Akatsuka Shinya 赤塚慎也

… Alternative Names

AKATSUKA Shinya 赤塚慎也

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Researcher Number	40437223
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2017 – 2024: 名古屋大学, 医学系研究科, 講師 2014: 名古屋大学, 医学系研究科, 講師 2012 – 2014: 名古屋大学, 医学(系)研究科(研究院), 講師 2012: 名古屋大学, 医学系研究科, 講師 2010 – 2011: 名古屋大学, 医学系研究科, 助教 2007 – 2008: Nagoya University, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Carcinogenesis / Laboratory animal science Except Principal Investigator Experimental pathology
Keywords	Principal Investigator 発がん / 酸化ストレス / がんゲノム進化 / フェロトーシス / 動物モデル / DNA修復 / DNA傷害 / クローン進化 / ゲノム変異 / ゲノム傷害 … More / 次世代シークエンシング / ゲノム解析 / ゲノム損傷 / 実験動物モデル / 発癌 / 染色体不安定性 / 病態モデル … More Except Principal Investigator 酸化ストレス / 鉄 / アスベスト / 中皮腫 / 多層オミクス解析 / 発がん / オミクス解析 / CTGF / 腫瘍 / 瀉血 / 腎癌 / オミクス / がん予防 / 予防 / マイクロアレイ解析 Less

多種および多系統の動物を用いた鉄関連酸化ストレス発がん過程の解明Principal Investigator
- Principal Investigator
  
  赤塚慎也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya University
発がんにおけるDNA損傷・修復ダイナミクスの実像解明Principal Investigator
- Principal Investigator
  
  赤塚慎也
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya University
Analyses based on iron dynamics and multiomics to overcome oxidative stress-induced carcinogenesis
- Principal Investigator
  
  Toyokuni Shinya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya University
Establishing preventive strategy for mesothelioma by elucidating its carcinogenic mechanism
- Principal Investigator
  
  TOYOKUNI SHINYA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya University
Elucidation of genomic distribution dynamics of DNA damage and repair in carcinogenesis processPrincipal Investigator
- Principal Investigator
  
  AKATSUKA Shinya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Nagoya University
Analysis of chromosomal alterations in an oxidative stress-induced animal carcinogenesis modelPrincipal Investigator
- Principal Investigator
  
  AKATSUKA Shinya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Nagoya University

[Book] 生命金属ダイナミクス　～生体内における金属の挙動と制御～2021
- Author(s)
  城宜嗣, 津本浩平, 古川良明, 神戸大朋, 赤塚慎也, 豊國伸哉, 他
- Total Pages
  511
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860437060
- Data Source
  KAKENHI-PROJECT-20K07588
[Journal Article] Environmental impact on carcinogenesis under BRCA1 haploinsufficiency2023
- Author(s)
  Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
- Journal Title
  
  Genes and Environment
  
  Volume: 45 Issue: 1 Pages: 2-2
- DOI
  10.1186/s41021-023-00258-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K07588
[Journal Article] BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile‐induced mesothelioma via ferroptosis resistance2023
- Author(s)
  Luo Yaguang、Akatsuka Shinya、Motooka Yashiro、Kong Yingyi、Zheng Hao、Mashimo Tomoji、Imaoka Tatsuhiko、Toyokuni Shinya
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1423-1436
- DOI
  10.1111/cas.15705
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-23K21752, KAKENHI-PROJECT-23H00367
[Journal Article] BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance2022
- Author(s)
  Kong Yingyi、Akatsuka Shinya、Motooka Yashiro、Zheng Hao、Cheng Zhen、Shiraki Yukihiro、Mashimo Tomoji、Imaoka Tatsuhiko、Toyokuni Shinya
- Journal Title
  
