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Ueno Toshihide  上野 敏秀

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… Alternative Names

上野 敏秀  ウエノ トシヒデ

UENO Toshihide  上野 敏秀

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Researcher Number 40381446
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help 2021 – 2023: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員
2018 – 2019: 国立研究開発法人国立がん研究センター, 研究所, 研究員
2017: 東京大学, 大学院医学系研究科(医学部), 助教
2013 – 2015: 東京大学, 医学(系)研究科(研究院), 助教
2012: 自治医科大学, 医学部, 助教 … More
2010: 自治医科大学, 医学部, 助教
2008: 自治医科大学, 医学部, 研究員
2007: Jichi Medical University, 医学部, ポストドクター
2006: 首都大学東京, 大学院理工学研究科, 客員研究員
2005: 首都大学東京, 都市教養学部・数理科学コース, 研究員 Less
Review Section/Research Field
Principal Investigator
Medical genome science / Basic Section 62010:Life, health and medical informatics-related / General mathematics (including Probability theory/Statistical mathematics)
Except Principal Investigator
Basic analysis
Keywords
Principal Investigator
変異解析 / バイオインフォマティクス / DNA・RNAシークエンシング / ゲノム解析 / 融合遺伝子検出 / がんゲノム個別化医療 / ヒトゲノム配列再解析 / 融合遺伝子探索 / 二次がん / ゲノム医療 … More / 次世代シークエンサー / ニュートン補間多項式 / Galerkin法 / 線の方法 / 境界スプライン / ウェイヴレット / 偏微分方程式 / sinc-interpolation法 / 高精度補間 / 誤差評価 / 離散近似 / ヘルダー連続関数 / Strang-Fix条件 / sinc関数 / スプライン / 標本補間 / サンプリング近似 … More
Except Principal Investigator
データ解析 / 逆問題 / Greedy アルゴリズム / 近似誤差評価 / 基底関数 / ラグランジュ補間関数 / サンプリング補間 / 正定型関数 / 不規則格子点 / 多変数関数近似 / サンプリング定理 / 実解析学 / ウェイブレット解析 / サンプリング近似 / 数値解析 / 実解析 Less
  • Research Projects

    (6 results)
  • Research Products

    (52 results)
  • Co-Researchers

    (29 People)
  •  DNAとRNAシークエンシングデータを用いた統合変異解析ツールの開発Principal Investigator

    • Principal Investigator
      上野 敏秀
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      National Cancer Center Japan
  •  Development of mutation analysis pipeline for cancer genomic medicinePrincipal Investigator

    • Principal Investigator
      Ueno Toshihide
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical genome science
    • Research Institution
      National Cancer Center Japan
      The University of Tokyo
  •  Construction of mutation analysis pipelines for identifying novel cancer genesPrincipal Investigator

    • Principal Investigator
      UENO Toshihide
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical genome science
    • Research Institution
      The University of Tokyo
  •  Computational harmonic analysis - approximation of function

    • Principal Investigator
      OKADA MASAMI
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic analysis
    • Research Institution
      Tokyo Metropolitan University
  •  Computational harmonic analysis, new development of approximation

    • Principal Investigator
      OKADA Masami
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic analysis
    • Research Institution
      Tokyo Metropolitan University
  •  スプラインによる数値調和解析の研究と非線形偏微分方程式への応用Principal Investigator

    • Principal Investigator
      上野 敏秀
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General mathematics (including Probability theory/Statistical mathematics)
    • Research Institution
      Jichi Medical University
      Tokyo Metropolitan University

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2013 2010 2009 2007 Other

All Journal Article Presentation

  • [Journal Article] Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer2024

    • Author(s)
      Takei S、Tanaka Y、Lin Yi-Tzu、Koyama S、Fukuoka S、Hara H、Nakamura Y、Kuboki Y、Kotani D、Kojima T、Bando H、Mishima S、Ueno T、Kojima S、Wakabayashi M、Sakamoto N、Kojima M、Kuwata T、Yoshino T、Nishikawa H、Mano H、Endo I、Shitara K、Kawazoe A
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 12 Issue: 2 Pages: 8210-8210

