ISAKA Masanori 井坂雅徳

… Alternative Names

井坂雅徳イサカマサノリ

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Researcher Number	40336673
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 助教 2016 – 2018: 名古屋市立大学, 大学院医学研究科, 助教 2012 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教 2014: 名古屋市立大学, 大学院医学研究科, 助教 2008: 名古屋市立大学, 大学院医学研究科, 助教 … More 2007 – 2008: 名古屋市立大学, 大学院・医学研究科, 助教 2005 – 2006: 名古屋市立大学, 大学院医学研究科, 助手 2002 – 2004: 名古屋市立大学, 大学院・医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Bacteriology (including Mycology) / Bacteriology (including Mycology) Except Principal Investigator Bacteriology (including Mycology) / Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Infectious disease medicine / Bacteriology (including Mycology)
Keywords	Principal Investigator A群連鎖球菌 / 立体構造 / センサータンパク質 / バイオフィルム / 二成分制御因子 / アレルギー / 粘膜免疫 / 貪食能 / マクロファージ / インテグリン … More / CD162 / セレクチン / 免疫回避 / 糖鎖結合タンパク質 / 二成分制御 / 組換えタンパク質 / 二成分制御系 / ヒスチジンキナーゼ / 環境因子 / 人食いバクテリア / 転写因子 / 劇症型感染症 / 経鼻投与 / 顔面神経麻痺 / 嗅球 / コレラ毒素 / 安全性 / IgE / ワクチン / サイトカイン / アジュバント / CTB … More Except Principal Investigator A群レンサ球菌 / 病原性 / 劇症型感染症 / 二成分制御系 / 粘膜ワクチン / 経鼻投与 / NADase / CpG / 結核ワクチン / BCG / 遅延型過敏反応 / 結核 / インターフェロンアルファ / 粘膜免疫 / CpG-ODN / ワクチン / アジュバント / 病原因子 / 薬剤耐性 / msr(D) / mef(A) / ファージ / マクロライド / fab / msrD / salK / salR / mefA / Sreptococcus / S. pyogenes / pyogenes / streptococcus / Ａ群レンサ球菌 / fabT / ゲノム / immune response / mucosal vaccine / thermostable direct hemolvsin / adhesin / colonization factor / pili / Vibrio parahaemolyticus / enterotoxigenic Escherichia coli / 免疫応答 / 耐熱性溶血毒 / アドヘシン / 定着因子 / 線毛 / 腸炎ビブリオ / 毒素原性大腸菌 / Respiratory infectious diseases / Capsular polysaccharide vaccine of Streptococcus pneumoniae / Influenza HA vaccine / Mucosal vaccine / Intranasal administration / Mucosal adjuvant / Recombinant / 粘膜アジュバント / 組換えコレラ毒素Bサブユキット / 呼吸器感染症 / 肺炎球菌莢膜多糖体ワクチン / インフルエンザワクチン / 粘膜アジュバンド / 組換えコレラ毒素Bサブユニット / 遺伝子発現 / 遺伝子制御 / 環境ストレス / 二成分制御系因子 / 劇症型 / A群連鎖球菌 / IFS / Nga Less

Group A Streptococcus glycoproteins evade immune defense mechanismsPrincipal Investigator
- Principal Investigator
  
  井坂雅徳
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagoya City University
天然型CpG DNAを取り入れたBCG免疫を賦活する経鼻結核ワクチンの開発基盤
- Principal Investigator
  
  前山順一
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Elucidation of the acid-sensitive mechanism and pathogenesis of the Group A Streptococcus spy1588 genePrincipal Investigator
- Principal Investigator
  
  Isaka Masanori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagoya City University
Elucidation of macrolide resistance mechanism and virulence of Streptococcus pyogenes focused on phage DNA
- Principal Investigator
  
  Hasegawa Tadao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Nagoya City University
Mechanism of a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates
- Principal Investigator
  
  Tatsuno Ichiro
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya City University
Search for genes involved in severe invasion of Streptococcus pyogenes and analysis of the mechanism of its onsetPrincipal Investigator
- Principal Investigator
  
  Isaka Masanori
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya City University
Analysis of the networks of the two-component sensor proteins in Streptococcus pyogenes
- Principal Investigator
  
  HASEGAWA Tadao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagoya City University
Characterization of the NAD-glycohydrolase in streptococcal strains
- Principal Investigator
  
  TATSUNO Ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagoya City University
コレラ毒素Bサブユニットの粘膜アジュバントのメカニズムと組織安全性に関する研究Principal Investigator
- Principal Investigator
  
