Hino Tomoya 日野智也

… Alternative Names

HINO Tomoya 日野智也

日野智也ヒノトモヤ

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Researcher Number	40373360
Other IDs	https://orcid.org/0000-0002-8813-4622
Affiliation (Current)	2024: 鳥取大学, 工学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 鳥取大学, 工学研究科, 准教授 2015: 鳥取大学, 工学(系)研究科(研究院), 准教授 2014: 鳥取大学, 大学院工学研究科, 講師 2011 – 2014: 鳥取大学, 工学(系)研究科(研究院), 講師 2012: 鳥取大学, 大学院・工学研究科, 講師 … More 2012: 鳥取大学, 工学研究科, 講師 2007: 独立行政法人理化学研究所, 城生体金属科学研究室, 客員研究員 2006: 独立行政法人理化学研究所, 城生体金属科学研究室, 協力研究員 2004 – 2005: 独立行政法人理化学研究所, 城生体金属科学研究室, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Complex systems / Basic Section 43040:Biophysics-related / Structural biochemistry / Functional biochemistry Except Principal Investigator Basic Section 52010:General internal medicine-related / Broad Section D / Science and Engineering / Structural biochemistry / Living organism molecular science
Keywords	Principal Investigator X線結晶構造解析 / イオンチャネル / TRPチャネル / 膜タンパク質 / クライオ電子顕微鏡 / 赤外分光 / 温度感受性タンパク質 / 温度感知タンパク質 / シリアルフェムト秒X線結晶構造解析 / 赤外分光法 … More / クライオ電顕 / 結晶化 / 機能性抗体 / 温度受容 / 構造生物学 / 温度感知 / 立体構造解析 / 酵母 / タンパク質発現 / タンパク質精製 / 分子進化 / 抗体 / 呼吸酵素 / 亜酸化窒素 / 一酸化窒素還元酵素 / 膜蛋白質 / 金属タンパク質 … More Except Principal Investigator ペプチド / エピトープ / 甲状腺癌 / 自己抗体 / ヘム / タンパク質 / 人工抗体 / 1分子シークエンス / 副腎皮質癌 / 悪性褐色細胞腫 / バイオナーカー / 診断 / バイオマーカー / X線構造解析 / 立体構造 / 合成ペプチド / ELISA / 予後 / coordination Chemistry / Metal-enzymes / Signal Transduction / Bio-synthesis / Metalloproteins / 非ヘム鉄 / 脱窒 / 一酸化窒素 / エチレンセンサー蛋白質 / 酵素センサー蛋白質 / ヒスチジンキナーゼ / 金属配位空間 / 感染症 / 老人性白内障 / キヌレニン経路 / トリプトファン代謝 / 配位構造 / X線結晶構造解析 / 一酸化窒素還元酵素 / センサー蛋白質 / 二成分情報伝達系 / 二原子酸素添加酵素 / ヘム鉄 / 配位化学 / 情報変換 / 金属蛋白質 / 物質変換 / 金属酵素 / ヒスタミン / 結晶構造解析 / GPCR / 花粉症 / アレルギー / 結晶構造 / 呼吸酵素 / 窒素循環 / 分子進化 / 呼吸 Less

Development of single-molecule peptide sequencing method
- Principal Investigator
  
  村上裕
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  Nagoya University
血液中の自己抗体を用いた難治性内分泌腫瘍の新規悪性度判定法開発
- Principal Investigator
  
  伊澤正一郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
高速分子動画でTRPチャネルの温度センサー部位を見極めるPrincipal Investigator
- Principal Investigator
  
  日野智也
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tottori University
高速分子動画撮影によるTRPチャネルの熱刺激応答機構の解明Principal Investigator
- Principal Investigator
  
  日野智也
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tottori University
Structural basis for multimodal sensation in TRP channelsPrincipal Investigator
- Principal Investigator
  