    • DOI

      10.1136/jitc-2023-008210

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02795
  • [Journal Article] Strategic Approach to Heterogeneity Analysis of Cutaneous Adnexal Carcinomas Using Computational Pathology and Genomics2023

    • Author(s)
      Nishimura Yuuki、Ryo Eijitsu、Inoue Satoshi、Kawazu Masahito、Ueno Toshihide、Namikawa Kenjiro、Takahashi Akira、Ogata Dai、Yoshida Akihiko、Yamazaki Naoya、Mano Hiroyuki、Yatabe Yasushi、Mori Taisuke
    • Journal Title

      JID Innovations

      Volume: 3 Issue: 6 Pages: 100229-100229

    • DOI

      10.1016/j.xjidi.2023.100229

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-23K06476, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K27389
  • [Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023

    • Author(s)
      Ishino Takamasa、Kawashima Shusuke、Tanji Etsuko、Ueno Toshihide、Ueda Youki、Ogasawara Sadahisa、Sato Kazuhito、Mano Hiroyuki、Ishihara Soichiro、Kato Naoya、Kawazu Masahito、Togashi Yosuke
    • Journal Title

      British Journal of Cancer

      Volume: 128 Issue: 6 Pages: 1166-1175

    • DOI

      10.1038/s41416-023-02165-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-21K12117
  • [Journal Article] Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland2023

    • Author(s)
      Kobayashi Kenya、Kawazu Masahito、Yoshimoto Seiichi、Ueno Toshihide、Omura Go、Saito Yuki、Ando Mizuo、Ryo Eigitsu、Sakyo Airi、Yoshida Akihiko、Yatabe Yasushi、Mano Hiroyuki、Mori Taisuke
    • Journal Title

      Laboratory Investigation

      Volume: 103 Issue: 10 Pages: 100213-100213

    • DOI

      10.1016/j.labinv.2023.100213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K09662, KAKENHI-PROJECT-23K06476, KAKENHI-PROJECT-21K09556, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K27389
  • [Journal Article] Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia2023

    • Author(s)
      Miyazaki Bunpei、Ueno Toshihide、Sugiyama Masanaka、Kojima Shinya、Arakawa Ayumu、Tao Kayoko、Tanimura Kazuki、Shiraishi Kouya、Yagishita Shigehiro、Kohsaka Shinji、Kato Mamoru、Kiyokawa Nobutaka、Goto Yasushi、Yatabe Yasushi、Hamada Akinobu、Mano Hiroyuki、Ogawa Chitose、Tanaka Yosuke
    • Journal Title

      npj Precision Oncology

      Volume: 7 Issue: 1 Pages: 132-132

    • DOI

      10.1038/s41698-023-00485-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K27389
  • [Journal Article] Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti?PD-1 Therapy2022

    • Author(s)
      Chida K、Kawazoe A、Suzuki T、Kawazu M、Ueno T、Takenouchi K、Nakamura Y、Kuboki Y、Kotani D、Kojima T、Bando H、Mishima S、Kuwata T、Sakamoto N、Watanabe J、Mano H、Ikeda M、Shitara K、Endo I、Nakatsura T、Yoshino T
    • Journal Title

      Clinical Cancer Research

      Volume: 28 Issue: 10 Pages: 2110-2117

    • DOI

      10.1158/1078-0432.ccr-22-0041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02772
  • [Journal Article] Tumor mutational burden measurement using comprehensive genomic profiling assay2022

    • Author(s)
      Kage Hidenori、Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、Ikegami Masachika、Zokumasu Koichi、Shinozaki-Ushiku Aya、Nagai Sumimasa、Aburatani Hiroyuki、Mano Hiroyuki、Oda Katsutoshi
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 52 Issue: 8 Pages: 925-929

    • DOI

      10.1093/jjco/hyac063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06779, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K12884, KAKENHI-PROJECT-19H01031, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21H03074
  • [Journal Article] Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing2022

