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NOGUCHI Miho  野口 実穂

ORCIDConnect your ORCID iD *help
Researcher Number 40455283
Affiliation *help 2016 : 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 主幹研究員(定常)
2016 : 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 主幹研究員(定常)
2015 : 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹
2013 : 独立行政法人日本原子力研究開発機構, 原子力科学研究部門先端基礎研究センター, 研究員
2013 : 独立行政法人日本原子力研究開発機構・ 原子力科学研究部門, 先端基礎研究セ ンター, 研究員 … More
2010 – 2012 : 独立行政法人日本原子力研究開発機構, 先端基礎研究センター, 研究員
2009 : 独立行政法人 日本原子力研究開発機構, 先端基礎研究センター, 研究員
2007 – 2008 : 日本原子力研, 研究員
2007 – 2008 : Japan Atomic Energy Agency, 先端基礎研究センター, 博士研究員
2008 : 独立行政法人日本原子力研究開発機構, 先端基礎研究センター, 研究員
2008 : Japan Atomic Energy Agency, 先端基礎研究センター, 研究職 Less
Review Section/Research Field
Principal Investigator
Radiation science / Risk sciences of radiation and chemicals
Except Principal Investigator
Risk sciences of radiation/Chemicals
Keywords
Principal Investigator
G2チェックポイント / 放射線 / 炭素線治療 / 老化様増殖停止 / Hsp90 / 粒子線治療 / 老化様細胞増殖停止 / Herbimycin / DNA二本鎖切断修復 / 炭素イオン線 … More / 増感 / 17-AAG / オートファジー / 細胞周期 / 放射線増感 … More
Except Principal Investigator
EPR / シンクロトロン放射 / クラスターDNA損傷 / 突然変異 / 塩基損傷 / 塩基除去修復 / 塩基除去修復酵素 / DNA損傷 / 点突然変異 / DNAラジカル / ラジカル / 電子常磁性共鳴装置 / 分子動力学法 / 軟X線 / DNA修復 / モンテカルロシミュレーション / トラック構造 / 不対電子種 / シンクロトロン放射光 / DNA鎖切断 / APサイト / 放射線 / 電子常磁性共鳴(EPR) / 放射線生物影響 / イオンビーム / 大腸菌 / クラスターDNA / LET / グリコシレース Less
  • Research Projects

    (4results)
  • Research Products

    (48results)
  • Co-Researchers

    (11People)
  •  放射線誘発オートファジーによる細胞死回避システムの解明Principal InvestigatorOngoing

    • Principal Investigator
      野口 実穂
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      National Institutes for Quantum and Radiological Science and Technology
      Japan Atomic Energy Agency
  •  Study of radiation-induced cluster DNA damage- its structure and repair susceptibility

    • Principal Investigator
      YOKOYA Akinari
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Japan Atomic Energy Agency
  •  Combination treatment with carbon ions and Hsp90 inhibitor 17-AAGPrincipal Investigator

    • Principal Investigator
      NOGUCHI Miho
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Radiation science
    • Research Institution
      Japan Atomic Energy Agency
  •  Physicochemical and biochemical study of radiation induced DNA damage

    • Principal Investigator
      YOKOYA Akinari
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Japan Atomic Energy Agency

All 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 診療放射線技師ポケットレビュー帳2008

    • Author(s)
      福士政弘(編集)、野口実穂、寺下貴美, ほか
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Significance of DNA Polymerase I in in vivo processing of clustered DNA damage2013

    • Author(s)
      Shikazono, N., Akamatsu, K., Takahashi, M., Noguchi, M., Urushibara, A., O’Neill, P. and Yokoya, A.
    • Journal Title

      Mutatation Research

      Volume : 749 Pages : 9-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21310041, KAKENHI-PROJECT-22310038, KAKENHI-PROJECT-25241010, KAKENHI-PROJECT-25740021
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      Noguchi, M., Urushibara, A., Yokoya
    • Journal Title

      Mutat. Res.

