KUBOTA HIROYUKI 久保田浩行

… Alternative Names

KUBOTA Hiroyuki 久保田浩行

久保田浩行クボタヒロユキ

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Researcher Number	40376603
Other IDs
Affiliation (Current)	2025: 九州大学, 生体防御医学研究所, 教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 九州大学, 生体防御医学研究所, 教授 2013: 東京大学, 理学(系)研究科(研究院), 研究員 2012: 東京大学, 理学(系)研究科(研究院), 助教 2010 – 2011: 東京大学, 大学院・理学系研究科, 助教 2006: 東京大学, 大学院理学系研究科, 寄付講座教員 2005: 東京大学, 大学院・新領域創成科学研究科, 産学官連携研究員
Review Section/Research Field	Principal Investigator Bioinformatics/Life informatics / Basic Section 43050:Genome biology-related / Complex systems / Biological Sciences / Cell biology Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields / Mathematical Sciences in Search of New Cooperation
Keywords	Principal Investigator システム生物学 / インスリン / トランスオミクス解析 / シグナル伝達 / システムバイオロジー / 肥満 / 数理モデル / シミュレーション / 時間情報コーディング / システムズバイオロジー … More / トランスオミクス / 肝臓 / マルチオミクス解析 / 脂肪肝 / 動的特性 / インスリン作用 / 多階層データ / 糖尿病 / インスリンシグナル伝達 / 多階層ネットワーク / ネットワーク / 数理解析 / メタボローム / リン酸化プロテオーム / システムバイオロジ- / 時間パターン / ゲノムワイドスクリーニング / TOR経路 / GCN経路 … More Except Principal Investigator データサイエンス / 精密医療 / データ駆動型 / プロテーム / ゲノム / バイオマーカー / ゲノミクス / ラジオミクス / プロテオミクス / データ駆動型予測 / 脳卒中 / リン酸化プロテオミクス / インスリン情報伝達機構 Less

脳卒中精密医療の基盤構築に関する研究
- Principal Investigator
  
  鴨打正浩
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kyushu University
Understanding of fatty liver progression using time-series Trans-omics analysisPrincipal Investigator
- Principal Investigator
  
  Kubota Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Kyushu University
Mathematical analysis of biological signaling networks across multiple layersPrincipal Investigator
- Principal Investigator
  
  Kubota Hiroyuki
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyushu University
Elucidation of insulin signal transduction mechanism with mathematical analysis of network dynamics
- Principal Investigator
  
  Matsuzaki Fumiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Mathematical Sciences in Search of New Cooperation
- Research Institution
  Kyushu University
数理モデルを用いた入力刺激パターンからの修飾シグナル病の理解Principal Investigator
- Principal Investigator
  
  久保田浩行
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  The University of Tokyo
Understanding of the in vivo temporal patterns of insulinPrincipal Investigator
- Principal Investigator
  
  KUBOTA Hiroyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
Analysis of information processing mechanisms of insulin temporal patternsPrincipal Investigator
- Principal Investigator
  
  KUBOTA Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
GCN経路とTOR経路を結ぶ分子のゲノムワイドスクリーニングPrincipal Investigator
- Principal Investigator
  