    • Author(s)
      Kishigami Fumishi、Tanaka Yosuke、Yamamoto Yoko、Ueno Toshihide、Kojima Shinya、Sato Kazuhito、Inoue Satoshi、Sugaya Saori、Ishihara Soichiro、Mano Hiroyuki、Kawazu Masahito
    • Journal Title

      Cancer Medicine

      Volume: 11 Issue: 18 Pages: 3457-3470

    • DOI

      10.1002/cam4.4710

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02772
  • [Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes2022

    • Author(s)
      Nagasaki Joji、Inozume Takashi、Yosuke Togashi et al.
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 5 Pages: 110331-110331

    • DOI

      10.1016/j.celrep.2022.110331

    • NAID

      120007192058

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K08152, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-22H00455
  • [Journal Article] High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer2022

    • Author(s)
      Mizuno Sho、Ikegami Masachika、Koyama Takafumi、Sunami Kuniko、Ogata Dai、Kage Hidenori、Yanagaki Mitsuru、Ikeuchi Hiroshi、Ueno Toshihide、Tanikawa Michihiro、Oda Katsutoshi、Osuga Yutaka、Mano Hiroyuki、Kohsaka Shinji
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 22 Issue: 2 Pages: 227-239

    • DOI

      10.1158/1535-7163.mct-22-0302

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-20K09662, KAKENHI-PROJECT-21H03074
  • [Journal Article] Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.2021

    • Author(s)
      Takeda Nakamura I, Kohsaka S, Ikegami M, Ueno T, Li K, Beyett T, Koyama T, Shimizu T, Yamamoto N, Takahashi F, Takahashi K, Eck M, Mano H.
    • Journal Title

      NPJ Precision Oncology

      Volume: 16 Issue: 1 Pages: 66-66

    • DOI

      10.1038/s41698-021-00204-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21K08187, KAKENHI-PROJECT-21K12117
  • [Journal Article] Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non?small Cell Lung Cancer PDX Models with Driver Genetic Alterations2021

    • Author(s)
      Jo Hitomi、Yagishita Shigehiro、Hayashi Yoshiharu、Ryu Shoraku、Suzuki Mikiko、Kohsaka Shinji、Ueno Toshihide、Matsumoto Yuji、Horinouchi Hidehito、Ohe Yuichiro、Watanabe Shun-ichi、Motoi Noriko、Yatabe Yasushi、Mano Hiroyuki、Takahashi Kazuhisa、Hamada Akinobu
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 21 Issue: 2 Pages: 359-370

    • DOI

      10.1158/1535-7163.mct-21-0371

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07036, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21K06900
  • [Journal Article] Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels2021

    • Author(s)
      Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S
    • Journal Title

      Nat Biomed Eng

      Volume: - Issue: 8 Pages: 914-925

    • DOI

      10.1038/s41551-021-00692-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-18K07059, KAKENHI-PROJECT-19K20654, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21K19878, KAKENHI-PLANNED-21H05230
  • [Journal Article] MicroSEC; Sequence error filtering pipeline for formalin-fixed and paraffin-embedded samples.2021

    • Author(s)
      Ikegami M, Kohsaka S, Hirose T, Ueno T, Inoue S, Konomata N, Yamauchi H, Mori T, Sekine S, Inamoto Y, Yatabe Y, Kobayashi H, Tanaka S, Mano H.
    • Journal Title

      Commun Biol

      Volume: 4 Issue: 1 Pages: 1396-1396

    • DOI

      10.1038/s42003-021-02930-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07708, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K09453, KAKENHI-PROJECT-21K12117
  • [Journal Article] Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities2021

    • Author(s)
      Tanaka Yosuke、Chiwaki Fumiko、Kojima Shinya、Kawazu Masahito、Komatsu Masayuki、Ueno Toshihide、Inoue Satoshi、Sekine Shigeki、Matsusaki Keisuke、Matsushita Hiromichi、Boku Narikazu、Kanai Yae、Yatabe Yasushi、Sasaki Hiroki、Mano Hiroyuki
    • Journal Title

      Nature Cancer

      Volume: 2 Issue: 9 Pages: 962-977

    • DOI

      10.1038/s43018-021-00240-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-21H02705, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K12117
  • [Journal Article] Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single-cell level2021

