Koyama Yoshihisa 小山佳久

Researcher Number	40397667
Other IDs
Affiliation (Current)	2022: 大阪大学, 大学院医学系研究科, 助教 2022: 地方独立行政法人大阪府立病院機構大阪精神医療センター(こころの科学リサーチセンター), こころの科学リサーチセンター, 特別研究員
Affiliation (based on the past Project Information) *help	2022: 大阪大学, 大学院医学系研究科, 助教 2018 – 2021: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 59020:Sports sciences-related / Basic Section 55060:Emergency medicine-related / Basic Section 56030:Urology-related / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 突発性難聴 / ストレス / 病態モデル動物 / 難聴 / 疼痛 / 潰瘍性大腸炎 / 酸化ストレス / 水素 / 抗酸化物質 / 抗炎症作用 / 精神症状 … More Except Principal Investigator … More 運動 / 慢性疼痛 / 大脳辺縁系 / 抗うつ効果 / 条件付け / オピオイド / 情動 / うつ病治療薬 / 嗅覚過敏 / 嫌悪学習 / 嗅覚 / 外傷後ストレス障害 / PTSD / 恐怖記憶 / 5-HT3受容体 / セロトニン３受容体 / 内因性物質 / セロトニン3受容体 / 内因性 / 抗うつ / 疼痛 / 創薬 / 神経炎症 / 水素 / 頭部外傷 / ミクログリア / 軸索伸長 / 前立腺肥大症 / 細菌叢 / 前立腺 / 老化 / 新規抗酸化剤 / 前庭動眼反射 / 加齢性平衡障害 / シリコン製剤 / マウスの平衡機能検査 Less

Elucidation of the mechanism of pain suppression by exercise and development of new analgesics
- Principal Investigator
  
  島田昌一
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Osaka University
neuroprotective effects after traumatic brain injury by enteric hydrogen generation from Si-based agent
- Principal Investigator
  
  細見早苗
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka University
前立腺細菌叢に着目した前立腺肥大症発症メカニズムの解明と個別化医療への応用
- Principal Investigator
  
  竹澤健太郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
加齢性平衡障害に対するシリコン製剤を用いた新しいアンチエイジング法の開発
- Principal Investigator
  
  滝本泰光
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Osaka University
Development of new antioxidant treatment for ulcerative colitis based on intestinal and brain symptom reliefPrincipal Investigator
- Principal Investigator
  
  小山佳久
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Molecular mechanism of chronic pain with its onset in the limbic system and development of new therapeutic agents
- Principal Investigator
  
  Shimada Shoichi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Osaka University
運動による抗うつ効果：内因性セロトニン３受容体アゴニストの関与について
- Principal Investigator
  
  中村雪子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka University
Study for the mechanism of exercise-induced antidepressant effects and the development of novel therapeutic drug for depression
- Principal Investigator
  
  KONDO Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka University
Establishment of model mice and elucidation of pathogenic mechanism in stress-induced hearing lossPrincipal Investigator
- Principal Investigator
  
  Koyama Yoshihisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Osaka University
Research into the causes and treatment of olfactory hypersensitivity
- Principal Investigator
  
  Shimada Shoichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Si-based hydrogen-producing nanoagent protects fetuses from miscarriage caused by mother-to-child transmission2021
- Author(s)
  Usui N, Togawa S, Sumi T, Kobayashi Y, Koyama Y, Nakamura Y, Kondo M, Shinoda K, Kobayashi H, Shimada S.
- Journal Title
  
  Front. Med. Technol.
  
  Volume: 3 Pages: 665506-665506
- DOI
  10.3389/fmedt.2021.665506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11440, KAKENHI-PROJECT-18H03862, KAKENHI-PROJECT-20K06872
[Journal Article] Pain-like behavior in mice can be induced by the environmental context in which the pain stimulus was previously given2021
- Author(s)
  Nakamura Y, Okano Y, Sato M, Kobayashi M, Yamaguchi T, Sumi T, Koyama Y, Kondo M, Usui N, Shimada S.
- Journal Title
  