  久保田浩行
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010

All Journal Article Presentation Book

[Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022
- Author(s)
  松﨑芙美子　久保田浩行
- Total Pages
  530
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-20H03237
[Book] 遺伝学の百科事典2022
- Author(s)
  久保田浩行
- Total Pages
  690
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-20H03237
[Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022
- Author(s)
  松﨑芙美子、久保田浩行
- Total Pages
  530
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] 遺伝学の百科事典2021
- Author(s)
  久保田浩行
- Total Pages
  690
- Publisher
  丸善出版
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] レディオミクス入門2021
- Author(s)
  久保田浩行
- Total Pages
  338
- Publisher
  オーム社
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] レディオミクス入門2021
- Author(s)
  2.久保田浩行
- Total Pages
  338
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-20H03237
[Book] 医薬品開発におけるオミクス解析技術2020
- Author(s)
  久保田浩行
- Total Pages
  181
- Publisher
  情報機構
- Data Source
  KAKENHI-PROJECT-20H03237
[Book] 血中インスリン濃度パターンによる肝臓シグナル分子の選択的制御2018
- Author(s)
  久保田浩行，黒田真也
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] 生物をシステムとして理解する‐細胞とラジオは同じ!?‐2018
- Author(s)
  久保田　浩行
- Total Pages
  149
- Publisher
  共立スマートセレクション
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] 1.はじめての数理モデルとシミュレーション2017
- Author(s)
  鈴木　貴，久保田　浩行　編集
- Total Pages
  238
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] 医学のあゆみ2016
- Author(s)
  久保田浩行、黒田真也
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- ISBN
- Data Source
  KAKENHI-PLANNED-16H06577
[Book] トランスオミクス解析：次なるシグナリング研究を担えるか!?2015
- Author(s)
  久保田浩行，柚木克之，黒田真也
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-25117712
[Book] Temporal coding of Insulin Signaling2015
- Author(s)
  Hiroyuki Kubota and Shinya Kuroda
- Total Pages
  13
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-25117712
[Book] AKT経路の情報多重化によるインスリン作用の時間情報コーディング2012
- Author(s)
  久保田　浩行, 黒田　真也
- Total Pages
  4
- Publisher
  新着論文レビュー
- Data Source
  KAKENHI-PROJECT-24650153
[Book] AKT経路の情報多重化によるインスリン作用の時間情報コーディング2012
- Author(s)
  久保田　浩行, 黒田　真也
- Total Pages
  4
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-24650153
[Journal Article] Comparison of hepatic responses to glucose perturbation between healthy and obese mice based on the edge type of network structures2023
- Author(s)
  Ito Yuki、Uda Shinsuke、Kokaji Toshiya、Hirayama Akiyoshi、Soga Tomoyoshi、Suzuki Yutaka、Kuroda Shinya、Kubota Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 4758-4758
- DOI
  10.1038/s41598-023-31547-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-20H03237
[Journal Article] In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states.2022
- Author(s)
  Kokaji T, Eto M, Hatano A, Yugi K, Morita K, Ohno S, Fujii M, Hironaka KI, Ito Y, Egami R, Uematsu S, Terakawa A, Pan Y, Maehara H, Li D, Bai Y, Tsuchiya T, Ozaki H, Inoue H, Kubota H, Suzuki Y, Hirayama A, Soga T, Kuroda S.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 13719-13719
- DOI
  10.1038/s41598-022-17964-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-20K19915, KAKENHI-PROJECT-21K14467, KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-20H03237, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-18H05431, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300
[Journal Article] Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans2022
- Author(s)
  Fujita Suguru、Karasawa Yasuaki、Fujii Masashi、Hironaka Ken-ichi、Uda Shinsuke、Kubota Hiroyuki、Inoue Hiroshi、Sumitomo Yohei、Hirayama Akiyoshi、Soga Tomoyoshi、Kuroda Shinya
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 8 Issue: 1 Pages: 6-6
- DOI
  10.1038/s41540-022-00213-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06577, KAKENHI-ORGANIZER-17H06299, KAKENHI-PUBLICLY-20H04847, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-18K16578, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-20H03237, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-17H06300
[Journal Article] Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism2022
- Author(s)
  Uematsu Saori、Ohno Satoshi、Tanaka Kaori Y.、Hatano Atsushi、Kokaji Toshiya、Ito Yuki、Kubota Hiroyuki、Hironaka Ken-ichi、Suzuki Yutaka、Matsumoto Masaki、Nakayama Keiichi I.、Hirayama Akiyoshi、Soga Tomoyoshi、Kuroda Shinya
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 2 Pages: 103787-103787
- DOI
  10.1016/j.isci.2022.103787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06577, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H05215, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-19J22134, KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-21K14467, KAKENHI-PROJECT-20H03237, KAKENHI-PROJECT-18H03979, KAKENHI-PROJECT-21H04759, KAKENHI-PLANNED-17H06300
[Journal Article] An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver2021
- Author(s)
  Matsuzaki Fumiko、Uda Shinsuke、Yamauchi Yukiyo、Matsumoto Masaki、Soga Tomoyoshi、Maehara Kazumitsu、Ohkawa Yasuyuki、Nakayama Keiichi I.、Kuroda Shinya、Kubota Hiroyuki
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 8 Pages: 109569-109569
- DOI
  10.1016/j.celrep.2021.109569
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06577, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H04847, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-18K15011, KAKENHI-PROJECT-20H03237, KAKENHI-PLANNED-17H06300
[Journal Article] Selective Regulation of the Insulin-Akt Pathway by Simultaneous Processing of Blood Insulin Pattern in the Liver.2021
- Author(s)
  Kubota H.
- Journal Title
  
