UENO Takahiro 上野高浩

… Alternative Names

上野高浩ウエノタカヒロ

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Researcher Number	40386008
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 兼任講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 日本大学, 医学部, 兼任講師 2015 – 2017: 日本大学, 医学部, 兼任講師 2011 – 2014: 日本大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related / Cardiovascular medicine / Clinical oncology
Keywords	Principal Investigator PIポリアミド / 脂質異常症 / 肥満 / カイロミクロン / PI polyamide / Sar1b Except Principal Investigator PIポリアミド / PI ポリアミド / 高血圧自然発症ラット / ジンクフィンガーヌクレアーゼ … More / 補体 / 高血圧 / 糖尿病 / プロテインS / 糖尿病性腎症 / 形質変換 / ゲノム編集 / 抗動脈硬化作用 / メタボリックシンドローム / アディポネクチン / 上皮間葉化現象 / E-box配列 / がん / ポリアミド / 抗腫瘍薬 / Myc / 抗腫瘍効果 / MYC / E-box / ピロール・イミダゾール・ポリアミド Less

Development of the novel gene modulator PI polyamide targeting protein S as a therapeutic agent for diabetes mellitus and diabetic nephropathy
- Principal Investigator
  
  TSUNEMI Akiko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nihon University
Involvement of C3 in the pathogenesis of hypertension with an activation of tissue renin-angiotensin system
- Principal Investigator
  
  FUKUDA Noboru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nihon University
Development of PI Polyamide targeting adiponectin gene
- Principal Investigator
  
  TSUNEMI Akiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nihon University
Development of PI polyamide targeting Sar1b genePrincipal Investigator
- Principal Investigator
  
  UENO Takahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Nihon University
Role of complement 3 in the pathogenesis of hypertension
- Principal Investigator
  
  FUKUDA Noboru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nihon University
Analysis of anti-cancer effect of PI polyamide, which suppress MYC downstream genes
- Principal Investigator
  
  SOMA Masayoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Nihon University

All 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets E-box.2014
- Author(s)
  134. Taniguchi M, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma T, Nagase H.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 328-334
- DOI
  10.1016/j.fob.2014.03.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300344, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23501313, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.2014
- Author(s)
  Ikeda K, Fukuda N, Ueno T, Endo M, Kobayashi N, Soma M, Matsumoto K.
- Journal Title
  
  Clinical and Experimental Hypertension
  
  Volume: 36(1) Issue: 1 Pages: 58-63
- DOI
  10.3109/10641963.2013.789042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591242
[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif Original Research Article2014
- Author(s)
  Taniguchi M, Fujiwara K, Nakai Y, Ozaki T, Koshikawa N, Toshio K, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma M, Nagase H
- Journal Title
  
  FEBS Open Bio
  
  Volume: (4) Pages: 328-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501313
[Journal Article] Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats2013
- Author(s)
  Ikeda K, Fukuda N, Ueno T, Endo M, Kobayashi N, Soma M, Matsumoto K
- Journal Title
  
  Clinical and Experimental Hypertension
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591242
[Journal Article] Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice.2013
- Author(s)
  Zhou X, Fukuda N, Matsuda H, Endo M, Wang X, Saito K, Ueno T, Matsumoto T, Matsumoto K, Soma M, Kobayashi N, Nishiyama A.
- Journal Title
  
