HASHIRAMOTO Mitsuru 柱本満

Researcher Number	40346680
External Links
Affiliation (based on the past Project Information) *help	2009 – 2011: 川崎医科大学, 医学部, 講師 2007: Kawasaki Medical School, Department of Medicine, Lecturer 2003 – 2005: 愛媛大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Biological Sciences Except Principal Investigator Metabolomics
Keywords	Principal Investigator GLUT4 / retrovirus expression system / glucose transporter / glucose transport / insulin action / レトロウィルス発現系 / 糖輸送担体 / グルコース輸送 / インスリン作用 / チアゾリジン誘導体 / PPARγ / GTP結合蛋白質(G蛋白) / 脂肪分化 … More Except Principal Investigator … More β-cell restoration / β-cell mass / oxidative stress / pioglitazone / diet therapy / LCM method / impaired β-cell function / db gene / 肥満2型糖尿病モデル / 膵ラ氏島遺伝子発現 / 膵β細胞機能 / db遺伝子ヘテロ接合体マウス / db遺伝子ホモ接合体マウス / 膵β細胞機能保護 / 膵β細胞量 / 酸化ストレス / ピオグリタゾン / 食事介入 / LCM法 / 膵β細胞機能不全 / db遺伝子 / Myofibroblasts / Retinopathy / Diabetes / 形質転換 / 平滑筋様細胞 / 糖尿病網膜症 / 筋線維芽細胞 / 筋繊維芽細胞 / 網膜症 / 糖尿病 / 脂肪細胞小型化 / アディポネクチン / VEGF / db/dbマウス / VCAM1 / HIF1 / 内臓脂肪 / 骨格筋 / インスリン抵抗性 / 血管新生 / 高血糖マウス / 血管内皮細胞特異的PDK1欠損 / メタボリックシンドローム Less

Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity control
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
新規脂肪細胞分化調節因子低分子量G蛋白質の解析と生理学的意義の解明Principal Investigator
- Principal Investigator
  
  柱本満
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Identification of novel factors regulating "insulin-responsiveness" by retrovirus expression system.Principal Investigator
- Principal Investigator
  
  HASHIRAMOTO Mitsuru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  EHIME UNIVERSITY
Molecular mechanism of proliferation of myofibroblasts in diabetic retinopathy
- Principal Investigator
  
  NISHIDA Wataru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University

All 2012 2011 2010 2009 2005

All Journal Article Presentation

[Journal Article] Ablationof 3-phosphoinositide-dependent protein kinase 1(PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis2012
- Author(s)
  Tawaramoto K, Sakaue H, et al
- Journal Title
  
  Mol Endocrinol
  
  Volume: Vol.26 Issue: 1 Pages: 95-109
- DOI
  10.1210/me.2010-0412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591151, KAKENHI-PROJECT-21591153, KAKENHI-PLANNED-22126011, KAKENHI-PUBLICLY-23126520, KAKENHI-PROJECT-24591333
[Journal Article] The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes2011
- Author(s)
  Shimoda M, Kanda Y, Hamamoto S, Tawaramoto K, Hashiramoto M, Matsuki M, Kaku K
- Journal Title
  
  Diabetologia
  
  Volume: 54(5) Issue: 5 Pages: 1098-1108
- DOI
  10.1007/s00125-011-2069-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic β cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010
- Author(s)
  Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 298(2) Issue: 2 Pages: 278-286
- DOI
  10.1152/ajpendo.00388.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009
- Author(s)
  Kanda Y, Shimoda M, Tawaramoto K, Hamamoto S, Tatsumi F, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Endocr J
  
  Volume: 56(8) Pages: 997-1008
- URL
  https://www.jstage.jst.go.jp/article/endocrj/56/8/56_K09E-028/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] 発病時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005
- Author(s)
  西田亙, 長谷部晋士, 川村良一, 柱本満, 大沼裕, 大澤春彦, 牧野英一
- Journal Title
  
