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YOSHINAGA Kosuke  吉永 浩介

ORCIDConnect your ORCID iD *help
Researcher Number 40343058
Affiliation (based on the past Project Information) *help 2012 – 2014: 東北大学, 医学(系)研究科(研究院), 非常勤講師
2012: 東北大学, 医学(系)研究科(研究院), その他
2012: 東北大学, 大学院・医学系研究科, 非常勤講師
2011: 東北大学, 大学病院, 准教授
2011: 東北大学, 病院, 准教授 … More
2010: 東北大学, 病院, 講師
2007 – 2009: Tohoku University, 病院, 助教
2008: Tohoku University, 病院, 助教授
2006: 東北大学, 病院・助手
2006: 東北大学, 大学病院, 助手
2006: 東北大学, 病院, 助手 Less
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology
Except Principal Investigator
Obstetrics and gynecology
Keywords
Principal Investigator
リンパ管密度 / 血管密度 / 血管新生 / 子宮内膜癌 / VEGF / vasohibin / Keapl遺伝子 / 遺伝子治療 / Nrf2遺伝子 / Keap1遺伝子 … More / 化学療法抵抗性 / 免疫染色 / 血管新生阻害物質 / 子宮頸癌 / 子宮頚癌 / endometrial cancer / lymphovessel density / microvessel density / Podoplanin / VEGF receptor II / angiogenesis / Vasohibin / VEGFR-2 … More
Except Principal Investigator
子宮内膜癌 / 薬剤耐性 / 子宮体癌 / マイクロアレイ / マイクロRNA / 漿液性腺癌 / Androstenedione / CRH / 5α-dihydrotestosterone / Testosterone / Estrogen / Intracrinology / LC-MS/MS法 / 子宮内膜異型増殖症 / steroid sulfatase / testosterone / estrogen / intracrinology / 癌―間質相互作用 / ノックアウトマウス / PTEN / 発癌 / タモキシフェン / ATP7B / Hrs / 婦人科癌 / 腹腔内播種モデル / in vivoイメージングシステム / ルシフェラーゼ / シスプラチン / 卵単癌 / 膀胱子宮靭帯後層 / 骨盤筋膜 / 広汎子宮全摘術 / 骨盤腹膜 / 神経温存術式 / 神経節 / 膀胱子宮靭帯 / 広汎子宮全摘出術 / RNA干渉 / ケモカイン / 微小転移 / 子宮頸癌 / リンパ節転移 / ミッドカイン Less
  • Research Projects

    (9 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (12 People)
  •  The role of micro RNA in chemo- resistance of uterine serous carcinoma

    • Principal Investigator
      NAGASE Satoru
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
      Tohoku University
  •  Development of Keap1 gene therapy for chemo-resistance endometrial cancer.Principal Investigator

    • Principal Investigator
      YOSHINAGA Kousuke
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  Research the regulators, including cytokine, of intratumoral biosynthesis of estrogen in endometrial cancer microenvironment

    • Principal Investigator
      ITO Kiyoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  establishment of model mouse getting endometrial cancer utilizing the biological difference between estrogen and tamoxifen

    • Principal Investigator
      NIIKURA Hitoshi
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas.Principal Investigator

    • Principal Investigator
      YOSHINAGA Kousuke
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  Real time analysis of chemokine effect to lymph node metastasis in uterine cancer by utilizing RNA interference

    • Principal Investigator
      NIIKURA Hitoshi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  Development of nerve-sparing radical hysterectomy based on autonomic nerve ganglion mapping

    • Principal Investigator
      NAGASE Satoru
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  リアルタイムin vivoイメージングシステムを用いた婦人科癌薬剤耐性機構の解析

    • Principal Investigator
      TAKANO Tadao
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University
  •  Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancerPrincipal Investigator

    • Principal Investigator
      YOSHINAGA Kousuke
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Small cell carcinoma of the uterine cervix: clinical outcome of concurrent chemoradiotherapy with a multidrug regimen.2013

    • Author(s)
      Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H, Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 229(1) Pages: 75-81

    • NAID

      10031143090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Decreased Expression of 14-3-3<i>σ</i> Is Predictive of Poor Prognosis for Patients with Human Uterine Papillary Serous Carcinoma2013

    • Author(s)
      1. Suzuki F, Nagase S, Suzuki K, Oba E, Hiroki E, Matsuda Y, Akahira J, Nishigori H, Sugiyama T, Otsuki T, Yoshinaga K, Takano T, Niikura H, Ito K, Sasano H, and Yaegashi N
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 231 Issue: 3 Pages: 193-199

    • DOI

      10.1620/tjem.231.193

    • NAID

      130004720755

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592471, KAKENHI-PROJECT-24592498
  • [Journal Article] Decreased expression of 14-3-3σ is predictive of poor prognosis for patients with human uterine papillary serous carcinoma.2013