  井坂雅徳
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagoya City University
Development of effective mucosal vaccine against bacterial afferent infectious diseases
- Principal Investigator
  
  TANIGUCHI Toru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGOYA CITY UNIVERSITY
コレラ毒素Bサブユニットの粘膜免疫アジュバント活性機構に関する研究Principal Investigator
- Principal Investigator
  
  井坂雅徳
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagoya City University
Development of mucosal vaccines for prevention of prevention of respiratory infectious diseases
- Principal Investigator
  
  TOCHIKUBO Kunio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagoya City University

[Book] 思考のパワー意識の力が細胞を変え、宇宙を変える2014
- Author(s)
  ブルース・リプトン／スティーブ・ベヘアーマン：著　千葉雅（井坂雅徳）：監訳　島津公美：訳
- Total Pages
  360
- Publisher
  ダイヤモンド社
- Data Source
  KAKENHI-PROJECT-26461512
[Journal Article] Association of CovRS Two-Component Regulatory System with NADase Induction by Clindamycin Treatment in <i>Streptococcus pyogenes</i>2024
- Author(s)
  Tatsuno I, Isaka M, Hasegawa T.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 77 Issue: 5 Pages: 247-252
- DOI
  10.7883/yoken.JJID.2023.451
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2024-09-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08605
[Journal Article] A greater effect on clarithromycin resistance of mef associated msr than mef associated msr in Streptococcus pyogenes2022
- Author(s)
  Tatsuno Ichiro、Isaka Masanori、Hasegawa Tadao
- Journal Title
  
  Microbiology and Immunology
  
  Volume: - Issue: 6 Pages: 299-306
- DOI
  10.1111/1348-0421.12974
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08443, KAKENHI-PROJECT-22K08605
[Journal Article] General Phenotype of NADase Induction by CLI Treatment in Streptococcus pyogenes2022
- Author(s)
  Tatsuno Ichiro、Isaka Masanori、Hasegawa Tadao
- Journal Title
  
  International Journal of Microbiology
  
  Volume: 2022 Pages: 1-8
- DOI
  10.1155/2022/4767765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08605, KAKENHI-PROJECT-18K08443
[Journal Article] Streptococcus pyogenes TrxSR Two-Component System Regulates Biofilm Production in Acidic Environments2021
- Author(s)
  Isaka Masanori、Okamoto Akira、Miura Yutaka、Tatsuno Ichiro、Maeyama Jun-ichi、Hasegawa Tadao
- Journal Title
  
  Infection and Immunity
  
  Volume: 89 Issue: 11
- DOI
  10.1128/iai.00360-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08443, KAKENHI-PROJECT-21K07035
[Journal Article] Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal Toxic Shock Syndrome in Japan.2019
- Author(s)
  Tatsuno I, Isaka M, Matsumoto M, Nishio N, Matsui H, Hasegawa T.
- Journal Title
  
  Microbiol Resour Announc
  
  Volume: 13 Issue: 24
- DOI
  10.1128/mra.00453-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08443, KAKENHI-PROJECT-19K11687, KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-16K01827
[Journal Article] Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition.2019
- Author(s)
  Tatsuno I, Isaka M, Matsumoto M, Hasegawa T.
- Journal Title
  
  Microbiol Immunol
  
  Volume: 63 Issue: 10 Pages: 413-426
- DOI
  10.1111/1348-0421.12739
- NAID
  40022036977
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08443, KAKENHI-PROJECT-15K09575
[Journal Article] Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes.2019
- Author(s)
  Hasegawa T, Matsumoto M, Hata N, Yano H, Isaka M, Tatsuno I.
- Journal Title
  
  APMIS
  
  Volume: 127 Issue: 2 Pages: 87-92
- DOI
  10.1111/apm.12914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-16K08782, KAKENHI-PROJECT-26461512, KAKENHI-PROJECT-18K08443
[Journal Article] Functional Predominance of msr(D), Which Is More Effective as mef(A)-Associated Than mef(E)-Associated, Over mef(A)/mef(E) in Macrolide Resistance in Streptococcus pyogenes2018
- Author(s)
  Tatsuno Ichiro、Isaka Masanori、Masuno Katsuaki、Hata Nanako、Matsumoto Masakado、Hasegawa Tadao
- Journal Title
  
