HIRATA Takao 平田孝夫

Researcher Number	40420533
Affiliation *help	2007 – 2009 : Yamaguchi University, 医学部・附属病院, 助教 2007 – 2009 : Yamaguchi Univ., Hospital, Assistant Professor 2008 : 山口大学, 医学部附属病院, 助手 2006 : 山口大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies Except Principal Investigator Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 好中球エラスターゼ / 海馬CA1 / カスパーゼ / 虚血性神経細胞死 / 蘇生学 / アポトーシス / 細胞外マトリックス / シベレスッタトNa / 虚血 / 一過性前脳虚血 … More Except Principal Investigator 高気圧酸素 / 前脳虚血 / 脳虚血耐性 / p38 MAP kinase / 炎症反応 / 脳虚血 / 術後高次脳機能障害 / クロストレランス / p38 MAPK / 脂肪塞栓 / Lipopolysaccharide / 耐性誘導 / neurotrophin / 中枢神経 / 神経栄養因子 / 耐性関連因子 / 脳梗塞 / immuno / forebrain ischemia / 虚血性神経細胞死 / ischemic tolerance / 虚血 / 遺伝子 / LPS / 虚血耐性 / 脳浮腫 / p38 / 脂肪塞 / 全身炎症反応 / hyperbric oxygen / inflammatory response / 海馬CA1 / 免疫・炎症 Less

高気圧酸素による虚血耐性誘導を応用した脳血管障害の新規予防・治療戦略の開発
- Principal Investigator
  
  坂部武史
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
The role of neutrophil elastase in the development of neuronal damage following transient forebrain ischemia.Principal Investigator
- Principal Investigator
  
  HIRATA Takao
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
The effect of systemic inflammation to ischemic brain damage and hypothermic protection
- Principal Investigator
  
  ISHIDA Kazuyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
虚血性中枢神経障害の病態解明と好中球エラスターゼ阻害薬の効果に関する検討Principal Investigator
- Principal Investigator
  
  平田孝夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Mechanism for ischemic crosstoleance in central nervous system and its therapeutic application
- Principal Investigator
  
  SAKABE Takefumi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University

All 2009 2007 2006 2005

All Journal Article Presentation

[Journal Article] Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.2009
- Author(s)
  Matayoshi H., Hirata T., Yamashita S., Ishida K., Mizukami Y., Gondo T., Matsumoto M., Sakabe T.
- Journal Title
  
  Brain Res. 1259
  
  Pages : 98-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791076
[Journal Article] The temporal profile of genomic responses and protein synthesis in isohemic tolerance of the rat brain induced by repeated hyperbaric oxygen.2007
- Author(s)
  Takao Hirata
- Journal Title
  
  Brain Research 1130
  
  Pages : 214-222
- Data Source
  KAKENHI-PROJECT-17390429
[Journal Article] The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen2007
- Author(s)
  Takao, Hirata, Ying, Jun, Cue, Takeshi, Funakoshi, Yoichi, Mizukami,Yu-ichiro, Ishikawa, Futoshi, Shibasaki, Mishiya, Matsumoto, Takefumi, Sakabe
- Journal Title
  
  Brain Research 1130(1)
  
  Pages : 214-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Journal Article] The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen.2007
- Author(s)
  Takao Hirata
- Journal Title
  
  Brain Research 1130
  
  Pages : 214-222
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390429
[Journal Article] Ischemic preconditioning in the central nervous system2005
- Author(s)
  Mishiya, Matsumoto, Kazuhiko, Nakakimura, Mitsuyoshi, Yoshida, Takao, Hirata, Takefumi, Sakabe
- Journal Title
  