  American Journal of Physiology Renal Physiology
  
  Volume: 305(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3はSHRで腎尿細管上皮間葉化(EMT)により腎内RA系を活性化し塩分感受性高血圧を起こしている2016
- Author(s)
  根岸英理子、福田　昇、上野高浩、遠藤守人、岡田一義、阿部雅紀、相馬正義.
- Organizer
  第39回　日本高血圧学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 高血圧自然発症ラット(SHR)での塩分感受性高血圧への補体C3の関与.2016
- Author(s)
  根岸英理子、福田昇、上野高浩、遠藤守人、阿部雅紀.
- Organizer
  第20回　心血管内分泌代謝学会総会
- Place of Presentation
  東京コンベンションホール（東京都中央区）
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3は腎尿細管上皮間葉化による組織RA系の活性化からＳＨＲの高血圧発症因子である2016
- Author(s)
  根岸英理子、福田　昇、上野高浩、阿部雅紀、岡田一義、相馬正義.
- Organizer
  第59回　日本腎臓学会総会
- Place of Presentation
  パシフィコ横浜（神奈川件横浜市）
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3は間葉系細胞脱分化および上皮間葉化現象(EMT)により心血管腎リモデリングを起こす2016
- Author(s)
  福田　昇、根岸英理子、片川まゆみ、上野高浩、松本太郎
- Organizer
  第15回　日本再生医療学会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区中之島）
- Year and Date
  2016-03-06
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] Complement 3 induces the salt-sensitive hypertension by induction of dedifferentiation of mesenchymal tissues with activation of renal RA system in SHR.2016
- Author(s)
  Eriko Negishi, Noboru Fukuda, Takahiro Ueno, Morito Endo, Kazutoshi Komatsu, Mayumi Katakawa, Akiko Tsunemi, Masanori Abe, Masayoshi Soma.
- Organizer
  17th International SHR Symposium.
- Place of Presentation
  秋葉原UDX GALLERY（東京都千代田区）
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 高血圧自然発症ラット(SHR)の高血圧腎リモデリングにおける補体C3の役割2015
- Author(s)
  根岸英理子、福田　昇、片川まゆみ、上野高浩、阿部雅紀、岡田一義、遠藤守人、松本紘一、相馬正義
- Organizer
  第58回　日本腎臓学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市熱田区西町）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3によるSHRの腎レニン・アンジオテンシン系の活性化から高血圧病態形成2015
- Author(s)
  根岸英理子、福田　昇、遠藤守人、片川まゆみ、常見明子、渡辺めぐみ、上野高浩、相馬正義
- Organizer
  第51回　高血圧関連疾患モデル学会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市新千里東町）
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 新規脂質吸収抑制薬であるSAR1B制御PIポリアミドの開発2015
- Author(s)
  小林洋樹、上野高浩、常見明子、田中　翔、畑中善成、田平和宣、羽毛田　公、福田　昇、相馬正義.
- Organizer
  第３8回日本高血圧学会
- Place of Presentation
  愛媛県県民文化会館（愛媛県松山市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25461378
[Presentation] Complement 3 Involved in the Hypertensive Endorgan Dameages Through Activation of RAS and Dedifferentiation of Mesenchymal Tissues2015
- Author(s)
  Noboru Fukuda, Eriko Negishi, Mayumi Katakawa, Akiko Tsunemi, Tahahiro Ueno, Morito Endo, Masayoshi Soma
- Organizer
  第38回　日本高血圧学会
- Place of Presentation
  ひめぎんホール（愛媛県松山市道後町）
- Year and Date
  2015-10-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3は間葉組織を脱分化し組織レニン・アンジオテンシン系の活性化から塩分感受性高血圧発症因子である2015
- Author(s)
  根岸英理子、福田　昇、上野高浩、相馬正義
- Organizer
  高血圧と冠動脈疾患研究会
- Place of Presentation
  大手町サンケイプラザ（東京都千代田区大手町）
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3による組織レニン・アンジオテンシン系の活性化から高血圧病態形成2015
- Author(s)
  根岸英理子、福田　昇、片川まゆみ、上野高浩、阿部雅紀、岡田一義、遠藤守人、松本紘一、相馬正義
- Organizer
  第38回　日本高血圧学会
- Place of Presentation
  ひめぎんホール（愛媛県松山市道後町）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 補体C3は腎髄質EMTによる組織RA系の活性化から高血圧病態を形成する2015
- Author(s)
  根岸英理子、福田　昇、片川まゆみ、常見明子、上野高浩、遠藤守人、相馬正義
- Organizer
  第19回　日本心血管内分泌代謝学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市中央区港島中町）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K09300
[Presentation] 小腸上皮細胞においてSAR1B発現を抑制する新規遺伝子発現制御薬ピロール･イミダゾール･ポリアミドの効果2015
- Author(s)
  小林洋樹、上野高浩、常見明子、田中　翔、畑中善成、田平和宣、羽毛田　公、福田　昇、相馬正義.
- Organizer
  第４7回日本動脈硬化学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25461378
[Presentation] HR/Izm全ゲノムシーケンスでの補体C3構造とジンクフィンガーヌクレアーゼ(ZFN)法によるC3ノックアウトSHR/Izmの病態解析2014
- Author(s)
  根岸英理子、福田　昇、片川まゆみ、上野高浩、相馬正義、真下知士
- Organizer
  第50回　高血圧関連疾患モデル学会
- Place of Presentation
  和歌山
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3は高血圧自然発症ラット(SHR)の間葉系組織を脱分化し組織RA系を介して高血圧を引き起こす2014
- Author(s)
  根岸英理子、福田　昇、片川まゆみ、上野高浩、小松一俊、相馬正義、真下知士
- Organizer
  第18回　日本心血管内分泌代謝学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] Complement 3 is involved in hypertension by activation of renal RA systems in SHR2014
- Author(s)
  Eriko Negishi, Noboru Fukuda, Takahiro Ueno, Masayoshi Soma
- Organizer
  The 16th International SHR Symposium
- Place of Presentation
  イタリア・ローマ
- Year and Date
  2014-06-17
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 腎尿細管上皮間葉化による腎臓内レニン・アンジオテンシン系の亢進.2013
- Author(s)
  Zhou Xueli、福田　昇、上野高浩、相馬正義、西山　成
- Organizer
  第86回　日本内分泌学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3は腎髄質上皮間葉化現象(EMT)により腎内レニン・アンジオテンシン(RA)系を活性化し高血圧およぎ腎硬化症を引き起こす2013
- Author(s)
  Zhou Xueli、福田　昇、上野高浩、遠藤守人、相馬正義、西山　成
- Organizer
  第49回　高血圧関連疾患モデル学会
- Place of Presentation
  日本大学会館（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3は腎尿細管上皮間葉化(EMT)により腎内レニン・アンジオテンシン(RA)系を活性化する2013
- Author(s)
  福田　昇、上野高浩、松田裕之、西山　成、松本紘一、相馬正義
- Organizer
  第42回　日本心脈管作動物質学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3は上皮間葉化(EMT)により腎尿細管でのレニン－アンジオテンシン(RA)系を活性化する2013
- Author(s)
  福田　昇、上野高浩、遠藤守人、松本紘一、相馬正義、西山　成
- Organizer
  第56回　日本腎臓学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 腎髄質尿細管上皮間葉化による補体C3を介した腎内レニン・アンジオテンシン系の活性化2012
- Author(s)
  Zhou Xueli、福田　昇、上野高浩、遠藤守人、松田裕之、松本紘一、相馬正義
- Organizer
  第35回　高血圧学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3による腎尿細管上皮間葉化(EMT)と腎内レニン-アンジオテンシン(RA)系の活性化2012
- Author(s)
  Zhou Xueli、福田　昇、上野高浩、松田裕之、西山　成、松本紘一、相馬正義
- Organizer
  第16回　心血管内分泌代謝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] Complement 3 activates the renal renin-angiotensin system by the epithelial-to-mesenchymal transition2012
- Author(s)
  Zhou Xueli, Noboru Fukuda, Takahiro Ueno, Koichi Matsumoto, Masayoshi Soma
- Organizer
  24th Meeting of the International Society of Hypertension
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 補体C3a-C3a受容体系は腎間葉系細胞脱分化および上皮間葉化現象(EMT)に関与する2012
- Author(s)
  福田　昇、Zhou Xueli、池田和也、上野高浩、松本太郎、相馬正義
- Organizer
  第11回　再生医療学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] Complement 3 induces renal renin generation through the epitheliao-mesenchymal transition2012
- Author(s)
  Zhou Xueli, Noboru Fukuda, Takahiro Ueno, Koichi Matsumoto, Masayoshi Soma
- Organizer
  15th International SHR Symposium
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24591242
[Presentation] 腎尿細管上皮間葉化現象(EMT)による腎内レニン-アンジオテンシン(RA)系活性化―補体C3の関与―2012
- Author(s)
  Zhou Xueli、福田　昇、上野高浩、遠藤守人、松本紘一、相馬正義、西山　成
- Organizer
  第3回　腎不全研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591242

