Zou Kun 鄒鶤

… Alternative Names

ZOU Kun 鄒鶤

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Researcher Number	40450837
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 准教授 2012 – 2016: 岩手医科大学, 薬学部, 講師 2010 – 2011: 岩手医科大学, 薬学部, 助教 2007 – 2008: Iwate Medical University, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アンギオテンシン変換酵素 / アルツハイマー病 / アミロイドベータ蛋白 / アミロイド / プレセニリン / 家族性アルツハイマー病 / Aβ変換活性 / アミロイドβタンパク / アンギオテンシン受容体 / アミロイド沈着 … More / 分泌 / リン酸化 / タウタンパク / プレセニリン変異 / アミロイド蓄積 / ACE阻害薬 / 知能指数 / ApoE分泌 / γセクレターゼ / 温度変化 / アンギオテンシンII受容体 / レニン・アンギオテンシン系 / 高血圧症 / Aβ43変換活性 / Aβ三変換活性 / 変換酵素 / 精神・神経疾患の病態と治療 / Aβ分解 / インテグリン / Aβ変換 Less

Elucidation of novel functions of presenilin in ApoE secretion and brain amyloid removalPrincipal Investigator
- Principal Investigator
  
  鄒鶤
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
Role of Abeta-converting activity in the pathogenesis of familial Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  鄒鶤
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
Role of renin-angiotensin system in regulation of brain amyloid depositionPrincipal Investigator
- Principal Investigator
  
  Zou Kun
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
Regulation of brian amyloid deposition by angiotensin receptor type IaPrincipal Investigator
- Principal Investigator
  
  ZOU KUN
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Iwate Medical University
Abeta43-converting enzyme and its role in amyloid depositionPrincipal Investigator
- Principal Investigator
  
  ZOU KUN
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Iwate Medical University
Clarification of the molecular mechanism underlying the neuronal death induced by ACE inhibition in APP transgenic mousePrincipal Investigator
- Principal Investigator
  
  ZOU Kun
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Iwate Medical University
Angiotensin-converting enzyme as an Aβ-degrading and Aβ42-to-Aβ40-converting enzymePrincipal Investigator
- Principal Investigator
  
  ZOU Kun
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Iwate Medical University

[Book] Handbook on Longevity : Genetics, Diet&disease, Chapter 11Be Young in Mind-Against Aging and Alzheimer's Disease2009
- Author(s)
  Kun Zou
- Total Pages
  11
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-19800040
[Book] Be Young in Mind-Against Aging and Alzheimer's Disease. Handbook on Longevity2009
- Author(s)
  Kun Zou
- Total Pages
  187
- Publisher
  Genetics, Diet&disease, Nova Science Publishers, Inc.(Chapter 11)
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases2024
- Author(s)
  Sun Y, Islam S, Michikawa M, Zou K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 25(3) Issue: 3 Pages: 1757-1757
- DOI
  10.3390/ijms25031757
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KF0156, KAKENHI-PROJECT-22K07352
[Journal Article] Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE.2023
- Author(s)
  Gao Y, Sun Y, Islam S, Nakamura T, Tomita T, Zou K, Michikawa M
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 15 Pages: 1098034-1098034
- DOI
  10.3389/fnagi.2023.1098034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20K07861, KAKENHI-PROJECT-23H00394
[Journal Article] Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex2023
- Author(s)
  Sun Y, Islam S, Gao Y, Nakamura T, Zou K, Michikawa M
- Journal Title
  
  J Neurochem
  
  Volume: 164 Issue: 6 Pages: 858-874
- DOI
  10.1111/jnc.15750
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352, KAKENHI-PROJECT-20K07861
[Journal Article] Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model.2023
- Author(s)
  Nakamura T, Hashita T, Chen Y, Gao Y, Sun Y, Islam S, Sato H, Shibuya Y, Zou K, Matsunaga T, Michikawa M
- Journal Title
  
