Eiraku Mototsugu 永樂元次

… Alternative Names

EIRAKU Mototsugu 永樂元次

永樂元次エイラクモトツグ

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Researcher Number	40415097
Other IDs
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都大学, 医生物学研究所, 教授 2017 – 2022: 京都大学, ウイルス・再生医科学研究所, 教授 2014 – 2016: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, ユニットリーダー 2012: 独立行政法人理化学研究所, 立体組織形成・解析ユニット, 副ユニットリーダー … More 2010: The Institute of Physical and Chemical Research, 立体組織形成・解析ユニット, 副ユニットリーダー 2009: The Institute of Physical and Chemical Research, 細胞分化・器官発生研究グループ, 研究員 2005: 独立行政法人理化学研究所, 神経細胞極性研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 44020:Developmental biology-related / Transformative Research Areas, Section (III) / Developmental biology / Neuroscience in general / Neuroscience in general Except Principal Investigator Biological Sciences / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49060:Virology-related / Transformative Research Areas, Section (III) / Developmental biology / Biological Sciences
Keywords	Principal Investigator 幹細胞 / 自己組織化 / 形態形成 / オルガノイド / 器官発生 / パターン形成 / イメージング / 神経発生 / ES細胞 / 嗅上皮 … More / 嗅神経細胞 / ECM / 発生生物学 / 分化制御 / 局所制御 / 発生制御 / 肢芽形成 / 初期発生 / 局所シグナル制御 / モルフォゲン / ヒトES細胞 / 大脳 / 網膜 / 発生時間 / ヒト発生 / 発生時間スケール / 遺伝子発現プロファイル / 網膜発生 / １細胞解析 / 発生時計 / 神経 / 種差 / 発生 / 種特異性 / 種特異的 / 種特異的発生機構 / 種特異的発生様式 / 多能性幹細胞 / シミュレーション / 極性 / 組織の三次元形態 / 立体組織形成 / 組織形成 / 試験管内再構築 … More Except Principal Investigator 大脳構築 / 細胞外環境 / 神経発生 / 神経幹細胞 / 発生時計 / 脳構築 / 風邪コロナウイルス / インフルエンザウイルス / オルガノイド / コロナウイルス / SARS-CoV-2 / 新型コロナウイルス / 広報 / 若手支援 / 研究資源共有化 / 技術支援 / 細胞外マトリックス / バイオメカ二クス / ３次元バーテックスモデル / バイオメカニクス / 器官形成 / 三次元バーテックスモデル / 分節時計 / 数理モデル / 細胞間シグナル / 顆粒細胞 / プルキンエ細胞 / 樹状突起 / DNER Less

領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
- Principal Investigator
  
  藤原裕展
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
より生体に近いオルガノイド創出のための細胞外環境制御技術の開発Principal Investigator
- Principal Investigator
  
  永樂元次
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
嗅上皮オルガノイドを用いた嗅受容体遺伝子発現制御機構の解明Principal Investigator
- Principal Investigator
  
  永樂元次
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kyoto University
中枢神経系細胞における新型コロナウイルス持続感染機構の解析
- Principal Investigator
  
  村本裕紀子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kyoto University
Development of a new culture system for human coronaviruses using organoids
- Principal Investigator
  
  Noda Takeshi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Interplay of developmental clock and extracellular environment in brain formation
- Principal Investigator
  
  影山龍一郎
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Interplay of developmental clock and extracellular environment in brain formation
- Principal Investigator
  
  Kageyama Ryoichiro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
  Kyoto University
Understanding the molecular basis that defines species-specific developmental timingPrincipal Investigator
- Principal Investigator
  
  Eiraku Mototsugu
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
  Institute of Physical and Chemical Research
Establishment of a new methodology for inducing early embryo-like structures from stem cellsPrincipal Investigator
- Principal Investigator
  
  Eiraku Mototsugu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto University
  Institute of Physical and Chemical Research
Stress field estimation in three-dimensional optic-cup by image-based modeling
- Principal Investigator
  
  Okuda Satoru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Developmental biology
- Research Institution
  Institute of Physical and Chemical Research
上皮組織の分化パターンと形態形成をつなぐ力学制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  永樂元次
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
神経上皮組織の自己組織的な形態形成の基盤となる細胞骨格動態の解明Principal Investigator
- Principal Investigator
  