  Methods of Mathematical Oncology,
  
  Volume: 1 Pages: 203-213
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06577
[Journal Article] Selective Regulation of the Insulin-Akt Pathway by Simultaneous Processing of Blood Insulin Pattern in the Liver2021
- Author(s)
  Hiroyuki Kubota
- Journal Title
  
  Methods of Mathematical Oncology
  
  Volume: 1 Pages: 203-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03237
[Journal Article] Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle2021
- Author(s)
  Egami Riku、Kokaji Toshiya、Hatano Atsushi、et al.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 3 Pages: 102217-102217
- DOI
  10.1016/j.isci.2021.102217
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-20K19915, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19J10234, KAKENHI-PROJECT-19J22134, KAKENHI-PROJECT-19K24361, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-16H06577, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-18KT0020, KAKENHI-PLANNED-18H05431, KAKENHI-PROJECT-20H03237
[Journal Article] Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity2020
- Author(s)
  Kokaji Toshiya、Hatano Atsushi、Ito Yuki、et al.
- Journal Title
  
  Science Signaling
  
  Volume: 13 Issue: 660 Pages: 1236-1236
- DOI
  10.1126/scisignal.aaz1236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-19K20382, KAKENHI-PROJECT-19K20394, KAKENHI-PROJECT-20K19915, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-19H04969, KAKENHI-PUBLICLY-19H05243, KAKENHI-PUBLICLY-20H04847, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-19K24361, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-16H06577, KAKENHI-PLANNED-18H05431, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-18KT0020, KAKENHI-PROJECT-20H03237
[Journal Article] Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise2020
- Author(s)
  Wada Takumi、Hironaka Ken-ichi、Wataya Mitsutaka、Fujii Masashi、Eto Miki、Uda Shinsuke、Hoshino Daisuke、Kunida Katsuyuki、Inoue Haruki、Kubota Hiroyuki、Takizawa Tsuguto、Karasawa Yasuaki、Nakatomi Hirofumi、Saito Nobuhito、Hamaguchi Hiroki、Furuichi Yasuro、Manabe Yasuko、Fujii Nobuharu L.、Kuroda Shinya
- Journal Title
  
  Cell Reports
  
  Volume: 32 Issue: 9 Pages: 108051-108051
- DOI
  10.1016/j.celrep.2020.108051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16578, KAKENHI-PROJECT-19K20382, KAKENHI-PUBLICLY-20H04847, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-20J14059, KAKENHI-PROJECT-19K22860, KAKENHI-ORGANIZER-17H06299, KAKENHI-PROJECT-18H03979, KAKENHI-PLANNED-16H06577, KAKENHI-PROJECT-20H03237
[Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells.2019
- Author(s)
  Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 9 Pages: 2901-2916
- DOI
  10.1016/j.celrep.2019.10.079
- NAID
  120006894616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-18H04801, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-16H06577
[Journal Article] Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.2019
- Author(s)
  Fujii M, Murakami Y, Karasawa Y, Sumitomo Y, Fujita S, Koyama M, Uda S, Kubota H, Inoue H, Konishi K, Oba S, Ishii S, Kuroda S.
- Journal Title
  
  NPJ Syst Biol Appl.
  