  Redox Biology
  
  Volume: 54 Pages: 102356-102356
- DOI
  10.1016/j.redox.2022.102356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-23K21752
[Journal Article] Ferroptosis resistance determines high susceptibility of murine <i>A/J</i> strain to iron‐induced renal carcinogenesis2021
- Author(s)
  Cheng Zhen、Akatsuka Shinya、Li Guang Hua、Mori Kiyoshi、Takahashi Takashi、Toyokuni Shinya
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 1 Pages: 65-78
- DOI
  10.1111/cas.15175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08682, KAKENHI-PUBLICLY-20H05502, KAKENHI-PROJECT-20K07588
[Journal Article] Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering2020
- Author(s)
  Toyokuni Shinya、Kong Yingyi、Cheng Zhen、Sato Kotaro、Hayashi Shotaro、Ito Fumiya、Jiang Li、Yanatori Izumi、Okazaki Yasumasa、Akatsuka Shinya
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 11 Pages: 3320-3320
- DOI
  10.3390/cancers12113320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-19H05462, KAKENHI-PUBLICLY-20H05502
[Journal Article] Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions2020
- Author(s)
  Akatsuka Shinya、Li Guang Hua、Kawaguchi Shinichi、Takahashi Takashi、Yoshihara Minako、Suyama Mikita、Toyokuni Shinya
- Journal Title
  
  Free Radical Research
  
  Volume: - Issue: 11-12 Pages: 1-11
- DOI
  10.1080/10715762.2020.1733548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07588, KAKENHI-PUBLICLY-20H05502
[Journal Article] Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice2020
- Author(s)
  Funahashi Satomi、Okazaki Yasumasa、Akatsuka Shinya、Takahashi Takashi、Sakumi Kunihiko、Nakabeppu Yusaku、Toyokuni Shinya
- Journal Title
  
  Free Radical Research
  
  Volume: N/A Issue: 2-3 Pages: 1-231
- DOI
  10.1080/10715762.2020.1743285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05462, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-16H02468, KAKENHI-PUBLICLY-20H05502
[Journal Article] Frequent homozygous deletion of Cdkn2a/2b in tremolite‐induced malignant mesothelioma in rats2020
- Author(s)
  Okazaki Yasumasa、Misawa Nobuaki、Akatsuka Shinya、Kohyama Norihiko、Sekido Yoshitaka、Takahashi Takashi、Toyokuni Shinya
- Journal Title
  
  Cancer Science
  
  Volume: N/A Issue: 4 Pages: 1180-1192
- DOI
  10.1111/cas.14358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05462, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-19H03527, KAKENHI-PROJECT-17K19628, KAKENHI-PROJECT-16H02468, KAKENHI-PUBLICLY-20H05502
[Journal Article] Superiority of rat over murine model for studies on the evolution of cancer genome2018
- Author(s)
  Akatsuka Shinya、Li Guang Hua、Toyokuni Shinya
- Journal Title
  
  Free Radical Research
  
  Volume: 52 Issue: 11-12 Pages: 1323-1327
- DOI
  10.1080/10715762.2018.1467562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-16H06276
[Journal Article] Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis.2017
- Author(s)
  Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
- Journal Title
  
  Free Radic Biol Med.
  
  Volume: 108 Pages: 610-616
- DOI
  10.1016/j.freeradbiomed.2017.04.024
- NAID
  120006343681
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-15K08398, KAKENHI-PROJECT-16K15257, KAKENHI-PROJECT-16H06276
[Journal Article] Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.2017
- Author(s)
  Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.
- Journal Title
  
  Pathol Int.
  
  Volume: 67 Issue: 11 Pages: 564-574
- DOI
  10.1111/pin.12598
- NAID
  120006382249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19913, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-16H02468
[Journal Article] Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma2014
- Author(s)
  Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S
- Journal Title
  
  J Pathol
  
  Volume: 233 Issue: 4 Pages: 402-414
- DOI
  10.1002/path.4377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134005, KAKENHI-PROJECT-23590394, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-26460423, KAKENHI-PROJECT-221S0001
[Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013
- Author(s)
  S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
- Journal Title
  
  Carcinogenesis
  
  Volume: 35(1) Issue: 1 Pages: 164-172
- DOI
  10.1093/carcin/bgt267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PLANNED-22134005, KAKENHI-PUBLICLY-23126513, KAKENHI-PROJECT-23590394, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-25250017, KAKENHI-PROJECT-25290053, KAKENHI-PROJECT-25293211, KAKENHI-PROJECT-25461347, KAKENHI-PROJECT-25860292, KAKENHI-PROJECT-221S0001
[Journal Article] Metamorphosis of mesothelial cells with active horizontal motility in tissue culture2013
- Author(s)
  Nagai H, Chew SH, Okazaki Y, Funahashi S, Namba T, Kato T, Enomoto A, Jiang L, Akatsuka S, Toyokuni S
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 1144-1144
- DOI
  10.1038/srep01144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701051, KAKENHI-PROJECT-23790440, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390094
[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2012
- Author(s)
  Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
- Journal Title
  
