TAKUWA HIROYUKI 田桑弘之

… Alternative Names

TAKUWA Hiroyuki 田桑弘之

Less

Researcher Number	40508347
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員 2021: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員 2016 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 研究員(任常) 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2012 – 2015: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 2011: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 90110:Biomedical engineering-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46030:Function of nervous system-related Except Principal Investigator Basic Section 51010:Basic brain sciences-related / General physiology / Fusional brain recording science / Non-invasive neuroimaging
Keywords	Principal Investigator 二光子顕微鏡 / PET / モデルマウス / 認知症 / 脳内クリアランス / マクロファージ / 2光子顕微鏡 / 神経細胞 / ミクログリア / タウ … More / 小動物PET / 脳萎縮 / 貪食 / アストロサイト / ニューロン / グリア細胞 / 脳外排出メカニズム / タウ病変 / ２光子顕微鏡 / 脳内伝播 / αシヌクレイン / in vivoイメージング / クリアランス / 神経変性疾患 / 応用光学・量子光工学 / 放射線 / 脳神経疾患 / 神経科学 / 実験装置開発 / 認知症モデル動物 / マルチモダルイメージング / ＰＥＴ / マルチスケールイメージング / 画像補正 / マルチモーダルイメージング / 生体脳イメージング / 蛍光顕微鏡 / 11C］flumazenil-PET / 脳循環代謝障害 / 神経細胞脱落 / 神経機能障害 / 脳血流 / 病態モデルマウス / 二光子励起レーザー顕微鏡 / モデル動物 / 脳卒中 / 慢性低灌流 … More Except Principal Investigator 脳微小循環 / カルシウムイメージング / 神経回路 / 磁気受容 / ニューロン活動 / バレル野 / 可塑的変化 / 生体光イメージング / マウス / 機能補償 / 微小循環 / 脳血流 / 生体医用光学 / 生物・生体工学 / 短拡散時間 / 拡散係数 / BOLD / 脳機能画像 / MRI / 拡散スペクトル / oscillating gradient / ラット / 高磁場MRI / 拡散時間 / 小脳 / 変調傾斜磁場 / 拡散MRI / 水分子拡散 Less

量子計測技術による脳内炎症の１細胞レベルでの可視化と制御Principal Investigator
- Principal Investigator
  
  田桑弘之
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  National Institutes for Quantum Science and Technology
広域カルシウムイメージングとVRシステム行動実験による磁覚情報処理の神経機構解明
- Principal Investigator
  
  八幡憲明
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51010:Basic brain sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
脳萎縮を引き起こす免疫細胞主体の老廃物脳外排出メカニズムの解明と制御Principal Investigator
- Principal Investigator
  
  田桑弘之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institutes for Quantum Science and Technology
Mechanism for the propagation and clearance of tau and alpha-synuclein proteins in neurodegenerative diseasePrincipal Investigator
- Principal Investigator
  
  Takuwa Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of a Simultaneous fluorescence microscope and PET Imaging System for Awake MicePrincipal Investigator
- Principal Investigator
  
  Takuwa Hiroyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Chronic effects of cerebral hypoperfusion on neural density and function using misery perfusion animal modelPrincipal Investigator
- Principal Investigator
  
  Takuwa Hiroyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
マウスの感覚機能補償にともなう神経活動と血流動態の適応機序に関する研究
- Principal Investigator
  
  松浦哲也
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Iwate University
Relation between optical intrinsic signal imaging on regulation of microcirculation on mice somatosensory cortex
- Principal Investigator
  
  KAWAGUCHI Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Fusional brain recording science
- Research Institution
  National Institute of Radiological Sciences
In vivo tissue characterization for normal and disease models using diffusion spectral imaging
- Principal Investigator
  
  JEFFREY Kershaw
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Non-invasive neuroimaging
- Research Institution
  National Institute of Radiological Sciences

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] 比較生理生化学　vol37 no12019
- Author(s)
  田桑弘之　加納正道
- Total Pages
  9
- Publisher
  日本比較生理生化学会
- Data Source
  KAKENHI-PROJECT-18K06542
[Book] 実験医学　vol37 No62019
- Author(s)
  樋口真人　田桑弘之
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18K06542
[Journal Article] Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases2024
- Author(s)
  Endo H, Ono M, Takado Y, Matsuoka K, Takahashi M, Tagai K, Kataoka Y, Hirata K, Takahata K, Seki C, Kokubo N, Fujinaga M, Mori W, Nagai Y, Mimura K, Kumata K, Kikuchi T, Shimozawa A, Mishra S. K, YamaguchiY , Shimizu H, Kakita A, Takuwa H, (10 authors skipped), Higuchi M
- Journal Title
  