  NeuroReport
  
  Volume: 32 Pages: 386-393
- DOI
  10.1097/wnr.0000000000001607
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11440, KAKENHI-PROJECT-19K23780
[Journal Article] Renoprotective and　neuroprotective effects of enteric　hydrogen generation from Si-based agent.2020
- Author(s)
  Kobayashi Y, Imamura R, Koyama Y, Kondo M, Kobayashi H, Nonomura N, Shimada S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 10 Pages: 5859-5859
- DOI
  10.1038/s41598-020-62755-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11440, KAKENHI-PROJECT-18K19617, KAKENHI-PROJECT-18H03862
[Journal Article] Yokukansan-induced reduction of ethanol preference is associated with T antagonism of 5-HT3 receptors.2019
- Author(s)
  Nakamura Y, Kondo M, Koyama Y, Shimada S.
- Journal Title
  
  Phytomedicine
  
  Volume: 59 Pages: 152897-152897
- DOI
  10.1016/j.phymed.2019.152897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11440, KAKENHI-PROJECT-18K19617
[Journal Article] SR 57227A is a partial agonist/partial antagonist of 5-HT3 receptor and inhibits subsequent 5-HT- or SR 57227A-induced 5-HT3 receptor current.2019
- Author(s)
  Nakamura Y, Kondo M, Koyama Y, Shimada S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 508 Pages: 590-596
- DOI
  10.1016/j.bbrc.2018.11.174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11440, KAKENHI-PROJECT-18K19617
[Patent] シリコン微粒子を含有する疾患の予防又は治療剤2021
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-097781
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 子宮内感染症の予防又は治療剤2020
- Inventor(s)
  島田昌一、臼井紀好、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-076561
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 発達障害、依存症、及び精神疾患を検査する方法2020
- Inventor(s)
  島田昌一、臼井紀好、山本雪子、近藤誠、小山佳久
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-070882
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] フレイルの予防又は治療剤2020
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-077075
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 注意欠陥多動性障害の予防又は治療剤2020
- Inventor(s)
  島田昌一、臼井紀好、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-068534
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 内臓不快感の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-212973
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 二日酔いの予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-147016
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 酸化ストレスに起因する疾患の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-106147
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] うつ病又はうつ状態の予防又は治療剤2019
- Inventor(s)
  島田昌一、近藤誠、小山佳久、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-116294
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 酸化ストレスに起因する疾患の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、大畠和也、猪原秀典、他
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 虚血性脳血管障害に伴う障害の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-213066
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 糖尿病の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-213065
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 難聴の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、大畠和也、猪原秀典、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-213067
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] パーキンソン病の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-204864
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 記憶障害の予防又は治療剤2019
- Inventor(s)
  島田昌一、近藤誠、小山佳久、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-210724
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 脊髄損傷後の障害もしくは症状の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-212974
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 自閉スペクトラム症の予防又は治療剤2019
- Inventor(s)
  島田昌一、臼井紀好、小山佳久、近藤誠、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-212971
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Patent] 関節炎の予防又は治療剤2019
- Inventor(s)
  島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-212972
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 潰瘍性大腸炎の新規治療薬の開発2022
- Author(s)
  小山佳久、小林悠輝、廣田郁詠、Yuanjie Sun、大津厳生、今井裕恵、吉岡芳親、柳川博斗、鷲見拓哉、小林光、島田昌一
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-21K15949
[Presentation] 自閉スペクトラム症モデルマウスにおける大脳皮質の形態学的特徴2021
- Author(s)
  臼井紀好、Berto Stefano、小西彩海、入江浩一郎、小山佳久、中村雪子、近藤誠、松﨑秀夫、Konopka Genevieve、島田昌一
- Organizer
  第97回日本解剖学会近畿支部学術集会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 幼少期ストレスが脳と行動に与える影響2021
- Author(s)
  臼井紀好、大野雄太、荒巻良子、Berto Stefano、入江浩一郎、小山佳久、中村雪子、近藤誠、Konopka Genevieve、松﨑秀夫、島田昌一
- Organizer
  第48回日本脳科学会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 自閉スペクトラム症モデルマウスにおける大脳皮質の形態学的特徴2021
- Author(s)
  臼井紀好、吉村武、Tian Xiaoye、張替若菜、Berto Stefano、小西彩海、戸川省吾、入江浩一郎、小山佳久、中村雪子、近藤誠、篠田晃、松﨑秀夫、Konopka Genevieve、片山泰一、島田昌一
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 幼少期社会環境による発達障害の発症メカニズム2020
- Author(s)
  臼井紀好、Berto Stefano、小山佳久、中村雪子、近藤誠、Konopka Genevieve、松崎秀夫、島田昌一
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 酸化ストレスに着目した新たな治療法の開発2020
- Author(s)
  上村直也、小山佳久、小林悠輝、臼井紀好、近藤誠、小林光、篠田晃、島田昌一
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 母子感染症における免疫活性化の影響2020
- Author(s)
  戸川省吾、臼井紀好、小山佳久、小林悠輝、中村雪子、近藤誠、小林光、篠田晃、島田昌一
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 脳や腸管を介した潰瘍性大腸炎の新たな治療戦略2020
- Author(s)
  小山佳久、小林悠輝、大津巌生、河野祐介、鈴木健吾、臼井紀好、近藤誠、小林光、島田昌一
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 社会性の形成に関わる神経基盤の探索2019
- Author(s)
  臼井紀好、松崎秀夫、小山佳久、中村雪子、近藤誠、島田昌一
- Organizer
  Neuro2019　第42回日本神経科学大会・第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 5-HT3受容体を介する新たな抗うつメカニズム2019
- Author(s)
  近藤誠、小山佳久、中村雪子、臼井紀好、島田昌一
- Organizer
  第1回医学系研究科-産業科学研究所懇話会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 運動効果に基づく新たなうつ病治療メカニズムの解明2019
- Author(s)
  近藤誠、小山佳久、中村雪子、臼井紀好、島田昌一
- Organizer
  Neuro2019　第42回日本神経科学大会・第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 酸化ストレスが関与する神経疾患の新規治療薬の開発2019
- Author(s)
  小山佳久、小林悠輝、近藤誠、臼井紀好、小林光、島田昌一
- Organizer
  Neuro2019　第42回日本神経科学大会・第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K11440
[Presentation] 5-HT3受容体を介する新たな抗うつメカニズム2019
- Author(s)
  近藤誠、小山佳久、中村雪子、臼井紀好、島田昌一
- Organizer
  第１２４回日本解剖学会総会全国学術集会
- Data Source
  KAKENHI-PROJECT-18K19617
[Presentation] A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects2018
- Author(s)
  Kondo M, Koyama Y, Nakamura Y, Usui N, Shimada S
- Organizer
  第６１回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K19617
[Presentation] The significance of complete distributional analysis of the 5-HT3A receptor2018
- Author(s)
  Koyama Y, kondo M, Shimada S
- Organizer
  第６１回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K19617