  HINO Tomoya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Tottori University
New diagnostic methods for detecting autoantibodies against thyroid carcinoma with poor prognosis
- Principal Investigator
  
  IZAWA Shoichiro
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Structural biology of thermosensation in humanPrincipal Investigator
- Principal Investigator
  
  Hino Tomoya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Structure determination of histamine H1 receptor
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Structural study on the generation mechanism of nitrous oxide by integral membrane protein nitric oxide reductasePrincipal Investigator
- Principal Investigator
  
  HINO Tomoya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tottori University
Crystallographic Studies on the Short-lived Respiratory Enzyme-Substrate Complex
- Principal Investigator
  
  NAGANO Shingo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
Bio-conversion of Substances and Information by Metal-containing Proteins and Enzymes
- Principal Investigator
  
  SHIRO Yoshitsugu
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2016 2015 2013 2012 2011 2006 2004

All Journal Article Presentation Patent

[Journal Article] Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins2023
- Author(s)
  Uegaki Tesshin、Takei Taisei、Yamaguchi Shuhei、Fujiyama Keisuke、Sato Yusuke、Hino Tomoya、Nagano Shingo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 1 Pages: 744-744
- DOI
  10.3390/ijms24010744
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H04753
[Journal Article] Crystal structure of the adenylation domain from an ε-poly-l-lysine synthetase provides molecular mechanism for substrate specificity2022
- Author(s)
  Takaki Okamoto, Kazuya Yamanaka, Yoshimitsu Hamano, Shingo Nagano, TomoyaHino*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 596 Pages: 43-48
- DOI
  10.1016/j.bbrc.2022.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05780, KAKENHI-PUBLICLY-20H05445
[Journal Article] Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes2022
- Author(s)
  Nagata Ryuhei、Suemune Hironori、Kobayashi Masaya、Shinada Tetsuro、Shin‐ya Kazuo、Nishiyama Makoto、Hino Tomoya、Sato Yusuke、Kuzuyama Tomohisa、Nagano Shingo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 20
- DOI
  10.1002/anie.202117430
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05445, KAKENHI-PUBLICLY-21H00283, KAKENHI-PROJECT-19J00870
[Journal Article] Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity2022
- Author(s)
  Hironori Suemune, Doukan Nishimura, Kenjiro Mizutani, Yusuke Sato, Tomoya Hino, Hiroshi Takagi, Yumi Shiozaki-Sato, Shunji Takahashi*, Shingo Nagano*
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 593 Pages: 144-150
- DOI
  10.1016/j.bbrc.2022.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05780, KAKENHI-PUBLICLY-20H05445, KAKENHI-PUBLICLY-21H00283, KAKENHI-PROJECT-22KK0080, KAKENHI-PROJECT-20H00416, KAKENHI-PROJECT-21K19099
[Journal Article] Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes2022
- Author(s)
  Nagata Ryuhei、Suemune Hironori、Kobayashi Masaya、Shinada Tetsuro、Shin‐ya Kazuo、Nishiyama Makoto、Hino Tomoya、Sato Yusuke、Kuzuyama Tomohisa、Nagano Shingo
- Journal Title
  
  Angewandte Chemie
  
  Volume: 134 Issue: 20
- DOI
  10.1002/ange.202117430
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H04753
[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022
- Author(s)
  Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
- Journal Title
  
  Cell Rep.
  