  PLoS One
  
  Volume: vol.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Iron overload signature in chrysotile-induced malignant mesothelioma.2012
- Author(s)
  Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S.
- Journal Title
  
  J Pathol
  
  Volume: 228 Issue: 3 Pages: 366-77
- DOI
  10.1002/path.4075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590394, KAKENHI-PROJECT-23591363, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-24591377, KAKENHI-PROJECT-221S0001
[Journal Article] 酸化ストレスによるゲノム変化と発がん2012
- Author(s)
  赤塚慎也,豊國伸哉
- Journal Title
  
  実験医学
  
  Volume: vol.30 Pages: 2779-2785
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-wide assessment of oxidatively generated DNA damage2012
- Author(s)
  Akatsuka S, Toyokuni S
- Journal Title
  
  Free Radic Res
  
  Volume: vol.46 Pages: 523-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-wide assessment of oxidatively generated DNA damage2012
- Author(s)
  Akatsuka S
- Journal Title
  
  Free Radic Res
  
  Volume: 46 Issue: 4 Pages: 523-530
- DOI
  10.3109/10715762.2011.633212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] 酸化ストレスによるゲノム変化と発がん2012
- Author(s)
  赤塚慎也
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 2779-2785
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats2011
- Author(s)
  Ohara H, Akatsuka S, Nagai H, Liu YT, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, Toyokuni S
- Journal Title
  
  Free Radic Res
  
  Volume: vol.45 Pages: 211-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-wide assessment of oxidatively generated DNA damage2011
- Author(s)
  Akatsuka S, Toyokuni S
- Journal Title
  
  Free Radical Research
  
  Volume: 46 Pages: 523-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-scale approaches to investigate oxidative DNA damage.2010
- Author(s)
  Akatsuka S, Toyokuni S.
- Journal Title
  
  Journal of Chnical Biochemistry and Nutrition
  
  Volume: 47 Pages: 91-97
- NAID
  130004879210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-scale approaches to investigate oxidative DNA damage2010
- Author(s)
  Akatsuka S, Toyokuni S
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: vol.47 Pages: 91-97
- NAID
  130004879210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500997
[Journal Article] Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma2009
- Author(s)
  Zhong Y, Onuki J, Yamasaki T, Ogawa O, Akatsuka S, Toyokuni S
- Journal Title
  
  Carcinogenesis vol.30
  
  Pages: 158-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500361
[Journal Article] 鉄・酸化ストレスによる発癌の分子機構を探る2008
- Author(s)
  赤塚慎也, 豊國伸哉
- Journal Title
  
  分子消化器病 vol.5
  
  Pages: 39-48
- Data Source
  KAKENHI-PROJECT-19500361
[Journal Article] 鉄・酸化ストレスによる発癌の分子機構を探る2008
- Author(s)
  赤塚慎也, 豊國伸哉
- Journal Title
  
  分子消化器病 5
  
  Pages: 39-48
- Data Source
  KAKENHI-PROJECT-19500361
[Journal Article] Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway2007
- Author(s)
  Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK, Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S
- Journal Title
  
