AOYAMA Hiroshi 青山洋史

Researcher Number	40374699
Affiliation *help	2015 – 2016 : 東京薬科大学, 薬学部, 准教授 2013 : 東京大学, 分子細胞生物学研究所, 助教 2011 – 2013 : 東京薬科大学, 薬学部, 准教授 2012 : 東京薬科大学, 薬学部, 講師 2007 – 2009 : The University of Tokyo, 分子細胞生物学研究所, 助教 2008 : 東大, 分子細胞生物学研究所, 助教 2007 : 東大, 分子細胞生物学研究所, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator C型肝炎 / HCV / 酵素阻害 / ホスホン酸エステル / 有機化学 / 虚血性疾患 / ミトコンドリア / 血液凝固 / 虚血／再灌流障害 / フォールディング … More Except Principal Investigator 酵素阻害剤 / 生理活性物質 / 核内受容体リガンド / 変異ロドプシン / 脱炭酸 / ジフェニルペンタン / 核内受容体 / 蛋白質相互作用 / 酵素選択性 / トラフィッキング / テンプレート / 構造活性相関 / トリアゾキノリン類 / サリドマイド / 結合定数 / 化合部物ライブラリー / ミミック / 光学分割 / 抗アンドロゲン / ホスホン酸 / ロドプシン / ホスホプロリン / マルチテンプレート / 医薬分子機能学 / 細胞内局在 / フォールディング異常症 / 抗ウイルス剤 / プロリン / ニーマン・ピック病Ｃ型 / ジペプチド / プロテアーゼ阻害剤 / 構造展開 / ホスホニル化反応 / 生物応答調節 / フォールディング / 生物活性 / 網膜色素変性症 / ホスフィン酸 / ケミカルジェネティクス / プロテアーゼ / 阻害形式 / 錯体形成 / ジペプチドイソスター / 蛋白変性症 / バイオイソスター / 生物応答調節剤創製法 / PPAR / 膜タンパク質 / 肝臓X受容体 Less

基質競合型プロテアーゼ阻害剤のリン原子導入による非競合化に関する基礎医薬基盤Principal InvestigatorOngoing
- Principal Investigator
  
  青山洋史
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Application of phosphate mimetics to development of biologically active compounds
- Principal Investigator
  
  Yokomatsu Tsutomu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Basic medicinal chemistry based on behavioral structure-building regulation of proteinPrincipal Investigator
- Principal Investigator
  
  AOYAMA hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Chemical control of protein dramatype
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Biological response modification based on multi-template and dramatype approaches.
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Basic medicinal chemistry in novel biologically active compounds based on behavioral regulation of proteinPrincipal Investigator
- Principal Investigator
  
  AOYAMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Synthesis of 5-aminobenzoimidazo[1,2-a]quinoline derivatives through one-pot two-step cascade reaction2016
- Author(s)
  J. Kato, Y. Ito, R. Ijuin, H. Aoyama, and T. Yokomatsu
- Journal Title
  
  Heterocycles
  
  Volume : xx
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate2015
- Author(s)
  Hiroshi Aoyama, Ryosuke Ijuin, Jun-ya Kato, Sarasa Urushiyama, Masashi Tetsuhashi, Yuichi Hashimoto, Tsutomu Yokomatsu
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume : 25 Pages : 3676-3680
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08033, KAKENHI-PROJECT-25460155
[Journal Article] Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.2013
- Author(s)
  Shinpei Murasawa　他８名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 20 Pages : 6384-6393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-24790119
[Journal Article] A Novel and Simple Method for the Preparation of (R)- and (S)-Pyrrolidine-2-phosphonic Acids: Phosphonic Acid Analogues of Proline2013
- Author(s)
  Babak Kaboudin, Jun-ya Kato, Hiroshi Aoyama, and Tsutomu Yokomatsu
- Journal Title
  
  Tetrahedron: Asymmetry
  
  Volume : 24 Pages : 1562-1566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] A Catalyst-free, Three-component Decarboxylative Coupling of Amino Acids with Aldehydes and H-dialkylphosphites for the Synthesis of α-Aminophosphonates2013
- Author(s)
  Babak Kaboudin, Leila Karami, Jun-ya Kato, Hiroshi Aoyama, and Tsutomu Yokomatsu
- Journal Title
  
  Tetrahedron Lett.
  
  Volume : 54 Pages : 4872-4875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines2013
- Author(s)
  Jun-ya Kato, Yutaro Ito, Ryosuke Ijuin, Hiroshi Aoyama, Tsutomu Yokomatsu
- Journal Title
  
  Organic Letters
  
  Volume : 15 Pages : 3794-3797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790119, KAKENHI-PROJECT-25460147
[Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]-azepin-6-one skeleton.2012
- Author(s)
  Atsushi Aoyama
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume : 55 Pages : 7360-7377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
[Journal Article] Fused heterocyclic amido compounds as anti-hepatitis C virus agents2011
- Author(s)
  H.Aoyama, K.Sugita, M.Nakamura, A.Aoyama, M.T.A.Salim, M.Okamoto, M.Baba, Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 19 Pages : 2675-2687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-11J09835
[Journal Article] Structural development studies of anti-hepatitis virus C virus agents2010
- Author(s)
  M.Nakamura, A.Aoyama, M.T.M.Salim, M.Okamoto, M.Baba, M.Baba, H.Miyachi, Y.Hashimoto, H.Aoyama
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume : 18 Pages : 2402-2411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Nitrogen-containing fused-heteroaromatic compounds as a anti-bovine diarrhea virus (BVDV) agents.2010
- Author(s)
  Aoyama H, Baba M, Hashimoto Y
- Journal Title
  
