Imazuru Tomohiro 今水流智浩

… Alternative Names

今水流智浩イマヅルトモヒロ

Less

Researcher Number	40359576
Affiliation (Current)	2026: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 帝京大学, 医学部, 教授 2018: 帝京大学, 医学部, 准教授 2015 – 2018: 帝京大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Cardiovascular surgery
Keywords	Principal Investigator ドナー特異的抗体 / 制御性T細胞 / マウス / 心臓移植 / PD-1 / BTLA / 心移植 / 抗体関連拒絶反応 / 細胞移植 / 抗PD-1抗体 … More / 抗BTLA抗体 / 抗体関連型拒絶反応 / 拒絶反応 / 冠動脈内膜肥厚 / 冠動脈 Less

Establishment of combination therapy with anti-BTLA antibody and anti-PD-1 antibody for antibody mediated rejectionPrincipal Investigator
- Principal Investigator
  
  Imazuru Tomohiro
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Teikyo University
Graft protective effect and induction of CD4+CD25+Foxp3+ T cell by combination of anti-BTLA mAb and anti-PD-1 mAbPrincipal Investigator
- Principal Investigator
  
  Imazuru Tomohiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Teikyo University

All 2024 2023 2022 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Graft protective effects and donor-specific antibody suppression by CD4+CD25+Foxp3+ regulatory T cell induced by HMG-CoA reductase inhibitor rosuvastatin in a murine heart transplant model2024
- Author(s)
  Iguchi Kazuhito、Yamamoto Yasuto、Uchiyama Masateru、Masaoka Hisanori、Nakamura Masahiro、Shizuka Hiroyuki、Imazuru Tomohiro、Shimokawa Tomoki
- Journal Title
  
  Journal of Cardiothoracic Surgery
  
  Volume: 19 Issue: 1
- DOI
  10.1186/s13019-024-02888-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08629, KAKENHI-PROJECT-24K11999
[Journal Article] Graft Protective and Intercellular Immunomodulatory Effects by Adoptive Transfer of an Agonistic Anti-BTLA mAb (3C10) Induced CD4+CD25+ Regulatory T Cells in Murine Cardiac Allograft Transplant Model2024
- Author(s)
  Masaoka Hisanori、Yamamoto Yasuto、Uchiyama Masateru、Iguchi Kazuhito、Nakamura Masahiro、Yagita Hideo、Imazuru Tomohiro、Shimokawa Tomoki
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 56 Issue: 3 Pages: 692-700
- DOI
  10.1016/j.transproceed.2024.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08629, KAKENHI-PROJECT-24K11999
[Journal Article] Saireito (TJ-114) Suppressed Donor-Specific Antibody through Immunomodulatory Effects and Regulatory T cell Induction in a Murine Heart Transplant Model.2022
- Author(s)
  Yasuto Yamamoto, Masateru Uchiyama*, Kento Kawai, Kazuhito Iguchi, Tomohiro Imazuru, Tomoki Shimokawa
- Journal Title
  
  Transplantation proceedings
  
  Volume: 54 Issue: 2 Pages: 482-486
- DOI
  10.1016/j.transproceed.2022.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08629
[Journal Article] Surgical treatment of a huge hepatic artery aneurysm without revascularization - Case report2018
- Author(s)
  Tomohiro Imazuru, Masateru Uchiyama, Shigefumi Matsuyama, Mitsuru Iida, Tomoki Shimokawa
- Journal Title
  
  International Journal of Surgery Case Reports
  
  Volume: 51 Issue: C Pages: 95-8
- DOI
  10.1016/j.ijscr.2018.08.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10224
[Journal Article] Seven Japanese Herbals Prolonged Cardiac Allograft Survival.2018
- Author(s)
  Enzhi Yin, Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Takako Yanagisawa, Akira Inoue, Yu Guo, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Masafumi Kawamura, and Masanori Niimi
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 印刷中 Issue: 9 Pages: 2789-93
- DOI
  10.1016/j.transproceed.2018.04.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10224, KAKENHI-PROJECT-15K19927, KAKENHI-PROJECT-26462093
[Journal Article] MVR+CABP術後IEによる僧帽弁位人工弁周囲逆流を生じた症例に対し、reMVRを右開胸で施行した1例2016
- Author(s)
  太田浩雄、飯田充、内山雅照、池田司、尾澤直美、松山重文、今水流智浩、下川智樹
- Journal Title
  
  心臓
  
  Volume: 48
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10224
[Journal Article] Yogurt Feeding Induced the Prolongation of Fully MHC-mismatched Murine Cardiac Graft Survival by induction of CD4+Foxp3+ cells2016
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Takako Yanagisawa, Xiangyuan Jin, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Koichiro Uchida, Masafumi Kawamura, Masanori Niimi.
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10224
[Journal Article] 特発性大動脈基部破裂の 1 例2015
- Author(s)
  原真範，今水流智浩，松山重文，尾澤直美，内山雅照，池田司，下川智樹
- Journal Title
  