  Volume: 5 Issue: 1 Pages: 31-31
- DOI
  10.1038/s41540-019-0108-1
- NAID
  120006939199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0020, KAKENHI-PROJECT-18K16578, KAKENHI-PROJECT-19K20382, KAKENHI-PUBLICLY-18H04801, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300, KAKENHI-PLANNED-16H06577
[Journal Article] Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data2018
- Author(s)
  Kawata Kentaro、Yugi Katsuyuki、Hatano Atsushi、Kokaji Toshiya、Tomizawa Yoko、Fujii Masashi、Uda Shinsuke、Kubota Hiroyuki、Matsumoto Masaki、Nakayama Keiichi I.、Kuroda Shinya
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 1 Pages: 82-93
- DOI
  10.1111/gtc.12655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-18H04801, KAKENHI-PROJECT-16K12508, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-18H02431, KAKENHI-PROJECT-15H05582, KAKENHI-PLANNED-16H06577, KAKENHI-PLANNED-18H05431
[Journal Article] Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects2018
- Author(s)
  Ohashi Kaoru、Fujii Masashi、Uda Shinsuke、Kubota Hiroyuki、Komada Hisako、Sakaguchi Kazuhiko、Ogawa Wataru、Kuroda Shinya
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 4 Issue: 1 Pages: 14-14
- DOI
  10.1038/s41540-018-0051-6
- NAID
  120006599090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12508, KAKENHI-PUBLICLY-16H01551, KAKENHI-PROJECT-17J02672, KAKENHI-PLANNED-16H06577
[Journal Article] In?Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver2018
- Author(s)
  Kubota Hiroyuki、Uda Shinsuke、Matsuzaki Fumiko、Yamauchi Yukiyo、Kuroda Shinya
- Journal Title
  
  Cell Systems
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1016/j.cels.2018.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04801, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300, KAKENHI-PLANNED-16H06577
[Journal Article] Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks2018
- Author(s)
  Kawata Kentaro、Hatano Atsushi、Yugi Katsuyuki、Kubota Hiroyuki、Sano Takanori、Fujii Masashi、Tomizawa Yoko、Kokaji Toshiya、Tanaka Kaori Y.、Uda Shinsuke、Suzuki Yutaka、Matsumoto Masaki、Nakayama Keiichi I.、Saitoh Kaori、Kato Keiko、Ueno Ayano、Ohishi Maki、Hirayama Akiyoshi、Soga Tomoyoshi、Kuroda Shinya
- Journal Title
  
  iScience
  
  Volume: 7 Pages: 212-229
- DOI
  10.1016/j.isci.2018.07.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-17H06011, KAKENHI-PLANNED-17H06301, KAKENHI-PUBLICLY-18H04801, KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-18H04000, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-16K12508, KAKENHI-PROJECT-17K19606, KAKENHI-ORGANIZER-17H06299, KAKENHI-PLANNED-17H06300, KAKENHI-PROJECT-15H05582, KAKENHI-PLANNED-16H06577
[Journal Article] Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects.2018
- Author(s)
  Ohashi K., Fujii M., Uda S., Kubota H., Komada H., Sakaguchi K., Ogawa W., and Kuroda S.
- Journal Title
  
  NPJ Syst Biol Appl.
  
  Volume: 14
- NAID
  120006599090
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06577
[Journal Article] Sparse Gaussian graphical model with missing values2017
- Author(s)
  Uda Shinsuke、Kubota Hiroyuki
- Journal Title
  
  Proceedings of the 21st Conference of Open Innovations Association
  
  Volume: - Pages: 336-343
- DOI
  10.23919/fruct.2017.8250201
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01551, KAKENHI-PLANNED-16H06577
[Journal Article] System identification of signaling dependent gene expression with different time-scale data.2017
- Author(s)
  Tsuchiya T., Fujii M., Matsuda N., Kunida K., Uda S., Kubota H., Konishi K., and Kuroda S.
- Journal Title
  
  PLoS Comput. Biol.
  