    • Author(s)
      Suzuki F, Nagase S, Suzuki K, Oba E, Hiroki E, Matsuda Y, Akahira J, Nishigori H, Sugiyama T, Otsuki T, Yoshinaga K, Takano T, Niikura H, Ito K, Sasano H, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 231(3) Pages: 193-9

    • NAID

      130004720755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Small cell carcinoma of the uterine cervix: clinical outcome of concurrent chemoradiotherapy with a multidrug regimen2013

    • Author(s)
      Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H,Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
    • Journal Title

      Tohoku J Exp Med

      Volume: 229(1) Pages: 75-81

    • NAID

      10031143090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Journal Article] Small cell carcinoma of the uterine cervix : clinical outcome of concurrent chemoradiotherapy with a multidrug regimen2013

    • Author(s)
      Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H, Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
    • Journal Title

      Tohoku J Exp Med

      Volume: 229(1) Pages: 75-81

    • NAID

      10031143090

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23269283

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Decreased expression of 14-3-3σis predictive of poor prognosis for patients with human uterine papillary serous carcinoma2013

    • Author(s)
      Suzuki F, Nagase S, Suzuki K, Oba E, Hiroki E, Matsuda Y, Akahira J, Nishigori H, Sugiyama T, Otsuki T, Yoshinaga K, Takano T, Niikura H, Ito K, Sasano H, Yaegashi N
    • Journal Title

      Tohoku J Exp Med

      Volume: 231(3) Pages: 193-199

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24201220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Prospective study of sentinel lymph node biopsy without further pelvic lymphadenectomy in patients with sentinel lymph node-negative cervical cancer2012

    • Author(s)
      Niikura H, Okamoto S, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T, Ito K, Watanabe M,Yaegashi N
    • Journal Title

      Int J Gynecol Cancer

      Volume: 22(7) Issue: 7 Pages: 1244-1250

    • DOI

      10.1097/igc.0b013e318263f06a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119, KAKENHI-PROJECT-23590771, KAKENHI-PROJECT-23592431, KAKENHI-PROJECT-23592432
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011

    • Author(s)
      Kousuke Yoshinaga
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 446-51

    • NAID

      10029290441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Journal Article] Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial Adenocarcinoma survival.2011

    • Author(s)
      Wong TF, Yoshinaga K, Monma Y, Ito K, Niikura H, Nagase S, Yamamoto M, Yaegashi N.
    • Journal Title

      Int J Gynecol Cancer.

      Volume: 21 Pages: 1428-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011

    • Author(s)
      Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 446-451

    • NAID

      10029290441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Association of Keap1 and Nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival2011

    • Author(s)
      Wong TF, Yoshinaga K, Monma Y, Ito K, Niikura H, Nagase S, Yamamoto M, Yaegashi N
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Issue: 8 Pages: 1428-1435

    • DOI

      10.1097/igc.0b013e31822d0eb2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21592119, KAKENHI-PROJECT-23592431
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas.2011

    • Author(s)
      Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H,
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 446-51

    • NAID

      10029290441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011

    • Author(s)
      Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
    • Journal Title

      Cancer Science

      Volume: 102(2) Pages: 446-451

    • NAID

      10029290441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Journal Article] Malignant transformation arising from mature cystic teratoma of theovary : a retrospective study of 20 cases.2010

    • Author(s)
      Sakuma M, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T, Nukura H, Ito K, Otomo K, Tase T, Watanabe Y, Yaegashi N.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 20(5) Pages: 766-771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Journal Article] Malignant transformation arising from mature cystic teratoma of the ovary: a retrospective study of 20 cases2010

    • Author(s)
      Sakuma M, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T, Niikura H, Ito K, Otomo K, Tase T,Watanabe Y, Yaegashi N
    • Journal Title

      Int J Gynecol Cancer

      Volume: 20(5) Pages: 766-771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Journal Article] Detection of micrometastases in cervical cancer with a system that evaluates both sentinel and nonsentinel lymph nodes.2009

    • Author(s)
      Okamoto S, Niikura H, Yoshinaga K, Nagase S, Takano T, Ito K, Yaegashi N.
    • Journal Title

      Int J Gynecol Cancer 19

      Pages: 708-711

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer2008

    • Author(s)
      Kousuke Yoshinaga, et al
    • Journal Title

      Cancer Sci. 99

      Pages: 914-919

    • NAID

      10024005878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791141
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer2008

    • Author(s)
      Yoshinaga K, Niikura H, Yaegashi N, et.al.
    • Journal Title

      Cancer Sci 99

      Pages: 914-919

    • NAID

      10024005878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591820
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer2008

