  Pages: 5201-5205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591852
[Journal Article] Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS : Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism.2008
- Author(s)
  Shibayama Y, Higashi T, Shimada K, Odani A, Mizokami A, Konaka H, Koh E, Namiki M.
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci (in press)
- NAID
  10028022490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659409
[Journal Article] Hormonal therapy2007
- Author(s)
  Namiki, M., Ueno, S., Kitagawa, Y., Konaka, H., Mizokami, A., Koh, E., Fukagai, T
- Journal Title
  
  Int J Olin Oncol 12(6)
  
  Pages: 427-32
- NAID
  10020114982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] Hormonal therapy.2007
- Author(s)
  Namiki M, Ueno S, Kitagawa Y, Konaka H, Mizokami A, Koh E, Fukagai T.
- Journal Title
  
  Int J Clin Oncol. 12
  
  Pages: 427-432
- NAID
  10020114982
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles.2007
- Author(s)
  Tamura K, Furihata M, Tsunoda T, Ashida S, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozaw K. Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 5117-5125
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles2007
- Author(s)
  Tamura, K., Furihata, M., Tsunoda, T., Ashida, S., Takata, R., Obara, W., Yoshioka, H., Daigo, Y., Nasu, Y., Kumon, H., Konaka, H., Namiki, M., Tozawa, K., Kohri, K., Tanji, N., Yokoyama, M., Shimazui, T., Akaza, H., Mizutani, Y., Mik,i T., Fujioka, T., Shuin, T., Nakamura, Y., Nakagawa, H
- Journal Title
  
  Cancer Res 67(11)
  
  Pages: 5117-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] Gold nanoparticle based immunochromatography using a resin modified micropipette tip for rapid and simple detection of human chorionic gonadotropin hormone and prostate-specific antigen.2006
- Author(s)
  Yuhi T, Nagatani N, Endo T, Kerman K, Takata M, Konaka H, Namiki M, Takamura Y, Tamiya E
- Journal Title
  
  Science and Technology of Advanced Materials 7
  
  Pages: 276-281
- Data Source
  KAKENHI-PROJECT-17659498
[Journal Article] Label-free bioelectronic immunoassay for the detection of human telomerase reverse transcriptase in urine.2006
- Author(s)
  Takata M, Kerman K, Nagatani N, Konaka H, Namiki M, Tamiya E
- Journal Title
  
  Journal of Electroanalytical Chemsitry 586
  
  Pages: 109-116
- Data Source
  KAKENHI-PROJECT-17659498
[Journal Article] Resin-based micropipette tip for immunochromatographic assays in urine Samples.2006
- Author(s)
  Yuhi T, Nagatani N, Endo T, Kerman K, Takata M, Konaka H, Namiki M, Takamura Y, Tamiya E
- Journal Title
  
  J Immunol Methods 312
  
  Pages: 54-60
- Data Source
  KAKENHI-PROJECT-17659498
[Presentation] Effect of adrenal androgens and HSD17B5 inhibitors on androgen receptor activity in prostate cancer microenvironment2011
- Author(s)
  熊木美紗子,溝上敦,金延任,島崇,大筆光夫,角野佳史,小中弘之,北川育秀,申珉京,並木幹夫
- Organizer
  第70回日本癌治療学会総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Data Source
  KAKENHI-PROJECT-23592328
[Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンと前立腺癌間質細胞の役割2010
- Author(s)
  溝上敦, 熊木美紗子, 島崇, 成本一隆, 小中弘之, 角野佳史, 北川育秀, 高栄哲, 並木幹夫
- Organizer
  第18回日本ステロイドホルモン学会
- Place of Presentation
  愛知県産業労働センター(愛知県)
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-20591852
[Presentation] 去勢抵抗性前立腺癌患者に対するエチニルエストラジオールの有効性2010
- Author(s)
  角野佳史, 泉浩二, 藤田博, 北川育秀, 小中弘之, 溝上敦, 高栄哲, 並木幹夫
- Organizer
  第26回前立腺シンポジウム
- Place of Presentation
  東京コンファレンスセンター(東京都)
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-20591852

1. MIZOKAMI Atsushi (50248580)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. KYO Satoru (50272969)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. KITAGAWA Yasuhide (00452102)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. NAMIKI Mikio (70155985)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. KADONO Yoshifumi (10397218)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. IZUMI Kouji (80646787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 民谷栄一 (60179893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. MIYAGI Toru (60467107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIGEHARA Kazuyoshi (20595459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高栄哲 (90283134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 江川雅之 (70313640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高倉正博 (20313661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

konaka hiroyuki 小中 弘之

KONAKA Hiroyuki 小中 弘之

Research Projects

Research Products

Co-Researchers

Depelopment of novel biokarker in metastasis of urological cancer using a novel circulating tumor cell detector system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of combined immune-oncology therapy targeting immune checkpoint for castration-resistant prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel therapeutic strategy for castration-refractory prostate cancer targeting ubiquitin-proteasome systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of CRPC and application for docetaxel treatment using flavonoids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment strategy for circulating tumor cell using telomerase activity with epithelial-mesenchymal transition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of Noscapine and its derivative, EM101, on renal cell cancer and their mechanisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel treatment strategy for castration-refractory prostate cancer targeting cross-talk between NF-kB and an intranuclear steroid receptor superfamilyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive elucidation of estrogen receptor mediated signal pathways in hormone refractory prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム病としての前立腺がん-内因性レトロウイルスとアンドロゲン調節領域-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ナノバイオテクノロジーを応用した中高年男性の健康度診断チップシステムの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of NE-κB activation and therapeutic strategies for targeting its pathway in androgen-independent prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

泌尿器悪性腫瘍に対するバイオ診断チップを用いたセルフスクリーニングシステム

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel integrative gene therapy for hormone refractory prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

konaka hiroyuki 小中弘之

KONAKA Hiroyuki 小中弘之