  永樂元次
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Dorsal and ventral specification in optic cup derived from ES cells in vitroPrincipal Investigator
- Principal Investigator
  
  EIRAKU Mototsugu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of neural tissue development using ES cells culture systemPrincipal Investigator
- Principal Investigator
  
  EIRAKU Mototsugu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
細胞間シグナルによる中枢神経系ニューロン・グリア突起の分岐パターン制御機構
- Principal Investigator
  
  見学美根子
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2005

All Journal Article Presentation

[Journal Article] Toward the formation of neural circuits in human brain organoids2019
- Author(s)
  Seto Yusuke、Eiraku Mototsugu
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 61 Pages: 86-91
- DOI
  10.1016/j.ceb.2019.07.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06485
[Journal Article] Self-organized formation of developing appendages from murine pluripotent stem cells2019
- Author(s)
  Mori Shunsuke、Sakakura Eriko、Tsunekawa Yuji、Hagiwara Masaya、Suzuki Takayuki、Eiraku Mototsugu
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 000-000
- DOI
  10.1038/s41467-019-11702-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06485, KAKENHI-PROJECT-18H02487
[Journal Article] Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.2018
- Author(s)
  Okuda S, Takata N, Hasegawa Y, Kawada M, Inoue Y, Adachi T, Sasai Y, Eiraku M.
- Journal Title
  
  Science Advances
  
  Volume: 4 Issue: 11
- DOI
  10.1126/sciadv.aau1354
- NAID
  120006539614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06485, KAKENHI-PROJECT-16H04799
[Journal Article] Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching2018
- Author(s)
  Okuda Satoru、Miura Takashi、Inoue Yasuhiro、Adachi Taiji、Eiraku Mototsugu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41598-018-20678-6
- NAID
  120006517791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06485, KAKENHI-PROJECT-16H04799
[Journal Article] Human brain development and its in vitro recapitulation.2018
- Author(s)
  Seto Y, Eiraku M.
- Journal Title
  
  Neurosci Res.
  
  Volume: 138 Pages: 33-42
- DOI
  10.1016/j.neures.2018.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06485
[Journal Article] Generation of a Three-Dimensional Retinal Tissue from Self-Organizing Human ESC Culture2017
- Author(s)
  Kuwahara Atsushi、Nakano Tokushige、Eiraku Mototsugu
- Journal Title
  
  Methods Mol Biol
  
  Volume: - Pages: 17-29
- DOI
  10.1007/978-1-4939-6949-4_2
- ISBN
  9781493969470, 9781493969494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine2017
- Author(s)
  Takata Nozomu、Eiraku Mototsugu
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Issue: 2 Pages: 165-178
- DOI
  10.1038/s10038-017-0348-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane2017
- Author(s)
  Okuda Satoru、Eiraku Mototsugu
- Journal Title
  
  Biomechanics and Modeling in Mechanobiology
  
  Volume: 16 Issue: 5 Pages: 1805-1818
- DOI
  10.1007/s10237-017-0920-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells2017
- Author(s)
  Okuda Satoru、Unoki Katsuyuki、Eiraku Mototsugu、Tsubota Ken-ichi
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 59 Issue: 5 Pages: 455-464
- DOI
  10.1111/dgd.12373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] Generation of Various Telencephalic Regions from Human Embryonic Stem Cells in Three-Dimensional Culture2017
- Author(s)
  Kadoshima Taisuke、Sakaguchi Hideya、Eiraku Mototsugu
- Journal Title
  
  Methods Mol Biol
  
  Volume: - Pages: 1-16
- DOI
  10.1007/978-1-4939-6949-4_1
- ISBN
  9781493969470, 9781493969494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells2017
- Author(s)
  Ohgushi Masatoshi、Minaguchi Maki、Eiraku Mototsugu、Sasai Yoshiki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 9 Issue: 1 Pages: 58-66
- DOI
  10.1016/j.stemcr.2017.05.003
- NAID
  120006325118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07395, KAKENHI-PROJECT-16H04799
[Journal Article] An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation2017
- Author(s)
  Takata Nozomu、Abbey Deepti、Fiore Luciano、Acosta Sandra、Feng Ruopeng、Gil Hyea Jin、Lavado Alfonso、Geng Xin、Interiano Ashley、Neale Geoffrey、Eiraku Mototsugu、Sasai Yoshiki、Oliver Guillermo
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 6 Pages: 1534-1549
- DOI
  10.1016/j.celrep.2017.10.041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Journal Article] Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism2017
- Author(s)
  Takata Nozomu、Sakakura Eriko、Eiraku Mototsugu、Kasukawa Takeya、Sasai Yoshiki
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41467-017-01105-2
- NAID
  120006822510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06485, KAKENHI-PROJECT-16H04799
[Journal Article] Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework2016
- Author(s)
  Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Taiji Adachi, and Yoshiki Sasai
- Journal Title
  
