NOGUCHI Miho 野口実穂

Researcher Number	40455283
Affiliation *help	2016 – 2018 : 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所　東海量子ビーム応用研究センター, 主幹研究員（定常） 2016 : 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所東海量子ビーム応用研究センター, 主幹研究員(定常) 2015 : 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門量子ビーム応用研究センター, 研究副主幹 2013 : 独立行政法人日本原子力研究開発機構, 原子力科学研究部門先端基礎研究センター, 研究員 2013 : 独立行政法人日本原子力研究開発機構・原子力科学研究部門, 先端基礎研究センター, 研究員 … More
Review Section/Research Field	Principal Investigator Radiation science / Risk sciences of radiation and chemicals Except Principal Investigator Risk sciences of radiation/Chemicals
Keywords	Principal Investigator G2チェックポイント / 放射線 / 炭素線治療 / 老化様増殖停止 / Hsp90 / 粒子線治療 / 老化様細胞増殖停止 / Herbimycin / DNA二本鎖切断修復 / 炭素イオン線 … More Except Principal Investigator EPR / シンクロトロン放射 / クラスターDNA損傷 / 突然変異 / 塩基損傷 / 塩基除去修復 / 塩基除去修復酵素 / DNA損傷 / 点突然変異 / DNAラジカル / ラジカル / 電子常磁性共鳴装置 / 分子動力学法 / 軟X線 / DNA修復 / モンテカルロシミュレーション / トラック構造 / 不対電子種 / シンクロトロン放射光 / DNA鎖切断 / APサイト / 放射線 / 電子常磁性共鳴(EPR) / 放射線生物影響 / イオンビーム / 大腸菌 / クラスターDNA / LET / グリコシレース Less

放射線誘発オートファジーによる細胞死回避システムの解明Principal InvestigatorOngoing
- Principal Investigator
  
  野口実穂
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
  Japan Atomic Energy Agency
Study of radiation-induced cluster DNA damage- its structure and repair susceptibility
- Principal Investigator
  
  YOKOYA Akinari
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Japan Atomic Energy Agency
Combination treatment with carbon ions and Hsp90 inhibitor 17-AAGPrincipal Investigator
- Principal Investigator
  
  NOGUCHI Miho
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Radiation science
- Research Institution
  Japan Atomic Energy Agency
Physicochemical and biochemical study of radiation induced DNA damage
- Principal Investigator
  
  YOKOYA Akinari
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Japan Atomic Energy Agency

All 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 診療放射線技師ポケットレビュー帳2008
- Author(s)
  福士政弘(編集)、野口実穂、寺下貴美, ほか
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Significance of DNA polymerase I in in vivo processing of clustered DNA damage.2013
- Author(s)
  Shikazono, N., Akamatsu, K., Takahashi, M., Noguchi, M., Urushibara, A., O’Neill, P. and Yokoya, A.
- Journal Title
  
  Mutation Research
  
  Volume : 749 Pages : 9-15
- DOI
  10.1016/j.mrfmmm.2013.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041, KAKENHI-PROJECT-22310038, KAKENHI-PROJECT-25241010, KAKENHI-PROJECT-25740021
[Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012
- Author(s)
  Noguchi, M., Urushibara, A., Yokoya
- Journal Title
  
  Mutat. Res.
  
  Volume : 732 Pages : 34-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041
[Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012
- Author(s)
  Miho Noguchi
- Journal Title
  
  Mutation Research
  
  Volume : 732 Pages : 34-42
- DOI
  10.1016/j.mrfmmm.2011.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041, KAKENHI-PROJECT-22310038
[Journal Article] A. A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He2+ ion irradiation2011
- Author(s)
  Yokoya, A., Shikazono, N., Fujii, K., Noguchi, M. and Urushibara
- Journal Title
  
  Radiat. Protect. Dosim
  
  Volume : 143 Pages : 219-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041
[Journal Article] Radioprotection by DMSO in Nitrogen Saturated Mammalian Cells Exposed to Helium Ion Beams2009
- Author(s)
  Ryoichi Hirayama, Yoshitaka Matsumoto, Yuki Kase, Miho Nougchi, Koichi Ando, Atsushi Ito, Ryuichi Okayasu, Yoshiya Furusawa
- Journal Title
  
  Radiation Physics and Chemistry (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009
- Author(s)
  Ryoichi Hirayama, Atsushi Ito, Masanori Tomita, Masako Izumi, Fumio Yatagai, Miho Noguchi, Yoshitaka Matsumoto, Yuki Kase, Koichi Ando, Ryuichi Okayasu and Yoshiya Furusawa
- Journal Title
  
  Radiation Research 171
  
  Pages : 212-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Sergey Druzhinin and Ryuichi Okayasu, Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009
- Author(s)
  Miho Noguchi, Ryoichi Hirayama
- Journal Title
  
  Radiation Physics and Chemistry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009
- Author(s)
  Naoya shikazono, Miho Noguchi, Kentaro Fujii, Ayumi Urushibara and Akinari Yokoya
- Journal Title
  