    • Author(s)
      Takeda Nakamura I, Ikegami M, Hasegawa N, Hayashi T, Ueno T, Kawazu M, Yagishita S, Goto Y, Shinno Y, Kojima Y, Takamochi K, Takahashi F, Takahashi K, Mano H, Kohsaka S
    • Journal Title

      Cancer Sci

      Volume: - Issue: 5 Pages: 2006-2019

    • DOI

      10.1111/cas.14821

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21K08187, KAKENHI-PROJECT-21K12117
  • [Journal Article] TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment2021

    • Author(s)
      Kawashima S, Inozume T, Kawazu M, Ueno T, Nagasaki J, Tanji E, Honobe A, Ohnuma T, Kawamura T, Umeda Y, Nakamura Y, Kawasaki T, Kiniwa Y, Yamasaki O, Fukushima S, Ikehara Y, Mano H, Suzuki Y, Nishikawa H, Matsue H, Togashi Y.
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 9 Issue: 11 Pages: e003134-e003134

    • DOI

      10.1136/jitc-2021-003134

    • NAID

      120007175403

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K08652, KAKENHI-PROJECT-21K06910, KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K12117
  • [Journal Article] Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer2021

    • Author(s)
      Namba Shinichi、Ueno Toshihide、Kojima Shinya、Kobayashi Kenya、Kawase Katsushige、Tanaka Yosuke、Inoue Satoshi、Kishigami Fumishi、Kawashima Shusuke、Maeda Noriko、Ogawa Tomoko、Hazama Shoichi、Togashi Yosuke、Ando Mizuo、Shiraishi Yuichi、Mano Hiroyuki、Kawazu Masahito
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1320-1320

    • DOI

      10.1038/s42003-021-02833-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K08711, KAKENHI-PROJECT-21K12117
  • [Journal Article] A Low Tumor Mutational Burden and <i>PTEN</i> Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors2021

    • Author(s)
      Chida Keigo, Kawazoe Akihito, Kawazu Masahito et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 27 Issue: 13 Pages: 3714-3724

    • DOI

      10.1158/1078-0432.ccr-21-0401

    • NAID

      130008144997

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K12117
  • [Journal Article] Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers.2021

    • Author(s)
      Hasegawa N, Kohsaka S, Kurokawa K, Shinno Y, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Suehara Y, Ishijima M, Goto Y, Kojima Y, Yonemori K, Hayashi T, Saito T, Shukuya T, Takahashi F, Takahashi K, Mano H.
    • Journal Title

      Cancer Sci

      Volume: 112 Issue: 10 Pages: 4393-4403

    • DOI

      10.1111/cas.15084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21K08187, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-21K20846, KAKENHI-PROJECT-19H03789
  • [Journal Article] Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation2020

    • Author(s)
      Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K
    • Journal Title

      Thorac Cancer

      Volume: 11 Issue: 1 Pages: 140-149

    • DOI

      10.1111/1759-7714.13255

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K09669
  • [Journal Article] Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers2020

    • Author(s)
      Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Kishikawa S, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H
    • Journal Title

      Journal of Thoracic Oncology

      Volume: - Issue: 6 Pages: 30098-8

    • DOI

      10.1016/j.jtho.2020.01.021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-17K09669
  • [Journal Article] Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma2019

    • Author(s)
      Yoshimoto Taichiro、Matsubara Daisuke、Soda Manabu、Ueno Toshihide、Amano Yusuke、Kihara Atsushi、Sakatani Takashi、Nakano Tomoyuki、Shibano Tomoki、Endo Shunsuke、Hagiwara Koichi、Fukayama Masashi、Denda‐Nagai Kaori、Irimura Tatsuro、Mano Hiroyuki、Niki Toshiro
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 9 Pages: 3006-3011

    • DOI

      10.1111/cas.14129

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07441, KAKENHI-PROJECT-19K10094, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K17106
  • [Journal Article] Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines2019

    • Author(s)
      Sai Eirin、Miwa Yoshiyuki、Takeyama Reina、Kojima Shinya、Ueno Toshihide、Yashiro Masakazu、Seto Yasuyuki、Mano Hiroyuki
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 8 Pages: 2643-2651

