sekiya michiko 関谷倫子

… Alternative Names

Sekiya Michiko 関谷倫子

SEKIYA Michiko 関谷倫子

MICHIKO Sekiya 関谷倫子

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Researcher Number	40367412
Other IDs
Affiliation (Current)	2026: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 副部長
Affiliation (based on the past Project Information) *help	2022 – 2026: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 副部長 2021 – 2022: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 副部長 2019 – 2020: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 室長 2018: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 研究員 2015: 国立研究開発法人国立長寿医療研究センター, アルツハイマー病研究部, 研究員 … More 2014: 独立行政法人国立長寿医療研究センター, アルツハイマー病研究部, 流動研究員 2009: Nigata University of Phermacy and Applied Life Sciences, 薬学部, 助教 2008: Nigata University of Phermacy and Applied Life Sciences, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related / Pathological medical chemistry / General internal medicine (including Psychosomatic medicine) Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator ショウジョウバエ / アルツハイマー病 / グリア細胞 / 神経変性疾患 / アポリポタンパク質E / マウスモデル / バイオマーカー / 神経血管ユニット / リスク遺伝子 / アミロイドβペプチド … More / アミロイドベータ / ミトコンドリア / iNOS / HO-1 / 藤縮性側索硬化症 / 生薬 / 温脾湯 / 漢方方剤 / 筋萎縮性側索硬化症 / 東洋医学 … More Except Principal Investigator 認知症 / アルツハイマー病 / ショウジョウバエ / 神経炎症 / グリア細胞 / 軸索変性 / セロトニン神経系 / アミロイドβ病理 / 抑うつ症状 / 神経軸索変性 / ノルアドレナリン神経 / 青斑核 / アミノ酸 / 貪食活性 / 神経変性疾患 / 食餌 / 神経変性 / 老化 / アストロサイト / マウス / アミロイドβ Less

脳老化に伴うグリア細胞の変容が介在する細胞外アミロイド形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  関谷倫子
- Project Period (FY)
  2026 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
APOEの遺伝的多様性と環境要因の相互作用が寿命と疾患感受性へ与える影響Principal Investigator
- Principal Investigator
  
  関谷倫子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
神経血管ユニットを構成するグリア終足分子のアルツハイマー病病理形成における役割Principal Investigator
- Principal Investigator
  
  関谷倫子
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
老年性認知症の抑うつ症状の原因となるセロトニン神経軸索変性の機序解明
- Principal Investigator
  
  榊原泰史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
アルツハイマー病初期の神経血管ユニットの破綻と青斑核神経細胞の軸索変性の機序解明
- Principal Investigator
  
  飯島浩一
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
Promoting brain health by enhancement of glial phagocytosis through dietary amino acids
- Principal Investigator
  
  Iijima Koichi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
Roles of reactive astrocyte in AD pathogenesis
- Principal Investigator
  
  IIJIMA Koichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
Genetic screen for disease-associated genes in glial cells using a novel Drosophila model of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Sekiya Michiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Center for Geriatrics and Gerontology
Mismetabolism of mitochondrial proteins in a Drosophila model of neurodegenerative disorder.Principal Investigator
- Principal Investigator
  
  SEKIYA Michiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Searching for therapeutical agents of ALS from Natural resources.Principal Investigator
- Principal Investigator
  
  MICHIKO Sekiya
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Nigata University of Phermacy and Applied Life Sciences

All 2025 2024 2023 2022 2021 2020 2019 2009 2008 Other

All Journal Article Presentation

[Journal Article] アルツハイマー病の遺伝学的リスク因子と診断・治療への薬理遺伝学的な意義2024
- Author(s)
  関谷倫子、飯島浩一
- Journal Title
  
