Kurosu Hiroshi 黒須洋

… Alternative Names

黒須洋クロスヒロシ

KUROSU Hiroshi 黒須洋

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Researcher Number	40468690
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 自治医科大学, 医学部, 准教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 2009 – 2010: Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 2008: Tokyo Women's Medical University, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine / Biological pharmacy / Risk sciences of radiation/Chemicals Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator Phex / DMP-1 / FGF-23 / DMP-I / PEX / リン / 慢性腎臓病 / ステロイドホルモン / pH / リン酸カルシウム … More / ビスホスホネート / 無機リン酸 / Klotho / 脳神経保護 / 脳神経疾患 / プロサイモシンα / 恒常性維持機構 / カドミウム … More Except Principal Investigator klotho / 線維芽細胞増殖因子23 / 骨ミネラル代謝異常 / 慢性腎臓病 / Klotho / 急性腎障害 / FGF23 Less

低リン血症性くる病骨軟化症発症機序、PHEX・DMP１・FGF23連関の解明Principal Investigator
- Principal Investigator
  
  黒須洋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Jichi Medical University
Novel therapeutic agents for kidney disease targeting the FGF23-Klotho system
- Principal Investigator
  
  Iwazu Yoshitaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Jichi Medical University
Research for expression mechanism of klotho in CKD model micePrincipal Investigator
- Principal Investigator
  
  Kurosu Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Jichi Medical University
脳領域特異的プロサイモシンα欠損による精神神経疾患誘導とその分子機能基盤の解明Principal Investigator
- Principal Investigator
  
  黒須洋
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Research for effect of cadmium induced-toxicity on FGF23 signalingPrincipal Investigator
- Principal Investigator
  
  KUROSU Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tokyo Women's Medical University

All 2023 2022 2021 2018 2013 2012 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs2023
- Author(s)
  Miura Marina、Miura Yutaka、Iwazu Yoshitaka、Mukai Hideyuki、Sugiura Takahiro、Suzuki Yuji、Kato Masami、Kano Mayumi、Nagata Daisuke、Shiizaki Kazuhiro、Kurosu Hiroshi、Kuro-o Makoto
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 15026-15026
- DOI
  10.1038/s41598-023-42273-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08316, KAKENHI-PROJECT-23K07679
[Journal Article] Quantification of Calciprotein Particles (CPPs) in Serum/Plasma Samples Using a Fluorescent Bisphosphonate2023
- Author(s)
  Miura Yutaka、Kurosu Hiroshi、Kuro-o Makoto
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2664 Pages: 333-341
- DOI
  10.1007/978-1-0716-3179-9_21
- ISBN
  9781071631782, 9781071631799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08316, KAKENHI-PROJECT-22H00473
[Journal Article] The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients.2022
- Author(s)
  Mukai H, Miura Y, Kotani K, Kotoda A, Kurosu H, Yamada T, Kuro-O M, Iwazu Y
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 21856-21856
- DOI
  10.1038/s41598-022-26166-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07921, KAKENHI-PROJECT-21K06423, KAKENHI-PROJECT-22K08316
[Journal Article] Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients.2022
- Author(s)
  Nakamura K, Isoyama N, Nakayama Y, Hiroyoshi T, Fujikawa K, Miura Y, Kurosu H, Matsuyama H, Kuro-o M.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 13030-13030
- DOI
  10.1038/s41598-022-17405-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08316
[Journal Article] Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression2021
- Author(s)
  Shiizaki Kazuhiro、Tsubouchi Asako、Miura Yutaka、....Itoh Hiroshi、....Kuro-o Makoto
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131 Issue: 16
- DOI
  10.1172/jci145693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-19K07921, KAKENHI-PROJECT-20K08613, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K21506
[Journal Article] Identification and quantification of plasma calciprotein particles with distinct physical properties in patients with chronic kidney disease2018
- Author(s)
  Miura Yutaka、Iwazu Yoshitaka、Shiizaki Kazuhiro、Akimoto Tetsu、Kotani Kazuhiko、Kurabayashi Masahiko、Kurosu Hiroshi、Kuro-o Makoto
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1256-1256
- DOI
  10.1038/s41598-018-19677-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08941, KAKENHI-PROJECT-15K09269, KAKENHI-PROJECT-16H05302, KAKENHI-PROJECT-17K09733
[Journal Article] The Body-wide Transcriptome Landscape of Disease Models.2018
- Author(s)
  Kozawa S, Ueda R, Urayama K, Sagawa F, Endo S, Shiizaki K, Kurosu H, Maria de Almeida G, Hasan SM, Nakazato K, Ozaki S, Yamashita Y, Kuro-O M, Sato TN.
- Journal Title
  
  iScience
  
  Volume: 2 Pages: 238-268
- DOI
  10.1016/j.isci.2018.03.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09733
[Journal Article] ＦＧＦ１９2013
- Author(s)
  黒須　洋
- Journal Title
  