      Volume : 732 Pages : 34-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      Miho Noguchi
    • Journal Title

      Mutation Research

      Volume : 732 Pages : 34-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21310041, KAKENHI-PROJECT-22310038
  • [Journal Article] A. A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He2+ ion irradiation2011

    • Author(s)
      Yokoya, A., Shikazono, N., Fujii, K., Noguchi, M. and Urushibara
    • Journal Title

      Radiat. Protect. Dosim

      Volume : 143 Pages : 219-225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA(Invited Review)2009

    • Author(s)
      Shikazono N,. Noguchi, M., Fujii, K., Urushibara, A. and Yokoya, A.
    • Journal Title

      J. Radiat. Res. 50

      Pages : 27-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Journal Article] A. The yield, processing, and biological consequences of clustered DNA2009

    • Author(s)
      Shikazono N., Noguchi, M., Fujii, K., Urushibara, A. and Yokoya
    • Journal Title

      J. Radiat. Res

      Volume : (Invited Review) Pages : 27-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009

    • Author(s)
      Ryoichi Hirayama, Atsushi Ito, Masanori Tomita, Masako Izumi, Fumio Yatagai, Miho Noguchi, Yoshitaka Matsumoto, Yuki Kase, Koichi Ando, Ryuichi Okayasu, Yoshiya Furusawa
    • Journal Title

      Radiation Research 171

      Pages : 212-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Contributions of Direct and Indirect Actions in Cell Killing by High LET Radiations2009

    • Author(s)
      Ryoichi Hirayama, Atsushi Ito, Masanori Tomita, Masako Izumi, Fumio Yatagai, Miho Noguchi, Yoshitaka Matsumoto, Yuki Kase, Koichi Ando, Ryuichi Okayasu and Yoshiya Furusawa
    • Journal Title

      Radiation Research 171

      Pages : 212-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Sergey Druzhinin and Ryuichi Okayasu, Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009

    • Author(s)
      Miho Noguchi, Ryoichi Hirayama
    • Journal Title

      Radiation Physics and Chemistry (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009

    • Author(s)
      Naoya shikazono, Miho Noguchi, Kentaro Fujii, Ayumi Urushibara and Akinari Yokoya
    • Journal Title

      Journal of Radiation Research 50

      Pages : 27-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation2009

    • Author(s)
      Naoya shikazono, Miho Noguchi, Kentaro Fujii, Ayumi Urushibara, Akinari Yokoya
    • Journal Title

      Journal of Radiation Research 50

      Pages : 27-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2009

    • Author(s)
      Miho Noguchi, Ryoichi Hirayama, Sergey Druzhinin, Ryuichi Okayasu
    • Journal Title

      Radiation Physics and Chemistry (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Radiobiology for Heavy-ion Radiotherapy2008

    • Author(s)
      Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada, Emiko Sekine
    • Journal Title

      Proceedings of NIRS-MDA Symposium on Clinical Issues for Particle Therapy

      Pages : 174-180

    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] Radiobiology for Heavy-ion Radiotherapy2008

    • Author(s)
      Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada and Emiko Sekine
    • Journal Title

      Proceedings of NIRS-MDA Symposium on Clinical Issues for Particle Therapy

      Pages : 174-180

    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] ゲルダナマイシン誘導体の併用による癌の放射線治療2007

    • Author(s)
      岡安 隆一、野口 実穂
    • Journal Title

      ISOTOPE NEWS 643

      Pages : 2-7

    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] 高LET重粒子線によるDNA二重鎖切断損傷とその修復2007

    • Author(s)
      岡安 隆一、岡田 真希、岡部 篤史、野口 実穂
    • Journal Title

      癌の臨床 53

      Pages : 371-375

    • Data Source
      KAKENHI-PROJECT-19890271
  • [Journal Article] ゲルダナマイシン誘導体の併用による癌の放射線治療

    • Author(s)
      岡安隆一、野口実穂
    • Journal Title

      ISOTOPE NEWS 643

      Pages : 2-7

    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Exposure to X-rays enhances autophagy in human fibroblast cells2015