  Microbial Drug Resistance
  
  Volume: in press Issue: 8 Pages: 1089-1097
- DOI
  10.1089/mdr.2017.0277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-16K08782, KAKENHI-PROJECT-26461512, KAKENHI-PROJECT-18K08443
[Journal Article] Further evidence on the functional predominance of msr(D) over mef(A) and mef(E) in macrolide resistance in Streptococcus pyogenes2017
- Author(s)
  Ichiro Tatsuno, Masanori Isaka, Katsuaki Masuno, Nanako Hata, Masakado Matsumoto, Tadao Hasegaw.
- Journal Title
  
  Microbiology
  
  Volume: inpress
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461512
[Journal Article] Female GADD34 mice develop age-related inflammation and hepatocellular carcinoma2017
- Author(s)
  Nishio Naomi、Hasegawa Tadao、Tatsuno Ichiro、Isaka Masanori、Isobe Ken-ichi
- Journal Title
  
  Geriatrics & Gerontology International
  
  Volume: 17 Issue: 12 Pages: 2593-2601
- DOI
  10.1111/ggi.13080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-16K01827, KAKENHI-PROJECT-26461512, KAKENHI-PROJECT-16H05280
[Journal Article] Characterisation of clinically isolated Streptococcus pyogenes from balanoposthitis patients, with special emphasis on emm89 isolates2017
- Author(s)
  Hasegawa Tadao、Hata Nanako、Matsui Hideyuki、Isaka Masanori、Tatsuno Ichiro
- Journal Title
  
  Journal of Medical Microbiology
  
  Volume: 66 Issue: 4 Pages: 511-516
- DOI
  10.1099/jmm.0.000460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-26461512
[Journal Article] Characterization of clinically isolated Streptococcus pyogenes from balanoposthitis patients with special emphasis on emm89 isolates.2017
- Author(s)
  Hasegawa T, Hata N, Matsui H, Isaka M, Tatsuno I
- Journal Title
  
  J. Med. Microbiol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08782
[Journal Article] The YvqE two-component system controls biofilm formation and acid production in Streptococcus pyogenes2016
- Author(s)
  Isaka M, Tatsuno I, Maeyama J, Matsui H, Zhang Y, Hasegawa T
- Journal Title
  
  APMIS
  
  Volume: In press Issue: 7 Pages: 574-85
- DOI
  10.1111/apm.12538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460558, KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-26461512
[Journal Article] Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK.2016
- Author(s)
  Tatsuno I, Okada R, Matsumoto M, Hata N, Matsui H, Zhang Y, Isaka M, Hasegawa T.
- Journal Title
  
  APMIS
  
  Volume: 124 Issue: 5 Pages: 414-24
- DOI
  10.1111/apm.12521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-26461512
[Journal Article] Predominant role of msr(D) over mef(A) in macrolide resistance in Streptococcus pyogenes.2016
- Author(s)
  Zhang Y, Tatsuno I, Okada R, Hata N, Matsumoto M, Isaka M, Isobe K, Hasegawa T.
- Journal Title
  
  microbiology
  
  Volume: 162 Issue: 1 Pages: 46-52
- DOI
  10.1099/mic.0.000206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-25293166, KAKENHI-PROJECT-26461512
[Journal Article] Analysis of the roles of NrdR and DnaB from Streptococcus pyogenes in response to host defense.2015
- Author(s)
  Zhang Y, Okada R, Isaka M, Tatsuno I, Isobe K, Hasegawa T.
- Journal Title
  
  APMIS
  
  Volume: 123 Issue: 3 Pages: 252-259
- DOI
  10.1111/apm.12340
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590531, KAKENHI-PROJECT-25293166, KAKENHI-PROJECT-26461512
[Journal Article] A palindromic CpG-containing phosphodiester oligodeoxynucleotides as a mucosal adjuvant stimulates plasmacytoid dendritic cell-mediated TH1 immunity2014
- Author(s)
  Maeyama JI, Takatsuka H, Suzuki F, Kubota A, Horiguchi S, Komiya T, Shimada I, Murata E, Osawa Y, Kitagawa H, Matsuki T, Yamamoto S, Iho S
- Journal Title
  
  Plos One
  
  Volume: 9巻 Issue: 2 Pages: e88846-e88846
- DOI
  10.1371/journal.pone.0088846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22591105, KAKENHI-PROJECT-25460558, KAKENHI-PROJECT-26461512
[Journal Article] Emergence of type I restriction modification system-negative emm1 type Streptococcus pyogenes clinical isolates in Japan.2014
- Author(s)
  Okada R, Matsumoto M, Zhang Y, Isaka M, Tatsuno I, Hasegawa T.
- Journal Title
  