  Farumashia
  
  Volume: 60 Issue: 3 Pages: 197-202
- DOI
  10.14894/faruawpsj.60.3_197
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24224
[Journal Article] Supplementation of essential amino acids suppresses age-associated sleep loss and sleep fragmentation but not loss of rhythm strength under yeast-restricted malnutrition in <i>Drosophila</i>2024
- Author(s)
  Chikamatsu Sachie、Sakakibara Yasufumi、Takei Kimi、Nishijima Risa、Iijima Koichi M、Sekiya Michiko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 177 Issue: 3 Pages: 225-237
- DOI
  10.1093/jb/mvae090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24224, KAKENHI-PROJECT-24K14693
[Journal Article] Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease2024
- Author(s)
  Sekiya Michiko、Sakakibara Yasufumi、Hirota Yu、Ito Naoki、Chikamatsu Sachie、Takei Kimi、Nishijima Risa、Iijima Koichi M.
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 202 Pages: 106694-106694
- DOI
  10.1016/j.nbd.2024.106694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18427, KAKENHI-PROJECT-23K24224, KAKENHI-PROJECT-23K27982, KAKENHI-PROJECT-24K14693
[Journal Article] Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology2023
- Author(s)
  Hirota Yu、Sakakibara Yasufumi、Takei Kimi、Nishijima Risa、Sekiya Michiko、Iijima Koichi M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 93 Issue: 3 Pages: 1065-1081
- DOI
  10.3233/jad-230121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224, KAKENHI-PROJECT-20H03571
[Journal Article] Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration2023
- Author(s)
  Sakakibara Yasufumi、Yamashiro Risa、Chikamatsu Sachie、Hirota Yu、Tsubokawa Yoko、Nishijima Risa、Takei Kimi、Sekiya Michiko、Iijima Koichi M.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 2 Pages: 105968-105968
- DOI
  10.1016/j.isci.2023.105968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224, KAKENHI-PROJECT-20H03571
[Journal Article] Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in <i>App</i> knock-in mouse models of amyloid-β amyloidosis2022
- Author(s)
  Hirota Yu、Sakakibara Yasufumi、Ibaraki Kyoko、Takei Kimi、Iijima Koichi M、Sekiya Michiko
- Journal Title
  
  Brain Communications
  
  Volume: 4 Issue: 6
- DOI
  10.1093/braincomms/fcac286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224, KAKENHI-PROJECT-20H03571
[Journal Article] Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease2021
- Author(s)
  Wang Minghui, Li Aiqun, Sekiya Michiko and et.al.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 2 Pages: 257-272.e14
- DOI
  10.1016/j.neuron.2020.11.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07517
[Journal Article] Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity2021
- Author(s)
  M. Sekiya, K.M. Iijima
- Journal Title
  
  STAR Protocols
  
  Volume: - Issue: 2 Pages: 100501-100501
- DOI
  10.1016/j.xpro.2021.100501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07517
[Journal Article] Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration.2020
- Author(s)
  Masataka Kikuchi, Michiko Sekiya, Norikazu Hara, Akinori Miyashita, Ryozo Kuwano, Takeshi Ikeuchi, Koichi M Iijima, Akihiro Nakaya
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 5 Pages: 817-833
- DOI
  10.1093/hmg/ddz320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07517, KAKENHI-PROJECT-17K15049
[Journal Article] Xanthones from Hypericum chinense and their cytotoxicity evaluation.2009
- Author(s)
  Tanaka N, Kashiwada Y, Kim SY, Sekiya M, Ikeshiro Y, Takaishi Y.
- Journal Title
  
  Phytochemistry 70(11-12)
  
  Pages: 1456-1461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Xanthones from Hypericum chinense and their cytotoxicity evaluation.2009
- Author(s)
  Tanaka N, Kashiwada Y, Kim SY, Sekiya M, Ikeshim Y, Takaishi Y
- Journal Title
  
  Phytochemistry 70
  
  Pages: 1456-1461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.2009
- Author(s)
  Tanaka N, Kashiwada Y, Kim SY, Hashida W, Sekiya M, Ikeshiro Y, Takaishi Y
- Journal Title
  
