Takeshima Hideyuki 竹島秀幸

… Alternative Names

TAKESHIMA Hideyuki 竹島秀幸

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Researcher Number	40432497
Affiliation (Current)	2025: 星薬科大学, 先端生命科学研究所, 准教授 2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 星薬科大学, 先端生命科学研究所, 特任准教授 2020 – 2021: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2018 – 2019: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2015 – 2016: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2011 – 2013: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology / Medical genome science Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator エピジェネティクス / DNAメチル化 / クロマチンリモデリング / 合成致死 / 慢性炎症 / エピジェネティック治療 / がん治療 / リキッドバイオプシー / マイクロアレイ / サイレンシング / がん抑制遺伝子 … More Except Principal Investigator … More 胃型腫瘍 / SNADET / 十二指腸 / がん予防 / DNAメチル化異常 / エピジェネティクス / 慢性炎症 / ヌクレオソーム振動 / DNAメチル化 / 合成致死 / エピゲノム Less

Investigation of the Molecular Mechanisms Underlying the Development of High-Grade Duodenal Tumors
- Principal Investigator
  
  佐々木亜希子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shonan Kamakura General Hospital, Medical Corporation Tokushukai (Center for Clinical and
慢性炎症によるヌクレオソーム振動の分子機構
- Principal Investigator
  
  牛島俊和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
クロマチンリモデリング因子SMARCA1のメチル化異常を標的としたがん治療開発Principal Investigator
- Principal Investigator
  
  竹島秀幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hoshi University
Mechanisms of severe induction of aberrant DNA methylation by the shift from innate to acquired immunityPrincipal Investigator
- Principal Investigator
  
  Takeshima Hideyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hoshi University
  National Cancer Center Japan
Synthetic lethality with gene silencing
- Principal Investigator
  
  Ushijima Toshikazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
  National Cancer Center Japan
Development of a novel liquid biopsy to monitor DNA demethylationPrincipal Investigator
- Principal Investigator
  
  Takeshima Hideyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Cancer Center Japan
Clarification of the role of SWI/SNF inactivation in carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Takeshima Hideyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Identification of novel tumor-suppressor genes by Outlier approachPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hideyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2023 2022 2021 2016 2015 2012 2011 Other

All Journal Article Presentation

[Journal Article] Severe induction of aberrant DNA methylation by nodular gastritis in adults2024
- Author(s)
  Sasaki Akiko、Takeshima Hideyuki、Yamashita Satoshi、Ichita Chikamasa、Kawachi Jun、Naito Wataru、Ohashi Yui、Takeuchi Chihiro、Fukuda Masahide、Furuichi Yumi、Yamamichi Nobutake、Ando Takayuki、Kobara Hideki、Kotera Tohru、Itoi Takao、Sumida Chihiro、Hamada Akinobu、Koizumi Kazuya、Ushijima Toshikazu
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 6 Pages: 442-456
- DOI
  10.1007/s00535-024-02094-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07928
[Journal Article] DNA methylation marker to estimate ovarian cancer cell fraction2022
- Author(s)
  Ebata Takahiro、Yamashita Satoshi、Takeshima Hideyuki、Yoshida Hiroshi、Kawata Yoshiko、Kino Nao、Yasugi Toshiharu、Terao Yasuhisa、Yonemori Kan、Kato Tomoyasu、Ushijima Toshikazu
- Journal Title
  
  Medical Oncology
  
  Volume: 39 Issue: 5 Pages: 78-78
- DOI
  10.1007/s12032-022-01679-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02773, KAKENHI-PROJECT-20K18180
[Journal Article] DNA methylation of the immediate upstream region of BRCA1 major transcription start sites is an independent favorable prognostic factor in patients with high-grade serous ovarian cancer2022
- Author(s)
  Ebata Takahiro、Yamashita Satoshi、Takeshima Hideyuki、Yoshida Hiroshi、Kawata Yoshiko、Kino Nao、Yasugi Toshiharu、Terao Yasuhisa、Yonemori Kan、Kato Tomoyasu、Ushijima Toshikazu
- Journal Title
  