    • DOI

      10.1111/cas.14111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02883, KAKENHI-PROJECT-17K07250
  • [Journal Article] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations2019

    • Author(s)
      Inoue Satoshi、Hirota Yasushi、Ueno Toshihide、十人省略、Tanaka Yosuke、Sakata Seiji、Takeuchi Kengo、Muraoka Ayako、Osuka Satoko、Saito Tsuyoshi、Oda Katsutoshi、Osuga Yutaka、Terao Yasuhisa、Kawazu Masahito、Mano Hiroyuki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-019-13708-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-19K07708, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-18K16757, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19K22670
  • [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens2019

    • Author(s)
      Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1464-1479

    • DOI

      10.1111/cas.13968

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-17K19608, KAKENHI-PROJECT-17K08730, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-17K07195, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-18H02677
  • [Journal Article] Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer2019

    • Author(s)
      Namba Shinichi、Sato Kazuhito、Kojima Shinya、Ueno Toshihide、Yamamoto Yoko、Tanaka Yosuke、Inoue Satoshi、Nagae Genta、Iinuma Hisae、Hazama Shoichi、Ishihara Soichiro、Aburatani Hiroyuki、Mano Hiroyuki、Kawazu Masahito
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 3 Pages: 1096-1104

    • DOI

      10.1111/cas.13937

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-18K08716, KAKENHI-PROJECT-17J00386, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K07143, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-19K07708
  • [Journal Article] Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter.2019

    • Author(s)
      Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 20047-20047

    • DOI

      10.1038/s41598-019-56377-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08730, KAKENHI-PROJECT-18K15329, KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K10987, KAKENHI-PROJECT-15KK0353
  • [Journal Article] A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination2019

    • Author(s)
      Takaoka Kensuke、Kawazu Masahito、Koya Junji、Yoshimi Akihide、Masamoto Yosuke、Maki Hiroaki、Toya Takashi、Kobayashi Takashi、Nannya Yasuhito、Arai Shunya、Ueno Toshihide、Ueno Hironori、Suzuki Kenshi、Harada Hironori、Manabe Atsushi、Hayashi Yasuhide、Mano Hiroyuki、Kurokawa Mineo
    • Journal Title

      Leukemia

      Volume: 印刷中 Issue: 7 Pages: 1773-1782

    • DOI

      10.1038/s41375-019-0385-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-18K16110, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-17K16181, KAKENHI-PROJECT-18K07320
  • [Journal Article] Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes2019

    • Author(s)
      Oga T, Yamashita Y, Soda M, Kojima S, Ueno T, Kawazu M, Suzuki N, Nagano H, Hazama S, Izumiya M, Koike K, Mano H
    • Journal Title

      Cancer Sci

      Volume: 110(9) Issue: 9 Pages: 2973-2981

    • DOI

      10.1111/cas.14127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08646, KAKENHI-PROJECT-17K07250
  • [Journal Article] Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion2018

    • Author(s)
      Kohsaka Shinji、Saito Tsuyoshi、Akaike Keisuke、Suehara Yoshiyuki、Hayashi Takuo、Takagi Tatsuya、Kaneko Kazuo、Ueno Toshihide、Kojima Shinya、Kohashi Ken-ichi、Mano Hiroyuki、Oda Yoshinao、Yao Takashi
    • Journal Title

      Human Pathology

      Volume: 72 Pages: 167-173

    • DOI

      10.1016/j.humpath.2017.08.017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K08722, KAKENHI-PROJECT-17K08730, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964
  • [Journal Article] Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia2018

    • Author(s)
      Tanaka Yosuke、Kawazu Masahito、Yasuda Takahiko、Tamura Miki、Hayakawa Fumihiko、Kojima Shinya、Ueno Toshihide、Kiyoi Hitoshi、Naoe Tomoki、Mano Hiroyuki
    • Journal Title

      Haematologica

      Volume: 103 Issue: 11 Pages: 522-526

    • DOI

      10.3324/haematol.2017.183152

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K16103, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17J10130
  • [Journal Article] Integrated molecular profiling of juvenile myelomonocytic leukemia2018