  Journal of Natural Products 72
  
  Pages: 1447-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities2009
- Author(s)
  Tanaka N, Kashiwada Y, Nakano T, Shibata H, Higuchi T, Sekiya M, Ikeshiro Y, Takaishi Y
- Journal Title
  
  Phytochemistry 70
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in ALS Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord.2009
- Author(s)
  Sekiya M, Ichiyanagi T, Ikeshiro Y, Yokozawa T
- Journal Title
  
  Biological & Pharmaceutical Bulletin 32
  
  Pages: 382-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities.2009
- Author(s)
  Tanaka N, Kashiwada Y, Nakano T, Shibata H, Higuchi T, Sekiya M, Ikeshiro Y, Takaishi Y.
- Journal Title
  
  Phytochemistry 70(1)
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in ALS Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord2009
- Author(s)
  Sekiya M, Ichiyanagi T, Ikeshiro Y, Yokozawa T
- Journal Title
  
  Biological & Pharmaceutical Bulletin 32
  
  Pages: 382-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.2009
- Author(s)
  Tanaka N, Kashiwada Y, Kim SY, Hashida W, Sekiya M, Ikeshiro Y, Takaishi Y.
- Journal Title
  
  Journal of Natural Products 72(8)
  
  Pages: 1447-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in ALS Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord.2009
- Author(s)
  Sekiya M, Ichiyanagi T, Ikeshiro Y, Yokozawa T.
- Journal Title
  
  Biological & Pharmaceutical Bulletin 32(3)
  
  Pages: 382-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Effect on both aglycone and sugar moiety towards PhaseIImetabolism of anthocyanins.2008
- Author(s)
  Ichiyanagi T, Shida Y, Rahman MM, Sekiya M, Hatano Y, Mtsumoto H, Hirayama M, Konishi T, Ikeshiro Y.
- Journal Title
  
  Food Chemistry 110(2)
  
  Pages: 493-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Active Compounds Isolated from Traditional Chinese Prescription Wen-Pi-Tang Protecting Against Peroxynitrite-Induced LLC-PK_1 Cell Damage2008
- Author(s)
  Rhyu DY, Kang KS, Sekiya M, Tanaka T, Park JC, Yokozawa T
- Journal Title
  
  The American Journal of Chinese Medicine 36
  
  Pages: 761-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron.2008
- Author(s)
  Hashida W, Tanaka N, Kashiwada Y, Sekiya M, Ikeshiro Y, Takaishi Y.
- Journal Title
  
  Phytochemistry 69(11)
  
  Pages: 2225-2230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron2008
- Author(s)
  Hashida W, Tanaka N, Kashiwada Y, Sekiya M, Ikeshiro Y, Takaishi Y
- Journal Title
  
  Phytochemistry 69
  
  Pages: 2225-2230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Active Compounds Isolated from Traditional Chinese Prescription Wen-Pi-Tang Protecting Against Peroxynitrite-Induced LLC-PK1 Cell Damage.2008
- Author(s)
  Rhyu DY, Kang KS, Sekiya M, Tanaka T, Park JC, Yokozawa T.
- Journal Title
  
  The American Journal of Chinese Medicine 36(4)
  
  Pages: 761-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Journal Article] Takaneones A-C, prenylated butylphloroglucinol derivatives from Hypericum sikokumontanum.2008
- Author(s)
  Tanaka N, Kashiwada Y, Sekiya M, Ikeshiro Y, Takaishi Y.
- Journal Title
  
  Tetrahedron Letters 49(17)
  