  Volume: 40(11) Issue: 11 Pages: 111323-111323
- DOI
  10.1016/j.celrep.2022.111323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428, KAKENHI-PUBLICLY-22H04753
[Journal Article] Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons2021
- Author(s)
  Fujiyama Keisuke、Kato Naoki、Re Suyong、Kinugasa Kiyomi、Watanabe Kohei、Takita Ryo、Nogawa Toshihiko、Hino Tomoya、Osada Hiroyuki、Sugita Yuji、Takahashi Shunji、Nagano Shingo
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 41 Pages: 22401-22410
- DOI
  10.1002/anie.202106186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06992, KAKENHI-PROJECT-19K12229, KAKENHI-PROJECT-20K15273, KAKENHI-PLANNED-19H05780, KAKENHI-PUBLICLY-20H05445, KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-20K05872, KAKENHI-PROJECT-21K19099, KAKENHI-PROJECT-19H05645, KAKENHI-PROJECT-20H00416, KAKENHI-PLANNED-17H06412
[Journal Article] Applicability of Styrene-Maleic Acid Copolymer for Two Microbial Rhodopsins, RxR and HsSRI.2020
- Author(s)
  Tetsuya Ueta, Keiichi Kojima, Tomoya Hino, Mikihiro Shibata, Shingo Nagano, Yuki Sudo*
- Journal Title
  
  Biophysical journal
  
  Volume: 119 Issue: 9 Pages: 1760-1770
- DOI
  10.1016/j.bpj.2020.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21122, KAKENHI-PROJECT-20K21482, KAKENHI-PUBLICLY-19H04727, KAKENHI-PUBLICLY-19H05257, KAKENHI-PUBLICLY-19H05396, KAKENHI-PUBLICLY-20H05445, KAKENHI-PROJECT-18H01836, KAKENHI-PROJECT-18H02411, KAKENHI-PROJECT-18K06156, KAKENHI-PROJECT-19K16090
[Journal Article] A novel method for detecting autoantibody to wd repeat domain 1: Clinical application for differentiating papillary thyroid carcinoma with poor clinical outcome2020
- Author(s)
  Izawa Shoichiro、Matsuzawa Kazuhiko、Matsumoto Kazuhisa、Fukaya Kenji、Fukuhara Takahiro、Wakahara Makoto、Koga Atsuro、Hino Tomoya、Yamamoto Kazuhiro
- Journal Title
  
  Endocrine Abstracts
  
  Volume: 70
- DOI
  10.1530/endoabs.70.aep957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07445
[Journal Article] Unique features of the ketosynthase domain in a nonribosomal peptide synthetase?polyketide synthase hybrid enzyme, tenuazonic acid synthetase 12020
- Author(s)
  Yun Choong-Soo、Nishimoto Kazuki、Motoyama Takayuki、Shimizu Takeshi、Hino Tomoya、Dohmae Naoshi、Nagano Shingo、Osada Hiroyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 33 Pages: 11602-11612
- DOI
  10.1074/jbc.ra120.013105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07742, KAKENHI-PROJECT-18K05420, KAKENHI-PROJECT-20K05820, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-18K06156
[Journal Article] The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism2020
- Author(s)
  Shimada Hiroto*、Kusakizako Tsukasa*、Dung Nguyen T. H.、Nishizawa Tomohiro、Hino Tomoya、Tominaga Makoto、Nureki Osamu (*equal contribution)
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 27 Issue: 7 Pages: 645-652
- DOI
  10.1038/s41594-020-0439-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15754, KAKENHI-PUBLICLY-20H05445, KAKENHI-PROJECT-20J13609, KAKENHI-PROJECT-18K06156, KAKENHI-PROJECT-16H06294
[Journal Article] Crystal structure of D-stereospecific amidohydrolase from Streptomyces sp. 82F2: insight into the structural factors for substrate specificity.2016
- Author(s)
  Arima J, Shimone K, Miyatani K, Tsunehara Y, Isoda Y, Hino T, Nagano S
- Journal Title
  
  FEBS Journal
  
  Volume: 283 Issue: 2 Pages: 337-349
- DOI
  10.1111/febs.13579
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06581, KAKENHI-PROJECT-26450124, KAKENHI-PROJECT-25291015, KAKENHI-PROJECT-25711004
[Journal Article] Crystal structure of the anion exchanger domain of human erythrocyte band 32015
- Author(s)
  Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S
- Journal Title
  