  Mol Brain
  
  Volume: 16 Issue: 1 Pages: 15-15
- DOI
  10.1186/s13041-023-01005-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352, KAKENHI-PROJECT-20K07861
[Journal Article] Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts2022
- Author(s)
  Zou K, Islam S, Sun Y, Gao Y, Nakamura T, Komano H, Tomita T, Michikawa M
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 14 Pages: 902525-902525
- DOI
  10.3389/fnagi.2022.902525
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352, KAKENHI-PROJECT-20K07861
[Journal Article] Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis2022
- Author(s)
  Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou, Makoto Michikawa
- Journal Title
  
  J Neurosci
  
  Volume: 42 Issue: 8 Pages: 1574-1586
- DOI
  10.1523/jneurosci.2039-21.2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19H01015
[Journal Article] Cholesterol Regulates Exosome Release in Cultured Astrocytes2021
- Author(s)
  Mohammad Abdullah, Tomohisa Nakamura, Taslima Ferdous, Yuan Gao, Yuxin Chen, Kun Zou, Makoto Michikawa
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 722581-722581
- DOI
  10.3389/fimmu.2021.722581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07846
[Journal Article] Oral dysfunctions and cognitive impairment/dementia2021
- Author(s)
  Nakamura T, Zou K, Shibuya Y, and Michikawa M
- Journal Title
  
  J Neurosci Res
  
  Volume: 99 Issue: 2 Pages: 518-528
- DOI
  10.1002/jnr.24745
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07861, KAKENHI-PROJECT-19K07846
[Journal Article] Interaction between Angiotensin Receptor and β-Adrenergic Receptor Regulates the Production of Amyloid β-Protein2020
- Author(s)
  Kota Kikuchi, Yu Fujita, Xuefeng Shen, Junjun Liu, Tomoki Terakawa, Daiki Nishikata, Sho Niibori, Takayuki Ito, Kazuyuki Ashidate, Takuya Kikuchi, Yu Kikuchi, Tomoji Maeda, Kun Zou, Hiroto Komano
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 4 Pages: 731-735
- DOI
  10.1248/bpb.b20-00007
- NAID
  130007825293
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07846
[Journal Article] Engulfment of Toxic Amyloid β-protein in Neurons and Astrocytes Mediated by MEGF102020
- Author(s)
  Yu Fujita, Tomoji Maeda, Chiharu Sato, Masaya Sato, Hatsune Hatakeyama, Yume Ota, Nozomi Iwabuchi, Komaki Tatesawa, Ayako Nomura, Kun Zou, Hiroto Komano
- Journal Title
  
  Neuroscience
  
  Volume: 443 Pages: 1-7
- DOI
  10.1016/j.neuroscience.2020.07.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-19K16503
[Journal Article] High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp902020
- Author(s)
  Arshad Ali Noorani, Hitoshi Yamashita, Yuan Gao, Sadequl Islam, Yang Sun, Tomohisa Nakamura, Hiroyuki Enomoto, Kun Zou, Makoto Michikawa
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 52 Pages: 18010-22
- DOI
  10.1074/jbc.ra120.013845
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-20K06450, KAKENHI-PROJECT-20K07861
[Journal Article] Current Biomarkers for Alzheimer's Disease: From CSF to Blood2020
- Author(s)
  Kun Zou, Mohammad Abdullah, Makoto Michikawa
- Journal Title
  
  J Pers Med
  
  Volume: 10 Issue: 3 Pages: 85-85
- DOI
  10.3390/jpm10030085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-20K07861, KAKENHI-PROJECT-19K17040
[Journal Article] A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice2019
- Author(s)
  Liu Shuyu、Ando Fujiko、Fujita Yu、Liu Junjun、Maeda Tomoji、Shen Xuefeng、Kikuchi Kota、Matsumoto Aoi、Yokomori Mirai、Tanabe-Fujimura Chiaki、Shimokata Hiroshi、Michikawa Makoto、Komano Hiroto、Zou Kun
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 25 Pages: 9760-9770
- DOI
  10.1074/jbc.ra118.006420
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846
[Journal Article] Regulation of Aβ production by angiotensin receptor type Ia2016
- Author(s)
  Kun Zou
- Journal Title
  
