UEKAWA KEN 植川顕

… Alternative Names

Uekawa Ken 植川顕

Less

Researcher Number	40448535
Other IDs	https://orcid.org/0000-0001-8952-7009
Affiliation (Current)	2026: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 大学院生命科学研究部(医), 助教 2020: 熊本大学, 病院, 非常勤講師 2019: 熊本大学, 病院, 非常勤診療医師
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator 腫瘍血管新生 / 殺腫瘍作用 / 悪性神経膠腫 / 腫瘍微小環境 / 腫瘍免疫 / 脳内腫瘍微小環境 / CD36/NADPH oxidase経路 / 脳常在型マクロファージ / アミロイドβ / 脳境界マクロファージ … More / 神経-免疫-血管ユニット / グリオーマ / 脳内マクロファージ / 脳内腫瘍免疫 / VEGF / 脳血管周囲マクロファージ / 骨髄由来免疫細胞 / CD36/NADPH oxidase / 血管新生 / マクロファージ / ミクログリア … More Except Principal Investigator 血液脳関門 / MRI / 免疫 / radiomics / 微小環境 / 脳腫瘍 / マルチオミクス解析 / 画像 / マクロファージ / 腫瘍微小環境 / 治療抵抗性 / 悪性化 / 膠芽腫 / グリオーマ / 周術期管理 / 麻酔 / 静脈麻酔 / 吸入麻酔 / もやもや病 / 脳虚血 Less

脳腫瘍の免疫血管微小環境と放射線画像radiomics解析の融合を基にした新規治療開発
- Principal Investigator
  
  武笠晃丈
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kumamoto University
脳常在型マクロファージのCD36を介した殺腫瘍作用による再発悪性神経膠腫の新規治療Principal Investigator
- Principal Investigator
  
  植川顕
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kumamoto University
Anesthetic-Induced Perioperative Blood–Brain Barrier Dysfunction in Cerebral Ischemia: Pathophysiology and Therapeutic Potential
- Principal Investigator
  
  Kaku Yasuyuki
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kumamoto University
The role of Neuro-Immuno-Vascular Unit in growth and invasion of GliomaPrincipal Investigator
- Principal Investigator
  
  Uekawa Ken
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kumamoto University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion2025
- Author(s)
  Kameno Koki、Kaku Yasuyuki、Ohmori Yuki、Takemoto Yushin、Uekawa Ken、Mukasa Akitake
- Journal Title
  
  Neurosurgical Review
  
  Volume: 48 Issue: 1 Pages: 48-48
- DOI
  10.1007/s10143-025-03185-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09102, KAKENHI-PROJECT-23K08572
[Journal Article] Perivascular Macrophage in Cerebrovascular Diseases2024
- Author(s)
  Hiroki Uchikawa, Ken Uekawa, Yu Hasegawa
- Journal Title
  
  Experimental Neurology
  
  Volume: 374 Pages: 114680-114680
- DOI
  10.1016/j.expneurol.2024.114680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09459, KAKENHI-PROJECT-19K18433, KAKENHI-PROJECT-23K08572
[Journal Article] tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice2024
- Author(s)
  Uekawa Ken、Anfray Antoine、Ahn Sung Ji、Casey Nicole、Seo James、Zhou Ping、Iadecola Costantino、Park Laibaik
- Journal Title
  
  Alzheimer's & Dementia
  
  Volume: 20 Issue: 7 Pages: 4572-4582
- DOI
  10.1002/alz.13878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08572
[Journal Article] Long-term outcomes of multidisciplinary treatment combining surgery and stereotactic radiotherapy with Novalis for craniopharyngioma2024
- Author(s)
  Shinojima Naoki、Yano Shigetoshi、Uchida Daichi、Mizukami Naohisa、Mabe Hiroyo、Kawashima Junji、Igata Motoyuki、Kondo Tatsuya、Uetani Hiroyuki、Yamamoto Takahiro、Uekawa Ken、Hide Takuichiro、Mikami Yoshiki、Hirai Toshinori、Mukasa Akitake
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 120 Pages: 138-146
- DOI
  10.1016/j.jocn.2024.01.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-23K27713, KAKENHI-PROJECT-19K23920, KAKENHI-PROJECT-23K15650
[Journal Article] Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage2023
- Author(s)
  Uchikawa Hiroki、Kameno Koki、Kai Keitaro、Kajiwara Sosho、Fujimori Kana、Uekawa Ken、Fujiwara Yukio、Mukasa Akitake、Kim-Mitsuyama Shokei、Hasegawa Yu
- Journal Title
  
  Neurocritical Care
  
  Volume: 39 Issue: 1 Pages: 207-217
- DOI
  10.1007/s12028-023-01754-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06362, KAKENHI-PROJECT-23K08572, KAKENHI-PROJECT-19K09459, KAKENHI-PROJECT-19K18433
[Journal Article] Macrophage colony‐stimulating factor potentially induces recruitment and maturation of macrophages in recurrent pituitary neuroendocrine tumors2022
- Author(s)
  Matsuzaki Hiroaki、Komohara Yoshihiro、Yano Hiromu、Fujiwara Yukio、Kai Keitaro、Yamada Rin、Yoshii Daiki、Uekawa Ken、Shinojima Naoki、Mikami Yoshiki、Mukasa Akitake
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 67 Issue: 2 Pages: 90-98
- DOI
  10.1111/1348-0421.13041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08622, KAKENHI-PROJECT-19K18433, KAKENHI-PROJECT-20H03792
[Journal Article] Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway.2022
- Author(s)
  Kai K, Komohara Y, Esumi S, Fujiwara Y, Yamamoto T, Uekawa K, Ohta K, Takezaki T, Kuroda J, Shinojima N, Hamasaki T, Mukasa A.
- Journal Title
  
