TAKAHASHI Shinichiro 高橋伸一郎

Researcher Number	40375069
Other IDs	https://orcid.org/0000-0003-0011-6065
Affiliation (Current)	2024: 東北医科薬科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北医科薬科大学, 医学部, 教授 2011 – 2015: 北里大学, 医療衛生学部, 教授 2006: 東北大学, 病院, 講師 2005 – 2006: 東北大学, 病院・助手 2005 – 2006: 東北大学, 病院, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 52010:General internal medicine-related / Hematology Except Principal Investigator Basic Section 43030:Functional biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 53010:Gastroenterology-related / Hematology
Keywords	Principal Investigator メタロチオネイン / 白血病 / PU.1 / バイオマーカー / エピゲノム修飾阻害剤 / 糖鎖合成阻害剤 / フコシル化阻害剤 / キナーゼ阻害剤 / 白血病分化誘導療法 / 細胞増殖 … More / 細胞分化 / 癌 / SIRPα / FLT3 / SIRPa / メタロチオネイン（MT） / AML / 効果予測マーカー / 抗がん剤 / エピジェネティック / 分化 / 内科 / シグナル伝達 / 遺伝子 … More Except Principal Investigator 糖鎖 / delta-like 1 / 膜受容体 / がん薬剤耐性 / GnT-III / 薬剤耐性 / 糖転移酵素 / N型糖鎖 / 炎症 / コアフコース / Fut8 / 免疫グロブリンG / 膵癌 / RNAi / erythropoiesis / bone marrow stromal cells / heat shock protein / 赤芽球 / 骨髄 / 造血 / siRNA / 赤芽球造血 / 骨髄間質細胞 Less

一般検診の基本的データを用いた人工知能による膵癌マススクリーニング法の確立
- Principal Investigator
  
  廣田衛久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Analysis of underlying molecular mechanism for the regulation of chemoresistance by GnT-III
- Principal Investigator
  
  顧建国
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of molecular mechanism for IgG levels regulated by L-fucose
- Principal Investigator
  
  顧建国
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tohoku Medical and Pharmaceutical University
Establishment of efficient leukemia differentiation therapy, and biomarker, through various inhibitorsPrincipal Investigator
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Clarifying the pathogenesis of hematological malignancies and development of diagnostic markers through analysing PU.1 target genesPrincipal Investigator
- Principal Investigator
  
  Takahashi Shinichiro
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku Medical and Pharmaceutical University
Role of PU.1 suppressive target gene, metallothionein, as a forecasting biomarker for anticancer agentsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shinichiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Kitasato University
Establishment of predictive marker for epigenetic drugs in hematological malignanciesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shinichiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kitasato University
Flt3経路を介した急性骨髄性白血病発症の分子機構の解明及び治療開発Principal Investigator
- Principal Investigator
  
  高橋伸一郎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Identification of molecules determining the stromal-cell dependent hematopoiesis
- Principal Investigator
  
  KAMEOKA Junichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University

[Book] Myeloid Leukemia/ Basic Mechanisms of Leukemogenesis (Editor: Steffen Koschmieder and Utz Krug), Chapter 132011
- Author(s)
  Takahashi S
- Total Pages
  24
- Publisher
  Intech Open Access Publisher
- Data Source
  KAKENHI-PROJECT-23590687
[Book] Trends in Signal Transduction Research (Chapter 8, FLT3 signal transduction and leukemia)2007
- Author(s)
  Takahashi S
- Publisher
  Nova Science Publishers, Inc. (in press)
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Progression of hemolysis in a patient with hereditary spherocytosis after the second dose of COVID-19 mRNA vaccine2023
- Author(s)
  Nomura Jun、Seki Masafumi、Abe Syori、Kobayashi Tadahiro、Okitsu Yoko、Fukuhara Noriko、Takahashi Shinichiro、Harigae Hideo、Kameoka Junichi
- Journal Title
  