  Pages: 2799-2803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] Tyrobp deficiency exacerbates degeneration of axons from subcortical cholinergic and noradrenergic nuclei in a mouse model of Aβ pathology2025
- Author(s)
  山本洵、廣田湧、高鳥翔、榊原泰史、竹井喜美、佐治多美子、関谷倫子、富田泰輔、飯島浩一
- Organizer
  名古屋市立大学　2024年度IBSリトリート
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] 老化とアミロイドβ蓄積に伴う大脳皮質での青斑核ノルアドレナリン神経軸索の変性様式2024
- Author(s)
  榊原泰史、廣田湧、森島真帆、佐野輝典、高尾昌樹、村山繁雄、齊藤祐子、関谷倫子、飯島浩一
- Organizer
  第43回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] アミロイド病理モデルマウスにおける血漿中ニコチンアミドの減少とアミロイド斑周囲のグリア細胞でのNAD+代謝の変化2024
- Author(s)
  廣田　湧，榊原泰史，伊藤尚基，竹井喜美，近松幸枝，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  6NCリトリート 2024
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Reduced plasma nicotinamide level and altered NAD+ metabolism in glial cells surrounding Aβ plaques in the mouse model of Alzheimer’s disease2024
- Author(s)
  Michiko Sekiya, Yasufumi Sakakibara, Yu Hirota, Naoki Ito, Kimi Takei, Sachie Chikamatsu, Risa Nishijima and Koichi M. Iijima
- Organizer
  AAIC 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] アミロイド病理モデルマウスにおける血漿中ニコチンアミドの減少とアミロイド斑周囲のグリア細胞でのNAD+代謝の変化2024
- Author(s)
  廣田湧、榊原泰史、伊藤尚基、近松幸枝、竹井喜美、西島里咲、飯島浩一、関谷倫子
- Organizer
  6NCリトリート2024
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] アルツハイマー型認知症のプレクリニカル期を検出する体液バイオマーカーと脳病態の関係2024
- Author(s)
  関谷倫子
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Reduced plasma nicotinamide level and altered NAD+ metabolism in glial cells surrounding Aβ plaques in the mouse model of Alzheimer’s disease2024
- Author(s)
  Michiko Sekiya, Yasufumi Sakakibara, Yu Hirota, Naoki Ito, Kimi Takei, Sachie Chikamatsu, Risa Nishijima, Koichi M. Iijima
- Organizer
  The Alzheimer's Association International Conference 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] アルツハイマー病プレクリニカル期におけるバイオマーカーリン酸化タウの脳内局在解析2024
- Author(s)
  廣田湧、榊原泰史、森島真帆、佐野輝典、高尾昌樹、村山繁雄、齊藤祐子、飯島浩一、関谷倫子
- Organizer
  第43回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] アミロイド病理モデルマウスにおける血漿中ニコチンアミドの減少とアミロイド斑周囲のグリア細胞でのNAD+代謝の亢進2024
- Author(s)
  関谷倫子、榊原泰史、廣田湧、伊藤尚基、近松幸枝、竹井喜美、西島里咲、飯島浩一
- Organizer
  国立長寿医療研究センター　第9回サマーリサーチセミナー
- Data Source
  KAKENHI-PROJECT-24K14693
[Presentation] Mechanisms underlying reductions of serotonergic axon projections to the cortex in App knock-in mouse model of Aβ pathology2024
- Author(s)
  Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iiji
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] ショウジョウバエモデルを用いた加齢時の睡眠障害の発症機序に関する研究2024
- Author(s)
  近松幸枝，竹井喜美，西島里咲, 佐治多美子, 粂和彦, 飯島浩一, 関谷倫子
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau 181 signals localize to demyelinated axons of parvalbumin-positive GABAergic interneurons in App knock-in mouse2023
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Koichi M. Iijima, Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference 2023 (AAIC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] アミロイド病理モデルマウスにおける縫線核セロトニン作動性神経の変性機序の解析2023
- Author(s)
  榊原泰史，廣田湧，茨木京子，竹井喜美，西島里咲，関谷倫子，飯島浩一
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] A Drosophila model of tau accumulation in noradrenaline/octopamine neurons2023
- Author(s)
  Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Kazuhiko Keme, Koichi M. Iijima, Michiko Sekiya
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] アミロイド病理が引き起こすアストロサイトの変容と神経血管ユニットの破綻2023
- Author(s)
  関谷倫子
- Organizer
  第96回日本生化学会大会，シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Biomarker-related phospho-tau 181 signals localize to axons of myelinated neurons but not unmyelinated neurons in App knock-in mouse2023
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Toll-like receptor exerts neuroprotection through p38 MAPK/SAPK in Drosophila model of tauopathy2023
- Author(s)
