SHIMIZU Takatsune 清水孝恒

Researcher Number	40407101
Other IDs
Affiliation *help	2012 – 2018 : 星薬科大学, 薬学部, 准教授 2011 : 慶應義塾大学, 医学部, 特任助教 2008 – 2010 : Keio University, 医学部, 助教
Review Section/Research Field	Principal Investigator Tumor biology / Tumor biology / Basic Section 50010:Tumor biology-related / Experimental pathology
Keywords	Principal Investigator 骨肉腫 / 治療抵抗性 / 腫瘍 / 癌微小環境 / dormancy / drug resistance / osteosarcoma / がん微小環境 / 癌 / 環境 … More

Development of novel therapeutic approaches based on the elucidation of disease specific metabolism in osteosarcomaPrincipal InvestigatorOngoing
- Principal Investigator
  
  清水孝恒
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
骨肉腫転移巣における治療抵抗性獲得の分子機構解明と克服Principal InvestigatorOngoing
- Principal Investigator
  
  清水孝恒
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Hoshi University
Investigation and conquest of the therapeutic resistant dormancy in osteosarcoma mediated by insulin-like growth factor (IGF) signalingPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKATSUNE
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Hoshi University
Investigation of the roles of tumor environment in osteosarcomaPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takatsune
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Establishment and analysis of mouse tumor models from multipotent bone marrow stromal cells overexpressing c-MYCPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takatsune
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 実験医学増刊号　がん微小環境と標的治療2015
- Author(s)
  清水孝恒
- Total Pages
  207
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24501320
[Book] モデル動物利用マニュアル　疾患モデルの作成と利用　がん2012
- Author(s)
  清水孝恒、佐谷秀行
- Total Pages
  633
- Publisher
  LIFE-SCIENCE INFORMATION CENTER
- Data Source
  KAKENHI-PROJECT-24501320
[Book] 最新医学2011
- Author(s)
  清水孝恒、吉田剛、佐谷秀行
- Total Pages
  6
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-22700887
[Book] がん幹細胞研究の動向と治療標的としての将来性.最新医学(特集:がん幹細胞と支持細胞を標的とする薬剤の開発)2011
- Author(s)
  清水孝恒, 吉田剛, 佐谷秀行
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Simvastatin-induced apoptosis in osteosarcoma cells: A key role of RhoA-AMPK/p38 MAPK signaling in antitumor activity2017
- Author(s)
  Kamel W, Sugihara E, Nobusue H, Yamaguchi-Iwai S, Onishi N, Maki K, Fukuchi Y, Matsuo K, Muto A, Saya H, Shimizu T.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume : 16 Pages : 182-192
- DOI
  10.1158/1535-7163.MCT-16-0499
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K06845, KAKENHI-PROJECT-16K07125
[Journal Article] Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells2015
- Author(s)
  Yamaguchi SI, Ueki A, Sugihara E, Onishi N, Yaguchi T, Kawakami Y, Horiuchi K, Morioka H, Matsumoto M, Nakamura M, Muto A, Toyama Y, Saya H, Shimizu T.
- Journal Title
  
  Cancer Science
  
  Volume : 106 Pages : 875-882
- DOI
  10.1111/cas.12686
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K06845, KAKENHI-PROJECT-15K20161, KAKENHI-PROJECT-26221005
[Journal Article] Glycan profiling of gestational choriocarcinoma using a lectin microarray2014
- Author(s)
  Kobayashi Y, Masuda K, Banno K, Kobayashi N, Umene K, Nogami Y, Tsuji K, Ueki A, Nomura H, Sato K, Tominaga E, Shimizu T, Saya H, Aoki D
- Journal Title
  
  Oncol Rep
  
  Volume : 31 Pages : 1121-1131
- DOI
  10.3892/or.2014.2979
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592530
[Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state2014
- Author(s)
  Mori T, Sato Y, Miyamoto K, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki R, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y and Miyamoto T
- Journal Title
  
  Oncogene
  
  Volume : 印刷中 Pages : 4236-4241
- DOI
  10.1038/onc.2013.545
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-25861341, KAKENHI-ORGANIZER-22130001
[Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation2014
- Author(s)
  Nobusue H
- Journal Title
  
  Nat Commun.
  
  Volume : 5 Pages : 3368-3368
- DOI
  10.1038/ncomms4368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.2014
- Author(s)
  Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
- Journal Title
  
  Cancer Res.
  
  Volume : 74 Pages : 6531-6541
- DOI
  10.1158/0008-5472.CAN-14-0914
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06657, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245, KAKENHI-PROJECT-26830082
[Journal Article] IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells2013
- Author(s)
  Osuka S. Sampetrean O, Shimizu T, Saga l, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
- Journal Title
  
  Stem Cells.
  
