Kimura Yukiko 木村有紀子

… Alternative Names

KANDA Yukiko 菅田有紀子

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Researcher Number	40351895
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2011: 川崎医科大学, 医学部, 講師 2009 – 2010: 川崎医科大学, 医学部, 助教 2007: Kawasaki Medical School, Department of Medicine, Assistant
Review Section/Research Field	Except Principal Investigator Metabolomics
Keywords	Except Principal Investigator β-cell restoration / β-cell mass / oxidative stress / pioglitazone / diet therapy / LCM method / impaired β-cell function / db gene / 肥満2型糖尿病モデル / 膵ラ氏島遺伝子発現 … More / 膵β細胞機能 / db遺伝子ヘテロ接合体マウス / db遺伝子ホモ接合体マウス / 膵β細胞機能保護 / 膵β細胞量 / 酸化ストレス / ピオグリタゾン / 食事介入 / LCM法 / 膵β細胞機能不全 / db遺伝子 / 脂肪細胞小型化 / アディポネクチン / VEGF / db/dbマウス / VCAM1 / HIF1 / 内臓脂肪 / 骨格筋 / インスリン抵抗性 / 血管新生 / 高血糖マウス / 血管内皮細胞特異的PDK1欠損 / メタボリックシンドローム Less

Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity control
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School

All 2012 2011 2010 2009 2007 2006

All Journal Article Presentation

[Journal Article] Self-inducible secretion ofglucagon-like peptide-1(GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival2012
- Author(s)
  Nakashima K, Shimoda M, Hamamoto S, Tatsumi F, Hirukawa H, Tawaramoto K, Kanda Y, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 349(2) Pages: 281-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Ablationof 3-phosphoinositide-dependent protein kinase 1(PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis2012
- Author(s)
  Tawaramoto K, Sakaue H, et al
- Journal Title
  
  Mol Endocrinol
  
  Volume: Vol.26 Issue: 1 Pages: 95-109
- DOI
  10.1210/me.2010-0412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591151, KAKENHI-PROJECT-21591153, KAKENHI-PLANNED-22126011, KAKENHI-PUBLICLY-23126520, KAKENHI-PROJECT-24591333
[Journal Article] The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes2011
- Author(s)
  Shimoda M, Kanda Y, Hamamoto S, Tawaramoto K, Hashiramoto M, Matsuki M, Kaku K
- Journal Title
  
  Diabetologia
  
  Volume: 54(5) Issue: 5 Pages: 1098-1108
- DOI
  10.1007/s00125-011-2069-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic {beta} cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist.2010
- Author(s)
  Kanda Y, et al
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic{beta}cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010
- Author(s)
  Kanda Y, et al
- Journal Title
  
  Am J Physiol Endocrinol Metab. 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic β cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010
- Author(s)
  Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 298(2) Issue: 2 Pages: 278-286
- DOI
  10.1152/ajpendo.00388.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009
- Author(s)
  Kanda Y, Shimoda M, Tawaramoto K, Hamamoto S, Tatsumi F, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K
- Journal Title
  
  Endocr J
  
  Volume: 56(8) Pages: 997-1008
- URL
  https://www.jstage.jst.go.jp/article/endocrj/56/8/56_K09E-028/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009
- Author(s)
  Kanda Y, et al
- Journal Title
  
  Endocr J 56
  
  Pages: 997-1008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591153
[Journal Article] Analysis of waist circumference in Japanese subjects with type 2 diabetes mellitus : Lack of propriety to define the current criteria of metabolic syndrome.2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Journal Title
  
  Diab Res Clin Pract 77
  
  Pages: 220-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Journal Article] Molecular mechanism of db gene induced pancreatic b cell dysfunction : Evideno for compensatory mechanism to reduce susceptibility to diabaetes in bd gem heterozygote.2006
- Author(s)
  Kanda Y, Kaku K et al.
- Journal Title
  
  Diabetologia 49(suippl 1)
  