  Volume: 13
- NAID
  120006555357
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06577
[Journal Article] Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data2014
- Author(s)
  Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, and Shinya Kuroda
- Journal Title
  
  Cell Reports
  
  Volume: 8 Pages: 1171-1183
- NAID
  120005537752
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25117712
[Journal Article] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2012
- Author(s)
  Hiroyuki Kubota, Rei Noguchi, Yu Toyoshima, Yu-ichi Ozaki, Shinsuke Uda, Kanako Watanabe, Wataru Ogawa and Shinya Kuroda
- Journal Title
  
  Molecular Cell
  
  Volume: 46(6) Issue: 6 Pages: 820-832
- DOI
  10.1016/j.molcel.2012.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06435, KAKENHI-PROJECT-21240025, KAKENHI-PROJECT-22700310, KAKENHI-PROJECT-24390234
[Journal Article] AKT経路の情報多重化によるインスリン作用の時間情報コーディング2012
- Author(s)
  久保田浩行、黒田真也
- Journal Title
  
  新着論文レビュー
- URL
  http://first.lifesciencedb.jp/archives/5054
- Data Source
  KAKENHI-PROJECT-22700310
[Journal Article] AKT経路の情報多重化によるインスリン作用の時間情報コーディング2012
- Author(s)
  久保田浩行、黒田真也
- Journal Title
  