  Seikagaku
  
  Volume: 88 Pages: 771-775
- NAID
  40021054398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430057
[Journal Article] Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.2015
- Author(s)
  Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, Tanabe C, Maeda T, Michikawa M, Komano H, Zou K.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 12059-12059
- DOI
  10.1038/srep12059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461375, KAKENHI-PROJECT-26430057, KAKENHI-PROJECT-15K15712
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2014
- Author(s)
  Liu S, Liu J, Miura Y, Tanabe C, Maeda T, Terayama Y, Turner AJ, Zou K, Komano H
- Journal Title
  
  J Neurosci Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Differential effects of angiotensin II receptor blockers on Aβgeneration2014
- Author(s)
  Liu, J., Liu, S., Tanabe, C., Maeda, T., Zou, K., Komano, H.
- Journal Title
  
  Neurosci Lett
  
  Volume: 567 Pages: 51-56
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2014
- Author(s)
  Shuyu Liu, Junjun Liu, Yukie Miura, Chiaki Tanabe, Tomoji Maeda, Yasuo Terayama, Anthony J. Turner, Kun Zou, Hiroto Komano
- Journal Title
  
  J Neurosci Res.
  
  Volume: 92 Issue: 9 Pages: 1178-1186
- DOI
  10.1002/jnr.23404
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430057
[Journal Article] ifferential effects of angiotensin II receptor blockers on Aβ generation.2014
- Author(s)
  Liu J, Liu S, Tanabe C, Maeda T, Zou K, Komano H
- Journal Title
  
  Neurosci Lett
  
  Volume: 567 Pages: 51-56
- DOI
  10.1016/j.neulet.2014.03.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme2014
- Author(s)
  Liu, S., Liu, J., Miura, Y., Tanabe, C., Maeda, T., Terayama, Y., Turner, A.J., Zou, K., Komano, H.
- Journal Title
  
  J Neurosci Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.2013
- Author(s)
  Zou K, Liu J, Watanabe A, Hiraga S, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Issue: 6 Pages: 2311-2331
- DOI
  10.1016/j.ajpath.2013.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383, KAKENHI-PROJECT-25461375
[Journal Article] Aβ43 is the earliest depositing Aβspecies in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2013
- Author(s)
  Zou, K., Liu, J., Watanabe, A., Hiraga, S., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., Komano, H.
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 2311-2331
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.2012
- Author(s)
  Tanabe C, Maeda T, Zou K, Liu J, Liu S, Nakajima T, Komano H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 53 Pages: 44203-44211
- DOI
  10.1074/jbc.m112.365296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590110, KAKENHI-PROJECT-23659176, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-24700383
[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloidβproduction by targeting a negative regulator ofγ-secretase, Rer 1, for degradation2012
- Author(s)
  Tanabe, C., Maeda, T., Zou, K., Liu, J., Liu, S., Nakajima, T., Komano, H.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 28 Pages: 44203-44211
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin2011
- Author(s)
  Toshihiro Marutani, Tomoji Maeda, Chiaki Tanabe, Kun Zou, Wataru Araki, Koichi Kokame, Makoto Michikawa, Hiroto Komano
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1810 Pages: 790-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] Differential appearance of serum Aβ43 and Aβ42 in the patients with Alzheimer's disease2011
- Author(s)
  Kun Zou, Shuyu Liu, Junjun Liu, Chiaki Tanabe, Tomoji Maeda, Yasuo Terayama, Satoshi Takahashi, Hiroto Komano
- Journal Title
  