  Yasufumi Sakakibara, Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] 脳内のAβ病理を反映する血液・髄液バイオマーカーリン酸化タウの脳内局在解析2023
- Author(s)
  廣田湧，榊原泰史，茨木京子，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Reduced density of serotonergic axons without prominent neuron loss or tau pathology in the dorsal raphe nucleus in App knock-in mouse models of amyloid-β pathology2023
- Author(s)
  Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's Association International Conference 2023 (AAIC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau181 signals are localized to myelinated axons of parvalbumin-positive interneurons in an App knock-in mouse model of amyloid-β pathology2023
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau 181 signals localize to demyelinated axons of parvalbumin-positive GABAergic interneurons in App knock-in mouse models of amyloid-β amyloidosis2023
- Author(s)
  Hirota Y., Sakakibara, Y., Takei, K., Nishijima, R., Sekiya, M., Iijima, K.M.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] A Drosophila ortholog of Toll-like receptors modulates c-Jun N-terminal kinase signaling and protects against tau-mediated neurodegeneration independent of innate immune response2022
- Author(s)
  Yasufumi Sakakibara，Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] ノルアドレナリン/オクトパミン神経に着目したアルツハイマー病タウ毒性モデルショウジョウバエの確立2022
- Author(s)
  近松幸枝，坪川陽子，西島里咲，竹井喜美，粂和彦，飯島浩一，関谷倫子
- Organizer
  第86回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] アミロイド病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析2022
- Author(s)
  関谷倫子，廣田　湧，榊原泰史，茨木京子，竹井喜美，飯島浩一
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] A Drosophila ortholog of Toll-like receptors modulates c-Jun N-terminal kinase signaling and protects against tau-mediated neurodegeneration independent of innate immune response2022
- Author(s)
  Yasufumi Sakakibara，Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] ウォルフラム症候群の原因遺伝子WFS1の欠損が加齢性脳病理に及ぼす影響の解析2022
- Author(s)
  榊原泰史，廣田湧，茨木京子，竹井喜美，西島里咲，田部勝也，谷澤幸生，関谷倫子，飯島浩一
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] 加齢ショウジョウバエの脳内浄化システムと寿命制御に関わるグリア細胞由来分泌因子の同定と解析2022
- Author(s)
  山城梨沙，関谷倫子，飯島浩一
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Reduced density of cholinergic fibers in App knock-in mouse models of Aβ amyloidosis2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Risa Nishijima, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Biomarker-related phospho-tau 181 signals localize to axons of myelinated neurons but not unmyelinated neurons in App knock-in mouse2022
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] 網羅的遺伝子発現解析によるアルツハイマー病早期変動遺伝子の同定2022
- Author(s)
  菊地正隆，廣田湧，原範和，榊原泰史，関谷倫子，宮下哲典，池内健，飯島浩一
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Toll-like receptor exerts neuroprotection through p38 MAPK/SAPK in Drosophila model of tauopathy2022
- Author(s)
  Yasufumi Sakakibara, Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] ショウジョウバエToll受容体9は自然免疫応答には影響を与えずJNKシグナル伝達経路を調節し神経保護作用を発揮する2022
- Author(s)
  山城梨沙，榊原泰史，近松幸枝，坪川陽子，西島里咲，竹井喜美，関谷倫子，飯島浩一
- Organizer
  第86回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Reduced density of cholinergic fibers in App knock-in mouse models of Aβ amyloidosis2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Risa Nishijima, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Aβ病理を呈するAppノックインマウスにおけるコリン作動性神経軸索の変性2022
- Author(s)
  廣田湧，榊原泰史，茨木京子，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] ノルアドレナリン／オクトパミン神経に着目したタウ毒性モデルショウジョウバエの確立2022
- Author(s)
  近松幸枝，坪川陽子，西島里咲，竹井喜美，粂和彦，飯島浩一，関谷倫子
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] アミロイド病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析，（シンポジウム，認知症のcomplexity：その理解と治療介入へ向けて）2022
- Author(s)
  関谷倫子，廣田湧，榊原泰史，茨木京子，竹井喜美，飯島浩一
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] Aβ病理を呈するAppノックインマウスにおけるコリン作動性神経軸索の変性2022
- Author(s)