  The American journal of pathology vol.171
  
  Pages: 1978-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] 鉄ニトリロ三酢酸誘発マウス腎発がん初期におけるゲノム内8-オキソグアニン分布2024
- Author(s)
  赤塚慎也，豊國伸哉
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] 鉄ニトリロ三酢酸誘発腎発がんモデルにおけるフェロトーシス抵抗性の意義2023
- Author(s)
  赤塚慎也, 程真, 孔穎怡, 豊國伸哉
- Organizer
  第34回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] マウス腎発がんモデルにおける酸化的DNA損傷のゲノム内分布2023
- Author(s)
  赤塚慎也，豊國伸哉
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] 鉄を介した酸化ストレス発がんモデルにおける8-オキソグアニン分布動態2023
- Author(s)
  赤塚慎也，豊國伸哉
- Organizer
  第76回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] A/Jマウスはフェロトーシス抵抗性を介して鉄ニトリロ三酢酸誘発腎がんに対して高い感受性を示す2022
- Author(s)
  赤塚慎也, 程真, 豊國伸哉
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] アスベスト誘発ラット中皮腫の全ゲノムシークエンスとトランスクリプトーム解析2021
- Author(s)
  赤塚慎也, 蒋麗, エルザワハリ・アスマ, 加藤護, 戸塚ゆ加里, 新井康仁, 柴田龍弘, 豊國伸哉
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] アスベスト誘発ラット中皮腫におけるゲノム変異の特徴2020
- Author(s)
  赤塚慎也, 蒋麗, エルザワハリ・アスマ, 加藤護, 戸塚ゆ加里, 柴田龍弘, 豊國伸哉
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] 鉄を介した酸化ストレスおよびアスベストによるゲノム変化と発がん2020
- Author(s)
  赤塚慎也、豊國伸哉
- Organizer
  第19回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] アスベスト誘発ラット中皮腫におけるゲノム変異の特徴解析2020
- Author(s)
  赤塚慎也, 蒋麗, 戸塚ゆ加里, 加藤護, エルザワハリ・アスマ, 柴田龍弘, 豊國伸哉
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K07588
[Presentation] マウス系統間における腎酸化ストレス応答の差異に関わる遺伝子の解析2019
- Author(s)
  金谷和樹、程　真、赤塚慎也、豊國伸哉
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] シンポジウム21：発がん過程におけるゲノムと環境因子の相互作用　鉄を介した酸化ストレスによる動物発がんモデルとゲノム変化2019
- Author(s)
  赤塚慎也、蒋麗、伊藤文哉、豊國伸哉
- Organizer
  第７８回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Role of ferroptosis in carcinogenesis and tumor biology.2019
- Author(s)
  Toyokuni S, Jiang L, Li Z, Ito F, Akatsuka S
- Organizer
  The 9th Biennial joing meeting of the Society for Free Radical Research Autralasia and Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] C型肝炎ウイルス排除後に生じた肝癌ゲノム変異の解析2018
- Author(s)
  岩田侑也、赤塚慎也、豊國伸哉
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Ptger2を分子標的とした中皮腫治療と予防2018
- Author(s)
  蒋麗、赤塚慎也、豊國伸哉
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] ８-オキソグアニン修復酵素欠損マウスにおける鉄ニトリロ三酢酸誘発腎発がん2018
- Author(s)
  赤塚慎也、李　光華、中別府雄作、豊國伸哉
- Organizer
  日本酸化ストレス学会東海支部第６回学術集会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] 悪性中皮腫の発がん過程における2価鉄トランスポーターの役割の解析2018
- Author(s)
  舟橋諭美、岡崎泰昌、赤塚慎也、豊國伸哉
- Organizer
  第29回日本微量元素学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] 悪性中皮腫発がん過程における2価鉄トランスポーターの解析2018
- Author(s)
  舟橋諭美、岡崎泰昌、赤塚慎也、高橋　隆、豊國伸哉
- Organizer
  第71回日本酸化ストレス学会第18回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] 悪性中皮種の発がん過程における2価鉄トランスポーターの役割と解析2017
- Author(s)
  舟橋諭美、岡崎泰昌、赤塚慎也、伊藤文哉、豊國伸哉
- Organizer
  がん予防大会2017大阪　第24回日本がん予防学会総会・第40回日本がん疫学・分子疫学研究会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Mutyh欠損マウスにおける鉄ニトリロ三酢酸誘発腎発がん2017
- Author(s)
  赤塚慎也、李　光華、中別府雄作、豊國伸哉
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Ferric nitrilotriacete induced renal carcinogenesis in MUTYH deficient mice.2017
- Author(s)
  赤塚慎也、李　光華、作見邦彦、中別府雄作、二口　充、鈴木　拓、豊國伸哉
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] 鉄ニトリロ三酢酸誘発腎発がんにおける MUTYH 発現の意義2017
- Author(s)
  落合晴菜、赤塚慎也、李光華、豊國伸哉
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Muthy欠損マウスにおける鉄ニトリロ三酢酸誘発腎発がん2017
- Author(s)
  赤塚慎也、李　光華、二口　充、豊國伸哉
- Organizer
  第32回発癌病理研究会
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] Mutyh欠損マウスにおける鉄ニトリロ三酢酸誘発腎発がん2017
- Author(s)
  赤塚慎也、李　光華、豊國伸哉
- Organizer
  第14回日本病理学会カンファレンス
- Data Source
  KAKENHI-PROJECT-17H04064
[Presentation] CTGF(CCN2)とベータカテニンはラット肉腫型中皮腫においてautocrine loopを形成する2014
- Author(s)
  豊國伸哉、蒋　麗、岡崎泰昌、赤塚慎也
- Organizer
  第５回JMIG研究会
- Place of Presentation
  京都私学会館（京都府京都市）
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] Cancer as a ferrotoxic disease: what we have learned from animal studies towards its prevention.2013
- Author(s)
  Toyokuni S, Jiang L, Okazaki Y and Akatsuka S.
- Organizer
  International BioIron Society (IBIS) Biennial Meeting
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] 酸化ストレスによるゲノム変化と発がん　シンポジウム２：細胞ストレス応答の破綻と病態2013
- Author(s)
  豊國伸哉、蒋　麗、岡崎泰昌、山下依子、赤塚慎也
- Organizer
  第１０２回日本病理学会総会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館、札幌
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] Critical factors in multi-walled carbon nanotubes for mesothelial carcinogenesis.2013
- Author(s)
  Toyokuni S, Nagai H, Okazaki Y, Chew SH, Akatsuka S, Jiang L and Ichihara G.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya Congress Center, Nagoya
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] ラットのアスベスト誘発中皮腫発がんモデルにおいてDeferasirox投与は間葉上皮移行を促進する2013
- Author(s)
  豊國伸哉、永井裕崇、岡崎泰昌、周　珊瑚、赤塚慎也
- Organizer
  第２８回発癌病理研究会
- Place of Presentation
  ユインチホテル南城、南城市
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] マウス腎発がん過程における酸化的DNA損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  京王プラザホテル[新宿区]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] マウス腎発がん過程における酸化的DNA損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  あわぎんホール[徳島市]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] シンポジウム1 : 鉄代謝の基礎と臨床過剰鉄と発がん機構の親和性2012