  Volume : 31 Pages : 627-640
- DOI
  10.1002/stem.1328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00382, KAKENHI-PROJECT-13J06657, KAKENHI-PROJECT-22249055, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24659645, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells2013
- Author(s)
  Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
- Journal Title
  
  Cancer Sci.
  
  Volume : (in press) Pages : 880-888
- DOI
  10.1111/cas.12163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24659789, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] Up-regulation of imp3 confers in vivo tumorigenicity on murine osteosarcoma cells2012
- Author(s)
  Ueki A, Shimizu T, Masuda K, Yamaguchi SI, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A, Toyama Y, Banno K, Aoki D, Saya H.
- Journal Title
  
  Plos One
  
  Volume : 7(11)
- DOI
  10.1371/journal.pone.0050621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24501320, KAKENHI-PLANNED-22130007
[Journal Article] Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012
- Author(s)
  Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y, Saya H
- Journal Title
  
  Mol. Cancer Res.
  
  Volume : 10 Pages : 454-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] LATS1/WARTS phosphorylates Myosin Phosphatase-Targeting Subunit 1 to counteract Polo-like Kinase 12012
- Author(s)
  Chiyoda, T.
- Journal Title
  
  J Cell Biol.
  
  Volume : 197 Pages : 625-41
- DOI
  10.1083/jcb.201110110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227006, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24116513
[Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012
- Author(s)
  Shimizu T, et al
- Journal Title
  
  Molecular Cancer Research
  
  Volume : 10 Pages : 454-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H
- Journal Title
  
  Am. J. Pathol
  
  Volume : 179 Pages : 1471-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, et al
- Journal Title
  
  American Journal of Pathology
  
  Volume : 179 Pages : 1471-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2011
- Author(s)
  Sugihara E, Shimizu T, et al
- Journal Title
  
  Oncogene
  
  Volume : (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
- Author(s)
  Takatsune Shimizu, et al.
- Journal Title
  
  Oncogene
  
  Volume : 29 Pages : 5687-5699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
- Author(s)
  Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
- Journal Title
  
  Oncogene
  
  Volume : 29 Pages : 5687-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] M-Csf inhibition selectively targets pathological angiogenesis and lymphangiogenesis2009
- Author(s)
  Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T.
- Journal Title
  