  Translational Medicine
  
  Volume: 1 Issue: 03 Pages: 3-4
- DOI
  10.4172/2161-1025.1000103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin2011
- Author(s)
  Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M and Komano H
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1810 Pages: 790-798
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] Differential appearance of serum Aβ43 and Aβ42 in the patients with Alzheimer's disease2011
- Author(s)
  Zou K, Liu S, Liu J, Tanabe C, Maeda T, Terayama Y, Takahashi S and Komano H
- Journal Title
  
  Translational Medic
  
  Volume: 1 Pages: 103-103
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] A novel Aβ-converting activity of angiotensin-converting enzyme and its role in Alzheimer's disease2010
- Author(s)
  Zou K., Michikawa M. and Komano H
- Journal Title
  
  Seikagaku
  
  Volume: 82 Pages: 1120-1124
- NAID
  10027880213
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] アンギオテンシン変換酵素の新しい顔:Aβ変換酵素2010
- Author(s)
  鄒鶤、道川誠、駒野宏人
- Journal Title
  
  生化学
  
  Volume: 第八十二巻 Pages: 1120-1124
- NAID
  10027880213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] New amyloid plaques or a game of hide-and-seek.2008
- Author(s)
  Kun Zou, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Journal Title
  
  International Journal of Biological Sciences 4
  
  Pages: 200-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Angiotensin-converting enzyme as a potential target for treament of Alzheimer's disease:inhibition or activation?2008
- Author(s)
  Kun Zou and Makoto Michikawa
- Journal Title
  
  Reviews in Neurosciences. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Angiotensin-Converting Enzyme as a Potential Target for Treatment of Alzheimer's Disease : Inhibition or Activation2008
- Author(s)
  Kun Zou and Makoto Michikawa
- Journal Title
  
  Rev Neurosci 19
  
  Pages: 203-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Novel role of presenilins in maturation and transport of integrinβ1.2008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa, Makoto Michikawa
- Journal Title
  
  Biochemistry 27
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] New amyloid plaques or a game of hide-and-seek2008
- Author(s)
  Kun, Zou, Tomoji, Maeda, Makoto, Michikawa and Hiroto, Komano
- Journal Title
  
  Int J Biol Sci 4
  
  Pages: 200-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Novel role of presenilins in maturation and transport of integrin β1.2008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa and Makoto Michikawa
- Journal Title
  
  Biochemishy 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Angiotensin-converting enzyme as a potential target for treatment of Alzheimer's disease : inhibition or activation.2008
- Author(s)
  Kun Zou, Makoto Michikawa
- Journal Title
  
  Reviews in Neurosciences 19
  
  Pages: 203-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Novel role of presenilins in maturation and transport of integrin beta12008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa and Makoto Michikawa
- Journal Title
  
  Biochemistry 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Angiotensin-converting enzyme converts amyloid β-protein 1-42(Aβ(1-42)to Aβ((1-40), and its inhibition enhances brain Aβ deposition.2007
- Author(s)
  Kun Zou, Haruyasu Yamaguchi, Hiroyasu Akatsu, Takaaki Sakamoto, Mihee Ko, Kazushige Mizoguchi, Jian-S heng Gong, Wenxin Yu, Takayuki Yamamoto, Kenji Kosaka, Katsuhiko Yanagisawa and Makoto Michikawa.
- Journal Title
  
  Journal of Neuroscience 27
  
  Pages: 8628-8635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition2007
- Author(s)
  Kun Zou, Haruyasu Yamaguchi, Hiroyasu Akatsu, Takaaki Sakamoto, Mihee Ko, Kazushige Mizoguchi, Jian-Sheng Gong, Wenxin Yu, Takayuki Yamamoto, Kenji Kosaka, Katsuhiko Yanagisawa and Makoto Michikawa
- Journal Title
  
  J Neurosci 27
  
  Pages: 8628-8635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Aging society and Alzheimer's disease
- Author(s)
  Kun Zou
- Journal Title
  