  APMIS
  
  Volume: 122 Pages: 914-921
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461512
[Journal Article] Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient2014
- Author(s)
  Masuno K, Okada R, Zhang Y, Isaka M, Tatsuno I, Shibata S, Hasegawa T
- Journal Title
  
  J. Med. Microbiol
  
  Volume: 63 Issue: 4 Pages: 504-507
- DOI
  10.1099/jmm.0.070300-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590531
[Journal Article] Relevance of the two-component sensor protein CiaH to acid and oxidative stress responses in Streptococcus pyogenes2014
- Author(s)
  Tatsuno I, Isaka M, Okada R, Zhang Y, Hasegawa T
- Journal Title
  
  BMC Res Notes
  
  Volume: 7 Issue: 1 Pages: 189-189
- DOI
  10.1186/1756-0500-7-189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590531, KAKENHI-PROJECT-26461512
[Journal Article] Characterization of NADase-inactive NAD+ glycohydrolase in Streptococcus pyogenes.2013
- Author(s)
  Tatsuno I, Isaka M, Hasegawa T.
- Journal Title
  
  Adv Microbiol
  
  Volume: 3 Pages: 91-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590531
[Journal Article] Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.2013
- Author(s)
  Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T.
- Journal Title
  
  BMC Res Notes.
  
  Volume: 6(1) Issue: 1 Pages: 126-126
- DOI
  10.1186/1756-0500-6-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790425, KAKENHI-PROJECT-24590531
[Journal Article] Characterization of the NAD-glycohydrolase in streptococcal strains2007
- Author(s)
  Tatsuno I, Sawai J, Okamoto A, Matsumoto M, Minami M, Isaka M, Ohta M, Hasegawa T
- Journal Title
  
  Microbiology 153
  
  Pages: 4253-4260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590452
[Journal Article] Recombinant cholera toxin B subunit(rCTB) as a mucosal adjuvant enhances induction of diphtheria and tetanus antitoxin antibodies in mice by intranasal administration with diphtheria-pertussis-tetanus(DPT) combination vaccine.2004
- Author(s)
  Isaka, Masanori
- Journal Title
  
  Vaccine 22・23-24
  
  Pages: 3061-3068
- Data Source
  KAKENHI-PROJECT-15590395
[Journal Article] Recombinant cholera toxin B subunit (rCTB) as a mucosal adjuvant enhances induction of diphtheria and tetanus antitoxin antibodies in mice by intranasal administration with diphtheria-pertussis-tetanus (DPT) combination vaccine2004
- Author(s)
  Isaka, Masanori et al.
- Journal Title
  
  Vaccine 22
  
  Pages: 3061-3068
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590395
[Journal Article] Recombinant cholera toxin B subunit (rCTB) as a mucosal adjuvant enhances induction of diphtheria and tetanus antitoxin antibodies in mice by intranasal administration with diphtheria-pertussis-tetanus (DPT) combination vaccine2004
- Author(s)
  Isaka Masanori et al.
- Journal Title
  
  Vaccine 22 (23/24)
  