  Biomechanics and Modeling in Mechanobiology
  
  Volume: 未定印刷中 Issue: 4 Pages: 1-1
- DOI
  10.1007/s10237-015-0724-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14534, KAKENHI-PUBLICLY-26112723
[Journal Article] Generation of functional hippocampal neurons from self-organizing human ES cell-derived dorsomedial telencephalic tissue.2016
- Author(s)
  坂口英哉、門嶋大輔、宗園美香、成井信博、石田義人、大串雅俊、高橋淳、永樂元次、笹井芳樹
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 10351-10351
- DOI
  10.1038/ncomms9896
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830088, KAKENHI-PUBLICLY-26112723
[Journal Article] Emergence of dorsal ventral polarity in ESC-derived retinal tissue2016
- Author(s)
  Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y
- Journal Title
  
  Development
  
  Volume: 143 Issue: 21 Pages: 3895-3906
- DOI
  10.1242/dev.134601
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06485, KAKENHI-PROJECT-16H04799
[Journal Article] Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.2016
- Author(s)
  Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 10351-10351
- DOI
  10.1038/ncomms10351
- NAID
  120006535047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15KT0086, KAKENHI-PROJECT-26650071, KAKENHI-PUBLICLY-26112723
[Journal Article] Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos2014
- Author(s)
  Imuta y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H
- Journal Title
  
  Mech Dev
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680037
[Journal Article] Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos2014
- Author(s)
  Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H
- Journal Title
  
  Mech Dev
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24112527
[Journal Article] Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.2013
- Author(s)
  Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Ssasai Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Issue: 50 Pages: 20284-20289
- DOI
  10.1073/pnas.1315710110
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24112527, KAKENHI-PROJECT-24680037
[Journal Article] Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance.2013
- Author(s)
  Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T
- Journal Title
  
  J Biomech
  
  Volume: 46 Issue: 10 Pages: 1705-1713
- DOI
  10.1016/j.jbiomech.2013.03.035
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24112527, KAKENHI-PROJECT-24680037
[Journal Article] Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis2013
- Author(s)
  Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T
- Journal Title
  
  Biomech Model Mechanobiol
  
  Volume: 12 Issue: 4 Pages: 627-44
- DOI
  10.1007/s10237-012-0430-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680037, KAKENHI-PUBLICLY-23127506
[Journal Article] Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework2013
- Author(s)
  Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi
- Journal Title
  
  Biomechanics and Modeling in Mechanobiology
  
  Volume: (in print) Issue: 5 Pages: 987-996
- DOI
  10.1007/s10237-012-0458-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01270, KAKENHI-PUBLICLY-24112527, KAKENHI-PROJECT-24680037, KAKENHI-PUBLICLY-23127506
[Journal Article] Self-formation of layered neural structures in three-dimensional culture of ES cells2012
- Author(s)
  Eiraku M, Sasai Y
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 22 Issue: 5 Pages: 768-77
- DOI
  10.1016/j.conb.2012.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680037, KAKENHI-PUBLICLY-24112527
[Journal Article] In vitro organogenesis in three dimensions : self-organising stem cells2012
- Author(s)
  Sasai Y, Eiraku M, Suga H
- Journal Title
  
  Development
  
  Volume: 139 Issue: 22 Pages: 4111-21
- DOI
  10.1242/dev.079590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680037, KAKENHI-PUBLICLY-24112527
[Journal Article] Self-formation of optic cups and storable stratified neural retina from human ESCs.2012
- Author(s)
  Nakano T
- Journal Title
  