  Alzheimer Dis Res J (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] プレセニリン１欠損/変異はACEのAβ42変換活性を阻害する2023
- Author(s)
  鄒鶤, 高原, 孫陽, Islam Sadequl, 中村知寿, 富田泰輔, 道川誠
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23KF0156
[Presentation] プレセニリン１欠損/変異はACEのAβ42変換活性を阻害する2023
- Author(s)
  鄒鶤, 高原, 孫陽, Islam Sadequl, 中村知寿, 富田泰輔, 道川誠
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] プレセニリン１欠損はACEのAβ42-to-Aβ40 およびアンギオテンシン変換活性を阻害する2023
- Author(s)
  鄒鶤, 高原, 孫陽, Islam Sadequl, 中村知寿, 富田泰輔, 道川誠
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] プレセニリン１欠損はACEのAβ42-to-Aβ40 およびアンギオテンシン変換活性を阻害する2023
- Author(s)
  鄒鶤, 高原, 孫陽, Islam Sadequl, 中村知寿, 富田泰輔, 道川誠
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-23KF0156
[Presentation] Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer’s disease pathogenesis2022
- Author(s)
  Kun Zou*, Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Makoto Michikawa
- Organizer
  NEURO2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] プレセニリン１欠損/変異はACEのAβ42-to-Aβ40 変換活性を阻害する2022
- Author(s)
  高原, 孫陽, Sadequl Islam, 高原,　中村知寿, 富田泰輔, 鄒鶤*, 道川誠
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] Presenilinの持つ多機能に関する研究～ApoE分泌ならびにAβ変換酵素ACE活性の制御～2022
- Author(s)
  鄒鶤
- Organizer
  第41回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] Apolipoprotein E4 inhibits γ-secretase activity via binding to γ-complex2022
- Author(s)
  鄒鶤*, 孫陽, Sadequl Islam, 高原, 中村知寿, 道川誠
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] γセクレターゼ活性制御におけるApoEの新機能2022
- Author(s)
  孫陽, Sadequl Islam, 高原, 中村知寿, 鄒鶤*, 道川誠
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07352
[Presentation] Presenilin is essential for ApoE secretion2021
- Author(s)
  Kun Zou, Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Makoto Michikawa
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] ApoE分泌におけるプレセニリンの制御作用2021
- Author(s)
  Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou, Makoto Michikawa
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] Molecular Mechanism of Aβ production regulated by Hsp90 at high temperature2020
- Author(s)
  鄒鶤, Noorani Arshad, 山下均, 高原, 孫陽, Islam Sadequl, 中村知寿, 榎本啓之, 道川誠
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] Role of temperature in production of amyloid beta-protein2020
- Author(s)
  鄒鶤, Noorani Arshad, 山下均, 高原, 孫陽, Islam Sadequl, 中村知寿, 榎本啓之, 道川誠
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice2019
- Author(s)
  鄒鶤
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] Heterozygous ACE deletion increases amyloid deposition in mice2019
- Author(s)
  鄒鶤
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] Inhibition of ACE impairs human intelligence and exacerbates Alzheimer's pathology in mice2019
- Author(s)
  鄒鶤
- Organizer
  Neuro 2019
- Data Source
  KAKENHI-PROJECT-19K07846
[Presentation] ACE deficiency increases amyloid　plaque burden in APP transgenic mouse brain2016
- Author(s)
  鄒鶤、劉しゅ余、劉俊俊、松元葵、沈雪峰、横森未来、下方浩史、道川誠、駒野宏人
- Organizer
  第35回日本認知症学会学術集会　東京 2016年12月1日
- Place of Presentation
  東京都
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Differential effects of angiotensin II receptor blockers on Aβ generation2015
- Author(s)
  劉俊俊、劉しゅう余、村上咲、菅川悠介、賀美綾子、田邊千晶、前田智司、鄒鶤、駒野宏人
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] レニン・アンギオテンシン系とAβ除去2015
- Author(s)
  鄒鶤、駒野宏人
- Organizer
  第34回日本認知症学会学術集会　シンポジウム
- Place of Presentation
  青森市
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type 1a receptor deficiency decreases amyloid β-protein production and ameliorates brain amyloid pathology2015
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Yusuke Sugakawa, Ayako Kami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  25th Meeting of The International Society For Neurochemistry
- Place of Presentation
  Cairns, Australia
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type 1a receptor deficiency ameliorates brain amyloid pathology by regulating γ-secretase complex formation2015
- Author(s)
  Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Yusuke Sugakawa, Ayako Kami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano, Kun Zou
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  矢巾町
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] アンギオテンシン受容体によるアミロイドβ蛋白産生制御2015
- Author(s)
  駒野宏人、鄒鶤
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学大会合同大会ワークショップ