  Curr. Bioactive Comp. 6(2)
  
  Pages : 118-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus(BVDV)activity.2009
- Author(s)
  Hiroshi Aoyama, 他6名
- Journal Title
  
  Heterocycles 77
  
  Pages : 779-785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity.2009
- Author(s)
  Hiroshi Aoyama, 他6名
- Journal Title
  
  Heterocycles 77(2)
  
  Pages : 779-785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Liver X receptor(LXR)modulators with dibenz[b,f][1,4]oxazepin-11-one,(Z)-dibenz[b,f]azocin-6-one, and 11, 12-dihydrodibenz[b,f]azocin-6-one skeleton.2009
- Author(s)
  Atsushi Aoyama, 他4名
- Journal Title
  
  Heterocycles 78
  
  Pages : 2209-2216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.2008
- Author(s)
  Sato S, Tetsuhashi M, Sekine K, Miyachi H, Naito M, Hashimoto Y, Aoyama H
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages : 4685-4698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Co-existence of alpha-glucosidase-inhibitory activity and liver X receptor-regulatory activities and their separation by structural development.2008
- Author(s)
  Dodo K, Aoyama H, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages : 4272-4285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Demonstration of direct binding of cIAP1 degradationpromoting bestatin analogs to BIR3 domain : synthesis and application of fluorescent bestatin ester analogs2008
- Author(s)
  S. Sato, H. Aoyama et.al.
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages : 3354-3358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Demonstration of Direct Binding of cIAP1 Degradation-promoting Bestatin Analogs to BIR3 Domain : Synthesis and Application of Fluorescent Bestatin Ester Analogs2008
- Author(s)
  Shinichi Sato, Hiroshi Aoyama, Hiroyuki Miyachi, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages : 3354-3358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Degradation-promoters of Cellular Inhibitor of Apoptosis Protein 1 Based on Bestatin and Actinonin2008
- Author(s)
  Shinichi Sato, Masashi Tetsuhashi, Keiko Sekine, Hiroyuki Miyachi, Mikihiko Naito, Yuichi Hashimoto, Hiroshi Aoyama
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages : 4685-4698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Degradationpromoters of Cellular Inhibitor of Apoptosis Protein 1 Based on B estatin and Actinonin2008
- Author(s)
  S. Sato, H. Aoyama et.al.
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages : 4685-4698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Basic Biological Characterization2008
- Author(s)
  Haruka Fujimoto, Hiroshi Aoyama, Tomomi Noguchi-Yachide, Yuichi Hashimoto, Hisayoshi Kobayashi
- Journal Title
  
  Chem. Pharm. Bull 56
  
  Pages : 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] LXR antagonists with a 5-substituted phenanthridin-6-one skeleton: Synthesis and LXR transrepression activities of conformationally restricted carba-To901317 analogs.2008
- Author(s)
  Atsushi Aoyama, 他5名
- Journal Title
  
  Heterocycles 76(1)
  
  Pages : 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton2007
- Author(s)
  Hiroshi Aoyama
- Journal Title
  
  Chem. Phann. Bull. 55
  
  Pages : 944-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Development of Tubulin-polymerization Inhibitors Based on the Thalidomide Skeleton2007
- Author(s)
  Hiroshi Aoyama, Tomomi Noguchi, Takashi Misawa, Takanori Nakamura, Hiroyuki Miyachi, Yuichi Hashimoto, Hisayoshi Kobayashi
- Journal Title
  
  Chem. Pharm. Bull 55
  
  Pages : 944-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790007
[Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton2007
- Author(s)
  H. Aoyama, 他6名
- Journal Title
  