  Pages: 3061-3068
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590395
[Presentation] Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition2020
- Author(s)
  立野一郎，井坂雅徳，松本昌門，長谷川忠男
- Organizer
  第９３回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K08443
[Presentation] Prevalence of emm1 Streptococcus pyogenes having a nobel type of genomic composition2020
- Author(s)
  Tatsuno Ichiro, Masanori Isaka, masakado Matsumoto, Tadao Hasegawa
- Organizer
  日本細菌学会
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition2019
- Author(s)
  立野一郎，井坂雅徳, 松本昌門, 長谷川忠男
- Organizer
  第５６回　日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-18K08443
[Presentation] A群連鎖球菌二成分制御因子SPY1588の酸感受性と自己リン酸化2019
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第９２回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K08443
[Presentation] A 群連鎖球菌二成分制御因子 SPY1588 の酸感受性と自己リン酸化について2019
- Author(s)
  井坂雅徳，立野一郎，前山順一，長谷川忠男
- Organizer
  第９２回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K08443
[Presentation] Functional Predominance of msr(D), over mef(E) in Macrolide Resistance in Streptococcus pyogenes2018
- Author(s)
  立野一郎、松本昌門、松井秀之、井坂雅徳、長谷川忠男
- Organizer
  日本細菌学会総会　福岡
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] 二成分制御センサータンパク質 SPY1588 は，バイオフィルム産生と mga プロモーター発現を促進させる2018
- Author(s)
  井坂雅徳，立野一郎，前山順一，長谷川忠男
- Organizer
  第９１回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] Functional predominance of msr(D), over mef(E) in macrolide resistance in Streptococcus pyogenes2018
- Author(s)
  立野一郎、松本昌門、松井秀之、井坂雅徳、長谷川忠男
- Organizer
  第91回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] Two component sensor system SPY1588 regulates biofilm production and promotes transcription of mga gene2018
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] Functional Predominance of msr(D), Which Is More Effective as mef(A)-Associated Than mef(E)-Associated, Over mef(A)/mef(E) in Macrolide Resistance in Streptococcus pyogenes2018
- Author(s)
  立野一郎、松本昌門、松井秀之、井坂雅徳、長谷川忠男
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] 二成分制御センサータンパク質SPY1588は、バイオフィルム産生とmgaプロモーター発現を促進させる2018
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第91回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] A群レンサ球菌におけるmef(A), mef(E)マクロライド耐性システムの解析2017
- Author(s)
  長谷川忠男、松本昌門、松井秀之、井坂雅徳、立野一郎
- Organizer
  第54回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-16K08782
[Presentation] Predominant role of msr(D) over mef(A) in macrolide-resistance in Streptococcus pyogenes2016
- Author(s)
  張顔，立野一郎，松本昌門，井坂雅徳，長谷川忠男
- Organizer
  第89回　日本細菌学会総会
- Place of Presentation
  大阪　国際交流センター(大阪市天王寺区)
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] Characterization of spontaneous fabT mutations in the novel-type Streptococcus pyogenes isolates2016
- Author(s)
  立野一郎、松本昌門、松井秀之、井坂雅徳、長谷川忠男
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター (大阪市)
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] Predominant role of msr (D) over mef (A) in macroride-resistance in Streptococcus pyogenes2016
- Author(s)
  張顔、立野一郎、松本昌門、井坂雅徳、長谷川忠男
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪市）
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] Characterization of spontaneous fabT mutations in the novel-type Streptococcus pyogenes isolates2016
- Author(s)
  立野一郎，松本昌門，松井秀之，井坂雅徳，長谷川忠男
- Organizer
  第89回　日本細菌学会総会
- Place of Presentation
  大阪　国際交流センター(大阪市天王寺区)
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] A群レンサ球菌におけるマクロライド系抗生物質耐性メカニズムの解明2016
- Author(s)
  長谷川忠男、立野一郎、井坂雅徳
- Organizer
  第45回東海乳酸菌研究会
- Place of Presentation
  中日パレス（名古屋市）
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K09575
[Presentation] Streptococcus pyogenes 二成分制御因子はバイオフィルム形成を制御する2015
- Author(s)
  井坂雅徳、立野一郎、岡本陽、前山順一、長谷川忠男
- Organizer
  第29回　日本バイオフィルム学会
- Place of Presentation
  ホテル竹島（愛知県蒲郡市）
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] 近年出現したA群レンサ球菌salR-salK欠損株に関する研究2014
- Author(s)
  立野一郎、岡田涼、張顔、松本昌門、畑七奈子、井坂雅徳、長谷川忠男
- Organizer
  第46回レンサ球菌研究会
- Place of Presentation
  東京大学農学部弥生キャンパス内フードサイエンス棟中島董一郎記念ホール（東京都・文京区）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-24590531
[Presentation] 二成分制御因子によるA群連鎖球菌のバイオフィルム形成機構の解析2014
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24590531
[Presentation] A群連鎖球菌二成分制御因子SPY1622のバイオフィルム形成機構の解析2013
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ国際会議場（千葉）
- Data Source
  KAKENHI-PROJECT-24590531
[Presentation] 劇症型感染症由来A群連鎖球菌によって菌体外に分泌されるNgaタンパク質と病態の関係2009
- Author(s)
  立野一郎、井坂雅徳、南正明、長谷川忠男
- Organizer
  日本細菌学会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590452
[Presentation] マウスモデルを用いたA群連鎖球菌劇症型感染症の発症抑制2008
- Author(s)
  立野一郎、井坂雅徳、南正明、長谷川忠男
- Organizer
  日本細菌学会中部支部総会
- Place of Presentation
  金沢
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19590452
[Presentation] 劇症型A群連鎖球菌臨床分離株の食菌抵抗性の検討2008
- Author(s)
  井坂雅徳、前山順一、立野一郎、南正明、松井秀之、長谷川忠男
- Organizer
  日本細菌学会
- Place of Presentation
  京都
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19590452
[Presentation] A群連鎖球菌Ngaタンパク質のNAD活性に関与する領域及び、劇症型感染症との因果関係についての解析2008
- Author(s)
  立野一郎、井坂雅徳、南正明、松井秀之、長谷川忠男
- Organizer
  日本細菌学会
- Place of Presentation
  京都
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19590452
[Presentation] S.pyogenes 二成分制御因子SPY1622の酸感受およびバイオフィルム形成の作用機序について
- Author(s)
  井坂雅徳、立野一郎、市川真理子、松井秀之、南正明、長谷川忠男
- Organizer
  第21回Lancefieldレンサ球菌研究会
- Place of Presentation
  大阪大学（大阪）
- Data Source
  KAKENHI-PROJECT-24590531
[Presentation] Molecule identification and property of biofilm formation produced by Streptococcus pyogenes
- Author(s)
  M isaka ,I Tatsuno, J Maeyama,T Hasegawa
- Organizer
  日本細菌学会総会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] A群連鎖球菌が産生するバイオフィルムの構成成分の同定とその特性について
- Author(s)
  井坂雅徳、立野一郎、前山順一、長谷川忠男
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  長良川国際会議場（岐阜県・岐阜市）
- Year and Date
  2015-03-26 – 2015-03-27
- Data Source
  KAKENHI-PROJECT-24590531
[Presentation] Relevance of MefA on macrolide resistance in novel emm1 S pyogenes
- Author(s)
  Y Zhang, M Matsumoto,M Isaka,I Tatsuno,T Hasegawa
- Organizer
  日本細菌学会総会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26461512
[Presentation] 近年出現した新規A群レンサ球菌の特性に関する研究
- Author(s)
  岡田涼、松本昌門、張顔、松井秀之、井坂雅徳、立野一郎、長谷川忠男
- Organizer
  第50回日本細菌学会中部支部総会
- Place of Presentation
  蒲郡　ホテル竹島
- Data Source
  KAKENHI-PROJECT-24590531

