NEMOTO TORU 根本徹

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NEMOTO Touru 根本徹

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Researcher Number	40458766
Affiliation (based on the past Project Information) *help	2015: 北里大学, 薬学部, 助教 2011 – 2013: 北里大学, 薬学部, 助教 2008: 北里大学, 薬学部, 講師 2007 – 2008: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 生物活性物質 / 作動薬 / δ受容体 / オピオイド / 医薬分子設計 / 医薬品化学 Except Principal Investigator 拮抗薬 / 作動薬 / オピオイド / 医薬分子設計 / 生物活性物質

高活性で高選択的なオピオイドδ受容体作動薬の合成Principal Investigator
- Principal Investigator
  
  根本徹
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Synthesis of highly selective and potent delta opioid receptor agonistsPrincipal Investigator
- Principal Investigator
  
  NEMOTO TORU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Investigation of binding sites of agonists or antagonists on opioid receptor ligands
- Principal Investigator
  
  NAGASE Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University

All 2013 2012 2011 2008 Other

All Journal Article Presentation

[Journal Article] The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists2013
- Author(s)
  Toru Nemoto, Yoshihiro Ida, Yusuke Iihara, Ryo Nakajima, Shigeto Hirayama, Takashi Iwai, Hideaki Fujii, Hiroshi Nagase
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry
  
  Volume: 21 Issue: 24 Pages: 7628-7647
- DOI
  10.1016/j.bmc.2013.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790139
[Journal Article] Synthesis of quinolinomorphinan-derivatives as highly selective δ opioid receptor ligands2012
- Author(s)
  Yoshihiro Ida , Ayaka Matsubara, Toru Nemoto, Manabu Saito, Shigeto Hirayama, Hideaki Fujii, Hiroshi Nagase
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 20 Issue: 19 Pages: 5810-5831
- DOI
  10.1016/j.bmc.2012.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790139
[Journal Article] Synthesis of quinolinomorphinan-4-ol derivatives asδopioid receptor agonists2012
- Author(s)
  Yoshihiro Ida, Toru Nemoto他8名
- Journal Title
  
  Bioorganic&Medicinal. Chemistry
  
  Volume: 20(2) Issue: 2 Pages: 949-961
- DOI
  10.1016/j.bmc.2011.11.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790139
[Journal Article] Synthesis of a stable iminium salt and propellane derivatives2008
- Author(s)
  Nagase, H. ; Yamamot, N. ; Nemoto, T. ; Yoza, K. ; Kamiya, K. ; Hirono, S. ; Momen, S. ; Izumimoto, N. ; Hasebe, K. ; Mochizuki, H. ; Fujii, H.
- Journal Title
  