  Science
  
  Volume: 350 Issue: 6261 Pages: 680-684
- DOI
  10.1126/science.aaa4335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08632, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25460398, KAKENHI-PROJECT-26305027, KAKENHI-PROJECT-25711004
[Journal Article] The crystal structure of heme acquisition system A from Yersinia pseudotuberculosis (HasA ypt): Roles of the axial ligand Tyr75 and two distal arginines in heme binding2015
- Author(s)
  Kanadani M., Sato T., Hino T., Nagano S., Ozaki S.
- Journal Title
  
  Journal of inorganic biochemistry
  
  Volume: 151 Pages: 26-33
- DOI
  10.1016/j.jinorgbio.2015.07.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25711004
[Journal Article] Structure and mechanism of the mammalian fructose transporter GLUT52015
- Author(s)
  Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D
- Journal Title
  
  Nature
  
  Volume: 526 Issue: 7573 Pages: 397-401
- DOI
  10.1038/nature14909
- NAID
  120005657713
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06968, KAKENHI-PLANNED-24108007, KAKENHI-PUBLICLY-26102725, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-25711004
[Journal Article] Crystal structures of the human adiponectin receptors.2015
- Author(s)
  Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S
- Journal Title
  
  Nature
  
  Volume: 520 Issue: 7547 Pages: 312-316
- DOI
  10.1038/nature14301
- NAID
  40020952688
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01507, KAKENHI-PROJECT-26253058, KAKENHI-PROJECT-26293216, KAKENHI-PROJECT-25711004, KAKENHI-PROJECT-26713032, KAKENHI-PROJECT-26000012
[Journal Article] Generation of functional antibodies for mammalian membrane protein crystallography.2013
- Author(s)
  Hino T, Iwata S, Murata T.
- Journal Title
  
  Curr Opin Struct Biol.
  
  Volume: 23 Issue: 4 Pages: 563-568
- DOI
  10.1016/j.sbi.2013.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24121715, KAKENHI-PROJECT-24370044
[Journal Article] Molecular Structure and Function of Bacterial Nitric Oxide Reductase2012
- Author(s)
  Hino T., Nagano S., Sugimoto H., Tosha T., Shiro Y.
- Journal Title
  
  Biochem. Biophys. Acta Bioenergetics
  
  Volume: 1817 Pages: 680-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus2012
- Author(s)
  Y. Matsumoto, T. Tosha, A. V. Pisliakov, T. Hino, H. Sugimoto, S. Nagano, Y. Sugita, Y. Shiro
- Journal Title
  
  Nature Struct. mol. Biol.
  
  Volume: 19 Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] 抗体と膜タンパク質の共結晶構造2012
- Author(s)
  日野智也、岩田想、村田武士
- Journal Title
  
  新機能抗体開発ハンドブック
  
  Volume: 第5章-3
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] 一酸化窒素還元酵素の結晶構造から見えてきた呼吸酵素の機能変換2012
- Author(s)
  日野智也、當舎武彦、城宜嗣
- Journal Title
  
  生物物理
  
  Volume: 52 Pages: 186-189
- NAID
  10030494649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Crystal Structure of Quinol-dependent Nitric Oxide Reductase from Geobacillus Stearothermophilus2012
- Author(s)
  Matsumoto Y., Tosha T., Pisliakov A. V., Hino T., Sugimoto H., Nagano S., Sugita Y., Shiro Y.
- Journal Title
  
  Nature Struct. Mol. Biol.
  
  Volume: 19 Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Molecular dynamics simulations reveal proton transfer pathways in cytochrome c-dependent nitric oxide reductase2012
- Author(s)
  A. V. Pisliakov, T. Hino, Y. Shiro, Y. Sugita
- Journal Title
  
  PLoS Computational Biology
  
  Volume: 8 Issue: 8 Pages: e1002674-e1002674
- DOI
  10.1371/journal.pcbi.1002674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Molecular dynamics simulations reveal proton transfer pathways in cytochrome c-dependent nitric oxide reductase2012
- Author(s)
  Pisliakov A. V., Hino T., Shiro Y., Sugita Y.
- Journal Title
  
  PLoS Comput.
  