  Human Vaccines & Immunotherapeutics
  
  Volume: 19 Issue: 1 Pages: 2165381-2165381
- DOI
  10.1080/21645515.2023.2165381
- Data Source
  KAKENHI-PROJECT-21K07346
[Journal Article] Suspected Immune Thrombocytopenic Purpura Induced by Lenalidomide for the Treatment of Myelodysplastic Syndrome with Deletion of Chromosome 5q: A Case Report2023
- Author(s)
  Furukawa Haruna、Nomura Jun、Kobayashi Masahiro、Abe Shori、Takeda Tomoki、Oka Yumiko、Shirota Yuko、Kodera Takao、Okitsu Yoko、Takahashi Shinichiro、Murakami Keigo、Kameoka Junichi
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 259 Issue: 2 Pages: 113-119
- DOI
  10.1620/tjem.2022.J104
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Data Source
  KAKENHI-PROJECT-21K07346
[Journal Article] Assessment of antibody titer and side effects after third doses of COVID-19 mRNA vaccination in healthy volunteers2022
- Author(s)
  Kozakai Rikei、Suzuki Susumu、Fukami Kana、Hoshi Kuniko、Izumi Yoshihiko、Takahashi Shinichiro
- Journal Title
  
  Journal of Laboratory Medicine
  
  Volume: 46 Issue: 3 Pages: 171-177
- DOI
  10.1515/labmed-2022-0057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07346
[Journal Article] Antibody titer 6 months after the third dose of COVID-19 mRNA vaccination2022
- Author(s)
  Kozakai Rikei、Suzuki Susumu、Hoshi Kuniko、Izumi Yoshihiko、Takahashi Shinichiro
- Journal Title
  
  Journal of Laboratory Medicine
  
  Volume: 47 Issue: 1 Pages: 41-45
- DOI
  10.1515/labmed-2022-0092
- Data Source
  KAKENHI-PROJECT-21K07346
[Journal Article] Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by <i>Serratia marcescens</i>: A Case Report and Literature Review2021
- Author(s)
  Akane Suzuki, Shori Abe, Kaori Koyama, Shinju Suzuki, Munenori Nagao, Masahiro Kobayashi, Jun Nomura, Tomomi Tsutsumi, Tomoki Takeda, Yumiko Oka, Yuko Shirota, Naruhiko Takasawa, Takao Kodera, Yoko Okitsu, Shinichiro Takahashi, Ryo Ichinohasama, Junichi Kameoka
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 6 Pages: 927-933
- DOI
  10.2169/internalmedicine.5820-20
- NAID
  130007998489
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Upregulation of Metallothionein-1G Accelerates G1/S Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells2021
- Author(s)
  Naomi Hirako, Shinichiro Takahashi
- Journal Title
  
  Ann Clin Lab Sci
  
  Volume: 51 Pages: 38-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system2020
- Author(s)
  Duan Chengwei、Fukuda Tomohiko、Isaji Tomoya、Qi Feng、Yang Jie、Wang Yuqin、Takahashi Shinichiro、Gu Jianguo
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 2 Pages: 3239-3252
- DOI
  10.1096/fj.201902313rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07049, KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-17K09019
[Journal Article] Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling2020
- Author(s)
  Takahashi Shinichiro
- Journal Title
  
  Leukemia Research Reports
  
  Volume: 13 Pages: 100187-100187
- DOI
  10.1016/j.lrr.2019.100187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Current Understandings of Myeloid Differentiation Inducers in Leukemia Therapy2020
- Author(s)
  Shinichiro Takahashi
- Journal Title
  
  Acta Haematol
  
  Volume: Nov20 Issue: 4 Pages: 1-9
- DOI
  10.1159/000510980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Common Variants in Signaling Transcription Factor Binding Sites Drive the Majority of Red Blood Cell Traits2020
- Author(s)
  Avik Choudhuri, Shinichiro Takahashi(23/33), et al.
- Journal Title
  
  Nat Genet
  
  Volume: 52(12) Issue: 12 Pages: 1333-1345
- DOI
  10.1038/s41588-020-00738-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] 消化器内科との連携によるリスクマネジメント～当院のHCV抗体陽性患者の拾い上げ～2020
- Author(s)
  2.小堺利恵、小暮高之、髙橋瑞恵、高渕優太朗、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、沖津庸子、髙橋伸一郎
- Journal Title
  