  Gynecologic Oncology
  
  Volume: 167 Issue: 3 Pages: 513-518
- DOI
  10.1016/j.ygyno.2022.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02773, KAKENHI-PROJECT-20K18180
[Journal Article] A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy2022
- Author(s)
  Ueda Sho、Yamashita Satoshi、Nakajima Miho、Kumamoto Tadashi、Ogawa Chitose、Liu Yu-yu、Yamada Harumi、Kubo Emi、Hattori Naoko、Takeshima Hideyuki、Wakabayashi Mika、Iida Naoko、Shiraishi Yuichi、Noguchi Masayuki、Sato Yukio、Ushijima Toshikazu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 31
- DOI
  10.1073/pnas.2123241119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02773
[Journal Article] Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming2021
- Author(s)
  Hattori Naoko、Asada Kiyoshi、Miyajima Nozomu、Mori Akiko、Nakanishi Yoko、Kimura Kana、Wakabayashi Mika、Takeshima Hideyuki、Nitani Chika、Hara Junichi、Ushijima Toshikazu
- Journal Title
  
  British Journal of Cancer
  
  Volume: 125 Issue: 12 Pages: 1647-1656
- DOI
  10.1038/s41416-021-01571-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02773
[Journal Article] Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.2016
- Author(s)
  Nakazato H, Takeshima H, Kishino T, Kubo E, Hattori N, Nakajima T, Yamashita S, Igaki H, Tachimori Y, Kuniyoshi Y, Ushijima T.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 1 Pages: e0147372-e0147372
- DOI
  10.1371/journal.pone.0147372
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18422
[Journal Article] Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.2012
- Author(s)
  Kikuyama, M, Takeshima, H, Kinoshita, T, Okochi-Takada, E, Wakabayashi, M, Akashi-Tanaka, S, Ogawa, T, Seto, Y and Ushijima, T.
- Journal Title
  
  Cancer Letters
  
  Volume: 322 Issue: 2 Pages: 204-212
- DOI
  10.1016/j.canlet.2012.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710227
[Journal Article] Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation2012
- Author(s)
  Kikuyama, M, Takeshima, H, Kinoshita, T, Okochi-Takada, E, Wakabayashi, M, Akashi-Tanaka, S, Ogawa, T, Seto, Y and Ushijima, T
- Journal Title
  
  Cancer Lett.
  
  Volume: 322 Pages: 204-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710227
[Journal Article] Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction2011
- Author(s)
  Takeshima H, Yamashita S, Shimazu T, Ushijima T.
- Journal Title
  
  Genomics
  
  Volume: 98 Issue: 3 Pages: 182-8
- DOI
  10.1016/j.ygeno.2011.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790554, KAKENHI-PROJECT-23710227
[Journal Article] Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction2011
- Author(s)
  Takeshima, H, Yamashita, S, Shimazu, T and Ushijima, T
- Journal Title
  