- Place of Presentation
  神戸市
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type Ia receptor regulates amyloid plaque formation.2013
- Author(s)
  鄒鶤，劉俊俊，劉姝余，松本幸乃，村上咲，田邉千晶，前田智司，道川誠，駒野宏人
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Angiotensin II type Ia receptor deficiency ameliorates brain amyloid pathology in a transgenic mouse model of Alzheimer’s disease.2013
- Author(s)
  Liu J, Liu S, Matsumoto Y, Tanabe C, Maeda T, Zou K, Komano H
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Conversion of Aβ43 to Aβ40 by combination of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2013
- Author(s)
  Liu S, Liu J, Miura Y, Tanabe C, Maeda T, Terayama Y, Turner AJ, Zou K, Komano H
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Angiotensin type Ia receptor deficiency ameliorates amyloid plaque formation.2013
- Author(s)
  Zou K, Liu J, Liu S, Matsumoto Y, Tanabe C, Maeda T, Michikawa M, Komano H
- Organizer
  23rd Alzheimer Europe Conference
- Place of Presentation
  Malta
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Analysis of Aβ42-to-Aβ40-converting activity and Aβ43 level in AD patient serum2012
- Author(s)
  Liu S ○, Liu J, Tanabe C, Maeda T, Terayama Y, Takahashi S, Zou K, Komano H
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2012
- Author(s)
  Zou K ○, Liu J, Watanabe A, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Early deposition of Aβ43 in APP transgenic mouse brain2012
- Author(s)
  鄒鶤,劉俊俊,渡邉淳,劉姝余,田邉千晶,前田智司,寺山靖夫,高橋智,道川誠,駒野宏人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Early deposition of Aβ43 in APP transgenic mouse brain2012
- Author(s)
  鄒鶤○,劉俊俊,渡邉淳，劉姝余, 田邉千晶,前田智司,寺山靖夫，高橋智，道川誠，駒野宏人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  筑波市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] アルツハイマー病モデルマウスにおけるAβ43 の脳内蓄積の解析2012
- Author(s)
  劉姝余, 劉俊俊, 平賀彩江子○, 松本幸乃, 三浦友希恵,田邉千晶, 前田智司, 鄒鶤, 駒野宏人
- Organizer
  日本生化学会東北支部　第78回　例会・シンポジウム
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Analysis of Aβ42-to-Aβ40- converting activity and Aβ43 level in AD patient serum2012
- Author(s)
  Liu, S., Liu, J., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Zou, K., Komano, H.
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] アルツハイマー病モデルマウスにおけるAβ43の脳内蓄積の解析2012
- Author(s)
  劉姝余,劉俊俊,平賀彩江子,松本幸乃,三浦友希恵,田邉千晶,前田智司,鄒鶤,駒野宏人
- Organizer
  日本生化学会東北支部第78回例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Aβ43 is the earliest depositing Aβspecies in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2012
- Author(s)
  Zou, K., Liu, J., Watanabe, A., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., Komano, H.
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Aβ変換酵素.特別シンポジウム「アルツハイマー病:創薬に向けての新たな展開」2012
- Author(s)
  鄒鶤
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Aβ43変換活性におけるACEの二つ活性ドメインの役割2011
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、渡邉淳、道川誠、駒野宏人
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  石川県加賀市
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] アンギオテンシン変換酵素の新しい顔:Aβ変換酵素2011
- Author(s)
  鄒鶤
- Organizer
  日本認知症学会主催-認知症研究を知る若手研究者の集まり
- Place of Presentation
  愛知県大府市
- Year and Date
  2011-07-29
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] アンギオテンシン変換酵素の新しい顔: Aβ変換酵素2011
- Author(s)
  鄒鶤
- Organizer
  塩野義製薬株式会社主催-第一回動脈硬化懇話会
- Place of Presentation
  大阪府堺市
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Two active domains of ACE are essential for Aβ43-converting activity2011
- Author(s)
  Kun Zou, Junjun Liu, Atsushi, Watanabe, Shuyu Liu, Chiaki tanabe, Tomoji Maeda, Ryutaro Oba, Makoto Michikawa, Hiroto Komano
- Organizer
  23^<rd> Biennial Meeting of International Society for Neuro chemistry
- Place of Presentation
  Athens, Greece
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Two active domains of ACE are essential for Aβ43-converting activity2011
- Author(s)
  鄒鶤、劉俊俊、渡邉淳、劉殊余、田邉千晶、前田智司、大葉龍太郎、道川誠、駒野宏人
- Organizer
  第23回国際神経化学会国際会議
- Place of Presentation
  アテネ
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] アンギオテンシン変換酵素の新しい顔: Aβ変換酵素2011
- Author(s)
  鄒鶤
- Organizer
  日本認知症学会主催-認知症研究を知る若手研究者の集まり
- Place of Presentation
  愛知県大府市
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] アンギオテンシン変換酵素の新しい顔:Aβ変換酵素2011
- Author(s)
  鄒鶤
- Organizer
  塩野義製薬株式会社主催-第一回動脈硬化懇話会
- Place of Presentation
  大阪府堺市(招待講演)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Aβ343変換活性におけるACEの二つ活性ドメインの役割2011