  Volume: 8(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article]2012
- Author(s)
  Shiro Y., Sugimoto H., Tosha T., Nagano S., Hino T.
- Journal Title
  
  Philos. Trans. Soc. Lond. B Biol. Sci.
  
  Volume: 367 Pages: 1195-1203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] G-protein coupled receptor inactivation by an allosteric inverse-agonist antibody2012
- Author(s)
  Hino T., Arakawa H., Iwanari H., Yurugi-Kobayashi T., Ikeda-Suno C., Nakada-Nakura Y., Kusano-Arai O., Weyand S., Shimamura T., Nomura N., Cameron A. D., Kobayashi T., Hamakubo T., Iwata S., Murata T.
- Journal Title
  
  Nature
  
  Volume: 482 Pages: 237-240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Molecular structure and function of bacterial nitric oxide reductase2012
- Author(s)
  Hino, T..,Nagano, S..,Sugimoto, H., Tosha, T., and *Shiro, Y.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1817 Issue: 4 Pages: 680-687
- DOI
  10.1016/j.bbabio.2011.09.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310137, KAKENHI-PROJECT-23770144
[Journal Article] アロステリックな逆作動薬としての活性をもつ機能性抗体によるGタンパク質共役型受容体の不活性化の分子機構2012
- Author(s)
  日野智也、岩田想、村田武士
- Journal Title
  
  新着論文レビュー
  
  Volume: 4560
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] 機能性抗体による創薬標的Gタンパク質共役型受容体の不活性化の分子機構2012
- Author(s)
  日野智也、岩田想、村田武士
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 186-189
- Data Source
  KAKENHI-PROJECT-23770144
[Journal Article] Structural Basis of Biological N_2O Generation by Bacterial Nitric Oxide Reductase2011
- Author(s)
  Tomoya Hino
- Journal Title
  
  Science
  
  Volume: 330 Pages: 1666-1670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310147
[Journal Article] Structural Basis of Biological N_20 Generation by Bacterial Nitric Oxide Reductase2011
- Author(s)
  Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Fukumori, Y., Murata, T., Iwata, S., Shiro, Y.
- Journal Title
  
  Science 330
  
  Pages: 1666-1670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310147
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of 02 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H. Sugimoto, S. Oda, T. Otsuki, T. HIno, T. Yoshida, Y. Shiro
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 2611-2616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of O_2 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H.Sugimoto, S.Oda, T.Otsuki, T.Hino, T.Yoshida, Y.Shiro
- Journal Title
  
  Poc. Natl. Acd. Sci. USA 103
  
  Pages: 2611-2616
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2,3-dioxygenase : Insight into the Catalytic Mechanism of O_2 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H.Sugimoto, S.Oda, T.Otsuki, T.Hino, T.Yoshida, Y.Shiro
- Journal Title
  
  Poc.Natl.Acd.Sci.USA 103
  
  Pages: 2611-2616
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of 02 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H. Sugimoto, S. Oda, T. Otsuki, T. Hino, T. Yoshida, Y. Shiro
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 2611-2616
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] NO Reduction by Nitric Oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa : Characterization of Reaction Intermediates That Appear in the Single-Turnover Cycle2004
- Author(s)
  H.Kumita, K.Matsuura, T.Hino, S.Takahashi, H.Hori, Y.Fukumori, I.Morishima, Y.Shiro
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 55247-55254
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] NO Reduction by Nitric Oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa : Characterization of Reaction Intermediates That Appear in the Single-Turnover Cycle2004
- Author(s)
  H. Kumita, K. Matsuura, T. Hino, S. Takahashi, H. Hori, Y. Fukumori, I. Morishima, Y. Shiro
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 55247-55254
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] NO Reduction by Nitric Oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa : Characterization of Reaction Interaediates That Appear in the Single-Turnover Cycle2004
- Author(s)
  H. Kumita, K. Matsuura, T. Hino, S. Takahashi, H. Hori, Y. Fukumori, I.Morishima, Y. Shiro
- Journal Title
  