  臨床病理
  
  Volume: 68巻1号 Pages: 48-54
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] High-resolution measurement of stretchability of left ventricular myocardium using phase-difference tracking method2019
- Author(s)
  黒川貴史, 中島博行, 西條芳文, 田中元直, 高橋伸一郎
- Journal Title
  
  Japanese Journal of Medical Technology
  
  Volume: 68 Issue: 1 Pages: 76-84
- DOI
  10.14932/jamt.18-58
- NAID
  130007557530
- ISSN
  0915-8669, 2188-5346
- Year and Date
  2019-01-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] A case of myelodysplastic syndrome with t(10;18)(q26;q21)2019
- Author(s)
  Ohba Yusuke、Yamada-Fujiwara Minami、Minagawa Tadanori、Watanabe Suguru、Okitsu Yoko、Izumi Yoshihiko、Kameoka Junichi、Takahashi Shinichiro
- Journal Title
  
  Journal of Laboratory Physicians
  
  Volume: 11 Issue: 04 Pages: 382-384
- DOI
  10.4103/jlp.jlp_61_19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019, KAKENHI-PROJECT-16K09819
[Journal Article] Rapid diagnosis of mixed phenotype acute leukemia after identifying a blood histogram abnormality2018
- Author(s)
  Saito R, Yokoyama H, Meguro K, Ohba Y, Izumi Y, Takahashi S
- Journal Title
  
  Practical Laboratory Medicine
  
  Volume: 12 Pages: e00101-e00101
- DOI
  10.1016/j.plabm.2018.e00101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Molecular functions of SIRPα and its role in cancer2018
- Author(s)
  Takahashi S
- Journal Title
  
  Biomedical Reports
  
  Volume: 9 Pages: 3-7
- DOI
  10.3892/br.2018.1102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09019
[Journal Article] Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib2016
- Author(s)
  Houessinon A, François C, Sauzay C, Louandre C, Mongelard G, Godin C, Bodeau S, Takahashi S, Saidak Z, Gutierrez L, Régimbeau JM, Barget N, Barbare JC, Ganne N, Chauffert B, Coriat R, Galmiche A
- Journal Title
  
  Mol Cancer
  
  Volume: 15 Issue: 1 Pages: 38-38
- DOI
  10.1186/s12943-016-0526-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460685
[Journal Article] PU.1標的遺伝子の同定による新たな骨髄球系細胞分化機構の解明2016
- Author(s)
  高橋伸一郎
- Journal Title
  
  生化学
  
  Volume: 88 Pages: 233-236
- Data Source
  KAKENHI-PROJECT-26460685
[Journal Article] Internal tandem duplication and tyrosine kinase domain mutations in FLT3 alter the response to daunorubicin in Ba/F3 cells2016
- Author(s)
  Takahashi S and Shirahama K
- Journal Title
  
  Biomedical Reports
  
  Volume: Jan 4(1) Pages: 83-86
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460685
[Journal Article] Positive and negative regulators of metallothionein gene2015
- Author(s)
  Takahashi S
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: in press Issue: 1 Pages: 795-799
- DOI
  10.3892/mmr.2015.3459
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-26460685
[Journal Article] Allo-antigen stimulated CD8+ T cells Suppress NF-κB and Ets-1 DNA Binding Activity, and Inhibit Phosphorylated NF-κB p65 Nuclear Localization in CD4+ T cells2014
- Author(s)
  Nagashima R, Kawakami F, Takahashi S, Obata F, Kubo M
- Journal Title
  
  Viral Immunology
  
  Volume: 27 Issue: 6 Pages: 305-315
- DOI
  10.1089/vim.2013.0113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-26460685
[Journal Article] A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation2014
- Author(s)
  Hirako N, Nakano H, Takahashi S
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 7 Pages: e103282-e103282
- DOI
  10.1371/journal.pone.0103282
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-26460685
[Journal Article] The differentiation effect of low dose cytosine arabinoside is disturbed in PU.1-knockdown K562 cells2014
- Author(s)
  Nakano H, Yanagita A and Takahashi S
- Journal Title
  
  Biomedical Reports
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] The differentiation effect of low dose cytosine arabinoside is disturbed in PU.1-knockdown K562 cells2014
- Author(s)
  Nakano H, Yanagita A, Takahashi S
- Journal Title
  