  Pages: 315-315
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] 血管内皮特異的PDK1欠損における肝、骨格筋内血管面積の解析ー高血糖による影響2012
- Author(s)
  俵本和仁、柱本満、木村友彦、蛭川英典、辰巳文則、濱本純子、下田将司、小川渉、春日雅人、加来浩平
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells in diabetic condition deteriorates vascularity only in skeletal muscles but not in liver2012
- Author(s)
  Tawaramoto K, Hashiramoto M, Kimura T, Hirukawa H, Shimoda M, Ogawa W, Kasuga M, Kaku K
- Organizer
  72^<nd> American Diabetes Association Scientific Session
- Place of Presentation
  Philadelphia
- Year and Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 高血糖状態での血管内皮細胞PDK1欠損は骨格筋内血管数減少と全身インスリン感受性悪化を惹起する2011
- Author(s)
  俵本和仁、柱本満、蛭川英典、辰巳文則、濱本純子、下田将司、菅田有紀子、小谷光、小川渉、春日雅人、加来浩平
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of PDK1 in vascular endothelial cells deteriorates systemic insulin sensitivity and angiogenesis of skeletal muscles in STZ-induced hyperglycemic mice2011
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Hirukawa H, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  71^<st> American Diabetes Association Scientific Session
- Place of Presentation
  San Diego
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of vascular endothelial phosphoinositide-dependent protein kinase 1 deteriorates the volume of blood flow in skeletal muscle2010
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  46th European Association for the Study of Diabetes Annual Meeting
- Place of Presentation
  Stockholm
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Ablation of Vascular Endothelial PDK1 in Diabetic db/db Mice Further Deteriorates Insulin Sensitivity through Defects of Angiogenesis in Skeletal Muscle and Adipose Tissue2009
- Author(s)
  Tawaramoto K, Hashiramoto M, Kotani K, Ogawa W, Tatsumi F, Hamamoto S, Shimoda M, Kanda Y, Kasuga M, Kaku K
- Organizer
  69^<th> American Diabetes Association Scientific Session
- Place of Presentation
  New Orleans
- Year and Date
  2009-06-08
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病での血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] 肥満2型糖尿病モデルでの血管内皮細胞PDK1欠損は筋肉内血管新生を低下させ、全身インスリン抵抗性を増悪させる2009
- Author(s)
  俵本和仁、柱本満、小谷光、小川渉、辰巳文則、濱本純子、下田将司、菅田有紀子、春日雅人、加来浩平
- Organizer
  第30回日本肥満学会
- Place of Presentation
  浜松
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21591153
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice:evidence for direct action as PPARg agonist2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes
- Place of Presentation
  Amsterdam,Holland
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice : evidence for direct action as PPARg agonist.2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Amsterdam
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of pioglitazone effect on the pancreatic beta cell preservation in diabetic db/db mice:evidence for direct action as PPARγ agonist2007
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 43rd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Amsterdam,Holland
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591008
[Presentation] Molecular mechanism of db gene induced pancreatic b cell dysfunction: Evidence for compensatory mechanism to reduce susceptibility to diabetes in bd gene heterozygote.2006
- Author(s)
  Kanda Y, Kaku K, et. al.
- Organizer
  The 42nd Annual Meeting of European Association of the Study of Diabetes.
- Place of Presentation
  Copenhagen, Denmark
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591008

1. KAKU Kohei (10116709)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. HASHIRAMOTO Mitsuru (40346680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. MATSUKI Michihiro (00165797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. TAWARAMOTO Kazuhito (70368629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. KOTANI Ko (10388928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMODA Masashi (60388957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 阪上浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Yukiko 木村 有紀子

KANDA Yukiko 菅田 有紀子

Research Projects

Research Products

Co-Researchers

Molecular mechanism of visceral obesity controlled by endothelial cell-related growth factors and the search for a new strategy of adipogenecity control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Self-inducible secretion ofglucagon-like peptide-1(GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival2012

Author(s)

Journal Title

Data Source

[Journal Article] Ablationof 3-phosphoinositide-dependent protein kinase 1(PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic {beta} cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist.2010

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic{beta}cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanism by which pioglitazone preserves pancreatic β cells in obese diabetic mice : Evidence for acute and chronic actions as a PPARγ agonist2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009

Author(s)

Journal Title

URL

Data Source

[Journal Article] Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction ; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote2009

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of waist circumference in Japanese subjects with type 2 diabetes mellitus : Lack of propriety to define the current criteria of metabolic syndrome.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Molecular mechanism of db gene induced pancreatic b cell dysfunction : Evideno for compensatory mechanism to reduce susceptibility to diabaetes in bd gem heterozygote.2006

Author(s)

Journal Title

Data Source

[Presentation] 血管内皮特異的PDK1欠損における肝、骨格筋内血管面積の解析ー高血糖による影響2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ablation of PDK1 in vascular endothelial cells in diabetic condition deteriorates vascularity only in skeletal muscles but not in liver2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 高血糖状態での血管内皮細胞PDK1欠損は骨格筋内血管数減少と全身インスリン感受性悪化を惹起する2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Kimura Yukiko 木村有紀子

KANDA Yukiko 菅田有紀子