  日本心臓血管外科学会雑誌
  
  Volume: 44 Pages: 155-158
- NAID
  130005078170
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] 抗BTLA抗体誘導性制御性T細胞の投与によるマウス移植心生着延長効果とドナー特異的抗体産生抑制効果について2024
- Author(s)
  正岡久典、山本康人、内山雅照、井口和人、中村将啓、八木田秀雄、今水流智浩、下川智樹
- Organizer
  日本獣医学会総会
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Anti-BTLA Antibody (6B2) Induced CD4+Foxp3+ Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model2023
- Author(s)
  Masateru Uchiyama, Yasuto Yamamoto, Koichiro Uchida, Kazuhito Iguchi, Masaoka Hisanori, Hideo Yagita, Hiroo Uehara, Naomi Ozawa, Shigefumi Matsuyama, Tomohiro Imazuru.
- Organizer
  アジア移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2) Induced Indefinite Murine Cardiac Survival and Suppressed Donor-Specific Antibody.2023
- Author(s)
  Masateru Uchiyama, Yasuto Yamamoto, Koichiro Uchida, Kazuhito Iguchi, Masaoka Hisanori, Hideo Yagita, Hiroo Uehara, Naomi Ozawa, Shigefumi Matsuyama, Tomohiro Imazuru.
- Organizer
  アジア移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Anti-BTLA Antibody (6B2) Induced CD4+Foxp3+ Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model.2023
- Author(s)
  Masateru Uchiyama, Yasuto Yamamoto, Koichiro Uchida, Kazuhito Iguchi, Masaoka Hisanori, Hideo Yagita, Hiroo Uehara, Naomi Ozawa, Shigefumi Matsuyama, Tomohiro Imazuru.
- Organizer
  アジア移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Adoptive Transfer of Agonistic Anti-BTLA mAb (3C10)-Induced CD4+CD25+ Regulatory T cells Maintained Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model.2023
- Author(s)
  Masaoka Hisanori, Yasuto Yamamoto, Masateru Uchiyama, Hideo Yagita, Tomohiro Imazuru, Tomoki Shimokawa
- Organizer
  アジア移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Anti-CD80/86 Antibody (RM80/GL-1) Suppressed murine Donor Specific Antibody through anergy CD4+ T cells.2022
- Author(s)
  Yasuto Yamamoto, Koichiro Uchida, Kazuhito Iguchi, Hiroo Ota, Hironori Masaoka, Tomohiro Imazuru, Masateru Uchiyama.
- Organizer
  アメリカ移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08629
[Presentation] Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft.2019
- Author(s)
  Yasuto Yamamoto, Masateru Uchiyama, Enzhi Yin, Tomohiro Imazuru and Masanori Niimi
- Organizer
  アメリカ移植学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Anti-CD272 antibody (6B2) induced prolongation of fully MHC-mismatched murine cardiac allograft and generation of Foxp3+ regulatory T cells.2017
- Author(s)
  Masateru Uchiyama, Xiangyuan Jin, Enzhi Yin, Takako Yanagisawa, Akira Inoue, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] 7 Components of Traditional Japanese Herbal Medicines Prolonged Survival of Fully Allogeneic Cardiac Grafts in Mice.2017
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Takako Yanagisawa, Akira Inoue, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Graft protective effect of HMG-CoA reductase inhibitor Pravastatin in murine cardiac allograft transplantation.2017
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Masanori Hara, Xiangyuan Jin, Takako Yanagisawa, Akira Inoue, Shigefumi Matsuyama, Tomohiro Imazuru, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Appetite Stimulation by Rikkunshito (TJ-43) Improved Reduction of Food Intake in Murine Cardiac Transplant Model2017
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Takako Yanagisawa, Akira Inoue, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Glycyrrhizic acid in Licorice prolonged cardiac allograft survival in mice.2017
- Author(s)
  Akira Inoue, Enzhi Yin, Masateru Uchiyama, Takako Yanagisawa, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Administration of Thrombomodulin (CD141) could improve cardiac allograft survival in mice.2017
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Shigefumi Matsuyama, Xiangyuan Jin, Takako Yanagisawa, Akira Inoue, Masanori Hara, Tomohiro Imazuru, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] The effects of a traditional Chinese herbal medicine “Huaier” in murine cardiac allograft transplantation.2017
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Takako Yanagisawa, Akira Inoue, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita, Masafumi Kawamura, and Masanori Niimi
- Organizer
  アジア移植学会2017
- Place of Presentation
  フィリピン・セブ
- Year and Date
  2017-11-27
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Anti-CD272 antibody (6B2) induced prolongation of fully MHC-mismatched murine cardiac allograft and generation of Foxp3+ regulatory T cells.2016
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Takako Yanagisawa, Xiangyuan Jin, Satoko Mizuno, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita and Masanori Niimi
- Organizer
  国際移植学会2016
- Place of Presentation
  中国・香港
- Year and Date
  2016-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] A Traditional Chinese Herbal Medicine “Huaier” Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft.2016
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Takako Yanagisawa, Xiangyuan Jin, Satoko Mizuno, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita and Masanori Niimi
- Organizer
  国際移植学会2016
- Place of Presentation
  中国・香港
- Year and Date
  2016-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.2016
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Takako Yanagisawa, Xiangyuan Jin, Satoko Mizuno, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita and Masanori Niimi
- Organizer
  アメリカ移植学会2016
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)2016
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Xiangyuan Jin, Takako Yanagisawa, Xiangyuan Jin, Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Hideo Yagita and Masanori Niimi
- Organizer
  アメリカ移植学会2016
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2).2015
- Author(s)
  Enzhi Yin, Masateru Uchiyama, Xiangyuan Jin, Tomohiro Imazuru, Tomoki Shimokawa, Hideo Yagita and Masanori Niimi
- Organizer
  American transplant Congess
- Place of Presentation
  アメリカ、フィラデルフィア
- Year and Date
  2015-05-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] 当院における胸部大動脈瘤破裂・切迫破裂への緊急TEVAR2015
- Author(s)
  今水流智浩　松山重文　飯田充　尾澤直美　内山雅照　太田浩雄　原田忠宜　池田司　佐賀俊文　中川かおり　下川智樹
- Organizer
  第68回日本胸部外科学会定期学術集会
- Place of Presentation
  神戸ポートピアホテル、神戸国際展示場
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K10224
[Presentation] Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.2015
- Author(s)
  Masateru Uchiyama, Enzhi Yin, Xiangyuan Jin, Tomohiro Imazuru,Tomoki Shimokawa, Hideo Yagita and Masanori Niimi
- Organizer
  American transplant Congess
- Place of Presentation
  アメリカ、フィラデルフィア
- Year and Date
  2015-05-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10224