1. TATSUNO Ichiro (50311642)

# of Collaborated Projects: 7 results

# of Collaborated Products: 50 results
2. HASEGAWA Tadao (10314014)

# of Collaborated Projects: 6 results

# of Collaborated Products: 47 results
3. 前山順一 (40199641)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. TANIGUCHI Tooru (00285199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 矢木宏和 (70565423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOCHIKUBO Kunio (30079991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YASUDA Yoko (70080009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. GOTO Norihisa (10100108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IIDA Tetsuya (90221746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 青山峰芳 (70363918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐々木永太 (40762216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHKUMA Kunio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IHO Sumiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 島田一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISAKA Masanori 井坂 雅徳

井坂 雅徳 イサカ マサノリ

Research Projects

Research Products

Co-Researchers

Group A Streptococcus glycoproteins evade immune defense mechanismsPrincipal Investigator

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天然型CpG DNAを取り入れたBCG免疫を賦活する経鼻結核ワクチンの開発基盤

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Elucidation of the acid-sensitive mechanism and pathogenesis of the Group A Streptococcus spy1588 genePrincipal Investigator

Principal Investigator

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Elucidation of macrolide resistance mechanism and virulence of Streptococcus pyogenes focused on phage DNA

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Mechanism of a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates

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Search for genes involved in severe invasion of Streptococcus pyogenes and analysis of the mechanism of its onsetPrincipal Investigator

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Analysis of the networks of the two-component sensor proteins in Streptococcus pyogenes

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Characterization of the NAD-glycohydrolase in streptococcal strains

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コレラ毒素Bサブユニットの粘膜アジュバントのメカニズムと組織安全性に関する研究Principal Investigator

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Development of effective mucosal vaccine against bacterial afferent infectious diseases

Principal Investigator

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コレラ毒素Bサブユニットの粘膜免疫アジュバント活性機構に関する研究Principal Investigator

Principal Investigator

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Development of mucosal vaccines for prevention of prevention of respiratory infectious diseases

Principal Investigator

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[Book] 思考のパワー 意識の力が細胞を変え、宇宙を変える2014

Author(s)

Total Pages

ISAKA Masanori 井坂雅徳

井坂雅徳イサカマサノリ

[Book] 思考のパワー意識の力が細胞を変え、宇宙を変える2014