  Biomedical Reports
  
  Volume: 2 Issue: 4 Pages: 564-568
- DOI
  10.3892/br.2014.265
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-26460685
[Journal Article] Epigenetic aberrations in myeloid malignancies2013
- Author(s)
  Takahashi S
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Fcγ receptor IIB gene polymorphism in adult Japanese patients with primary immune thrombocytopenia.2013
- Author(s)
  Satoh T1, Miyazaki K, Shimohira A, Amano N, Okazaki Y, Nishimoto T, Akahoshi T, Munekata S, Kanoh Y, Ikeda Y, Higashihara M, Takahashi S, Kuwana M.
- Journal Title
  
  Blood
  
  Volume: Sep 12;122 Issue: 11 Pages: 1991-2
- DOI
  10.1182/blood-2013-05-501858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-24590703
[Journal Article] Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells2013
- Author(s)
  Suzuki S, Nakano H, Takahashi S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 433 Issue: 3 Pages: 349-53
- DOI
  10.1016/j.bbrc.2013.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Epigenetic aberrations in myeloid malignancies (Review).2013
- Author(s)
  Takahashi S.
- Journal Title
  
  Int J Mol Med.
  
  Volume: Sep;32 Issue: 3 Pages: 532-8
- DOI
  10.3892/ijmm.2013.1417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Molecular functions of metallothionein and its role in hematological malignanceis2012
- Author(s)
  Takahashi S
- Journal Title
  
  Journal of Hematology & Oncology
  
  Volume: 5 Issue: 1 Pages: 41-41
- DOI
  10.1186/1756-8722-5-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Opposing Role, Depending on the Stage, of PU.1 during Erythroid Differentiation2012
- Author(s)
  Takahashi S
- Journal Title
  
  Journal of Blood & Lymph
  
  Volume: 2 Issue: 02
- DOI
  10.4172/2165-7831.1000e108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] The differentiating and apoptotic effects of 2-aza-5’-deoxycytidine are dependent on the PU.1 expression level in PU.1-transgenic K562 cells2012
- Author(s)
  Aoyama S, Nakano H, Danbara M, Higashihara M, Harigae H, Takahashi S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press Issue: 4 Pages: 775-781
- DOI
  10.1016/j.bbrc.2012.03.071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] The expressions of PU.1 and signal regulatory protein alfa 1 are correlated in PU.1 transgenic K562 cells2012
- Author(s)
  Iseki Y, Nakahara M, Kubo M, Obata F, Harigae H, Takahashi S
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 29(2) Pages: 319-23
- DOI
  10.3892/ijmm.2011.827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Gene Expression Profiling Identifies HOXB4 as a Direct Downstream Target of GATA-2 in Human CD34+ Hematopoietic Cells2012
- Author(s)
  Fujiwara T, Yokoyama H, Okitsu Y, Kamata M, Fukuhara N, Onishi Y, Fujimaki S, Takahashi S, Ishizawa K, Bresnick E and Harigae H
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 9 Pages: e40959-e40959
- DOI
  10.1371/journal.pone.0040959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687, KAKENHI-PROJECT-23687024, KAKENHI-PROJECT-23791067, KAKENHI-PUBLICLY-23118502
[Journal Article] Effects of albumin bound fatty acids on the growth of the human T lymphoblastic cell line Jurkat2011
- Author(s)
  Okazaki T, Iwasaki T, Fukuoka A, Suzuki M, Katagiri H, Okano T, Takahashi S
- Journal Title
  
  In Vitro Cellular & Developmental Biology-Animal
  
  Volume: 47(9) Issue: 9 Pages: 615-617
- DOI
  10.1007/s11626-011-9454-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Activation of ERK and p38 by the addition of arsenic trioxide in Flt3-ITD cells2011
- Author(s)
  Suzuki S, Inaba H, Satoh T, Okazaki T, Takahashi S
- Journal Title
  
  Open Journal of Blood Diseases
  
  Volume: 1(2) Issue: 02 Pages: 9-11
- DOI
  10.4236/ojbd.2011.12003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications2011
- Author(s)
  Takahashi S
- Journal Title
  