  Cell Stem Cell
  
  Volume: 10 Issue: 6 Pages: 771785-771785
- DOI
  10.1016/j.stem.2012.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570195, KAKENHI-PROJECT-24570242, KAKENHI-PROJECT-24680037, KAKENHI-PLANNED-22122006, KAKENHI-PUBLICLY-23111534, KAKENHI-PUBLICLY-23111535, KAKENHI-PUBLICLY-24112527
[Journal Article] Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture2012
- Author(s)
  Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e53024-e53024
- DOI
  10.1371/journal.pone.0053024
- NAID
  120006626411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680037, KAKENHI-PLANNED-22122006, KAKENHI-PUBLICLY-24112527
[Journal Article] Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.2011
- Author(s)
  Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y
- Journal Title
  
  J Neurosci. 31
  
  Pages: 1919-1933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] Self-organizing optic-cup morphogenesis in three-dimensional culture.2011
- Author(s)
  Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y
- Journal Title
  
  Nature 472
  
  Pages: 51-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] Self-organizing optic-cup morphogenesis in three-dimensional culture2011
- Author(s)
  Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi A, Sasai Y.
- Journal Title
  
  Nature
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.2011
- Author(s)
  Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y.
- Journal Title
  
  Journal of Nuroscience
  
  Volume: 31 Pages: 1919-1933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.2010
- Author(s)
  Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y
- Journal Title
  
  Cell Stem Cell 7
  
  Pages: 225-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.2010
- Author(s)
  Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 7 Pages: 225-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700367
[Journal Article] DNER acts as a neuron-specific Notch ligand during Bergmann glial development2005
- Author(s)
  Eiraku, Mototsugu
- Journal Title
  
  Nature Neuroscience 8(7)
  