  廣田　湧，榊原泰史，茨木京子，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Aβ病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Koichi M. Iijima，Michiko Sekiya
- Organizer
  Neuro2022（第45回日本神経科学大会，第65回日本神経化学会大会，第32回日本神経回路学会大会，合同）
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Aβ病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Koichi M. Iijima，Michiko Sekiya
- Organizer
  Neuro2022（第45回日本神経科学大会，第65回日本神経化学会大会，第32回日本神経回路学会大会，合同）
- Data Source
  KAKENHI-PROJECT-20H03571
[Presentation] SULFONYLUREA RECEPTOR/SUR DEFICIENCY INCREASED VULNERABILITY TO NEURODEGENERATION IN DROSOPHILA MODELS OF ALZHEIMER’S DISEASE2020
- Author(s)
  Michiko Sekiya, Xiuming Quan, Yasufumi Sakakibara, Sachie Chikamatsu, Koichi M. Iijima
- Organizer
  The 15th International Conference on Alzheimer’s and Parkinson’s Diseases (ADPD 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] 遺伝子ネットワーク解析を用いたアルツハイマー病の発症機序解明と創薬標的の探索2020
- Author(s)
  関谷倫子，Wang Minghui，榊原泰史，近松幸枝，Zhang Bin，飯島浩一
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] アルツハイマー病におけるATP感受性K+チャネル機能の役割2020
- Author(s)
  関谷倫子，権秀明，榊原泰史，近松幸枝，飯島浩一
- Organizer
  第39 回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] Deficiency in a fly ortholog of HS-Aging related gene, sulfonylurea receptor/Sur, increased vulnerability to neurodegeneration in Drosophila models of Alzheimer’s disease2020
- Author(s)
  Michiko Sekiya, Xiuming Quan, Yasufumi Sakakibara, Sachie Chikamatsu, Koichi M. Iijima
- Organizer
  Alzheimer's Association International Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] 新規アルツハイマー病モデルショウジョウバエの作製2019
- Author(s)
  関谷倫子，榊原泰史，近松幸枝，飯島浩一
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] A Drosophila model of Alzheimer's disease2019
- Author(s)
  Michiko Sekiya
- Organizer
  The 5th NCGG ICAH symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] A novel Drosophila model of Alzheimer’s disease2019
- Author(s)
  Michiko Sekiya, Yasufumi Sakakibara, Sachie Chikamatsu, Koichi M. Iijima
- Organizer
  AAIC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07517
[Presentation] 筋萎縮性側索硬化症モデルにおける温脾湯の抗酸化を介した作用2009
- Author(s)
  関谷倫子, 横澤隆子
- Organizer
  グアニジノ化合物研究会
- Place of Presentation
  筑波
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(3)-かきのもとの分化促進作用成分について-2009
- Author(s)
  鎌倉孝法, 三浦恵理, 柏田良樹, 関谷倫子, 一柳孝司, 池城安正, 高石喜久
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(4)-青ジソ根部の分化抑制作用成分について-2009
- Author(s)
  佐々木久子, 阿部有里子, 柏田良樹, 関谷倫子, 池城安正, 高石喜久
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 筋萎縮性側索硬化症モデルにおける温脾湯の抗酸化を介した作用2009
- Author(s)
  関谷倫子, 横澤隆子
- Organizer
  第30回グアニジノ化合物研究会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(4) -青ジソ根部の分化抑制作用成分について-2009
- Author(s)
  佐々木久子, 阿部有里子, 柏田良樹, 関谷倫子, 池城安正, 高石喜久
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(3) -かきのもとの分化促進作用成分について-2009
- Author(s)
  鎌倉孝法, 三浦恵理, 柏田良樹, 関谷倫子, 一柳孝司, 池城安正, 高石喜久
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 筋萎縮性側索硬化症モデルマウスを用いた温脾湯の検討(2)2009
- Author(s)
  関谷倫子, 一柳孝司, 池城安正, 東田千尋, 横澤隆子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] アントシアニンの構造と消化管吸収の関係2008
- Author(s)
  一柳孝司, 関谷倫子, 田原愛, 波田野義比古, 池城安正
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] スイゼンジナ(Gynura bicolor DC. )に含まれる抗酸化成分の研究(その1)2008
- Author(s)
  田原愛, 一柳孝司, 関谷倫子, 池城安正
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] 筋萎縮性側索硬化症モデルマウスを用いた温脾湯の検討2008
- Author(s)
  関谷倫子, 田原愛, 一柳孝司, 池城安正, 東田千尋, 横澤隆子
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790478
[Presentation] ALTERED PROTEOSTASIS ENVIRONMENT CAUSES MISMETABOLISM OF MITOCHONDRIAL PROTEINS IN A DROSOPHILA MODEL OF ALZHEIMER’S DISEASE
- Author(s)
  Michiko Sekiya, Akiko Maruko-Otake, Emiko Suzuki, Kanae Ando, Koichi M. Iijima
- Organizer
  12th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-18 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-26870921