  Journal of Hematology and Oncology
  
  Volume: 4(13) Issue: 1 Pages: 1-10
- DOI
  10.1186/1756-8722-4-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Current findings for recurring mutations in acute myeloid leukemia2011
- Author(s)
  Takahashi S
- Journal Title
  
  Journal of Hematology and Oncology
  
  Volume: 4(36) Issue: 1 Pages: 1-11
- DOI
  10.1186/1756-8722-4-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590687
[Journal Article] Inhibition of MEK/MAPK signal transduction pathway strongly impairs the growth of Flt3-ITD cells2006
- Author(s)
  Takahashi S
- Journal Title
  
  American Journal of Hematology 81(2)
  
  Pages: 154-155
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] (医学用語解説)Flt32006
- Author(s)
  高橋伸一郎
- Journal Title
  
  炎症と免疫 14(5)
  
  Pages: 179-188
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Differential gene expression profiling between wild type and ALAS2-null erythroblasts : Identification of novel heme-regulated genes2006
- Author(s)
  Fujiwara T, Harigae H, Takahashi S.et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun 340・1
  
  Pages: 105-110
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Inverse correlation between Flt3 and PU. 1 expression in acute myeloblastic leukemias2006
- Author(s)
  Inomata M, Takahashi S et al.
- Journal Title
  
  Leukemia Research 30(6)
  
  Pages: 659-644
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Inhibition of the MEK/MAPK signal transduction pathway strongly impairs the growth of Flt3-ITD cells2006
- Author(s)
  Takahashi S
- Journal Title
  
  American Journal of Hematology 81・2
  
  Pages: 154-155
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication2006
- Author(s)
  Takahashi S et al.
- Journal Title
  
  International Journal of Hematology 84(3)
  
  Pages: 256-261
- NAID
  10018304106
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Identification of flt3 internal tandem duplications downstream targets by high-throughput immunoblotting protein array system2006
- Author(s)
  Takahashi S
- Journal Title
  
  American Journal of Hematology 81(9)
  
  Pages: 717-719
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] Over-expression of Flt3 induces NFkB pathway and increases the expression of IL-62005
- Author(s)
  Takahashi S et al.
- Journal Title
  
  Leukemia Research 29・8
  
  Pages: 893-899
- Data Source
  KAKENHI-PROJECT-17790635
[Journal Article] AML1B transcriptional repressor function is impaired by the Fit3 internal tandem duplication2005
- Author(s)
  Takahashi S et al.
- Journal Title
  