  Pages: 873-880
- Data Source
  KAKENHI-PROJECT-17024062
[Presentation] ヒト鼻腔オルガノイドを用いた新型コロナウイルスの増殖機構の解析2022
- Author(s)
  村本裕紀子、鈴木和也、中野雅博、平林愛、大串雅俊、羽田早織、谷山暢子、大西知帆、永樂元次、野田岳志
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07086
[Presentation] Studies on SARS-CoV-2 replication in human nasal organoids2022
- Author(s)
  Yukiko Muramoto, Kazuya Suzuki, Masahiro Nakano, Ai Hirabayashi, Masatoshi Ohgushi, Saori Hada, Nobuko Taniyama, Chiho Onishi, Mototsugu Eiraku, Takeshi Noda
- Organizer
  OPTIONS XI for the Control of INFLUENZA
- Data Source
  KAKENHI-PROJECT-22K07086
[Presentation] Self-organization of patterned functional tissues from pluripotent stem cells2019
- Author(s)
  Mototsutu Eiraku
- Organizer
  119th International Titisee Conference:Tissue formation and regeneration: from molecules to models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned functional tissues from pluripotent stem cells2019
- Author(s)
  Mototsutu Eiraku
- Organizer
  119th International Titisee Conference:Tissue formation and regeneration: from molecules to models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] 多能性幹細胞からの神経組織形成～海馬組織の再構成はできるか？～2018
- Author(s)
  永樂元次
- Organizer
  第27回海馬と高次脳機能学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2018
- Author(s)
  Mototsugu Eiraku
- Organizer
  EMBO Workshop :Molecular mechanisms of developmental and regenerative biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] 発生システムの試験管内構築と制御2018
- Author(s)
  永樂元次
- Organizer
  日本発生生物学会秋季シンポジウム2018
- Invited
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2018
- Author(s)
  Mototsugu Eiraku
- Organizer
  EMBO Workshop :Molecular mechanisms of developmental and regenerative biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] 多細胞体の自己組織的なパターン形成および形態形成メカニズム2018
- Author(s)
  永樂元次
- Organizer
  Cell aggregation meeting 2018
- Invited
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organized formation of neural organoids from stem cells2018
- Author(s)
  Mototsugu Eiraku
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] Self-organized formation of neural organoids from stem cells2018
- Author(s)
  Mototsugu Eiraku
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] 発生システムの試験管内構築と制御2018
- Author(s)
  永樂元次
- Organizer
  日本発生生物学会秋季シンポジウム2018
- Invited
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] 多能性幹細胞からの神経組織形成～海馬組織の再構成はできるか？～2018
- Author(s)
  永樂元次
- Organizer
  第27回海馬と高次脳機能学会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] 多細胞の自己組織発生制御によるin vitro での機能的な神経組織形成2018
- Author(s)
  永樂元次
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  DB Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  Cold Spring Harbor Laboratory
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  CDB Symposium 2017
- Place of Presentation
  RIKEN CDB, Kobe, Japan
- Year and Date
  2017-03-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] 実器官の多細胞ダイナミクスを解析する汎用三次元バーテックスモデルの開発2017
- Author(s)
  奥田覚，永樂元次
- Organizer
  日本機械学会第29回バイオエンジニアリング講演会
- Place of Presentation
  ウィンク愛知（愛知県名古屋市）
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  DB Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  CDB Symposium 2017
- Place of Presentation
  RIKEN CDB, Kobe, Japan
- Year and Date
  2017-03-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] Self-organization of patterned tissues from mouse and human stem cells2017
- Author(s)
  Mototsugu Eiraku
- Organizer
  Cold Spring Harbor Laboratory Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] 細胞の自己組織化能を利用したin vitroでの機能的立体組織の構築2016
- Author(s)
  永樂元次
- Organizer
  再生医療学会大会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-26112723
[Presentation] Self-organization of patterned tissues from pluripotent stem cells2016
- Author(s)
  Mototsugu Eiraku
- Organizer
  SDB 75th Annual Meeting/ISD 19th International Conference
- Place of Presentation
  Marriott Copley Place, Boston, USA
- Year and Date
  2016-08-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] 多細胞の三次元組織形成シミュレーションのためのアポトーシスの数理モデル化2016
- Author(s)
  奥田覚，井上康博，安達泰治，永樂元次
- Organizer
  日本機械学会第28回バイオエンジニアリング講演会
- Place of Presentation
  東京工業大学（東京都・目黒区）
- Year and Date
  2016-01-09
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] Self-organization of patterned tissues from pluripotent stem cells2016
- Author(s)
  Mototsugu Eiraku
- Organizer
  Engineering the embryo beyond systems biology
- Place of Presentation
  Institut Pasteur, Paris, France
- Year and Date
  2016-11-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] Self-organization of patterned tissues from pluripotent stem cells2016
- Author(s)
  Mototsugu Eiraku
- Organizer
  SDB 75th Annual Meeting/ISD 19th International Conference
- Place of Presentation
  Marriott Copley Place, Boston, USA
- Year and Date
  2016-08-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06485
[Presentation] Mechanical regulatory mechanism of 3D multicellular dynamics during epithelial invagination2016
- Author(s)
  Satoru Okuda, Mototsugu Eiraku
- Organizer
  The 54th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] Self-organization of patterned tissues from pluripotent stem cells2016
- Author(s)
  Mototsugu Eiraku
- Organizer
  Engineering the embryo beyond systems biology
- Place of Presentation
  Institut Pasteur, Paris, France
- Year and Date
  2016-11-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04799
[Presentation] Self-organized formation of complex tissues from stem cells2016
- Author(s)
  Mototsugu Eiraku
- Organizer
  CDB symposium 2016
- Place of Presentation
  理化学研究所CDB（兵庫県・神戸市）
- Year and Date
  2016-03-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26112723
[Presentation] Mechanical regulatory mechanism of 3D multicellular dynamics during optic-cup morphogenesis2016
- Author(s)
  Satoru Okuda, Mototsugu Eiraku
- Organizer
  The 39th Annual Meeting of the Molecular biology Society of Japan
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] "Vertex dynamics simulations of viscosity-dependent deformation during 3D multicellular morphogenesis2015
- Author(s)
  Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Taiji Adachi, Yoshiki Sasai
- Organizer
  International Congress of Biorheology and 8th International Conference on Clinical Hemorheology
- Place of Presentation
  Korea University, Korea
- Year and Date
  2015-05-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] Versatile modeling of three-dimensional multicellular morphogenesis: application to apically-convex invagination during optic-cup formation2015
- Author(s)
  Satoru Okuda, Yasuhiro Inoue, Taiji Adachi, Yoshiki Sasai, Mototsugu Eiraku
- Organizer
  The 26th CDB meeting: Mechanistic Perspectives of Multicellular Organization
- Place of Presentation
  理化学研究所（兵庫県・神戸市）
- Year and Date
  2015-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14534
[Presentation] Self-organization of complex tissues from stem cells2015
- Author(s)
  Mototsugu Eiraku
- Organizer
  日本分子生物学会大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PUBLICLY-26112723
[Presentation] Self-driven morphogenesis in stem cell culture2015
- Author(s)
  Mototsugu Eiraku
- Organizer
  The 6th CDB Meeting: Mechanistic Perspectives of Multicellular Organization
- Place of Presentation
  理化学研究所CDB（兵庫県・神戸市）
- Year and Date
  2015-09-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26112723
[Presentation] Self-organized formation of complex tissues from stem cells2015
- Author(s)
  Mototsugu Eiraku
- Organizer
  日本発生生物学会大会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2015-06-02
- Invited
- Data Source
  KAKENHI-PUBLICLY-26112723
[Presentation] Self-organized formation of optic cup in vitro2012
- Author(s)
  Mototsugu Eiraku
- Organizer
  16^<th> Stem Cell Network Workshop
- Place of Presentation
  University of Western Sydney, Campbell, Australia(招待講演)
- Year and Date
  2012-04-16
- Data Source
  KAKENHI-PROJECT-24680037
[Presentation] Self-organized formation of optic cup in vitro2012
- Author(s)
  Eiraku Mototsugu
- Organizer
  the 16th NSW Stem Cell Network Workshop: Stem Cell Treatments for Eye Diseases.
- Place of Presentation
  University of Western Sydney Medical School, Australia
- Year and Date
  2012-04-06
- Invited
- Data Source
  KAKENHI-PUBLICLY-24112527
[Presentation] Self-organized formation of optic cup in vitro2012
- Author(s)
  Eiraku Mototsugu
- Organizer
  Joint Meeting of JSDB 45^<th> & JSCB 64^<th>
- Place of Presentation
  Kobe International Conference Center(招待講演)
- Year and Date
  2012-05-30
- Data Source
  KAKENHI-PROJECT-24680037
[Presentation] Self-organized formation of optic cup in vitro2012
- Author(s)
  Eiraku Mototsugu
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  Kobe International Conference Center The Kobe Chamber of Commerce and Industry, Kobe
- Year and Date
  2012-05-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-24112527
[Presentation] ES細胞を活用したヒト組織構築技術の現状と将来展望2012
- Author(s)
  永樂元次
- Organizer
  日本化学工業協会新LRI研究報告会
- Place of Presentation
  ベルサール八重洲、東京(招待講演)
- Year and Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-24680037
[Presentation] ES細胞からの大脳皮質神経組織分化について2009
- Author(s)
  永樂元次、笹井芳樹
- Organizer
  第32回に本神経科学大会シンポジウム
- Place of Presentation
  名古屋国際会議場・名古屋
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-21700367