1. 内山雅照 (60713295)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
2. 飯田充 (20386022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 松山重文 (90713420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
4. 尾澤直美 (60713435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Imazuru Tomohiro 今水流 智浩

今水流 智浩 イマヅル トモヒロ

Research Projects

Research Products

Co-Researchers

&#61548;Establishment of combination therapy with anti-BTLA antibody and anti-PD-1 antibody for antibody mediated rejectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Graft protective effect and induction of CD4+CD25+Foxp3+ T cell by combination of anti-BTLA mAb and anti-PD-1 mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Graft protective effects and donor-specific antibody suppression by CD4+CD25+Foxp3+ regulatory T cell induced by HMG-CoA reductase inhibitor rosuvastatin in a murine heart transplant model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Graft Protective and Intercellular Immunomodulatory Effects by Adoptive Transfer of an Agonistic Anti-BTLA mAb (3C10) Induced CD4+CD25+ Regulatory T Cells in Murine Cardiac Allograft Transplant Model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Saireito (TJ-114) Suppressed Donor-Specific Antibody through Immunomodulatory Effects and Regulatory T cell Induction in a Murine Heart Transplant Model.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Surgical treatment of a huge hepatic artery aneurysm without revascularization - Case report2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Seven Japanese Herbals Prolonged Cardiac Allograft Survival.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MVR+CABP術後IEによる僧帽弁位人工弁周囲逆流を生じた症例に対し、reMVRを右開胸で施行した1例2016

Author(s)

Journal Title

Data Source

[Journal Article] Yogurt Feeding Induced the Prolongation of Fully MHC-mismatched Murine Cardiac Graft Survival by induction of CD4+Foxp3+ cells2016

Author(s)

Journal Title

Data Source

[Journal Article] 特発性大動脈基部破裂の 1 例2015

Author(s)

Journal Title

NAID

Data Source

[Presentation] 抗BTLA抗体誘導性制御性T細胞の投与によるマウス移植心生着延長効果とドナー特異的抗体産生抑制効果について2024

Author(s)

Organizer

Data Source

[Presentation] Anti-BTLA Antibody (6B2) Induced CD4+Foxp3+ Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model2023

Author(s)

Organizer

Data Source

[Presentation] Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2) Induced Indefinite Murine Cardiac Survival and Suppressed Donor-Specific Antibody.2023

Author(s)

Organizer

Data Source

[Presentation] Anti-BTLA Antibody (6B2) Induced CD4+Foxp3+ Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model.2023

Author(s)

Organizer

Data Source

[Presentation] Adoptive Transfer of Agonistic Anti-BTLA mAb (3C10)-Induced CD4+CD25+ Regulatory T cells Maintained Regulatory T cells and Suppressed Donor-Specific Antibody in Murine Cardiac Allograft Transplant Model.2023

Author(s)

Organizer

Data Source

[Presentation] Anti-CD80/86 Antibody (RM80/GL-1) Suppressed murine Donor Specific Antibody through anergy CD4+ T cells.2022

Author(s)

Organizer

Data Source

[Presentation] Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft.2019

Imazuru Tomohiro 今水流智浩

今水流智浩イマヅルトモヒロ

Establishment of combination therapy with anti-BTLA antibody and anti-PD-1 antibody for antibody mediated rejectionPrincipal Investigator