    • Author(s)
      Kousuke Yoshinaga
    • Journal Title

      Cancer Science 99

      Pages: 914-9

    • NAID

      10024005878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791141
  • [Journal Article] Phase I trial of concurrent chemoradiation with weekly nedaplatin in patients with squamous cell carcinoma of the uterine cervix2007

    • Author(s)
      Yoshinaga K, Niikura H, et.al.
    • Journal Title

      Gynecol Oncol 104

      Pages: 36-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591820
  • [Journal Article] Vaginal tumors with histological and immunocytochemical feature of GIST : two cases and review of the literature2007

    • Author(s)
      Nagase S, Mikami Y, Moriya T, Niikura H, Yoshinaga K, Takano T et al.
    • Journal Title

      Int J Gynecol Cancer (in press)

    • Data Source
      KAKENHI-PROJECT-18659480
  • [Journal Article] Surgical anatomy of intrapelvicand vesico-uterine ligament in nerve-sparing radical hysterectomy with fresh cadaver dissections2007

    • Author(s)
      Niikura H, Katahira A, Utsunomiya H, Takano T, Ito K, Nagase S, Yoshinaga K, Tokunaga H, Toyoshima M, Kinugasa Y, Uchiyama E, Murakami G, Yabuki Y, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med. 212

      Pages: 403-413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591821
  • [Journal Article] Phase I trial of concurrent chemoradiation with weekly nedaplatin in patients with squamous cell carcinoma of the uterine cervix.2007

    • Author(s)
      Yoshinaga K, Niikura H, Ogawa Y, Nemoto K, Nagase S, Takano T et al.
    • Journal Title

      Gynecologic Oncology 104

      Pages: 36-40

    • Data Source
      KAKENHI-PROJECT-18659480
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor, in endometrial cancer

    • Author(s)
      Kousuke Yoshinaga
    • Journal Title

      Cancer Science (In press)

    • NAID

      10024005878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791141
  • [Journal Article] Detection of micrometastases in cervical cancer with a system that evaluates both sentinel and nonsentinel lymph nodes

    • Author(s)
      Okamoto S, Niikura H, Yoshinaga K, Nagase S, Takano T, Ito K, Yaegashi N
    • Journal Title

      Int J Gynecol Cancer

      Volume: 19 Pages: 708-711

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas

    • Author(s)
      Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 446-451

    • NAID

      10029290441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592119
  • [Presentation] Identification of novel estrogen receptorαtarget gene and its function in endometrial cancer2012

    • Author(s)
      Shigeta S , Utsunomiya H, Ito K, Niikura H, Nagase S, Yoshinaga K, Sasano H, Yaegashi N
    • Organizer
      60th Annual Clinical Meeting of the American College of Obstetricians and Gynecologists
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-05-07
    • Data Source
      KAKENHI-PROJECT-23592431
  • [Presentation] The role of the intrinsic angiogensis inhibitor, vasohibin, in cervical carcinomas2011

    • Author(s)
      Yoshinaga K
    • Organizer
      102th AACR
    • Place of Presentation
      Orland, USA
    • Year and Date
      2011-04-05
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Presentation] 子宮頸癌における新規血管新生阻害因子vasohibinの発現検討2011

    • Author(s)
      吉永浩介
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Presentation] 子宮頸癌における新規血管新生阻害因子vasohibinの発現検討2010

    • Author(s)
      吉永浩介
    • Organizer
      日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Presentation] 新規血管新生阻害因子Vasohibinを用いた子宮頚癌における血管新生阻害薬開発2009

    • Author(s)
      吉永浩介
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-21791538
  • [Presentation] Vasohibin, a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity2008

    • Author(s)
      Kousuke Yoshinaga
    • Organizer
      98th Association of American Cancer Research
    • Place of Presentation
      ワシントンD.C, USA
    • Year and Date
      2008-04-05
    • Data Source
      KAKENHI-PROJECT-18791141
  • [Presentation] a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity2008

    • Author(s)
      Kousuke Yoshinaga. Vasohibin
    • Organizer
      98th Association of American Cancer Research
    • Place of Presentation
      Washington D,C
    • Year and Date
      2008-04-05
    • Data Source
      KAKENHI-PROJECT-18791141
  • 1.  NAGASE Satoru (00292326)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  NIIKURA Hitoshi (80261634)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 3.  ITO Kiyoshi (70241594)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 4.  YAEGASHI Nobuo (00241597)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  SAITO Sumika (60509595)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MURAKAMI Gen (30157747)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  TAKANO Tadao (40282058)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 8.  OTSUKI Takeo (40531330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  KAIHO Michiko (50531331)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  SUZUKI Takashi (10261629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  SUSUKI Fumihiko (20400343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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