- Author(s)
  豊國伸哉、蒋麗、岡崎泰昌、赤塚慎也、山下依子
- Organizer
  第36回日本鋏バイオサイエンス学会学術集会
- Place of Presentation
  札幌、京王プラザホテル札幌(招待演者)
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] マウス腎発がん過程における酸化的 DNA 損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  あわぎんホール[徳島市]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] マウス腎発がん過程における酸化的 DNA 損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌[札幌市]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] マウス腎発がん過程における酸化的 DNA 損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  京王プラザホテル[新宿区]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] マウス腎発がん過程における酸化的DNA損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌[札幌市]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] マウス腎発がん過程における酸化的DNA損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  フォーラム2012：衛生薬学・環境トキシコロジ―
- Place of Presentation
  名古屋観光ホテル[名古屋市]
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Asbestos surface provides a niche for oxidative modification : a novel role of free radicals in carcinogenesis.2012
- Author(s)
  Nagai H, Okazaki Y, Jiang L, Akatsuka S, Yamashita Y and Toyokuni S.
- Organizer
  Society for Free Radical Research Internat ional 16 th Biennial Meeting
- Place of Presentation
  Imperial College London, UK
- Data Source
  KAKENHI-PROJECT-24390094
[Presentation] マウス腎発がん過程における酸化的 DNA 損傷のゲノム内分布2012
- Author(s)
  赤塚慎也
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジ-
- Place of Presentation
  名古屋観光ホテル[名古屋市]).
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] 鉄ニトリロ三酢酸誘発腎癌モデルを用いた酸化ストレス発がん機構の解析2011
- Author(s)
  赤塚慎也
- Organizer
  第26回発癌病理研究会
- Place of Presentation
  ルネッサンスホテル(札幌)
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] 鉄ニトリロ三酢酸誘発腎癌モデルを用いた酸化ストレス発がん機構の解析2011
- Author(s)
  赤塚慎也
- Organizer
  第26回発癌病理研究会
- Place of Presentation
  ルネッサンスサッポロホテル[札幌市]
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Ferric nitrilotriacetate-induced rat renal cancer exhibits extensive chromosomal instability.2010
- Author(s)
  Akatsuka S
- Organizer
  15th Japan-Korea Cancer Research Workshop
- Place of Presentation
  シェラトン仁川ホテル(仁川市,韓国)
- Year and Date
  2010-12-22
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Ferric nitrilotriacetate-induced rat renal cancer exhibits extensive chromosomal instability.2010
- Author(s)
  Akatsuka S
- Organizer
  8th International Workshop on Genetic Systems in the Rat
- Place of Presentation
  京都大学国際交流ホール(京都市)
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Ferric nitrilotriacetate- induced rat renal cancer exhibits extensive chromosomal instability2010
- Author(s)
  Akatsuka S
- Organizer
  8th International Workshop on Genetic Systems in the Rat
- Place of Presentation
  京都大学国際交流ホール[京都市]
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Ferric nitrilotriacetate- induced rat renal cancer exhibits extensive chromosomal instability2010
- Author(s)
  Akatsuka S
- Organizer
  15th Japan-Korea Cancer Research Workshop
- Place of Presentation
  シェラトン仁川ホテル[仁川,韓国])
- Year and Date
  2010-12-22
- Data Source
  KAKENHI-PROJECT-22500997
[Presentation] Analysis of chromosomal alterations in oxidative stress-induced rat renal cell carcinomas using array-based CGH2008
- Author(s)
  赤塚慎也
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] Analysis of chromosomal alterations in oxidative stress-induced rat renal carcinomas using array-based CGH2008
- Author(s)
  Akatsuka S
- Organizer
  The International Symposium on Lipid Peroxidation 2008
- Place of Presentation
  軽井沢プリンスホテル
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] アレイCGHを用いた酸化ストレス誘発ラット腎癌における染色体変化の解析2008
- Author(s)
  赤塚慎也
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] アレイCGHを用いた酸化ストレス誘発ラツト腎癌における染色体変化の解析2008
- Author(s)
  赤塚慎也
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] Analysis of chromosomal alterations in oxidative stress-induced rat renal carcinomas using array-based CGH2007
- Author(s)
  Akatsuka S
- Organizer
  4th Joint Meeting of the Society for Free Radical Research Australasia and Japan
- Place of Presentation
  京都大学国際交流ホール
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] Analysis of chromosomal alterations in oxidative stress-induced rat renal cell carcinomas using array-based CGH2007
- Author(s)
  赤塚慎也
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] Analysis of chromosomal alterations in oxidative stress-induced rat renal cell carcinomas using array-based CGH2007
- Author(s)
  赤塚慎也
- Organizer
  第8回文部科学省特定領域研究「がん」5領域若手研究者ワークショップ
- Place of Presentation
  アートランドホテル蓼科
- Data Source
  KAKENHI-PROJECT-19500361
[Presentation] シンポジウム１「鉄と腫瘍」　過剰鉄による発がん機構の解明からその予防へ
- Author(s)
  豊國伸哉、蒋　麗、岡崎泰昌、赤塚慎也
- Organizer
  第３８回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2014-09-06 – 2014-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-24390094
[]