- Author(s)
  鄒鶤、劉俊俊、劉妹余、田邉千晶、前田智司、渡邉淳、道川誠、駒野宏人
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  石川県加賀市
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] ACE阻害によるアルツハイマー病モデルマウス脳内変化の解析2010
- Author(s)
  鄒鶤、劉俊俊、劉〓余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第53回日本神経化学学会、第33回日本神経科学大会、第20回日本神経回路学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Enhanced Alzheimer's-like pathology by ACE inhibition in APP transgenic mouse brain2010
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] ACE阻害によるアルツハイマー病モデルマウス脳内変化の解析2010
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第53回日本神経化学学会、第33回日本神経科学大会、第20回日本神経回路学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Enhanced Alzheimer's-like pathology by ACE inhibition in APP transgenic mouse brain.2010
- Author(s)
  鄒鶤、劉俊俊、劉〓余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain.2010
- Author(s)
  Kun Zou, Shuyu Liu, Junjun Liu, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain2010
- Author(s)
  鄒鶤、劉殊余、劉俊俊、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  2010年国際アルツハイマー病協会国際会議
- Place of Presentation
  ホノルル
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] アンギオテンシン変換酵素のもつAbetaの変換作用2008
- Author(s)
  Kun Zou et.al.
- Organizer
  第47回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学薬学部
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] アンギオテンシン変換酵素のもつAbetaの変換作用2008
- Author(s)
  Kun Zou, et al.
- Organizer
  第47回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] アルツハイマー病におけるアミロイドベータ蛋白の作用2008
- Author(s)
  Kun Zou
- Organizer
  第2回ミッドカイン研究会
- Place of Presentation
  名古屋大学医学部
- Year and Date
  2008-03-13
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] プレセニリン欠損によるインチグリンβ1の成熟促進作用2008
- Author(s)
  Kun Zou et.al.
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Identification of ACE domain converting Abeta42 to Abeta402008
- Author(s)
  Kun Zou, et al.
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市神戸ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Presenilin regulates the maturation of membrane protein in opposite directions2008
- Author(s)
  Kun Zou, et al.
- Organizer
  第27回日本認知症学会
- Place of Presentation
  群馬県前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] プレセニリン欠損によるインチグリンβ1の成熟促進作用2008
- Author(s)
  Kun Zou, et al.
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京都東京国際フォーラム
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Presenilin regulates the maturation of membrane protein in opposite directions2008
- Author(s)
  Kun Zou et.al.
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Identification of ACE domain converting Abeta42 to Abeta402008
- Author(s)
  Kun Zou et.al.
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Abetal-42 to Abetal-40 and its inhibition enhances brain Abeta deposition.2007
- Author(s)
  Kun Zou, et. al.
- Organizer
  第30回分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition2007
- Author(s)
  Kun Zou et.al.
- Organizer
  第13回国際老年精神医学会・第22回日本老年精神医学会・第26回日本認知症学会合同大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition2007
- Author(s)
  Kun Zou et.al.
- Organizer
  第30回分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition.2007
- Author(s)
  Kun Zou, et. al.
- Organizer
  第13回国際老年精神医学会・第22回日本老年精神医学会・第26回日本認知症学会合同大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition2007
- Author(s)
  Kun Zou et.al.
- Organizer
  Society for Neuroscience, the 37^<th> annual meeting
- Place of Presentation
  San Diego Convention Center, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition.2007
- Author(s)
  Kun Zou, et. al.
- Organizer
  Society for Neuroscience, the 37^<th> annual meeting
- Place of Presentation
  San Diego convention center, CA, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] Angiotensin type 1a receptor deficiency attenuates amyloid beta-protein production and ameliorates brain amyloid pathology.
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] アンギオテンシン受容体による脳内アミロイド蓄積制御機構の解明.
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  第57回日本神経化学会大会
- Place of Presentation
  奈良市
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme-2 and angiotensin-converting enzyme.
- Author(s)
  Shuyu Liu, Kun Zou, Junjun Liu, Yu Fujita, Tomoji Maeda, Yasuo Terayama, Anthony J. Turner, Hiroto Komano
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26430057