  British Journal of Haematology 130・3
  
  Pages: 428-436
- Data Source
  KAKENHI-PROJECT-17790635
[Presentation] The effect of Fucosylation Inhibitor 6-Alkynyl-Fucose on Myeloid Differentiation2022
- Author(s)
  Takahashi S
- Organizer
  The 2nd TMPU-Academia Sinica Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07346
[Presentation] 消化器内科との連携によるリスクマネジメント～当院の HCV 抗体陽性患者の拾い上げ～2019
- Author(s)
  小堺利恵、小暮高之、髙橋瑞恵、高渕優太朗、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、沖津庸子、髙橋伸一郎
- Organizer
  第51回日本臨床検査医学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] グリコヘモグロビン分析装置ADAMS A1c HA-8190Vの有用性2019
- Author(s)
  高渕優太朗、小堺利恵、髙橋瑞恵、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、高澤德彦、髙橋伸一郎
- Organizer
  第51回みやぎ医学検査学会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 新規発売試薬「エクルーシス試薬FT4III」の基礎的検討2019
- Author(s)
  高渕優太朗、小堺利恵、髙橋瑞恵、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、髙橋伸一郎
- Organizer
  019年度日本臨床衛生検査技師会北日本支部医学検査学会(第8回)
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] HBs抗体試薬4社の基礎的検討2019
- Author(s)
  髙橋瑞恵、小堺利恵、高渕優太朗、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、髙橋伸一郎
- Organizer
  2019年度日本臨床衛生検査技師会北日本支部医学検査学会(第8回)
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] HBs抗体価測定における測定方法間差2019
- Author(s)
  髙橋瑞恵、小堺利恵、桑島仁、阿部裕有子、高渕優太朗、金子ひろみ、高橋恵美子、岩渕淑子、泉義彦、高澤德彦、髙橋伸一郎
- Organizer
  第51回みやぎ医学検査学会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 東北医科薬科大学病院検査部採血部門の最近の取り組み2019
- Author(s)
  星くに子、高橋恵美子、泉義彦、髙橋伸一郎
- Organizer
  第51回日本臨床検査医学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] Rapid diagnosis and prompt treatment of mixed phenotype acute leukemia after identifying a histogram abnormality of an automatic blood cell analyzer (Received Poster Award)2018
- Author(s)
  Rie Saito, Hisayuki Yokoyama, Kuniaki Meguro, Hideaki Hitomi, Yusuke Ohba, Yoshihiko Izumi, Shinichiro Takahashi
- Organizer
  11th Cherry Blossom Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] cobas8000 e801を用いた甲状腺関連項目の基礎性能評価2018
- Author(s)
  古川結菜，小堺利恵，高渕優太朗，金子ひろみ，高橋恵美子，岩渕淑子，泉義彦，髙橋伸一郎
- Organizer
  第50回日本臨床検査医学会東北支部総会、第29回日本臨床化学会東北支部総会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 東北医科薬科大学病院検査部輸血部門におけるISO 15189取得に向けての取り組み2018
- Author(s)
  齊藤梨絵、浅野裕子、佐藤裕季、藤田智咲、大場祐輔、櫻田明美、泉義彦、沖津庸子、高橋伸一郎
- Organizer
  第114回日本輸血・細胞治療学会東北支部例会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 当院における夜間休日担当者への輸血業務スキル調査とトレーニングの取り組み2018
- Author(s)
  佐藤裕季、齊藤梨絵、浅野裕子、櫻田明美、大場祐輔、藤田智咲、泉義彦、高橋伸一郎、沖津庸子
- Organizer
  第113回日本輸血・細胞治療学会東北支部例会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 東北医科薬科大学病院検査部の検体検査管理における診療支援について2018
- Author(s)
  高橋伸一郎、小堺利恵、沖津庸子、泉義彦
- Organizer
  第50回日本臨床検査自動化学会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] Signal regulatory protein α 発現低下K562細胞は低血清培養下で増殖が亢進する2018
- Author(s)
  高渕優太朗，泉義彦，張替秀郎，高橋伸一郎
- Organizer
  第８回日本検査血液学会東北支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] Causes of isolated prolonged APTT in Tohoku University Hospital over the past seven years2018
- Author(s)
  Kameoka J, Okitsu Y, Kobayashi M, Ichikawa S, Shirota Y, Oka Y, Kodera T, Takahashi S, Harigae H
- Organizer
  The 80th annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] PU.1標的遺伝子メタロチオネインの単球系分化における機能の解明2017
- Author(s)
  高渕優太朗、泉義彦、張替秀郎、高橋伸一郎
- Organizer
  第7回日本検査血液学会東北支部学術集会
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] PU.1標的遺伝子メタロチオネインの単球系分化における機能の解明2017
- Author(s)
  高渕優太朗、泉義彦、張替秀郎、高橋伸一郎
- Organizer
  第7回日本検査血液学会東北支部学術集会
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 急性骨髄性白血病と遺伝子異常～遺伝子異常から分かる病態と未来（教育講演）2017
- Author(s)
  高橋伸一郎
- Organizer
  第49回みやぎ医学検査学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 急性骨髄性白血病と遺伝子異常2017
- Author(s)
  高橋伸一郎
- Organizer
  第7回日本検査血液学会東北支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] 急性骨髄性白血病と遺伝子異常（特別講演）2017
- Author(s)
  高橋伸一郎
- Organizer
  第7回日本検査血液学会東北支部学術集会(招待講演)
- Invited
- Data Source
  KAKENHI-PROJECT-17K09019
[Presentation] 稀な染色体異常であるt(10;18)を伴う骨髄異形成症候群の一例2017
- Author(s)
  大場祐輔、皆川忠徳、渡部卓、櫻田明美、齊藤梨絵、浅野裕子、藤田智咲、泉義彦、藤原実名美、高橋伸一郎
- Organizer
  第18回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] 急性骨髄性白血病と遺伝子異常～遺伝子異常から分かる病態と未来2017
- Author(s)
  高橋伸一郎
- Organizer
  第49回みやぎ医学検査学会
- Invited
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] メタロチオネイン1G発現の顆粒球分化効率予測因子としての可能性2015
- Author(s)
  高橋伸一郎
- Organizer
  日本輸血・細胞治療学会
- Place of Presentation
  京王プラザホテル（新宿、東京都）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] PU.1標的遺伝子MTの好中球分化における役割2015
- Author(s)
  高橋伸一郎
- Organizer
  メタルバイオサイエンス研究会2015
- Place of Presentation
  名古屋国際センター（名古屋、愛知県）
- Year and Date
  2015-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] Downregulation of SIRPa1 results in the aberrant cell growth in low serum culture2015
- Author(s)
  Takahashi S, Waki H, Nakano H
- Organizer
  日本血液学会
- Place of Presentation