    • Author(s)
      Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y, Muramatsu H
    • Journal Title

      Blood

      Volume: 131 Issue: 14 Pages: 1576-1586

    • DOI

      10.1182/blood-2017-07-798157

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K07816, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-18K12273, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-18H02690, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K19311, KAKENHI-PROJECT-17K16248
  • [Journal Article] Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability?High Colorectal Cancers2018

    • Author(s)
      Sato Kazuhito、Kawazu Masahito、Yamamoto Yoko、Ueno Toshihide、Kojima Shinya、Nagae Genta、Abe Hiroyuki、Soda Manabu、Oga Takafumi、Kohsaka Shinji、Sai Eirin、Yamashita Yoshihiro、Iinuma Hisae、Fukayama Masashi、Aburatani Hiroyuki、Watanabe Toshiaki、Mano Hiroyuki
    • Journal Title

      Clinical Cancer Research

      Volume: 25 Issue: 1 Pages: 378-389

    • DOI

      10.1158/1078-0432.ccr-18-1574

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-18K08716, KAKENHI-PROJECT-17J00386, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K07143
  • [Journal Article] High-Throughput Functional Evaluation of Variants of Unknown Significance inERBB22018

    • Author(s)
      Nagano Masaaki、Kohsaka Shinji、Ueno Toshihide、Kojima Shinya、Saka Kanju、Iwase Hirotaro、Kawazu Masahito、Mano Hiroyuki
    • Journal Title

      Clinical Cancer Research

      Volume: 24 Issue: 20 Pages: 5112-5122

    • DOI

      10.1158/1078-0432.ccr-18-0991

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-16K09200
  • [Journal Article] Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation2018

    • Author(s)
      Morita Keigo、Hama Yutaro、Izume Tamaki、Tamura Norito、Ueno Toshihide、Yamashita Yoshihiro、Sakamaki Yuriko、Mimura Kaito、Morishita Hideaki、Shihoya Wataru、Nureki Osamu、Mano Hiroyuki、Mizushima Noboru
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Issue: 11 Pages: 3817-3828

    • DOI

      10.1083/jcb.201804132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K14694, KAKENHI-PUBLICLY-17H05690, KAKENHI-PROJECT-18J20411
  • [Journal Article] Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.2017

    • Author(s)
      Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M,Takahashi T, Mano H, Niki T.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 9 Pages: 1888-1896

    • DOI

      10.1111/cas.13313

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-17K07250, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H02468
  • [Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer2017

    • Author(s)
      Kohsaka Shinji、Nagano Masaaki、Ueno Toshihide、Suehara Yoshiyuki、Hayashi Takuo、Shimada Naoko、Takahashi Kazuhisa、Suzuki Kenji、Takamochi Kazuya、Takahashi Fumiyuki、Mano Hiroyuki
    • Journal Title

      Science Translational Medicine

      Volume: 9 Issue: 416 Pages: 6566-6566

    • DOI

      10.1126/scitranslmed.aan6566

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K10691, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964, KAKENHI-PROJECT-26461200
  • [Journal Article] Recurrent CDC25C mutations drive malignant transformation in FPD/AML2014

    • Author(s)
      Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka H, Nakagawa M, Nannya Y, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Ichikawa M, Mano H, Kurokawa M
    • Journal Title

      Nature communications

      Volume: 5 Issue: 1 Pages: 4770-4770

    • DOI

      10.1038/ncomms5770

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24390268, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461611, KAKENHI-PROJECT-25670482, KAKENHI-PROJECT-25830139, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-26461598, KAKENHI-PROJECT-26860474
  • [Journal Article] Cancer-associated missense mutations of caspase-8 activate nuclear factor-κB signaling2013

    • Author(s)
      Ando M, Kawazu M, Ueno T, Fukumura K, Yamato A, Soda M, Yamashita Y, Choi YL, Yamasoba T, Mano H.
    • Journal Title

      Cancer Sci.