1. 見学美根子 (10303801)

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Eiraku Mototsugu 永樂 元次

EIRAKU Mototsugu 永樂 元次

永樂 元次 エイラク モトツグ

Research Projects

Research Products

Co-Researchers

領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営

Principal Investigator

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より生体に近いオルガノイド創出のための細胞外環境制御技術の開発Principal Investigator

Principal Investigator

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嗅上皮オルガノイドを用いた嗅受容体遺伝子発現制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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中枢神経系細胞における新型コロナウイルス持続感染機構の解析

Principal Investigator

Project Period (FY)

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Review Section

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Development of a new culture system for human coronaviruses using organoids

Principal Investigator

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Review Section

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Interplay of developmental clock and extracellular environment in brain formation

Principal Investigator

Project Period (FY)

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Interplay of developmental clock and extracellular environment in brain formation

Principal Investigator

Project Period (FY)

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Understanding the molecular basis that defines species-specific developmental timingPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Establishment of a new methodology for inducing early embryo-like structures from stem cellsPrincipal Investigator

Principal Investigator

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Stress field estimation in three-dimensional optic-cup by image-based modeling

Principal Investigator

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上皮組織の分化パターンと形態形成をつなぐ力学制御メカニズムの解明Principal Investigator

Principal Investigator

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神経上皮組織の自己組織的な形態形成の基盤となる細胞骨格動態の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Dorsal and ventral specification in optic cup derived from ES cells in vitroPrincipal Investigator

Principal Investigator

Eiraku Mototsugu 永樂元次

EIRAKU Mototsugu 永樂元次

永樂元次エイラクモトツグ