  J. Exp. Med. 206
  
  Pages : 1089-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] マウス骨肉腫幹細胞と疾患克服への挑戦2017
- Author(s)
  清水孝恒
- Organizer
  日本薬学会東海支部特別講演会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] Novel therapeutic approach with statins for lethal osteosarcoma2016
- Author(s)
  槇健太、清水孝恒、福地由美、武藤章弘
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38 via suppression of mevalonate pathway2016
- Author(s)
  Kamel A W, Sugihara, E, Yamaguchi, S, Nobusue, H, Maki, K, Muto, A, Saya, H and Shimizu, T
- Organizer
  American Association for Cancer Research Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38 via suppression of mevalonate pathway2016
- Author(s)
  Kamel AW, Sugihara E, Yamaguchi S, Nobusue H, Maki K, Muto A, Saya H, Shimizu T
- Organizer
  American Association for Cancer Research Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] スタチン系薬剤はメバロン酸合成経路を阻害し、AMPK、p38MAPKの活性化を介して骨肉腫に抗腫瘍効果を発揮する2016
- Author(s)
  カメル・ワリード、杉原英志、山口さやか、信末博行、大西伸幸、武藤章弘、佐谷秀行、清水孝恒
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] 新規B 細胞リンパ腫モデルを用いたリンパ腫発症及び維持におけるFas の抑制制御2015
- Author(s)
  杉原英志、橋本典諭、植野さやか、清水孝恒、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] イマチニブとアドリアマイシンの併用は、PDGFR を発現する骨肉腫に対し、相乗的な抗腫瘍効果を呈する2015
- Author(s)
  山口さやか、杉原英志、大西伸幸、菊田一貴、堀内圭輔、森岡秀夫、佐谷秀行、清水孝恒
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] アクチン細胞骨格動態に基づく脂肪分化制御による骨肉腫幹細胞の治療戦略2015
- Author(s)
  信末博行、大西伸幸、清水孝恒、杉原英志、沖嘉尚、千代田達幸、高橋信博、赤司浩一、加野浩一郎、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] ROCK 阻害剤は骨肉腫幹細胞の脂肪細胞への終末分化を誘導する2015
- Author(s)
  高橋信博、信末博行、清水孝恒、大西伸幸、杉原英志、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] インスリンシグナルによる骨肉腫休眠状態は微小残存病変につながる2013
- Author(s)
  清水孝恒、石川智樹、山口さやか、杉原英志、植木有紗、大西伸幸、國仲慎治、武藤章弘、安積彩香、大久保智啓、佐谷秀行
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] Characterization and conquest of mouse osteosarcoma stem cells2013
- Author(s)
  Takatsune Shimizu, Akihiro Muto, Hideyuki Saya
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] Multifunctional roles of Fibroblast growth factor-2(Fgf2) in the histopathology of murine osteosarcoma2011
- Author(s)
  清水孝恒
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Multifunctional roles of Fibroblast growth factor-2 (Fgf2) in the histopat hology of murine osteosarcoma2011
- Author(s)
  清水孝恒
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Mesenchymal differentiation potentials modify osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  101th Annual Meeting of American Association of Cancer Research
- Place of Presentation
  Washington
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Mesenchymal differentiation potentials modified osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  第101回アメリカ癌学会
- Place of Presentation
  Walter E.ワシントンコンベンションセンター
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Mesenchymal differentiation potentials modify osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  American Association for cancer research 101^<st> Annual meeting 2010
- Place of Presentation
  Washington, U. S. A.
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Establishment and application of mouse osteosarcoma stem cells2009
- Author(s)
  清水孝恒
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establishment and application of mouse osteosarcoma stem cells2009
- Author(s)
  清水孝恒
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establisment of osteosarcoma stem cell from bone marrow stromal cells2008
- Author(s)
  清水孝恒
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establishment of osteosarcoma stem cell from bone marrow stromal cells2008
- Author(s)
  清水孝恒
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Molecular mechanism of in vivo tumorigenesis
- Author(s)
  Takatsune Shimizu
- Organizer
  The 11th Korea-Japan-Germany Joint Symposium on Cancer and Aging
- Place of Presentation
  Gyeongju, Korea
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] マウス骨肉腫幹細胞の樹立とその特徴
- Author(s)
  清水孝恒、佐谷秀行
- Organizer
  第１０回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] マウス骨肉腫幹細胞の同定と克服への挑戦
- Author(s)
  清水孝恒、武藤章弘、佐谷秀行
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] インスリン様増殖因子シグナルは骨肉腫細胞に治療抵抗性休眠状態を誘導する
- Author(s)
  清水孝恒
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-24501320

1. TOMINGA Eiichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
2. SUGIYAMA Naoyuki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
3. ISHIHAMA Yasushi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
4. MIYAMOTO Takeshi

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
5. MIYAMOTO Kana

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
6. MORI Masaki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. Akashi Koichi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. 杉原英志

# of Collaborated Projects : 0results

# of Collaborated Products : 7results
9. 高野晋吾

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. 大西伸幸

# of Collaborated Projects : 0results

# of Collaborated Products : 5results
11. 植木有紗

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 河上裕

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 國仲慎治

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
14. 佐谷秀行

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
15. 森岡秀夫

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 松崎有未

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 戸口田淳也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

SHIMIZU Takatsune 清水 孝恒

Research Projects

Research Products

Co-Researchers

Development of novel therapeutic approaches based on the elucidation of disease specific metabolism in osteosarcomaPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨肉腫転移巣における治療抵抗性獲得の分子機構解明と克服Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation and conquest of the therapeutic resistant dormancy in osteosarcoma mediated by insulin-like growth factor (IGF) signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the roles of tumor environment in osteosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment and analysis of mouse tumor models from multipotent bone marrow stromal cells overexpressing c-MYCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学増刊号 がん微小環境と標的治療2015

Author(s)

Total Pages

Publisher

Data Source

[Book] モデル動物利用マニュアル 疾患モデルの作成と利用 がん2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新医学2011

Author(s)

Total Pages

Publisher

Data Source

[Book] がん幹細胞研究の動向と治療標的としての将来性.最新医学(特集:がん幹細胞と支持細胞を標的とする薬剤の開発)2011

Author(s)

Data Source

[Journal Article] Simvastatin-induced apoptosis in osteosarcoma cells: A key role of RhoA-AMPK/p38 MAPK signaling in antitumor activity2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycan profiling of gestational choriocarcinoma using a lectin microarray2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.2014

Author(s)

Journal Title

SHIMIZU Takatsune 清水孝恒

[Book] 実験医学増刊号　がん微小環境と標的治療2015

[Book] モデル動物利用マニュアル　疾患モデルの作成と利用　がん2012