  石川県立音楽堂ほか（金沢市、石川県）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] 免疫性血小板減少症におけるトロンボポエチンに対する自己抗体の解析2014
- Author(s)
  佐藤隆司、宮崎浩二、大沢絵莉子、茂出木菜穂美、喜多晃子、栗原紗恵子、川崎友里、小平祐衣、東原正明、高橋伸一郎
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Analysis of anti-thrombopoietin antibody in patients with immune thrombocytopenia2014
- Author(s)
  Satoh T, Miyazaki K, Shimada N, Nagane K, Kita A, Kurihara S, Kawasaki Y, Kodaira Y, Osawa E, Modegi N, Higashihara M, Takahashi S
- Organizer
  日本血液学会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Detection of Anti-Thrombopoietin antibodies in patients with immune thrombocytopenia2014
- Author(s)
  Satoh T, Miyazaki T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
- Organizer
  American Society of Hematology Meeting
- Place of Presentation
  San Francisco Mascone Convention Center, San Francisco, USA
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Detection of anti-thrombopoietin autoantibody among immune thrombocytopenic patients2014
- Author(s)
  Miyazaki T, Satoh T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
- Organizer
  19th Congress of European Hematology Association Meeting
- Place of Presentation
  Milano Congressi, Milan, Italy
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] Acute myeloid leukemia biology: recurrent mutations, and analysis of PU.1 target genes2014
- Author(s)
  Takahashi S
- Organizer
  Time on advances in haematological disorders, the “target therapy”
- Place of Presentation
  Ospedale Vincenzo Cervello, Palermo, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Detection of anti-thrombopoietin autoantibody among immune thrombocytopenic patients2014
- Author(s)
  Miyazaki T, Satoh T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
- Organizer
  19th Congress of European Hematology Association Meeting
- Place of Presentation
  Milano Congressi, Milan, Italy
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] 急性前骨髄性白血病(NB4)細胞におけるメタロチオネイン1G過剰発現の細胞分化・ストレス反応への影響2014
- Author(s)
  平子奈緒美、中野博子、高橋伸一郎
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] メタロチオネイン1-Gの過剰発現は全トランス型レチノイン酸による急性前骨髄球性白血病細胞分化を阻害する2014
- Author(s)
  高橋伸一郎
- Organizer
  日本検査血液学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2014-07-20
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] メタロチオネイン1-Gの過剰発現は全トランス型レチノイン酸による急性前骨髄球性白血病細胞分化を阻害する2014
- Author(s)
  高橋伸一郎
- Organizer
  日本検査血液学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2014-07-20
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] 免疫性血小板減少症におけるトロンボポエチンに対する自己抗体の解析2014
- Author(s)
  佐藤隆司、宮崎浩二、大沢絵莉子、茂出木菜穂美、喜多晃子、栗原紗恵子、川崎友里、小平祐衣、東原正明、高橋伸一郎
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] 急性前骨髄性白血病(NB4)細胞におけるメタロチオネイン1G過剰発現の細胞分化・ストレス反応への影響2014
- Author(s)
  平子奈緒美、中野博子、高橋伸一郎
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] Analysis of anti-thrombopoietin antibody in patients with immune thrombocytopenia2014
- Author(s)
  Satoh T, Miyazaki K, Shimada N, Nagane K, Kita A, Kurihara S, Kawasaki Y, Kodaira Y, Osawa E, Modegi N, Higashihara M, Takahashi S
- Organizer
  日本血液学会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] Detection of Anti-Thrombopoietin antibodies in patients with immune thrombocytopenia2014
- Author(s)
  Satoh T, Miyazaki T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
- Organizer
  American Society of Hematology Meeting
- Place of Presentation
  San Diego Convention Center, San Diego, USA
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-26460685
[Presentation] MT-1G disturbs ATRA induced differentiation of NB4 cells through the inhibition of p532013
- Author(s)
  Hirako N, Nakano H and Takahashi S
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育会館（札幌）
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] 免疫性血小板減少症における抗トロンボポエチン抗体の解析2013
- Author(s)
  佐藤隆司、宮崎浩二、大沢絵莉子、茂出木菜穂美、喜多晃子、栗原紗恵子、川崎友里、小平祐衣、東原正明、高橋伸一郎
- Organizer
  日本臨床免疫学会総会
- Place of Presentation
  海峡メッセ下関（下関）
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] NB4細胞分化におけるPU.1標的遺伝子メタロチオネイン（MT）-1及びビメンチン（VIM）発現解析2011
- Author(s)
  鈴木佐和美、高橋伸一郎他
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] 5-aza-2'-deoxycytidineの細胞周期への影響はPU.1の発現量と関連する2011
- Author(s)
  青山紗由里、高橋伸一郎他
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Over-expression of Metallothionein-1 inhibits retinoic acid induced NB4 cell differentiation
- Author(s)
  Takahashi S, Hirako N, Suzuki S and Nakano H
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590687
[Presentation] Analysis of Fcg receptor 2A, 2B and 3A polymorphisms in adults with immune thrombocytopenia
- Author(s)
  Satoh T, Shimohira A, Amano N, Okazaki Y, Nishimoto T, Akahoshi T, Munekata S, Knoh Y, Okada J, Ikeda Y, Miyazaki K, Higashihara M, Kuwana M and Takahashi S
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590687