1. KOMANO Hiroto (40170378)

# of Collaborated Projects: 4 results

# of Collaborated Products: 51 results
2. MICHIKAWA Makoto (40270912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
3. MAEDA Tomoji (60303294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. ISLAM MD SADEQUL

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. TANABE Chiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 堂前純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zou Kun 鄒 鶤

ZOU Kun 鄒 鶤

Research Projects

Research Products

Co-Researchers

Elucidation of novel functions of presenilin in ApoE secretion and brain amyloid removalPrincipal Investigator

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Role of Abeta-converting activity in the pathogenesis of familial Alzheimer's diseasePrincipal Investigator

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Role of renin-angiotensin system in regulation of brain amyloid depositionPrincipal Investigator

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Regulation of brian amyloid deposition by angiotensin receptor type IaPrincipal Investigator

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Abeta43-converting enzyme and its role in amyloid depositionPrincipal Investigator

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Clarification of the molecular mechanism underlying the neuronal death induced by ACE inhibition in APP transgenic mousePrincipal Investigator

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Angiotensin-converting enzyme as an Aβ-degrading and Aβ42-to-Aβ40-converting enzymePrincipal Investigator

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[Book] Handbook on Longevity : Genetics, Diet&disease, Chapter 11Be Young in Mind-Against Aging and Alzheimer's Disease2009

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[Book] Be Young in Mind-Against Aging and Alzheimer's Disease. Handbook on Longevity2009

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[Journal Article] Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases2024

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[Journal Article] Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE.2023

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[Journal Article] Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex2023

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[Journal Article] Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model.2023

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[Journal Article] Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts2022

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Zou Kun 鄒鶤

ZOU Kun 鄒鶤