  Genomics
  
  Volume: 98 Pages: 182-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] メチル化合成致死：胃がんにおけるCHFRメチル化とKRAS阻害2023
- Author(s)
  竹島秀幸、江畑貴大、古市ゆみ、山下聡、牛島俊和
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] G0S2メチル化胃がん、大腸がんにおける合成致死スクリーニング2023
- Author(s)
  古市ゆみ、竹島秀幸、江畑貴大、大橋由依、岡野圭一、牛島俊和
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] DNAメチル化を利用したパラログ合成致死2023
- Author(s)
  江畑貴大、竹島秀幸、古市ゆみ、牛島俊和
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] DNAメチル化を利用したパラログによる合成致死2023
- Author(s)
  江畑貴大、竹島秀幸、古市ゆみ、牛島俊和
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] CHFRメチル化がん細胞を標的とした合成致死2023
- Author(s)
  大橋由依、竹島秀幸、江畑貴大、古市ゆみ、益子諒真、奥輝明、牛島俊和
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] 胃がん、大腸がんにおけるメチル化合成致死スクリーニング2023
- Author(s)
  古市ゆみ、竹島秀幸、江畑貴大、岡野圭一、牛島俊和
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] Screening of methylation synthetic lethality in gastric and colon cancers2023
- Author(s)
  Furuichi Yumi、Takeshima Hideyuki、Ebata Takahiro、Okano Keiichi、Ushijima Toshikazu
- Organizer
  Singapore Gastric Cancer Consortium 14th Annual Scientific Meeting in 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] Methylation synthetic lethality: CHFR methylation and KRAS inhibition in gastric cancers2023
- Author(s)
  Takeshima Hideyuki、Ebata Takahiro、Furuichi Yumi、Yamashita Satoshi、Ushijima Toshikazu
- Organizer
  Annual Meeting of AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] メチル化合成致死：胃がんにおけるCHFRメチル化とKRAS阻害2023
- Author(s)
  竹島秀幸、江畑貴大、古市ゆみ、大橋由依、奥輝明、山下聡、牛島俊和
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] Single cell analysis of gene expression and epigenomic changes by optimization of Paired-seq.2022
- Author(s)
  Hideyuki Takeshima and Toshikazu Ushijima
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] シングルセルレベルでの遺伝子発現・エピゲノム変化同時解析を目指したPaired-seqの最適化.2022
- Author(s)
  竹島秀幸、牛島俊和
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] Methylation synthetic lethality: methylation-silenced genes as a rich source of combination partners for synthetic lethality2022
- Author(s)
  Ushijima Toshikazu、Yamashita Satoshi、Takeshima Hideyuki、Ebata Takahiro、Furuichi Yumi
- Organizer
  12th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] DNAメチル化サイレンシングに着目したパラログ合成致死の同定2022
- Author(s)
  江畑貴大、竹島秀幸、古市ゆみ、牛島俊和
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] 慢性炎症に曝露した組織のシングルセル遺伝子発現・エピゲノム変化解析を目指したPaired-seq条件の最適化2022
- Author(s)
  竹島秀幸、牛島俊和
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] 消化器がんにおいて遺伝子Aのメチル化は遺伝子B阻害と合成致死を示す2022
- Author(s)
  古市ゆみ、竹島秀幸、江畑貴大、岡野圭一、牛島俊和
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] Methylation synthetic lethality: large-scale isolation of candidate combinations2021
- Author(s)
  山下聡、竹島秀幸、牛島俊和
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] エピジェネティック制御因子は異常メチル化に抵抗性だが、SETD6は胃がんにおいてメチル化サイレンシングされる2021
- Author(s)
  Takeshima H, Nishiyama K and Ushijima T
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] Methylation synthetic lethality: large scale isolation of candidate combinationse2021
- Author(s)
  山下聡、竹島秀幸、牛島俊和
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] ESCC cells with Gene A methylation show synthetic lethality with Gene B inhibition2021
- Author(s)
  西山和宏、竹島秀幸、山下聡、小濱和貴、牛島俊和
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] エピジェネティック制御因子は異常メチル化に抵抗性だが、SETD6は胃がんにおいてメチル化サイレンシングされる2021
- Author(s)
  竹島秀幸, 西山和宏 and 牛島俊和
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] 遺伝子Cがメチル化された食道扁平上皮癌は遺伝子D阻害と合成致死性を示す2021
- Author(s)
  Furuichi Y, Takeshima H, Nishiyama K, Yamashita S, Okano K and Ushijima T
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level.2021
- Author(s)
  Takeshima H, Yoda Y and Ushijima T.
- Organizer
  The 39th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07928
[Presentation] ESCC cells with Gene C methylation show synthetic lethality with Gene D knockdown2021
- Author(s)
  Furuichi Yumi、Takeshima Hideyuki、Nishiyama Kazuhiro、Yamashita Satoshi、Okano Keiichi、Ushijima Toshikazu
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21H02773
[Presentation] Suppression of Tet genes is a potential mechanism of aberrant DNA methylation induction by chronic inflammation.2016
- Author(s)
  Takeshima, H.
- Organizer
  Kick-off Symposium in NCU
- Place of Presentation
  名古屋
- Year and Date
  2016-02-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18422
[Presentation] Role of chromatin remodeler alterations in gastric field cancerization.2015
- Author(s)
  Takeshima, H., Niwa T., Wakabayashi, M., and Ushijima, T.
- Organizer
  GRL Korea-Japan Epigenome Medicine Meeting 2015
- Place of Presentation
  那覇
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18422
[Presentation] Tet遺伝子の発現は慢性炎症により低下する.2015
- Author(s)
  竹島秀幸, 丹羽　透, 若林美香, 山下　聡 and 牛島俊和.
- Organizer
  第9回エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15K18422
[Presentation] Role of chromatin remodeler alterations in gastric field cancerization.2015
- Author(s)
  Takeshima, H. and Ushijima, T.
- Organizer
  74th JCA annual meeting
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K18422
[Presentation] The outlier approach discriminates drivers from passengers among genes methylated in cancer2012
- Author(s)
  Kikuyama, M, Takeshima, H, Kinoshita, T, Okochi-Takada, E, Wakabayashi, M, Akashi-Tanaka, S, Ogawa, T, Seto, Y and Ushijima, T
- Organizer
  AACR annual meeting 2012
- Place of Presentation
  シカゴ(米国)
- Year and Date
  2012-04-03
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] エピジェネティックに不活化された遺伝子の中からがん抑制遺伝子を選別する方法の開発2011
- Author(s)
  菊山みずほ, 竹島秀幸, 大河内(髙田)江里子, 明石(田中)定子, 木下貴之, 小川利久, 瀬戸泰之 and 牛島俊和
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] 繰り返し配列LINE及びSINEはDNAメチル化異常誘発に対する感受性を与える2011
- Author(s)
  竹島秀幸, 山下聡, 島津太一 and 牛島俊和
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] エピジェネティックに不活化された遺伝子の中からがん抑制遺伝子を選別する方法の開発2011
- Author(s)
  菊山みずほ, 竹島秀幸, 大河内(髙田)江里子, 小川利久, 瀬戸泰之 and 牛島俊和
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] ゲノム構造及びエピジェネティック因子は独立してメチル化異常誘発に対する感受性に影響する2011
- Author(s)
  竹島秀幸, 山下聡, 島津太一 and 牛島俊和
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] エピジェネティックに不活化された遺伝子の中からがん抑制遺伝子を選別する方法の開発.2011
- Author(s)
  菊山みずほ, 竹島秀幸, 大河内(高田)江里子, 小川利久, 瀬戸泰之 and 牛島俊和.
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23710227
[Presentation] The outlier approach discriminates drivers from passengers among genes methylated in cancers
- Author(s)
  Kikuyama, M, Takeshima, H, Kinoshita, T, Okochi-Takada, E, Wakabayashi, M, Akashi-Tanaka, S, Ogawa, T, Seto, Y and Ushijima, T
- Organizer
  AACR annual meeting 2012
- Place of Presentation
  アメリカ・シカゴ
- Data Source
  KAKENHI-PROJECT-23710227