  J. Biol. Chen. 279
  
  Pages: 55247-55254
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Patent] 芳香族スルホン酸化合物を用いた新規Clear Native電気泳動法2013
- Inventor(s)
  日野智也
- Industrial Property Rights Holder
  独立行政法人科学技術振興機構、村田武士
- Acquisition Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-23770144
[Patent] アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体2012
- Inventor(s)
  小笠原諭、日野智也
- Industrial Property Rights Holder
  独立行政法人科学技術振興機構、島村達郎(他5名)
- Industrial Property Number
  2012-049812
- Filing Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 高速分子動画でTRPチャネルの温度センサーを見極める2022
- Author(s)
  〇日野智也、桝さつき、遠藤鴻志郎、永野真吾
- Organizer
  新学術領域「高速分子動画」国際シンポジウムThe molecular movies and beyond
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04753
[Presentation] 脂質nanodiscに再構成した温度感受性チャネルTRPV4のCryo-EMによる単粒子解析に向けて2022
- Author(s)
  〇桝さつき、細川航輔、重松秀樹、佐藤裕介、永野真吾、日野智也
- Organizer
  第48回生体分子科学討論会
- Data Source
  KAKENHI-PUBLICLY-22H04753
[Presentation] スクアレン合成酵素に類似した放線菌由来新規カルバゾールプレニル基転移酵素の結晶構造と反応機構2021
- Author(s)
  末宗周憲, 永田隆平, 小林正弥, 品田哲郎, 西山真, 葛山智久, 佐藤裕介, 日野智也, 永野真吾
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] RAD23A-UBA2によるK48鎖特異的認識機構の構造基盤2021
- Author(s)
  佐藤裕介、瓜島絢日野智也、永野真吾
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] タウリン水酸化酵素の時分割シリアルフェムト秒X線結晶構造解析に向けた微結晶化と構造解析2021
- Author(s)
  三坂圭生,宮﨑麻紗美,日野智也,佐藤裕介,永野真吾
- Organizer
  令和3年 (2021年) 度日本結晶学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] 酵母を用いた高発現化GPCR変異体のスクリーニング手法の検討2021
- Author(s)
  岡部勇輝、中嶋萌生、永野真吾、日野智也
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] 人工低分子リガンドHPPUと特異的に結合する人工抗体Monobodyの複合体結晶化に向けた精製条件の検討2021
- Author(s)
  遠藤鴻志郎, 都築成晃, 佐藤裕介, 村上裕, 永野真吾, 日野智也
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] スクアレン合成酵素に類似した放線菌由来新規カルバゾールプレニル基転移酵素の結晶構造と反応機構2021
- Author(s)
  末宗周憲, 永田隆平, 小林正弥, 品田哲郎, 西山真, 葛山智久, 佐藤裕介, 日野智也, 永野真吾
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] トマチンを代謝する2種類の酸化酵素の結晶構造が示す意外な分子メカニズム2021
- Author(s)
  宮崎麻紗美, 藤山敬介, 佐藤祐介, 日野智也, 水谷正治, 秋山遼太, 加藤純平, 重田育照, 庄司光男, 永野真吾,
- Organizer
  令和3年 (2021年) 度日本結晶学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] ジャガイモやトマトに含まれる有毒なスピロソランを代謝変換する16位水酸化酵素と20位脱水素酵素の反応メカニズム2021
- Author(s)
  宮崎麻紗美, 藤山敬介, 佐藤祐介, 日野智也, 水谷正治, 秋山遼太, 加藤純平, 重田育照, 庄司光男, 永野真吾,
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] A Novel Method for Detecting Autoantibody to WD Repeat Domain 1: Clinical Application for Differentiating Papillary Thyroid Carcinoma with Poor Clinical Outcome2020
- Author(s)
  Shoichiro Izawa, Kazuhiko Matsuzawa, Kazuhisa Matsumoto, Kenji Fukaya, Takahiro Fukuhara, Makoto Wakahara, Atsuro Koga, Tomoya Hino, and Kazuhiro Yamamoto
- Organizer
  22nd European Congress of Endocrinology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07445
[Presentation] A novel method for detecting autoantibody to wd repeat domain 1: Clinical application for differentiating papillary thyroid carcinoma with poor clinical outcome2020
- Author(s)
  Shoichiro Izawa, Kazuhiko Matsuzawa, Kazuhisa Matsumoto, Kenji Fukaya, Takahiro Fukuhara, Makoto Wakahara, Atsuro Koga, Tomoya Hino, Kazuhiro Yamamoto
- Organizer
  22nd European Congress of Endocrinology (eECE 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07445