  Journal of Radiation Research 50
  
  Pages : 27-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] A. The yield, processing, and biological consequences of clustered DNA2009
- Author(s)
  Shikazono N., Noguchi, M., Fujii, K., Urushibara, A. and Yokoya
- Journal Title
  
  J. Radiat. Res
  
  Volume : (Invited Review) Pages : 27-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310041
[Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009
- Author(s)
  Naoya shikazono, Miho Noguchi, Kentaro Fujii, Ayumi Urushibara, Akinari Yokoya
- Journal Title
  
  Journal of Radiation Research 50
  
  Pages : 27-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009
- Author(s)
  Ryoichi Hirayama, Atsushi Ito, Masanori Tomita, Masako Izumi, Fumio Yatagai, Miho Noguchi, Yoshitaka Matsumoto, Yuki Kase, Koichi Ando, Ryuichi Okayasu, Yoshiya Furusawa
- Journal Title
  
  Radiation Research 171
  
  Pages : 212-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009
- Author(s)
  Miho Noguchi, Ryoichi Hirayama, Sergey Druzhinin, Ryuichi Okayasu
- Journal Title
  
  Radiation Physics and Chemistry (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Radiobiology for Heavy-ion Radiotherapy2008
- Author(s)
  Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada, Emiko Sekine
- Journal Title
  
  Proceedings of NIRS-MDA Symposium on Clinical Issues for Particle Therapy
  
  Pages : 174-180
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] Radiobiology for Heavy-ion Radiotherapy2008
- Author(s)
  Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada and Emiko Sekine
- Journal Title
  
  Proceedings of NIRS-MDA Symposium on Clinical Issues for Particle Therapy
  
  Pages : 174-180
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] 高LET重粒子線によるDNA二重鎖切断損傷とその修復2007
- Author(s)
  岡安隆一、岡田真希、岡部篤史、野口実穂
- Journal Title
  
  癌の臨床 53
  
  Pages : 371-375
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] ゲルダナマイシン誘導体の併用による癌の放射線治療2007
- Author(s)
  岡安隆一、野口実穂
- Journal Title
  
  ISOTOPE NEWS 643
  
  Pages : 2-7
- Data Source
  KAKENHI-PROJECT-19890271
[Journal Article] ゲルダナマイシン誘導体の併用による癌の放射線治療
- Author(s)
  岡安隆一、野口実穂
- Journal Title
  