1. Ushijima Toshikazu (90232818)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 山下聡 (80321876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. 佐々木亜希子 (40994819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 野口雅之 (00198582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIMAZU Taichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshima Hideyuki 竹島 秀幸

TAKESHIMA Hideyuki 竹島 秀幸

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Investigation of the Molecular Mechanisms Underlying the Development of High-Grade Duodenal Tumors

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慢性炎症によるヌクレオソーム振動の分子機構

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クロマチンリモデリング因子SMARCA1のメチル化異常を標的としたがん治療開発Principal Investigator

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Mechanisms of severe induction of aberrant DNA methylation by the shift from innate to acquired immunityPrincipal Investigator

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Synthetic lethality with gene silencing

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Development of a novel liquid biopsy to monitor DNA demethylationPrincipal Investigator

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Clarification of the role of SWI/SNF inactivation in carcinogenesisPrincipal Investigator

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Identification of novel tumor-suppressor genes by Outlier approachPrincipal Investigator

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[Journal Article] Severe induction of aberrant DNA methylation by nodular gastritis in adults2024

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[Journal Article] DNA methylation marker to estimate ovarian cancer cell fraction2022

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[Journal Article] DNA methylation of the immediate upstream region of BRCA1 major transcription start sites is an independent favorable prognostic factor in patients with high-grade serous ovarian cancer2022

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[Journal Article] A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy2022

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[Journal Article] Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming2021

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[Journal Article] Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.2016

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Takeshima Hideyuki 竹島秀幸

TAKESHIMA Hideyuki 竹島秀幸