  Japanese Journal of Reanimatology 24
  
  Pages : 76-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] 好中球エラスタ-ゼ阻害薬ONO-5046はラット-過性脳虚血後の海馬CA1神経細胞死を軽減させる2009
- Author(s)
  平田孝夫
- Organizer
  日本麻酔科学会第56会学術集会
- Place of Presentation
  神戸
- Year and Date
  2009-08-16
- Data Source
  KAKENHI-PROJECT-20791076
[Presentation] 好中球エラスターゼ阻害薬ONO-5046はラット一過性脳虚血後の海馬CA1神経細胞死を軽減させる2009
- Author(s)
  平田孝夫, 又吉宏昭, 山下敦夫, 福田志朗, 石田和慶, 松本美志也, 坂部武史
- Organizer
  日本麻酔科学会第56回学術集会
- Place of Presentation
  神戸
- Year and Date
  2009-08-16
- Data Source
  KAKENHI-PROJECT-20791076
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in ratbrain: Time window and genome-wide gene and protein expression2007
- Author(s)
  Takao Hirata
- Organizer
  The 23^<rd> International Symposium on Cerebral Blood Flow, Metabolism and Function. The 8^<th> International Conference on Quantification of Brain Function with PET.
- Place of Presentation
  Osaka
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen In rat brain:Time window and genome-wide gene and protein expression2007
- Author(s)
  Takao Hirata, et. al.
- Organizer
  Brain'07 & Brain PET'07
- Place of Presentation
  Osaka
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in rat brain : Time window and genome-wide gene and protein expression2007
- Author(s)
  Takao, Hirata, Ying, Jun Cui, Takeshi, Funakoshi, Yoichi, Mizukami, Yu-ichiro, Ishikawa, Futoshi, Shibasaki, Mishiya, Matsumoto, Takefumi, Sakabe
- Organizer
  The 8th International Conference on Quantification of Brain Function with PET
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in rat brain : Time window and genome-wide gene and protein expression2007
- Author(s)
  Takao, Hirata, Ying, Jun, Cui, Takeshi, Funakoshi, Yoichi, Mizukami, Yu-ichiro, Ishikawa, Futoshi, Shibasaki, Mishiya, Matsumoto, Takefumi, Sakabe
- Organizer
  The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] 高気圧酸素による脳虚血耐性と遺伝子変化2006
- Author(s)
  平田孝夫
- Organizer
  日本麻酔科学会第53回学術集会
- Place of Presentation
  神戸
- Year and Date
  2006-06-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance and genomic responses induced by hyperbaric oxygen2006
- Author(s)
  Takao, Hirata, Ying, Jun, Cui, Mishiya, Matsumoto, Takefumi, Sakabe
- Organizer
  The 53rd Annual Meeting of Japanese Society of Anesthesiologists
- Place of Presentation
  Kobe, Japan
- Year and Date
  2006-06-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in rat brain2006
- Author(s)
  Hirata, T, Cui, YJ, Funakoshi, T, Mizukami, Y, Ishikawa, Y, Shibasaki, F, Matsumoto, M, Sakabe, T
- Organizer
  The 2nd Japan-China-Kores Joint Symposium for Neuroanesthesia
- Place of Presentation
  Osaka
- Year and Date
  2006-04-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390429
[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in rat brain2006
- Author(s)
  Takao Hirata
- Organizer
  The 2^<nd> Japan-China-Kores Joint Symposium for Neuroanesthesia
- Place of Presentation
  Osaka
- Year and Date
  2006-04-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390429

1. SAKABE Takefumi (40035225)

# of Collaborated Projects : 3results

# of Collaborated Products : 6results
2. MATSUMOTO Mishiya (60243664)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
3. MIZUKAMI Youichi (80274158)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
4. ISHIDA Kazuyoshi (80314813)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. IIDA Yasuhiko (90304485)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 森本康裕 (60325230)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 福田志朗 (70322245)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

HIRATA Takao 平田 孝夫

Research Projects

Research Products

Co-Researchers

高気圧酸素による虚血耐性誘導を応用した脳血管障害の新規予防・治療戦略の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of neutrophil elastase in the development of neuronal damage following transient forebrain ischemia.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of systemic inflammation to ischemic brain damage and hypothermic protection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

虚血性中枢神経障害の病態解明と好中球エラスターゼ阻害薬の効果に関する検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for ischemic crosstoleance in central nervous system and its therapeutic application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.2009

Author(s)

Journal Title

Data Source

[Journal Article] The temporal profile of genomic responses and protein synthesis in isohemic tolerance of the rat brain induced by repeated hyperbaric oxygen.2007

Author(s)

Journal Title

Data Source

[Journal Article] The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Ischemic preconditioning in the central nervous system2005

Author(s)

Journal Title

Description

Data Source

[Presentation] 好中球エラスタ-ゼ阻害薬ONO-5046はラット-過性脳虚血後の海馬CA1神経細胞死を軽減させる2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 好中球エラスターゼ阻害薬ONO-5046はラット一過性脳虚血後の海馬CA1神経細胞死を軽減させる2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen in ratbrain: Time window and genome-wide gene and protein expression2007

Author(s)

Organizer

Place of Presentation

Year and Date

Description

Data Source

[Presentation] Ischemic tolerance induced by repeated hyperbaric oxygen In rat brain:Time window and genome-wide gene and protein expression2007

Author(s)

Organizer

Place of Presentation

HIRATA Takao 平田孝夫