1. KAMEOKA Junichi (30261621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 顧建国 (40260369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 福田友彦 (40433510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SATOH Takashi (90407114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. SASAKI Takeshi (50110656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 廣田衛久 (70400364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤賢一 (10282055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中の三弥子 (40397724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 下平秀樹 (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山口芳樹 (90323451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 伊左治知弥 (80433514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

TAKAHASHI Shinichiro 高橋 伸一郎

Research Projects

Research Products

Co-Researchers

一般検診の基本的データを用いた人工知能による膵癌マススクリーニング法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of underlying molecular mechanism for the regulation of chemoresistance by GnT-III

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism for IgG levels regulated by L-fucose

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of efficient leukemia differentiation therapy, and biomarker, through various inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarifying the pathogenesis of hematological malignancies and development of diagnostic markers through analysing PU.1 target genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of PU.1 suppressive target gene, metallothionein, as a forecasting biomarker for anticancer agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of predictive marker for epigenetic drugs in hematological malignanciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Flt3経路を介した急性骨髄性白血病発症の分子機構の解明及び治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of molecules determining the stromal-cell dependent hematopoiesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Myeloid Leukemia/ Basic Mechanisms of Leukemogenesis (Editor: Steffen Koschmieder and Utz Krug), Chapter 132011

Author(s)

Total Pages

Publisher

Data Source

[Book] Trends in Signal Transduction Research (Chapter 8, FLT3 signal transduction and leukemia)2007

Author(s)

Publisher

Data Source

[Journal Article] Progression of hemolysis in a patient with hereditary spherocytosis after the second dose of COVID-19 mRNA vaccine2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suspected Immune Thrombocytopenic Purpura Induced by Lenalidomide for the Treatment of Myelodysplastic Syndrome with Deletion of Chromosome 5q: A Case Report2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Assessment of antibody titer and side effects after third doses of COVID-19 mRNA vaccination in healthy volunteers2022

TAKAHASHI Shinichiro 高橋伸一郎