  Human Cell
  
  Volume: Jan;35(1) Issue: 1 Pages: 226-237
- DOI
  10.1007/s13577-021-00619-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09485, KAKENHI-PROJECT-20K07227, KAKENHI-PROJECT-19K18433, KAKENHI-PROJECT-20H03792
[Presentation] tPA鼻腔内投与によるアミロイド過剰発現マウスの神経血管反応性と認知機能の改善効果2024
- Author(s)
  植川　顕, Antoine Anfray, Sung Ji Ahn, Nicole Casey, James Seo, Ping Zhou, Constantino Iadecola, Laibaik Park, 武笠晃丈
- Organizer
  第43回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08572
[Presentation] tPA鼻腔内投与はTg2576マウスの神経血管反応と認知機能の障害を改善しアミロイド血管症を減少させる2024
- Author(s)
  植川　顕, Antoine Anfray, Sung Ji Ahn, Nicole Casey, James Seo, Ping Zhou, Constantino Iadecola, Laibaik Park, 武笠晃丈
- Organizer
  第23回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-23K08572
[Presentation] tPA鼻腔内投与はTg2576マウスの脳血管反応を改善しアミロイド血管症を軽減し認知障害を改善する2024
- Author(s)
  植川　顕, Antoine Anfray, Sung Ji Ahn, Nicole Casey, James Seo, Ping Zhou, Constantino Iadecola, Laibaik Park, 武笠晃丈
- Organizer
  第67回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08572
[Presentation] 脳血管周囲マクロファージが産生する活性酸素種は脳アミロイド血管症を進行させる2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18433
[Presentation] 脳血管周囲マクロファージはCD36を介して活性酸素種を産生し脳アミロイド血管症と認知機能障害を引き起こす2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第23回日本分子脳神経外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18433
[Presentation] 脳境界マクロファージは脳血管周囲でCD36を介して酸化ストレスを産生し脳アミロイド血管症を悪化させる2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第66回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08572
[Presentation] 脳境界マクロファージは脳血管周囲でCD36を介して酸化ストレスを産生し脳アミロイド血管症を悪化させる2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第66回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18433
[Presentation] 脳血管周囲マクロファージが産生する活性酸素種は脳アミロイド血管症を進行させる2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08572
[Presentation] 脳血管周囲マクロファージはCD36を介して活性酸素種を産生し脳アミロイド血管症と認知機能障害を引き起こす2023
- Author(s)
  植川　顕、服部　頼都、Laibaik Park、Costantino Iadecola、武笠　晃丈
- Organizer
  第23回日本分子脳神経外科学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08572

1. 武笠晃丈 (90463869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Kaku Yasuyuki (20626882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 岳元裕臣 (50883021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 大森雄樹 (60599116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 平井俊範 (40274724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菰原義弘 (40449921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 永江玄太 (10587348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJIWARA Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 長谷川雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 近藤龍也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 吉井大貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 篠島直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UEKAWA KEN 植川 顕

Uekawa Ken 植川 顕

Research Projects

Research Products

Co-Researchers

脳腫瘍の免疫血管微小環境と放射線画像radiomics解析の融合を基にした新規治療開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳常在型マクロファージのCD36を介した殺腫瘍作用による再発悪性神経膠腫の新規治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anesthetic-Induced Perioperative Blood&#8211;Brain Barrier Dysfunction in Cerebral Ischemia: Pathophysiology and Therapeutic Potential

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Neuro-Immuno-Vascular Unit in growth and invasion of GliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Artificial dural regeneration matrix as a substitute for autologous tissue in indirect bypass in Moyamoya disease: Investigation of a rat model of chronic cerebral hypoperfusion2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Perivascular Macrophage in Cerebrovascular Diseases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term outcomes of multidisciplinary treatment combining surgery and stereotactic radiotherapy with Novalis for craniopharyngioma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage colony‐stimulating factor potentially induces recruitment and maturation of macrophages in recurrent pituitary neuroendocrine tumors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway.2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] tPA鼻腔内投与によるアミロイド過剰発現マウスの 神経血管反応性と認知機能の改善効果2024

Author(s)

Organizer

Data Source

[Presentation] tPA鼻腔内投与はTg2576マウスの神経血管反応と認知機能の障害を改善しアミロイド血管症を減少させる2024

Author(s)

Organizer

Data Source

[Presentation] tPA鼻腔内投与はTg2576マウスの脳血管反応を改善し アミロイド血管症を軽減し認知障害を改善する2024

Author(s)

Organizer

Data Source

[Presentation] 脳血管周囲マクロファージが産生する活性酸素種は脳アミロイド血管症を進行させる2023

Author(s)

Organizer

Data Source

UEKAWA KEN 植川顕

Uekawa Ken 植川顕

Anesthetic-Induced Perioperative Blood–Brain Barrier Dysfunction in Cerebral Ischemia: Pathophysiology and Therapeutic Potential

[Presentation] tPA鼻腔内投与によるアミロイド過剰発現マウスの神経血管反応性と認知機能の改善効果2024

[Presentation] tPA鼻腔内投与はTg2576マウスの脳血管反応を改善しアミロイド血管症を軽減し認知障害を改善する2024