      Volume: 104(8) Issue: 8 Pages: 1002-8

    • DOI

      10.1111/cas.12191

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25830139
  • [Journal Article] STK10 missense mutations associated with anti-apoptotic function2013

    • Author(s)
      Fukumura K, Yamashita Y, Kawazu M, Sai E, Fujiwara S, Nakamura N, Takeuchi K, Ando M, Miyazono K, Ueno T, Ozawa K, Mano H.
    • Journal Title

      Oncol Rep.

      Volume: 30(4) Issue: 4 Pages: 1542-8

    • DOI

      10.3892/or.2013.2605

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25830139
  • [Journal Article] Approximate sampling theorem and the order of smoothness of the Besov space.2010

    • Author(s)
      Stephane Jaffard, Masami Okada, Toshihide Ueno,
    • Journal Title

      To appear in RIMS Kokyuroku, Bessatsu, ed.T.Ozawa, RIMS, Kyoto Univ., (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] Approximate sampling theorem and order of smoothness of the Besov space.2010

    • Author(s)
      Stephane Jaffard, Masami Okada, Toshihide Ueno
    • Journal Title

      RIMS Kokyuroku, Bessatsu B18

      Pages: 45-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] Non-separable splines and numerical computation of evolution equations by the Galerkin methods.2009

    • Author(s)
      Toshihide Ueno, Masami Okada
    • Journal Title

      Journal of Computational and Applied Mathematics 223巻

      Pages: 159-176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] Some remarks on approximate sampling theorems : estimate with Besov norm and an application2009

    • Author(s)
      Masami okada, Toshihide Ueno
    • Journal Title

      RIMS共同研究確率数値解析に於ける諸問題VIII 1620巻

      Pages: 147-149

    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] Some remarks on approximate sampling theorems : estimate with Besov norm and an application2009

    • Author(s)
      Okada Masaml Ueno Toshihide
    • Journal Title

      RIMS共同研究確率数値解析に於ける諸問題VII 1620

      Pages: 147-149

    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] Non-separable splines and numerical computation of evolution equations by the Galerkin methods.2009

    • Author(s)
      Ueno Toshihide Okada Masami
    • Journal Title

      Journal of Computational and Applied Mathematics 223

      Pages: 159-176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20540183
  • [Journal Article] New spline basis functions for sampling approximations

    • Author(s)
      Toshihide Ueno, Simon Truscott, Masami Okada
    • Journal Title

      Journal of Computational and Applied Mathematics (掲載決定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17740064
  • [Journal Article] Non-separable splines and numerical computation of evolution equations by the Galerkin methods

    • Author(s)
      Toshihide Ueno, Masami Okada
    • Journal Title

      Numerical Algorithms (掲載決定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17740064
  • [Presentation] 君にもできるゲノミクス:体細胞変異解析入門12023

    • Author(s)
      上野 敏秀
    • Organizer
      第82回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K12117
  • [Presentation] 2.君にもできるゲノミクス:体細胞変異解析入門22023

    • Author(s)
      上野 敏秀
    • Organizer
      第82回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K12117
  • [Presentation] 滑らかな函数を補間する"最適"スプライン函数の構成2007

    • Author(s)
      上野敏秀、Simon Truscott、岡田正已
    • Organizer
      日本応用数理学会2007年度年会(ウェーブレット)
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-09-17
    • Data Source
      KAKENHI-PROJECT-17740064
  • 1.  OKADA Masami (00152314)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  OZAWA Kazufumi (20100753)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KURATA Kazuhiro (10186489)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  YOSHITOMI Kazushi (40304729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SHIMOMURA Akihiro (00365066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MORITOU SHINYA (30273832)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SAWANO YOSHIHIRO (40532635)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  立澤 一哉 (80227090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MATSYBARA Daisuk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  HARADA Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  SAITO Tsuyoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  高橋 和久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 13.  高橋 史行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 14.  小笠原 定久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  冨樫 庸介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  岡田 正己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 17.  原田 浩徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  高阪 真路
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 19.  元井 紀子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  八代 正和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  河津 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 22.  井上 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  永井 純正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  谷田部 恭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  猪爪 隆史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  末原 義之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  池原 譲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  永野 浩昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  川添 彬人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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