  内分泌・糖尿病・代謝内科 (内分泌ホルモンのすべて)
  
  Volume: 36 Pages: 329-335
- Data Source
  KAKENHI-PROJECT-24590115
[Journal Article] Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands.2012
- Author(s)
  Goetz R, Ohnishi M, Ding X, Kurosu H, Wang L, Akiyoshi J, Ma J, Gai W, Sidis Y, Pitteloud N, Kuro-O M, Razzaque MS, Mohammadi M.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 32 Issue: 10 Pages: 1944-1954
- DOI
  10.1128/mcb.06603-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590115
[Journal Article] Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis.2012
- Author(s)
  Sugiura H, Yoshida T, Shiohira S, Kohei J, Mitobe M, Kurosu H, Kuro-o M, Nitta K, Tsuchiya K.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 302 Issue: 10 Pages: F1252-F1264
- DOI
  10.1152/ajprenal.00294.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591204, KAKENHI-PROJECT-24590115
[Journal Article] Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.2012
- Author(s)
  Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 287 Issue: 34 Pages: 29134-29146
- DOI
  10.1074/jbc.m112.342980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590115
[Journal Article] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.2010
- Author(s)
  Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M
- Journal Title
  
  Proc Natl Acad Sci USA 107
  
  Pages: 407-412
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Mangelsdorf DJ, Kliewer SA Research resource : Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.2010
- Author(s)
  Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M
- Journal Title
  
  Mol Endocrinol 24
  
  Pages: 2050-2064
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.2009
- Author(s)
  Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-o M, Huang CL
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 9805-9810
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] The Klotho gene family as a regulator of endocrine fibroblast growth factors.2009
- Author(s)
  Hiroshi Kurosu
- Journal Title
  
  Molecular and Cellular Endocrinology 299
  
  Pages: 72-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] KlothoとFGF19サブファミリー2009
- Author(s)
  黒須洋
- Journal Title
  
  季刊腎と骨代謝 22
  
  Pages: 113-126
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] KlothoとFGF19サブファミリー2009
- Author(s)
  黒須洋、黒尾誠
- Journal Title
  
  季刊腎と骨代謝 22
  
  Pages: 113-126
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Endocrine fibroblast growth factors as regulators of metabolic homeostasis2009
- Author(s)
  Hiroshi Kurosu
- Journal Title
  
  Biofactors 35
  
  Pages: 52-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Regulation of renal outer medullary potassium channel and renal K^+ excretion by klotho.2009
- Author(s)
  Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe OW, Huang CL
- Journal Title
  
  Mol Pharmacol 38
  
  Pages: 38-46
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Endocrine FGFs as regulators of metabolic homeostasis.2009
- Author(s)
  黒須洋, 黒尾誠
- Journal Title
  
  Biofactors Review 35
  
  Pages: 52-60
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] NaF activates MAPKs and induces apoptosis in odontoblast-like cells2009
- Author(s)
  Karube H, Nishitai G, Inageda K, Kurosu H, Matsuoka M
- Journal Title
  
  J Dent Res 88
  
  Pages: 461-465
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] The Klotho gene family as a regulator of endocrine fibroblast growth factors.2009
- Author(s)
  黒須洋, 黒尾誠
- Journal Title
  
  Mol Cell Endocrinol. Review 299
  
  Pages: 72-78
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Klotho分子ファミリーとエンドクラインFGPによる生体の恒常性維持制御2008
- Author(s)
  黒須洋
- Journal Title
  
  内分泌・糖尿病科 26
  
  Pages: 527-535
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] The Klotho gene family and the endocrine fibroblast growth factors.2008
- Author(s)
  Hiroshi Kurosu
- Journal Title
  
  Current Opinion in Nephrology and Hypertension 17
  
  Pages: 368-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] KlothoファミリーとエンドクラインFGFによる生体の恒常性維持制御2008
- Author(s)
  黒須洋、黒尾誠
- Journal Title
  