[Presentation] SFXによるTRPチャネルの熱刺激感知機構の解明に向けた微結晶試料の作製2020
- Author(s)
  〇三坂圭生,前田朋輝,細川航輔,永野真吾,日野智也
- Organizer
  令和2年度新学術領域「高速分子動画」シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] TRPチャネルの熱刺激応答機構を解明したい2020
- Author(s)
  ◯日野智也
- Organizer
  令和2年度新学術領域「高速分子動画」シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05445
[Presentation] TRPV3の微結晶品質をいかに向上させるか2020
- Author(s)
  ◯日野智也
- Organizer
  令和2年度新学術領域「高速分子動画」シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] SFXによるTRPチャネルの熱刺激感知機構の解明に向けた微結晶試料の作製2020
- Author(s)
  〇三坂圭生,前田朋輝,細川航輔,永野真吾,日野智也
- Organizer
  令和2年度新学術領域「高速分子動画」シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] 合成ペプチドを用いた癌特異的自己抗体検出による進行甲状腺癌の血清学的診断法2019
- Author(s)
  伊澤　正一郎, 松本和久, 松澤和彦, 福原隆宏, 三宅成智, 藤原和典, 若原誠, 高木雄三, 古賀敦朗, 日野智也, 大倉毅, 谷口晋一, 山本一博
- Organizer
  第92回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07445
[Presentation] ヒト由来TRPV3の精製及び結晶化2019
- Author(s)
  前田朋輝、小島要、細川航輔、永野真吾、日野智也
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] 合成ペプチドを用いた癌特異的自己抗体検出による進行甲状腺癌の血清学的診断法2019
- Author(s)
  伊澤　正一郎、松本和久、松澤和彦、福原隆宏、三宅成智、藤原和典、若原誠、高木雄三、古賀敦朗、日野智也、大倉毅、谷口晋一、山本一博
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07445
[Presentation] 結晶化に向けたヒト由来TRPV4変異体の構築2019
- Author(s)
  細川航輔、前田朋輝、永野真吾、日野智也
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] 温度感受性イオンチャネルhTRPV4の精製及び結晶化2019
- Author(s)
  細川航輔、前田朋輝、野村弥生、佐藤有美、野村紀通、岩田想、永野真吾、日野智也
- Organizer
  令和元年度結晶学会
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] TRPV3のnanodisc再構成における脂質添加量の影響2018
- Author(s)
  前田朋輝、小島要、永野真吾、日野智也
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-18K06156
[Presentation] ヒト由来TRPM8の立体構造解析に向けた高純度精製試料調製の検討2015
- Author(s)
  川越雄斗，落合晶也，三牧裕哉，日野智也，永野真吾
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25711004
[Presentation] 膜タンパク質結晶化促進ツールとしての抗体利用2012
- Author(s)
  日野智也
- Organizer
  日本生物工学会西日本支部シンポジウム
- Place of Presentation
  鳥取
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 膜タンパク質結晶化促進ツールとしての抗体利用2012
- Author(s)
  日野智也
- Organizer
  日本生物工学会西日本支部シンポジウム(招待講演)
- Place of Presentation
  鳥取
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 抗体を用いた膜タンパク質結晶化の実際2011
- Author(s)
  日野智也
- Organizer
  日本蛋白質科学会(招待講演)
- Place of Presentation
  大阪
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 緑膿菌由来一酸化窒素還元酵素の結晶構造解析2011
- Author(s)
  日野智也
- Organizer
  日本蛋白質科学会
- Place of Presentation
  大阪
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 緑膿菌由来一酸化窒素還元酵素の結晶構造解析2011
- Author(s)
  日野智也
- Organizer
  日本蛋白質科学会第11回年会
- Place of Presentation
  大阪
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 一酸化窒素還元酵素の立体構造から探る呼吸酵素の分子進化2011
- Author(s)
  日野智也
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  姫路
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 緑膿菌由来膜タンパク質一酸化窒素還元酵素の抗体を用いた結晶化と構造解析2011
- Author(s)
  日野智也
- Organizer
  日本生化学会(招待講演)
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 一酸化窒素還元酵素の立体構造から探る呼吸酵素の分子進化2011
- Author(s)
  日野智也
- Organizer
  日本生物物理学会(招待講演)
- Place of Presentation
  姫路
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23770144
[Presentation] 緑膿菌由来膜タンパク質一酸化窒素還元酵素の抗体を用いた結晶化と構造解析2011
- Author(s)
  日野智也
- Organizer
  日本生化学会第84回年会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23770144