1. TOYOKUNI Shinya (90252460)

# of Collaborated Projects: 4 results

# of Collaborated Products: 49 results
2. OKAZAKI Yasumasa (30403489)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 山下享子 (50754975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KATO Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 細田公則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 作見邦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山下依子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akatsuka Shinya 赤塚 慎也

AKATSUKA Shinya 赤塚 慎也

Research Projects

Research Products

Co-Researchers

多種および多系統の動物を用いた鉄関連酸化ストレス発がん過程の解明Principal Investigator

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発がんにおけるDNA損傷・修復ダイナミクスの実像解明Principal Investigator

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Analyses based on iron dynamics and multiomics to overcome oxidative stress-induced carcinogenesis

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Establishing preventive strategy for mesothelioma by elucidating its carcinogenic mechanism

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Elucidation of genomic distribution dynamics of DNA damage and repair in carcinogenesis processPrincipal Investigator

Principal Investigator

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Analysis of chromosomal alterations in an oxidative stress-induced animal carcinogenesis modelPrincipal Investigator

Principal Investigator

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[Book] 生命金属ダイナミクス ～生体内における金属の挙動と制御～2021

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[Journal Article] Environmental impact on carcinogenesis under BRCA1 haploinsufficiency2023

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[Journal Article] BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile‐induced mesothelioma via ferroptosis resistance2023

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[Journal Article] BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance2022

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[Journal Article] Ferroptosis resistance determines high susceptibility of murine <i>A/J</i> strain to iron‐induced renal carcinogenesis2021

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[Journal Article] Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering2020

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[Journal Article] Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions2020

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[Journal Article] Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice2020

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Akatsuka Shinya 赤塚慎也

AKATSUKA Shinya 赤塚慎也

[Book] 生命金属ダイナミクス　～生体内における金属の挙動と制御～2021