    • Author(s)
      野口実穂、横谷明徳、鈴木啓司、藤井健太郎
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K16131
  • [Presentation] Molecular and Cellular Effect of Ionizing Radiation2013

    • Author(s)
      Yokoya, A. , Oka, T. , Fujii, K. , Shiina, T. , Sugaya, Y. , Shiraishi, I. , Urushibara, A. , Narita1, A. , Noguchi, M. and Watanabe, R.
    • Organizer
      The 16th SANKEN International The 11th SANKEN Nanotechnology Symposium
    • Place of Presentation
      saka, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Presentation] 8-oxoGを含むクラスターDNA損傷の誘発突然変異2010

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Presentation] 同一鎖上に配置されたクラスターDNA損傷のプロセシングについて2009

    • Author(s)
      野口実穂
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Presentation] Mutagenic potential of clustered DNA damage containing single strand break and 8-oxoGs2009

    • Author(s)
      Miho Noguchi
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Verona, Italy
    • Data Source
      KAKENHI-PROJECT-21310041
  • [Presentation] Mutagenic potential of 8-oxo-7,8-dihydroguanine depends on the location of a single strand break within a cluster2008

    • Author(s)
      M. Noguchi
    • Organizer
      10th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Urabandai, Fukushima, Japan
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] 非二本鎖切断型クラスター損傷(8-oxoG と鎖切断)の突然変異誘発2008

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州国際会議場、北九州
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] Mutagenic Potential of 8-Oxo-7,8-dihydroguanine Depends on the Location of a Single Strand Break within a Cluster2008

    • Author(s)
      Miho Noguchi
    • Organizer
      10th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      福島
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] Radiobiology for heavy-ion radiotherapy2008

    • Author(s)
      Ryuichi Okayasu, Takamitsu Kato, Miho Noguchi, Maki Okada, Emiko Sekine
    • Organizer
      NIRS-MDA Symposium on Clinical Issues for Particle Therapy
    • Place of Presentation
      Houston, USA
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Mutagenic potential of 8-oxo-7,8-dihydroguanine depends on single strand break location2008

    • Author(s)
      Miho Noguchi, Ayumi Urushibara, Akinari Yokoya, Peter O'Neill, Naoya Shikazono
    • Organizer
      10th International Workshop Radiation Damage to DNA
    • Place of Presentation
      Urabandai, Japan
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Contribution of indirect action of X-irradiation under oxic and hypoxic conditions in different radiosensitivity cells2008

    • Author(s)
      Ryoichi Hirayama, Yoshiya Furusawa, Atsushi Ito, Miho Noguchi, Yoshitaka Matsumoto, Akiko Uzawa, Koichi Ando, Ryuichi Okayasu
    • Organizer
      10th International Workshop Radiation Damage to DNA
    • Place of Presentation
      Urabandai, Japan
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2008

    • Author(s)
      Miho Noguchi, Ryoichi Hirayama, Sergey Druzhinin, Ryuichi Okayasu
    • Organizer
      The 2nd Asia-Pacific Symposium on Radiation Chemistry
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Enhanced Radiation Induced Cell Killing by Herbimycin A Pre-treatment2008

    • Author(s)
      Miho Noguchi
    • Organizer
      The 2nd Asia-Pacific Symposium on Radiation Chemistry
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Mutagenic potential of 8-oxo-7,8-dihydroguanine depends on single strand break location2008

    • Author(s)
      Miho Noguchi,
    • Organizer
      10th International Workshop Radiation Damage to DNA
    • Place of Presentation
      裏磐梯
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 非二本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2008

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] NHEJ修復欠損xrs6細胞における放射線作用の細胞致死効果2008

    • Author(s)
      平山亮一, 古澤佳也, 伊藤敦, 野口実穂, 松本孔貴, 鵜澤玲子, 安藤興一, 岡安隆一
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 8-oxoGを含むクラスターDNA損傷誘発突然変異における一本鎖切断の影響2008