  実験医学
  
  Volume: 30巻 Pages: 2609-2612
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] Trans-omic analysis of obesity revealed time-dependent regulation across multiple omic layer.2022
- Author(s)
  Kubota H.
- Organizer
  Hot Spring Harbor International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] Trans-omic analysis of inulin response in the liver.2022
- Author(s)
  2.Matsuzaki F., Uda S., Yamauchi Y., Matumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama K. I., Kuroda S., Kubota H.
- Organizer
  Hot Spring Harbor International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] Trans-omic analysis of insulin response in the liver.2022
- Author(s)
  Matsuzaki F., Uda S., Yamauchi Y., Kubota H.
- Organizer
  International Symposium on Evolutionary Genomics and Bioinformatics 2022 (ISEGB2022),
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] トランスオミクス解析による生命現象の理解2022
- Author(s)
  久保田浩行
- Organizer
  最先端バイオインフォマティクス研究ミニシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] トランスオミクス解析を用いたマウス肝臓におけるインスリン作用の全体像の理解2021
- Author(s)
  久保田　浩行
- Organizer
  第３回日本メディカルAI学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] トランスオミクス解析を用いた疾患の理解2021
- Author(s)
  久保田浩行
- Organizer
  第46回日本脳卒中学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] トランスオミクス解析を用いた疾患の理解2021
- Author(s)
  久保田　浩行
- Organizer
  日本脳卒中学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] Selective regulation of the Insulin-AKT pathway by simultaneous processing of blood insulin pattern in the liver.2020
- Author(s)
  Hiroyuki Kubota
- Organizer
  Fusion of Mathematics and Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] Selective regulation of the Insulin-AKT pathway by simultaneous processing of blood insulin pattern in the liver2020
- Author(s)
  Hiroyuki Kubota.
- Organizer
  Establishing International Research Network of Mathematical Oncology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Comparison of hepatic responses to glucose perturbation between normal and obese mice using edge ontology.2020
- Author(s)
  Yuki Ito, Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Shinya Kuroda and Hiroyuki Kubota
- Organizer
  Fusion of Mathematics and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03237
[Presentation] Comparison of hepatic responses to glucose perturbation between normal and obese mice using edge ontology.2020
- Author(s)
  Yuki Ito, Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Shinya Kuroda and Hiroyuki Kubota.
- Organizer
  Fusion of Mathematics and Biology, Online Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Selective regulation of the Insulin-AKT pathway by simultaneous processing of blood insulin pattern in the liver.2020
- Author(s)
  Hiroyuki Kubota.
- Organizer
  Fusion of Mathematics and Biology, Online Meeting.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Integrated analysis through multiple molecular layers: transomic network dynamics. The 29th Hot Spring Harbor International Symposium, Cutting Edge of Technical Innovations in Trans-Omics.2020
- Author(s)
  Matsuzaki F., Uda S., Yamauchi Y., Matsumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama K. I., Kuroda S., Kubota H.
- Organizer
  The 20th International Conference on Systems Biology.
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Regulation of insulin action by temporal patterns of insulin.2019
- Author(s)
  Hiroyuki Kubota
- Organizer
  iTHEMSセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Regulation of insulin action by temporal patterns of insulin.2019
- Author(s)
  Hiroyuki Kubota.
- Organizer
  JSMB2019 Conference
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] In vivo decoding mechanisms of the temporal patterns of blood insulin by the insulin-AKT pathway in the liver.2019
- Author(s)
  Hiroyuki Kubota
- Organizer
  1st international symposium on interdisciplinary approaches to integrative understanding of biological signaling networks,
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] 時系列トランスオミクス解析2019
- Author(s)
  松崎芙美子、宇田新介、山内幸代、松本雅記、曽我朋義、前原一満、大川恭行、中山敬一、黒田真也、久保田浩行
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] 血中インスリンパターンによる生体応答の制御2019
- Author(s)
  久保田浩行
- Organizer
  生物物理リズム若手研究会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] 肝臓と筋肉におけるAkt経路の定量的な比較2019
- Author(s)
  加藤寛彬、宇田新介、松崎芙美子、久保田浩行
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] トランスオミクス解析を用いた生体応答のシステム的理解2018
- Author(s)
  久保田　浩行
- Organizer
  科学技術未来戦略ワークショップ
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] トランスオミクス解析を用いたインスリン作用の理解2018
- Author(s)
  久保田　浩行
- Organizer
  第22回日本心血管内分泌代謝学会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] 単純なネットワーク構造と入力刺激パターンが生み出す生命応答の制御2018
- Author(s)
  久保田　浩行
- Organizer
  数理シグナル第３回若手ワークショップ
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] An estimation method of sparse partial correlation matrix for omics data analysis.2017
- Author(s)
  Uda, S. and Kubota, H.
- Organizer
  11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] インスリンパターンによる生体内シグナル分子の選択的制御2017
- Author(s)
  久保田　浩行、宇田　新介、松崎　芙美子、山内　幸代、黒田　真也
- Organizer
  2017年度　生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] 定量的トランスオミクス解析の試み2017
- Author(s)
  松崎芙美子, 宇田新介, 久保田浩行
- Organizer
  定量生物学の会　第八回年会
- Place of Presentation
  岡崎
- Year and Date
  2017-01-08
- Data Source
  KAKENHI-PROJECT-15KT0108
[Presentation] Sparse Gaussian Graphical Model with Missing values.2017
- Author(s)
  Uda, S. and Kubota H.
- Organizer
  The 21st Conference of Open Innovations Association FRUCT.
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Trans-Omic analysis of the acute insulin action in the liver =Toward in vivo trans-omic analysis-2017
- Author(s)
  Kubota H., Uda S., Matsuzaki F. and Kuroda S.
- Organizer
  The 1st International Symposium for Trans-Omics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Toward in vivo Trans-omic analysis2016
- Author(s)
  Kubota H., Fumiko M., Shinsuke, U. and Kuroda S.
- Organizer
  14th JHUPO Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Trans-omic analysis of insulin action - toward in vivo trans-omic analysis-2016
- Author(s)
  Kubota H.
- Organizer
  The 26th Hot Spring Harbor International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] マウス肝臓におけるインスリン作用のトランスオミクス解析2016
- Author(s)
  松崎芙美子、久保田浩行
- Organizer
  第1回代謝モデリング勉強会
- Data Source
  KAKENHI-PLANNED-16H06577
[Presentation] Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data.2015
- Author(s)
  Hiroyuki Kubota, Yugi Katsuyuki and Shinya Kuroda
- Organizer
  2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  東京
- Year and Date
  2015-01-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-25117712
[Presentation] インスリン作用のトランスオミクス解析2014
- Author(s)
  久保田浩行，柚木克之，黒田真也
- Organizer
  日本プロテオーム学会
- Place of Presentation
  筑波
- Year and Date
  2014-07-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-25117712
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway2012
- Author(s)
  久保田浩行
- Organizer
  Joint meeting of JSDB 45th & JSCB 64th
- Place of Presentation
  神戸・神戸国際会議場
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2012
- Author(s)
  Kubota, H., Noguchi, R., Toyoshima, Y., Ozaki, Y., Uda, S., Watanabe, K., Ogawa, W. and Kuroda, S.
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡　福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24650153
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2012
- Author(s)
  久保田浩行
- Organizer
  JSDB&JSCB2012、
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2012
- Author(s)
  Kubota, H., Noguchi, R., Toyoshima, Y., Ozaki, Y., Uda, S., Watanabe, K., Ogawa, W., Kuroda, S
- Organizer
  Joint meeting of JSDB 45th & JSCB 64th
- Place of Presentation
  神戸　神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24650153
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway2011
- Author(s)
  久保田浩行
- Organizer
  ICSB2011
- Place of Presentation
  ドイツ・ハイデルベルグ
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] AKT経路の情報多重化によるインスリン作用の時間情報コード2011
- Author(s)
  久保田浩行
- Organizer
  BMB2011
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2011
- Author(s)
  iroyuki Kubota
- Organizer
  ICSB2011
- Place of Presentation
  Heidelberg, Germany
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway2011
- Author(s)
  久保田浩行
- Organizer
  MBSJ 2011
- Place of Presentation
  横浜・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] インスリンシグナル伝達経路の時系列解析2010
- Author(s)
  久保田浩行
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22700310
[Presentation] インスリン作用のAKT経路による多重情報コード2010
- Author(s)
  久保田浩行
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22700310