  Chelnica1 & Pharmaceutical Bullietin 55
  
  Pages : 944-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Synthesis of a-Aminophosphonates from a;-Amino Acids by Catalyst-free Three-component Decarboxylative Coupling Reactions2014
- Author(s)
  B． Kaboudin, L． Karami, J． Kato，H．Aoyama, and T. Yokomatsu
- Organizer
  20th International Conference on Phosphorus Chemistry
- Place of Presentation
  Ｄｏｕｂｌｉｎｅ，　Ｉｒｅｌａｎｄ
- Data Source
  KAKENHI-PROJECT-25460155
[Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012
- Author(s)
  青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Liver X Receptor (LXR)リガンドの構造展開によるTransrepression作用選択的リガンドの創製2012
- Author(s)
  青山惇, 他6名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 免疫調節作用選択的な肝臓Ｘ受容体（ＬＸＲ）リガンドの創製2012
- Author(s)
  青山惇　他９名
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子（鳥取県）
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] LXRリガンドの構造展開による選択的IL-6産生抑制剤の創製2011
- Author(s)
  青山惇, 他4名
- Organizer
  日本レチノイド研究会第22回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] LXRを介した抗炎症作用を有する選択的リガンドの創製2010
- Author(s)
  青山惇, 他6名
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] フタルイミド骨格を基盤としたトリプターゼ阻害剤の創製2009
- Author(s)
  鉄橋正士、橋本祐一、青山洋史
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 配座固定を基盤とした核内受容体LXRの新規リガンド創製2009
- Author(s)
  青山惇、他7名
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 3,3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009
- Author(s)
  谷内出友美、鉄橋正士、青山洋史、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 抗BVDV活性を指標とした3環性γ-カルボリン類縁体による抗ウイルス効果2008
- Author(s)
  青山洋史、他8名
- Organizer
  第52回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 配座固定を基盤とした核内受容体LXRの新規アンタゴニスト創製2008
- Author(s)
  青山惇、他7名
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 配座固定を基盤とした核内受容体LXRの新規リガンド創製2008
- Author(s)
  青山惇、他7名
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Fusarielin Aの生物活性とその分子基盤2008
- Author(s)
  藤本悠、青山洋史、谷内出(野口)友美、橋本祐一、小林久芳
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19790007
[Presentation] タンパク質寿命制御に立脚した新規アポトーシス誘導剤創製研究2008
- Author(s)
  佐藤伸一、青山洋史、鉄橋正士、宮地弘幸、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19790007
[Presentation] cIAP1減少を介した新規アポトーシス誘導剤の合成研究2007
- Author(s)
  佐藤伸一、青山洋史、内藤幹彦、宮地弘幸、橋本祐一、棚谷綾
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19790007
[Presentation] cIAP1減少を介した新規アポトーシス誘導剤創製研究2007
- Author(s)
  佐藤伸一、青山洋史、棚谷綾、内藤幹彦、宮地弘幸、橋本祐一
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  相模原
- Year and Date
  2007-11-28
- Data Source
  KAKENHI-PROJECT-19790007
[Presentation] Fusarielin Aの生物活性とその分子基盤2007
- Author(s)
  藤本悠、青山洋史、谷内出(野口)友美、橋本祐一、小林久芳
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-19790007
[Presentation] 多置換[1,2,4]トリアゾロ[1,5-a]キノリン類の新規合成法の開発
- Author(s)
  加藤淳也、成瀬央、伊集院良祐、青山洋史、横松力
- Organizer
  第44回複素環討論会
- Place of Presentation
  札幌市
- Year and Date
  2014-09-10 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460155
[Presentation] Synthesis of a-Aminophosphonates from a-Amino Acids by Catalyst-free Three-component Decarboxylative Coupling Reactions
- Author(s)
  B. Kaboudin, L. Karami, J. Kato, H. Aoyama, and T. Yokomatsu
- Organizer
  20th International Conference on Phosphorus Chemistry
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2014-06-28 – 2014-07-02
- Data Source
  KAKENHI-PROJECT-25460155

1. NOGUCHI Tomomi (20401284)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
2. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects : 2results

# of Collaborated Products : 9results
3. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. ISHIKAWA Minoru (70526839)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
5. SUGITA Kazuyuki (60542090)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
6. MATSUMOTO Yotaro (90420041)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. MISAWA Takashi (40709820)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. Yokomatsu Tsutomu (70158369)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
9. 伊集院良祐 (40442925)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
10. KABOUDIN Babak

# of Collaborated Projects : 1results

# of Collaborated Products : 4results

AOYAMA Hiroshi 青山 洋史

Research Projects

Research Products

Co-Researchers

基質競合型プロテアーゼ阻害剤のリン原子導入による非競合化に関する基礎医薬基盤Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of phosphate mimetics to development of biologically active compounds

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic medicinal chemistry based on behavioral structure-building regulation of proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical control of protein dramatype

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological response modification based on multi-template and dramatype approaches.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic medicinal chemistry in novel biologically active compounds based on behavioral regulation of proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

[Journal Article] Synthesis of 5-aminobenzoimidazo[1,2-a]quinoline derivatives through one-pot two-step cascade reaction2016

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[Journal Article] Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate2015

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[Journal Article] Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.2013

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[Journal Article] A Novel and Simple Method for the Preparation of (R)- and (S)-Pyrrolidine-2-phosphonic Acids: Phosphonic Acid Analogues of Proline2013

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[Journal Article] A Catalyst-free, Three-component Decarboxylative Coupling of Amino Acids with Aldehydes and H-dialkylphosphites for the Synthesis of α-Aminophosphonates2013

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[Journal Article] Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines2013

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[Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]-azepin-6-one skeleton.2012

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[Journal Article] Fused heterocyclic amido compounds as anti-hepatitis C virus agents2011

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[Journal Article] Structural development studies of anti-hepatitis virus C virus agents2010

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[Journal Article] Nitrogen-containing fused-heteroaromatic compounds as a anti-bovine diarrhea virus (BVDV) agents.2010

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AOYAMA Hiroshi 青山洋史