  糖尿病 (In press)
- Data Source
  KAKENHI-PROJECT-15590946
[Journal Article] A case of fulminant type 1 diabetes associated with high titer of Coxsackie B3 virus antibody2005
- Author(s)
  Nishida W, Hasebe S, Kawamura R, Hashiramoto M, Onuma H, Osawa H, Makino H
- Journal Title
  
  Journal of the Japan Diabetes Society (in press)
- NAID
  10016604665
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590946
[Journal Article] 発症時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005
- Author(s)
  西田亙, 長谷部晋士, 川村良一, 柱本満, 大沼裕, 大澤春彦, 牧野英一
- Journal Title
  
  糖尿病 (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590946
[Presentation] 血管内皮特異的PDK1欠損における肝、骨格筋内血管面積の解析ー高血糖による影響2012
- Author(s)
  俵本和仁、柱本満、木村友彦、蛭川英典、辰巳文則、濱本純子、下田将司、小川渉、春日雅人、加来浩平
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells in diabetic condition deteriorates vascularity only in skeletal muscles but not in liver2012
- Author(s)
  Tawaramoto K, Hashiramoto M, Kimura T, Hirukawa H, Shimoda M, Ogawa W, Kasuga M, Kaku K
- Organizer
  72^<nd> American Diabetes Association Scientific Session
- Place of Presentation
  Philadelphia
- Year and Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells deteriorates systemic insulin sensitivity and angiogenesis of skeletal muscles in STZ-induced hyperglycemic mice2011
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Hirukawa H, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  71^<st> American Diabetes Association Scientific Session
- Place of Presentation
  San Diego
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 高血糖状態での血管内皮細胞PDK1欠損は骨格筋内血管数減少と全身インスリン感受性悪化を惹起する2011
- Author(s)
  俵本和仁、柱本満、蛭川英典、辰巳文則、濱本純子、下田将司、菅田有紀子、小谷光、小川渉、春日雅人、加来浩平
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of vascular endothelial phosphoinositide-dependent protein kinase 1 deteriorates the volume of blood flow in skeletal muscle2010
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  46th European Association for the Study of Diabetes Annual Meeting
- Place of Presentation
  Stockholm
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of Vascular Endothelial PDK1 in Diabetic db/db Mice Further Deteriorates Insulin Sensitivity through Defects of Angiogenesis in Skeletal Muscle and Adipose Tissue2009
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  69^<th> American Diabetes Association Scientific Session
- Place of Presentation
  New Orleans
- Year and Date
  2009-06-08
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病での血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病モデルでの血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第30回日本肥満学会
- Place of Presentation
  浜松
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21591153

1. NISHIDA Wataru (80271089)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. ONUMA Hiroshi (00294794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KAKU Kohei (10116709)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. KANDA Yukiko (40351895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. MAKINO Hideichi (50009578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. OSAWA Haruhiko (90294800)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. MATSUKI Michihiro (00165797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. TAWARAMOTO Kazuhito (70368629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. KOTANI Ko (10388928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMODA Masashi (60388957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 阪上浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASHIRAMOTO Mitsuru 柱本 満

Research Projects

Research Products

Co-Researchers

Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規脂肪細胞分化調節因子低分子量G蛋白質の解析と生理学的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel factors regulating "insulin-responsiveness" by retrovirus expression system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of proliferation of myofibroblasts in diabetic retinopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ablationof 3-phosphoinositide-dependent protein kinase 1(PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic β cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009

Author(s)

Journal Title

URL

Data Source

[Journal Article] 発病時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005

Author(s)

Journal Title

Data Source

[Journal Article] A case of fulminant type 1 diabetes associated with high titer of Coxsackie B3 virus antibody2005

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] 発症時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005

Author(s)

Journal Title

Description

Data Source

[Presentation] 血管内皮特異的PDK1欠損における肝、骨格筋内血管面積の解析ー高血糖による影響2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ablation of PDK1 in vascular endothelial cells in diabetic condition deteriorates vascularity only in skeletal muscles but not in liver2012

Author(s)

Organizer

Place of Presentation

Year and Date

HASHIRAMOTO Mitsuru 柱本満