  ISOTOPE NEWS 643
  
  Pages : 2-7
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Exposure to X-rays enhances autophagy in human fibroblast cells2015
- Author(s)
  野口実穂、横谷明徳、鈴木啓司、藤井健太郎
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16131
[Presentation] Molecular and Cellular Effect of Ionizing Radiation2013
- Author(s)
  Yokoya, A. , Oka, T. , Fujii, K. , Shiina, T. , Sugaya, Y. , Shiraishi, I. , Urushibara, A. , Narita1, A. , Noguchi, M. and Watanabe, R.
- Organizer
  The 16th SANKEN International The 11th SANKEN Nanotechnology Symposium
- Place of Presentation
  saka, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] 8-oxoGを含むクラスターDNA損傷の誘発突然変異2010
- Author(s)
  野口実穂
- Organizer
  日本放射線影響学会第53回大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] 同一鎖上に配置されたクラスターDNA損傷のプロセシングについて2009
- Author(s)
  野口実穂
- Organizer
  第52回日本放射線影響学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] Mutagenic potential of clustered DNA damage containing single strand break and 8-oxoGs2009
- Author(s)
  Miho Noguchi
- Organizer
  15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
- Place of Presentation
  Verona, Italy
- Data Source
  KAKENHI-PROJECT-21310041
[Presentation] Mutagenic potential of 8-oxo-7,8-dihydroguanine depends on single strand break location2008
- Author(s)
  Miho Noguchi,
- Organizer
  10th International Workshop Radiation Damage to DNA
- Place of Presentation
  裏磐梯
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Mutagenic potential of 8-oxo-7,8-dihydroguanine depends on single strand break location2008
- Author(s)
  Miho Noguchi, Ayumi Urushibara, Akinari Yokoya, Peter O'Neill, Naoya Shikazono
- Organizer
  10th International Workshop Radiation Damage to DNA
- Place of Presentation
  Urabandai, Japan
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Contribution of indirect action of X-irradiation under oxic and hypoxic conditions in different radiosensitivity cells2008
- Author(s)
  Ryoichi Hirayama, Yoshiya Furusawa, Atsushi Ito, Miho Noguchi, Yoshitaka Matsumoto, Akiko Uzawa, Koichi Ando, Ryuichi Okayasu
- Organizer
  10th International Workshop Radiation Damage to DNA
- Place of Presentation
  Urabandai, Japan
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2008
- Author(s)
  Miho Noguchi, Ryoichi Hirayama, Sergey Druzhinin, Ryuichi Okayasu
- Organizer
  The 2nd Asia-Pacific Symposium on Radiation Chemistry
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2008
- Author(s)
  Miho Noguchi
- Organizer
  The 2nd Asia-Pacific Symposium on Radiation Chemistry
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] NHEJ修復欠損xrs6細胞における放射線作用の細胞致死効果2008
- Author(s)
  平山亮一, 古澤佳也, 伊藤敦, 野口実穂, 松本孔貴, 鵜澤玲子, 安藤興一, 岡安隆一
- Organizer
  日本放射線影響学会第51回大会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 8-oxoGを含むクラスターDNA損傷誘発突然変異における一本鎖切断の影響2008
- Author(s)
  野口実穂, 漆原あゆみ, 横谷明徳, 鹿園直哉
- Organizer
  日本放射線影響学会第51回大会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 鎖切断と脱塩基部位からなるクラスターDNA損傷の生物効果2008
- Author(s)
  鹿園直哉, 野口実穂, 漆原あゆみ, Peter O'Neill, 横谷明徳
- Organizer
  日本放射線影響学会第51回大会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 8-oxoGを含むクラスターDNA損傷誘発突然変異における一本鎖切断の影響2008
- Author(s)
  野口実穂
- Organizer
  日本放射線影響学会第51回大会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Radiobiology for heavy-ion radiotherapy2008
- Author(s)
  Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada, Emiko Sekine
- Organizer
  NIRS-MDA Symposium on Clinical Issues for Particle Therapy
- Place of Presentation
  Houston, USA
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] The mutation frequency of 8-oxo-7,8-dihydroguanine when single strand break is closely present on the same or the opposite strand2007
- Author(s)
  Miho Noguchi,
- Organizer
  The 7th International Symposium on Advanced Science Research
- Place of Presentation
  茨城県つくば市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] DNA損傷で観たin vitroとin vivoにおける酸素効果2007
- Author(s)
  平山亮一, 鵜沢玲子, 野口実穂, 松本孔貴, 渡辺雅彦, 小池幸子, 古澤佳也, 安藤興一, 岡安隆一
- Organizer
  第46回日本医学放射線学会生物部会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] Hsp90阻害剤による放射線増感〜DNA二本鎖切断修復への影響〜2007
- Author(s)
  野口実穂, 于冬, 平山亮一, 窪田宜夫, 岡安隆一
- Organizer
  第46回日本医学放射線学会生物部会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tomor cells irradiated with carbon ions2007
- Author(s)
  Miho Noguchi, Ryoichi Hirayama, Dong Yu, Koichi Ando, Ryuichi Okayasu
- Organizer
  13th International Congress of Radiation Research
- Place of Presentation
  サンフランシスコ(米国)
- Year and Date
  2007-01-10
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 非二本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2007
- Author(s)
  野口実穂
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 非二本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2007
- Author(s)
  野口実穂、漆原あゆみ、横谷明徳、鹿園直哉
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] The mutation frequency of 8-oxo-7, 8-dihydroguanine when single strandbreak is closely present on the saiae or the opposite strand2007
- Author(s)
  Miho Nogucbi, Ayumi Urushibara, Akinari Yokoya, Naoya Shikazono
- Organizer
  The 7th International Symposium on Advanced Scfence Research
- Place of Presentation
  茨城県東海村
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19890271
[Presentation] 大気下ならびに無酸素下でのOHラジカルによる間接作用の細胞致死効果2007
- Author(s)
  平山亮一、野口実穂、伊藤敦、安藤興一、古澤佳也、岡安隆一
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19890271

1. WATANABE Ritsuko (10360439)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
2. YOKOYA Akinari (10354987)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
3. FUJII Kentaro (00360404)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
4. SHIKAZONO Naoya (10354961)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
5. AKAMATSU Ken (70360401)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. URUSHIBARA Ayumi (80391275)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
7. HIGUCHI Mariko (90370460)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. OKA Toshitaka (70339745)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
9. 山下真一 (20511489)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. O'NEILL Peter

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. NIKJOO Hooshang

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

NOGUCHI Miho 野口 実穂

Research Projects

Research Products

Co-Researchers

放射線誘発オートファジーによる細胞死回避システムの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of radiation-induced cluster DNA damage- its structure and repair susceptibility

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combination treatment with carbon ions and Hsp90 inhibitor 17-AAGPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physicochemical and biochemical study of radiation induced DNA damage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 診療放射線技師ポケットレビュー帳2008

Author(s)

Publisher

Data Source

[Journal Article] Significance of DNA polymerase I in in vivo processing of clustered DNA damage.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

Author(s)

Journal Title

Data Source

[Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A. A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He2+ ion irradiation2011

Author(s)

Journal Title

Data Source

[Journal Article] Radioprotection by DMSO in Nitrogen Saturated Mammalian Cells Exposed to Helium Ion Beams2009

Author(s)

Journal Title

Data Source

[Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009

Author(s)

Journal Title

Data Source

[Journal Article] Sergey Druzhinin and Ryuichi Okayasu, Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009

Author(s)

Journal Title

Data Source

[Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009

Author(s)

Journal Title

Data Source

[Journal Article] A. The yield, processing, and biological consequences of clustered DNA2009

Author(s)

Journal Title

Data Source

[Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009

Author(s)

Journal Title

Data Source

[Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009

Author(s)

Journal Title

Data Source

[Journal Article] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009

Author(s)

NOGUCHI Miho 野口実穂