Nakamoto Nobuhiro 中本伸宏

… Alternative Names

NAKAMOTO Nobuhiro 中本伸宏

Less

Researcher Number	40383749
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2018: 慶應義塾大学, 医学部(信濃町), 講師 2015: 慶應義塾大学, 医学部(信濃町), 専任講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 2010 – 2013: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 52:General internal medicine and related fields / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 腸内細菌 / 脂肪性肝炎 / 肝線維化 / 免疫学 / マクロファージ / 急性肝障害 / 肝臓 / 免疫難病 / 体内侵入菌 / 臓器連関 … More / Resident memory T細胞 / 肝線維化修復 / NASH / T細胞 / アポトーシス / 星細胞 / 組織常在性T細胞 / 組織常在型T細胞 / 組織常在型CD8 T細胞 / 線維化修復 / 肝臓線維化 / 細胞療法 / CCL25 / CCR9 / 形質細胞様樹状細胞 / 樹状細胞 / 急性肝不全 / 腸肝相関 / IL-17 / 原発性硬化性胆管炎 / ケモカイン / Toll様受容体 / 免疫寛容 / 肝硬変 / トランスレーショナルリサーチ / ケモカイン受容体 / 肝臓学 … More Except Principal Investigator exhaustion / NKT細胞 / CD8T細胞 / C型慢性肝炎 / T細胞の疲弊 / HCV特異的T細胞 / 腸肝相関 / 免疫寛容 / NK細胞 / CD8 T細胞 / C型肝炎 / 獲得免疫 / T細胞疲弊 / C型肝炎ウイルス Less

体内侵入菌による臓器相関を介した免疫難病の病態解明と治療応用Principal Investigator
- Principal Investigator
  
  中本伸宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Keio University
Involvement of host invading bacteria in the development and carcinogenesis of non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  中本伸宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Keio University
Therapeutic effect of plasmacytoid dendritic cells transplantation for acute liver failurePrincipal Investigator
- Principal Investigator
  
  Nakamoto Nobuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
Elucidation of the mechanism of NASH resolution via the gut-liver axis for future clinical applicationPrincipal Investigator
- Principal Investigator
  
  NAKAMOTO NOBUHIRO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Keio University
Role of gut microbiota in the pathogenesis of primly sclerosing cholangitisPrincipal Investigator
- Principal Investigator
  
  NAKAMOTO NOBUHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
The interaction between the intestinal microbiota and hepatic macrophages in the pathogenesis of liver fibrosisPrincipal Investigator
- Principal Investigator
  
  Nakamoto Nobuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Comprehensive analysis of dysfunctional HCV specific CD8 T cell during persistent HCV infection
- Principal Investigator
  
  Ishibashi Yuka
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liverPrincipal Investigator
- Principal Investigator
  
  NAKAMOTO Nobuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2022 2021 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells2021
- Author(s)
  Koda Yuzo、Teratani Toshiaki、Chu Po-Sung、Hagihara Yuya、Mikami Yohei、Harada Yosuke、Tsujikawa Hanako、Miyamoto Kentaro、Suzuki Takahiro、Taniki Nobuhito、Sujino Tomohisa、Sakamoto Michiie、Kanai Takanori、Nakamoto Nobuhiro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4474-4474
- DOI
  10.1038/s41467-021-24734-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-21H02906, KAKENHI-PROJECT-21K18272, KAKENHI-PROJECT-20H04129
[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019
- Author(s)
  Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 4 Issue: 3 Pages: 492-503
- DOI
  10.1038/s41564-018-0333-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18K15794, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16K09374, KAKENHI-PROJECT-16K15293, KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-16H05186, KAKENHI-PROJECT-16K08091
[Journal Article] Does the Intestinal Microbiota Explain Differences in the Epidemiology of Liver Disease between East and West?2016
- Author(s)
  Nobuhiro Nakamoto and Bernd Schnabl
- Journal Title
  
  Inflammatory Intestinal Diseases
  
  Volume: 1 Issue: 1 Pages: 3-8
- DOI
  10.1159/000443196
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860559
[Journal Article] CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.2012
- Author(s)
  Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, Handa T,Matsumoto A, Nakamoto N, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T.
- Journal Title
  
  Immunol Lett
  
  Volume: 146 Pages: 64-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590744
[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.2012
- Author(s)
  Nakamoto N, Ebinuma H, Kanai T, Chu PS, Ono Y, Mikami Y, Ojiro K, Lipp M, Love PE, Saito H, Hibi T.
- Journal Title
  
  Gastroenterology
  
  Volume: 142 Pages: 366-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590744
[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis2012
- Author(s)
  Nobuhiro Nakamoto, et.al.
- Journal Title
  