1. IIJIMA Koichi (50632535)

# of Collaborated Projects: 5 results

# of Collaborated Products: 32 results
2. 榊原泰史 (20734099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 伊藤尚基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sekiya michiko 関谷 倫子

Sekiya Michiko 関谷 倫子

SEKIYA Michiko 関谷 倫子

MICHIKO Sekiya 関谷 倫子

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脳老化に伴うグリア細胞の変容が介在する細胞外アミロイド形成メカニズムの解明Principal Investigator

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APOEの遺伝的多様性と環境要因の相互作用が寿命と疾患感受性へ与える影響Principal Investigator

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神経血管ユニットを構成するグリア終足分子のアルツハイマー病病理形成における役割Principal Investigator

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老年性認知症の抑うつ症状の原因となるセロトニン神経軸索変性の機序解明

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アルツハイマー病初期の神経血管ユニットの破綻と青斑核神経細胞の軸索変性の機序解明

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Promoting brain health by enhancement of glial phagocytosis through dietary amino acids

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Roles of reactive astrocyte in AD pathogenesis

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Genetic screen for disease-associated genes in glial cells using a novel Drosophila model of Alzheimer's diseasePrincipal Investigator

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Mismetabolism of mitochondrial proteins in a Drosophila model of neurodegenerative disorder.Principal Investigator

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Searching for therapeutical agents of ALS from Natural resources.Principal Investigator

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[Journal Article] アルツハイマー病の遺伝学的リスク因子と診断・治療への薬理遺伝学的な意義2024

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[Journal Article] Supplementation of essential amino acids suppresses age-associated sleep loss and sleep fragmentation but not loss of rhythm strength under yeast-restricted malnutrition in <i>Drosophila</i>2024

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[Journal Article] Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease2024

sekiya michiko 関谷倫子

Sekiya Michiko 関谷倫子

SEKIYA Michiko 関谷倫子

MICHIKO Sekiya 関谷倫子