  J. Org. Chem. 73
  
  Pages: 8093-8096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Journal Article] Novel cleavage reaction of the C16-N17 bond in naltrexone derivatives2008
- Author(s)
  Fujii, H. ; Imaide, S. ; Watanabe, A. ; Nemoto, T. ; Nagase, H.
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Journal Article] Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction2008
- Author(s)
  Fujii, H. ; Osa, Y. ; Ishihara, M. ; Hanamura, S. ; Nemoto, T. ; Nakajima, M. ; Hasebe, K. ; Mochizuki, H. ; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 4978-4981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] オピオイドδ受容体作動薬KNT-127誘導体の構造活性相関2013
- Author(s)
  根本徹, 他4名
- Organizer
  第31回白金シンポジウム
- Place of Presentation
  白金
- Year and Date
  2013-12-17
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] オピオイドδ受容体作動薬KNT-127誘導体の構造活性相関2013
- Author(s)
  根本徹, 他5名
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] オピオイドδ受容体作動薬KNT-127の17位窒素置換基による受容体結合能及び作動活性への影響2013
- Author(s)
  根本徹, 他7名
- Organizer
  第8回北里化学シンポジウム
- Place of Presentation
  相模原
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規キノリノモルヒナン骨格を有するオピオイドδ受容体リガンドの合成2013
- Author(s)
  岡田卓大、根本徹, 他6名
- Organizer
  第8回北里化学シンポジウム
- Place of Presentation
  相模原
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012
- Author(s)
  飯原　祐輔、平山重人、根本　徹、藤井秀明、長瀬　博
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012
- Author(s)
  飯原祐輔、根本徹, 他3名
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012
- Author(s)
  飯原祐輔、根本徹, 他3名
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012
- Author(s)
  飯原　祐輔、平山重人、根本　徹、藤井秀明、長瀬　博
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  昭和大学（東京都）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 高選択的高活性オピオイドδ受容体作動薬の合成2011
- Author(s)
  松原彩香、根本徹, 他3名
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] Structure-Activity Relationship of a Novel delta Opioid Receptor Agonist, SN-282011
- Author(s)
  Toru Nemoto, Yoshihiro Ida, Shigeto Hirayama, Hideaki Fujii, Masayuki Imai, Takashi Nakamura, Toshiyuki Kanemasa, Akira Kato, Hiroshi Nagase
- Organizer
  Italian-Japanese International Seminar for Neurosciences
- Place of Presentation
  東北薬科大学（宮城県）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] Structure-Activity Relationship of a Novel delta Opioid Receptor Agonist2011
- Author(s)
  Toru Nemoto, 他8名
- Organizer
  SN-28. Italian-Japanese International Seminar for Neurosciences
- Place of Presentation
  Sendai.
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] フッ素を有する17位窒素置換基を導入したオピオイドδ受容体リガンドの合成2011
- Author(s)
  飯原祐輔、根本徹, 他3名
- Organizer
  第7回北里化学シンポジウム
- Place of Presentation
  白金
- Year and Date
  2011-12-22
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] Synthesis of SN-28 Derivatives and Their Pharmacologies2011
- Author(s)
  Yoshihiro Ida, Toru Nemoto, Shigeto Hirayama, Hideaki Fujii, Masayuki Imai, Takashi Nakamura, Toshiyuki Kanemasa, Akira Kato, Hiroshi Nagase
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル（東京都）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] フッ素を有する17位窒素置換基を導入したオピオイドδ受容体リガンドの合成2011
- Author(s)
  飯原祐輔、根本徹, 他3名
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 高選択的高活性オピオイドδ受容体作動薬の合成2011
- Author(s)
  松原　彩香、平山重人、根本　徹、藤井秀明、長瀬　博
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学（千葉県）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 高選択的高活性オピオイドδ受容体作動薬の合成2011
- Author(s)
  松原　彩香、平山重人、根本　徹、藤井秀明、長瀬　博
- Organizer
  AKPS集会第６回北里化学シンポジウム
- Place of Presentation
  北里大学（東京都）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 高選択的高活性オピオイドδ受容体作動薬の合成2011
- Author(s)
  松原彩香、根本徹, 他3名
- Organizer
  第7回北里化学シンポジウム
- Place of Presentation
  白金
- Year and Date
  2011-12-22
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] Synthesis of SN-28 Derivatives and Their Pharmacologies. AIMECS112011
- Author(s)
  Yoshihiro Ida, Toru Nemoto, 他7名
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Shinjuku
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成
- Author(s)
  根本　徹、井田善洋、平山重人、岩井孝志、藤井秀明、長瀬　博
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県広島市）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] オピオイドδ受容体作動薬KNT-127の17位窒素置換基による受容体結合能及び作動活性への影響
- Author(s)
  根本　徹、井田善洋、飯原祐輔、中嶋龍、平山重人、岩井孝志、藤井秀明、長瀬　博
- Organizer
  第8回北里化学シンポジウム
- Place of Presentation
  北里大学（神奈川県相模原市）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] オピオイドδ受容体作動薬KNT-127誘導体の構造活性相関
- Author(s)
  根本　徹、平山重人、岩井孝志、藤井秀明、長瀬　博
- Organizer
  第31回白金シンポジウム
- Place of Presentation
  北里大学（東京都港区）
- Data Source
  KAKENHI-PROJECT-23790139
[Presentation] 新規キノリノモルヒナン骨格を有するオピオイドδ受容体リガンドの合成
- Author(s)
  岡田卓大、根本　徹、飯原祐輔、野村俊宗、平山重人、岩井孝志、藤井秀明、長瀬　博
- Organizer
  第8回北里化学シンポジウム
- Place of Presentation
  北里大学（神奈川県相模原市）
- Data Source
  KAKENHI-PROJECT-23790139

1. SUZUKI Tsutomu (90130757)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NAGASE Hiroshi (70383651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. FUJII Hideaki (30458757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

NEMOTO TORU 根本 徹

NEMOTO Touru 根本 徹

Research Projects

Research Products

Co-Researchers

高活性で高選択的なオピオイドδ受容体作動薬の合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of highly selective and potent delta opioid receptor agonistsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of binding sites of agonists or antagonists on opioid receptor ligands

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of quinolinomorphinan-derivatives as highly selective δ opioid receptor ligands2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of quinolinomorphinan-4-ol derivatives asδopioid receptor agonists2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of a stable iminium salt and propellane derivatives2008

Author(s)

Journal Title

Data Source

[Journal Article] Novel cleavage reaction of the C16-N17 bond in naltrexone derivatives2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction2008

Author(s)

Journal Title

Data Source

[Presentation] オピオイドδ受容体作動薬KNT-127誘導体の構造活性相関2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] オピオイドδ受容体作動薬KNT-127誘導体の構造活性相関2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] オピオイドδ受容体作動薬KNT-127の17位窒素置換基による受容体結合能及び作動活性への影響2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 新規キノリノモルヒナン骨格を有するオピオイドδ受容体リガンドの合成2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 新規オピオイドδ受容体リガンドとしてのキノリノモルヒナンの合成2012

NEMOTO TORU 根本徹

NEMOTO Touru 根本徹