  Gastroenterology
  
  Volume: 142 Issue: 2 Pages: 366-376
- DOI
  10.1053/j.gastro.2011.10.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590744
[Patent] Pore-forming Klebsiella pneumoniae strains enriched in primary sclerosing cholangitis trigger bacterial translocation and pathogenic Th17 priming in the liver2018
- Inventor(s)
  中本伸宏
- Industrial Property Rights Holder
  中本伸宏
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K09374
[Presentation] Roles of CD8 resident memory T cells in the liver fibrosis resolution2022
- Author(s)
  Yuzo Koda, Nobuhiro Nakamoto, Takanori Kanai
- Organizer
  第63回日本消化器病学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04129
[Presentation] 形質細胞様樹状細胞を用いた急性発症型自己免疫性肝炎の病態制御2021
- Author(s)
  幸田裕造、中本伸宏、金井隆典
- Organizer
  第107回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K21607
[Presentation] Gut pathobionts underlie intestinal barrier dysfunction and liver Th17 immune responses in primary sclerosing cholangitis2019
- Author(s)
  Nobuhiro Nakamoto
- Organizer
  EASL annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09374
[Presentation] Collaboration of intestinal microbiota induces bacterial translocation and Th17 immune response in primary sclerosing cholangitis2017
- Author(s)
  中本伸宏
- Organizer
  米国肝臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09374
[Presentation] 原発性硬化性胆管炎の病態における腸内細菌の関与2017
- Author(s)
  中本伸宏
- Organizer
  日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-16K09374
[Presentation] The gut-liver axis plays a crucial role in murine immune tolerance in the liver2016
- Author(s)
  中本伸宏
- Organizer
  The Ameriac association for immunologists 2016 annual meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09374
[Presentation] The gut-liver axis plays a crucial role in murine immune tolerance in the liver2015
- Author(s)
  Nobuhiro Nakamoto
- Organizer
  AASLD 2015 annual meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860559
[Presentation] ケモカイン・ケモカイン受容体ＣＣＬ２５／ＣＣＲ９を介する肝線維化促進機序：マウス肝線維化モデルでの検討2013
- Author(s)
  楮柏松、中本伸宏
- Organizer
  第50回日本消化器免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860559
[Presentation] マウスCon A急性肝不全モデルでの病因性CCR9陽性マクロファージの発見から、肝臓各病態形成への関与2013
- Author(s)
  中本伸宏
- Organizer
  日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] Newly identified TNF-α-producing CCR9^+ macrophages induce acute liver inflammation in mice2011
- Author(s)
  Nobuhiro Nakamoto, et.al.
- Organizer
  62^<nd> Annual Meeting of the AASLD
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] Newly identified TNF-α-producing CCR9+ macrophages induce acute liver inflammation in mice2011
- Author(s)
  Nobuhiro Nakamoto et.al
- Organizer
  62nd Annual Meeting of the AASLD
- Place of Presentation
  San Francisco,USA
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] 自己免疫応答性急性肝障害の病態形成におけるCCR9 陽性マクロファージの役割2011
- Author(s)
  中本伸宏
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] マウスPlasmacytoid DCの肝臓免疫寛容への関与2010
- Author(s)
  中本伸宏
- Organizer
  第38回日本肝臓学会東部会
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] マウス肝臓内免疫担当細胞の免疫寛容への関与2010
- Author(s)
  中本伸宏
- Organizer
  第38回日本肝臓学会東部会
- Place of Presentation
  東京・京王プラザホテル
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22590744
[Presentation] A distinct role for the TLR9 pathway in immune activation and tolerance during acute liver injury in mice
- Author(s)
  中本伸宏
- Organizer
  米国肝臓学会
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-09 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25860559
[Presentation] C型慢性肝炎難治例における抗ウイルス療法中の末梢血HCV特異的CD8 T細胞機能の経時的変化と補助シグナル阻害による機能修飾の検討
- Author(s)
  中本伸宏
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790720

1. KANAI Takanori (40245478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Ishibashi Yuka (60528305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 須田亙 (20590847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 福田真嗣 (80435677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. CHU Po-Sung

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANIKI Nobuhito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TERATANI Toshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 筋野智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamoto Nobuhiro 中本 伸宏

NAKAMOTO Nobuhiro 中本 伸宏

Research Projects

Research Products

Co-Researchers

体内侵入菌による臓器相関を介した免疫難病の病態解明と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of host invading bacteria in the development and carcinogenesis of non-alcoholic steatohepatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic effect of plasmacytoid dendritic cells transplantation for acute liver failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of NASH resolution via the gut-liver axis for future clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of gut microbiota in the pathogenesis of primly sclerosing cholangitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The interaction between the intestinal microbiota and hepatic macrophages in the pathogenesis of liver fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of dysfunctional HCV specific CD8 T cell during persistent HCV infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Does the Intestinal Microbiota Explain Differences in the Epidemiology of Liver Disease between East and West?2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.2012

Author(s)

Journal Title

Data Source

[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.2012

Author(s)

Journal Title

Data Source

[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis2012

Author(s)

Journal Title

DOI

Nakamoto Nobuhiro 中本伸宏

NAKAMOTO Nobuhiro 中本伸宏