1. Shimada Shoichi (20216063)

# of Collaborated Projects: 8 results

# of Collaborated Products: 19 results
2. 中村雪子 (90548083)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. KONDO Makoto (50633012)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. 臼井紀好 (00784076)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
5. 小林悠輝 (40723557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 細見早苗 (90644005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小倉裕司 (70301265)

# of Collaborated Projects: 1 results

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8. 伊藤弘 (80836594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林光 (90195800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 竹澤健太郎 (90648015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 福原慎一郎 (20609870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 木内寛 (70403053)

# of Collaborated Projects: 1 results

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13. 滝本泰光 (00624298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 原田祥太郎 (10824740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 今井貴夫 (80570663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koyama Yoshihisa 小山 佳久

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Development of new antioxidant treatment for ulcerative colitis based on intestinal and brain symptom reliefPrincipal Investigator

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Establishment of model mice and elucidation of pathogenic mechanism in stress-induced hearing lossPrincipal Investigator

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[Journal Article] Si-based hydrogen-producing nanoagent protects fetuses from miscarriage caused by mother-to-child transmission2021

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[Journal Article] Pain-like behavior in mice can be induced by the environmental context in which the pain stimulus was previously given2021

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[Journal Article] Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent.2020

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[Journal Article] Yokukansan-induced reduction of ethanol preference is associated with T antagonism of 5-HT3 receptors.2019

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[Journal Article] SR 57227A is a partial agonist/partial antagonist of 5-HT3 receptor and inhibits subsequent 5-HT- or SR 57227A-induced 5-HT3 receptor current.2019

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Koyama Yoshihisa 小山佳久

[Journal Article] Renoprotective and　neuroprotective effects of enteric　hydrogen generation from Si-based agent.2020