1. NAGANO Shingo (60286440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. IZAWA Shoichiro (30572599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. SHIMAMURA Tatsuro (90391979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IWATA So (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ASADA Hidetsugu (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OGASAWARA Satoshi (30546685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIMOTO Hiroshi (90344043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 松本悠史 (40443030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平野聡 (10446528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山田斉爾 (20360662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 汲田英之 (70332286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西澤知宏 (80599077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 福原隆宏 (80403418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. 田辺晶代 (00236655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 村上裕 (10361669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 林剛介 (40648268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. LEURS Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KUMA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. ARIMA Jiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. TAKITA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 濱崎直孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 柴田幹大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 本山高幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 野村紀通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 山内敏正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 小林拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 寿野良二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 井上明俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 草木迫司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hino Tomoya 日野 智也

HINO Tomoya 日野 智也

日野 智也 ヒノ トモヤ

Research Projects

Research Products

Co-Researchers

Development of single-molecule peptide sequencing method

Principal Investigator

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血液中の自己抗体を用いた難治性内分泌腫瘍の新規悪性度判定法開発

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高速分子動画でTRPチャネルの温度センサー部位を見極めるPrincipal Investigator

Principal Investigator

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高速分子動画撮影によるTRPチャネルの熱刺激応答機構の解明Principal Investigator

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Structural basis for multimodal sensation in TRP channelsPrincipal Investigator

Principal Investigator

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New diagnostic methods for detecting autoantibodies against thyroid carcinoma with poor prognosis

Principal Investigator

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Structural biology of thermosensation in humanPrincipal Investigator

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Structure determination of histamine H1 receptor

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Structural study on the generation mechanism of nitrous oxide by integral membrane protein nitric oxide reductasePrincipal Investigator

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Crystallographic Studies on the Short-lived Respiratory Enzyme-Substrate Complex

Principal Investigator

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Bio-conversion of Substances and Information by Metal-containing Proteins and Enzymes

Principal Investigator

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Research Institution

[Journal Article] Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins2023

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[Journal Article] Crystal structure of the adenylation domain from an ε-poly-l-lysine synthetase provides molecular mechanism for substrate specificity2022

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Journal Title

Hino Tomoya 日野智也

HINO Tomoya 日野智也

日野智也ヒノトモヤ