1. Matsuzaki Fumiko (10631773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. MATSUMOTO Masaki (60380531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 今井哲郎 (10436173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 宇田新介 (20599609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 鴨打正浩 (80346783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吾郷哲朗 (30514202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中島直樹 (60325529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松尾龍 (60744589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 北園孝成 (70284487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kuroda Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 中山敬一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 藤井雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井上啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 濱崎純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小鍛治俊也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 唐沢康暉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBOTA HIROYUKI 久保田 浩行

KUBOTA Hiroyuki 久保田 浩行

久保田 浩行 クボタ ヒロユキ

Research Projects

Research Products

Co-Researchers

脳卒中精密医療の基盤構築に関する研究

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Understanding of fatty liver progression using time-series Trans-omics analysisPrincipal Investigator

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Mathematical analysis of biological signaling networks across multiple layersPrincipal Investigator

Principal Investigator

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Elucidation of insulin signal transduction mechanism with mathematical analysis of network dynamics

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数理モデルを用いた入力刺激パターンからの修飾シグナル病の理解Principal Investigator

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Understanding of the in vivo temporal patterns of insulinPrincipal Investigator

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Analysis of information processing mechanisms of insulin temporal patternsPrincipal Investigator

Principal Investigator

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GCN経路とTOR経路を結ぶ分子のゲノムワイドスクリーニングPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022

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[Book] 遺伝学の百科事典2022

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[Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022

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[Book] 遺伝学の百科事典2021

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[Book] レディオミクス入門2021

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[Book] レディオミクス入門2021

KUBOTA HIROYUKI 久保田浩行

KUBOTA Hiroyuki 久保田浩行

久保田浩行クボタヒロユキ