  内分泌・糖尿病科 26
  
  Pages: 527-535
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Klotho遺伝子からみた老化2008
- Author(s)
  黒須洋、黒尾誠
- Journal Title
  
  Surgery Frontier 387-393
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] Klotho遺伝子からみた老化2008
- Author(s)
  黒須洋
- Journal Title
  
  Surgery Frontier 15
  
  Pages: 387-393
- Data Source
  KAKENHI-PROJECT-20510068
[Journal Article] The Klotho gene family and the endocrine fibroblast growth factors.2008
- Author(s)
  黒須洋, 黒尾誠
- Journal Title
  
  Curr Opin Nephrol Hypertens. Review 17
  
  Pages: 368-372
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] 急性腎障害(虚血再灌流)モデルにおいてFGF23阻害ペプチド投与は腎障害を軽減する2022
- Author(s)
  岩津好隆, 黒須洋, 山田俊幸, 黒尾誠
- Organizer
  第69回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08613
[Presentation] 尿細管リン排泄と尿細管間質線維化の関係2021
- Author(s)
  向井秀幸, 岩津好隆, 椎崎和弘, 三浦裕, 林宏栄, 黒須洋, 黒尾誠
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-20K08613
[Presentation] Klothoマウス2018
- Author(s)
  黒須　洋
- Organizer
  第18回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09733
[Presentation] プロサイモシンαミクログリア活性化機構の解析2009
- Author(s)
  黒須洋
- Organizer
  第62回日本薬理学会西南部会
- Place of Presentation
  松山
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] リゾホスファチジン酸によるミクログリア活性化とATP遊離を介する間接的BDNF産生機構
- Author(s)
  植村朋香、藤田亮介、黒須洋、植田弘師
- Organizer
  第82回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] 九州支部会モルヒネ鎮痛耐性を制御するアンチオピオイド機能の解明
- Author(s)
  三浦裕、西建也、荒木康平、内田仁司、黒須洋、植田弘師
- Organizer
  第27回日本薬学会
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] 西南部会プロサイモシンαミクログリア活性化機構の解析
- Author(s)
  黒須洋、植村朋香、藤村一輝、黒須洋、植田弘師
- Organizer
  第62回日本薬理学会
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] フッ化ナトリウム曝露による象牙芽細胞様細胞株のアポトーシス軽部
- Author(s)
  裕代、西躰元、黒須洋、松岡雅人
- Organizer
  第79回日本衛生学会
- Data Source
  KAKENHI-PROJECT-20510068
[Presentation] 九州支部会オピオイド受容体欠損マウスへの脳領域特異的遺伝子レスキューと疼痛モダリティーとの関連
- Author(s)
  西建也、三浦裕、荒木康平、内田仁司、黒須洋、植田弘師
- Organizer
  第27回日本薬学会
- Data Source
  KAKENHI-PROJECT-20510068

1. MATSUOKA Masato (50209516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Iwazu Yoshitaka (40424014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 黒尾誠 (10716864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KOTANI Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. SHIOHIRA Shunji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山田俊幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 長谷川一宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 伊藤裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 土谷まり子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 土谷健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kurosu Hiroshi 黒須 洋

黒須 洋 クロス ヒロシ

KUROSU Hiroshi 黒須 洋

Research Projects

Research Products

Co-Researchers

低リン血症性くる病骨軟化症発症機序、PHEX・DMP１・FGF23連関の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic agents for kidney disease targeting the FGF23-Klotho system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for expression mechanism of klotho in CKD model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳領域特異的プロサイモシンα欠損による精神神経疾患誘導とその分子機能基盤の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for effect of cadmium induced-toxicity on FGF23 signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantification of Calciprotein Particles (CPPs) in Serum/Plasma Samples Using a Fluorescent Bisphosphonate2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] The effects for inflammatory responses by CPP with different colloidal properties in hemodialysis patients.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and quantification of plasma calciprotein particles with distinct physical properties in patients with chronic kidney disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Body-wide Transcriptome Landscape of Disease Models.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ＦＧＦ１９2013

Author(s)

Journal Title

Data Source

[Journal Article] Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands.2012

Author(s)

Journal Title

DOI

Kurosu Hiroshi 黒須洋

黒須洋クロスヒロシ

KUROSU Hiroshi 黒須洋