    • Author(s)
      野口実穂, 漆原あゆみ, 横谷明徳, 鹿園直哉
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 鎖切断と脱塩基部位からなるクラスターDNA損傷の生物効果2008

    • Author(s)
      鹿園直哉, 野口実穂, 漆原あゆみ, Peter O'Neill, 横谷明徳
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 8-oxoGを含むクラスターDNA損傷誘発突然変異における一本鎖切断の影響2008

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] The mutation frequency of 8-oxo-7,8-dihydroguanine when single strand break is closely present on the same or the opposite strand2007

    • Author(s)
      Miho Noguchi,
    • Organizer
      The 7th International Symposium on Advanced Science Research
    • Place of Presentation
      茨城県つくば市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 大気下ならびに無酸素下でのOHラジカルによる間接作用の細胞致死効果2007

    • Author(s)
      平山 亮一、野口 実穂、伊藤 敦、安藤 興一、古澤 佳也、岡安 隆一
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] DNA損傷で観たin vitroとin vivoにおける酸素効果2007

    • Author(s)
      平山 亮一, 鵜沢 玲子, 野口 実穂, 松本 孔貴, 渡辺 雅彦, 小池 幸子, 古澤 佳也, 安藤 興一, 岡安 隆一
    • Organizer
      第46回日本医学放射線学会生物部会
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2007-07-21
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Hsp90阻害剤による放射線増感〜DNA二本鎖切断修復への影響〜2007

    • Author(s)
      野口 実穂, 于 冬, 平山 亮一, 窪田 宜夫, 岡安 隆一
    • Organizer
      第46回日本医学放射線学会生物部会
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2007-07-21
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 17-allylamino-17-demethoxygeldanamycin enhances the cytotoxicity of tomor cells irradiated with carbon ions2007

    • Author(s)
      Miho Noguchi, Ryoichi Hirayama, Dong Yu, Koichi Ando, Ryuichi Okayasu
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2007-01-10
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] 非2本鎖切断型クラスター損傷(8-oxoG と鎖切断)の突然変異誘発2007

    • Author(s)
      野口実穂
    • Organizer
      放射線影響学会
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] 非二本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2007

    • Author(s)
      野口実穂
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-19890271
  • [Presentation] Mutagenic potential of non-DSB clustered damage containing 8-oxoG and single strand break2007

    • Author(s)
      M. Noguchi
    • Organizer
      The 7th International Symposium on Advanced Science Research: Charged Particle and Photon Interaction with Matter
    • Place of Presentation
      JAEA-Tokai, Ibaraki, Japan
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] 非2本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2007

    • Author(s)
      野口 実穂
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市(幕張メッセ),千葉県
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] Biologcal consequences of bistanded clustered DNA damage in Escherichia coli2007

    • Author(s)
      Miho Noguchi
    • Organizer
      The 7th International Symposium on Advanced Science Research;Charged Particle and Photon Interaction Kith Matter
    • Place of Presentation
      東海村(日本原子力研究開発機溝),茨城県
    • Data Source
      KAKENHI-PROJECT-18310041
  • [Presentation] 非二本鎖切断型クラスター損傷(8-oxoGと鎖切断)の突然変異誘発2007

    • Author(s)
      野口 実穂、漆原 あゆみ、横谷 明徳、鹿園 直哉
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19890271
  • 1.  WATANABE Ritsuko (10360439)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 1results
  • 2.  YOKOYA Akinari (10354987)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 7results
  • 3.  FUJII Kentaro (00360404)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 4results
  • 4.  SHIKAZONO Naoya (10354961)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 5results
  • 5.  AKAMATSU Ken (70360401)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 6.  URUSHIBARA Ayumi (80391275)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 7.  HIGUCHI Mariko (90370460)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 8.  OKA Toshitaka (70339745)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 9.  山下 真一 (20511489)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 10.  O'NEILL Peter
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  NIKJOO Hooshang
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results

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