1. FUKUDA Noboru (40267050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
2. TSUNEMI Akiko (90646035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SOMA Masayoshi (30246855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. FUJIWARA Kyoko (40595708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NAGASE Hiroki (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. NISHIYAMA Akira (10325334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. MASHIMO Tomoji (80397554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KOMATSU Kazutoshi (50297800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 阿部雅紀 (70459890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UENO Takahiro 上野 高浩

上野 高浩 ウエノ タカヒロ

Research Projects

Research Products

Co-Researchers

Development of the novel gene modulator PI polyamide targeting protein S as a therapeutic agent for diabetes mellitus and diabetic nephropathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of C3 in the pathogenesis of hypertension with an activation of tissue renin-angiotensin system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of PI Polyamide targeting adiponectin gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of PI polyamide targeting Sar1b genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of complement 3 in the pathogenesis of hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of anti-cancer effect of PI polyamide, which suppress MYC downstream genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets E-box.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif Original Research Article2014

Author(s)

Journal Title

Data Source

[Journal Article] Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats2013

Author(s)

Journal Title

Data Source

[Journal Article] Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice.2013

Author(s)

Journal Title

Data Source

[Presentation] 補体C3はSHRで腎尿細管上皮間葉化(EMT)により腎内RA系を活性化し塩分感受性高血圧を起こしている2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 高血圧自然発症ラット(SHR)での塩分感受性高血圧への補体C3の関与.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 補体C3は腎尿細管上皮間葉化による組織RA系の活性化からＳＨＲの高血圧発症因子である2016

Author(s)

Organizer

Place of Presentation

Year and Date

UENO Takahiro 上野高浩

上野高浩ウエノタカヒロ