  Neuron
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21399
[Journal Article] Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion2023
- Author(s)
  Urushihata Takuya、Takuwa Hiroyuki、Takahashi Manami、Kershaw Jeff、Shibata Sayaka、Nitta Nobuhiro、Tachibana Yasuhiko、Yasui Masato、Higuchi Makoto、Obata Takayuki
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 1071272-1071272
- DOI
  10.3389/fnins.2022.1071272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21399
[Journal Article] Capillary responses to functional and pathological activations rely on the capillary states at rest2023
- Author(s)
  Suzuki Hiroki、Takeda Hiroshi、Takuwa Hiroyuki、Ji Bin、Higuchi Makoto、Kanno Iwao、Masamoto Kazuto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 未定 Issue: 6 Pages: 271678231156372-271678231156372
- DOI
  10.1177/0271678x231156372
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07317, KAKENHI-PROJECT-22KJ1373, KAKENHI-PROJECT-23K21399
[Journal Article] Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model.2023
- Author(s)
  Kudo T, Takuwa H, Takahashi M, Urushihata T, Shimojo M, Sampei K, Yamanaka M, Tomita Y, Sahara N, Suhara T, Higuchi M
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106342-106342
- DOI
  10.1016/j.isci.2023.106342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06929, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-23K21399, KAKENHI-PROJECT-21K07580
[Journal Article] Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice2022
- Author(s)
  Tachida Yuriko、Miura Saori、Muto Yui、Takuwa Hiroyuki、Sahara Naruhiko、Shindo Akihiro、Matsuba Yukio、Saito Takashi、Taniguchi Naoyuki、Kawaguchi Yasushi、Tomimoto Hidekazu、Saido Takaomi、Kitazume Shinobu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Issue: 6 Pages: 101880-101880
- DOI
  10.1016/j.jbc.2022.101880
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-21H00446, KAKENHI-PROJECT-23K21399, KAKENHI-PROJECT-21H02831
[Journal Article] Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin2021
- Author(s)
  Ikoma Yoko、Takuwa Hiroyuki、Nishino Asuka、Maeda Jun、Kawamura Kazunori、Obata Takayuki、Zhang Ming-Rong、Higuchi Makoto、Suhara Tetsuya
- Journal Title
  
  Annals of Nuclear Medicine
  
  Volume: 35 Issue: 8 Pages: 955-965
- DOI
  10.1007/s12149-021-01633-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21399
[Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies2021
- Author(s)
  Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, (24人省略), Shimada H.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 1 Pages: 42-58
- DOI
  10.1016/j.neuron.2020.09.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H03362, KAKENHI-PROJECT-19H03583
[Journal Article] Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin2021
- Author(s)
  Yoko Ikoma, Hiroyuki Takuwa, Asuka Nishino, Jun Maeda, Kazunori Kawamura, Takayuki Obata, Ming-Rong Zhang, Makoto Higuchi, Tetsuya Suhara
- Journal Title
  
  Annals of Nuclear Medicine
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06542
[Journal Article] Three‐dimensional microvascular network reconstruction from in vivo images with adaptation of the regional inhomogeneity in the signal‐to‐noise ratio2021
- Author(s)
  Sugashi Takuma、Yuki Hiroya、Niizawa Tomoya、Takuwa Hiroyuki、Kanno Iwao、Masamoto Kazuto
- Journal Title
  
  Microcirculation
  
  Volume: in press Issue: 5
- DOI
  10.1111/micc.12697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07795, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-23K21399
[Journal Article] A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 72021
- Author(s)
  Kubota Manabu、Seki Chie、Kimura Yasuyuki、Takahata Keisuke、Shimada Hitoshi、Takado Yuhei、Matsuoka Kiwamu、Tagai Kenji、Sano Yasunori、Yamamoto Yasuharu、Okada Maki、Kikuchi Tatsuya、Ichise Masanori、Kawamura Kazunori、Zhang Ming-Rong、Higuchi Makoto
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 41 Issue: 11 Pages: 2928-2943
- DOI
  10.1177/0271678x211004150
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-20K07935, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons2021
- Author(s)
  Hatakeyama N., Unekawa M., Tomita Y. Suzuki N. Nakahara J. Takuwa H., Kanno I., Matsui K., Tanaka K.F., Masamoto K.
- Journal Title
  
  J Cereb Blood Flo Metab
  
  Volume: - Issue: 10 Pages: 2676-2689
- DOI
  10.1177/0271678x211010355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-19K07795, KAKENHI-PUBLICLY-20H05046, KAKENHI-PROJECT-19H03338, KAKENHI-PROJECT-21K06443, KAKENHI-PLANNED-20H05896, KAKENHI-PROJECT-23K21399
[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021
- Author(s)
  Sato H、Takado Y、Toyoda S、Tsukamoto-Yasui M、Minatohara K、Takuwa H、Urushihata T、Takahashi M、Shimojo M、Ono M、Maeda J、Orihara A、Sahara N、Aoki I、Karakawa S、Isokawa M、Kawasaki N、Kawasaki M、Ueno S、Kanda M、Nishimura M、Suzuki K、Mitsui A、Nagao K、Kitamura A、Higuchi M
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 43 Pages: 1-11
- DOI
  10.1126/sciadv.abd5046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI.2021
- Author(s)
  Urushihata Takuya, Takuwa Hiroyuki, Manami Takahashi, Tachibana Yasuhiko, Jeffrey Kershaw, Nitta Nobuhiro, Shibata Sayaka, Masato Yasui, Higuchi Makoto, Obata Takayuki
- Journal Title
  
  European radiology experimental
  
  Volume: 44 Issue: 1 Pages: 44-44
- DOI
  10.1186/s41747-021-00244-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10385, KAKENHI-PROJECT-23K21399
[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021
- Author(s)
  Takado Yuhei、Takuwa Hiroyuki、Sampei Kazuaki、Urushihata Takuya、Takahashi Manami、Shimojo Masafumi、Uchida Shoko、Nitta Nobuhiro、Shibata Sayaka、Nagashima Keisuke、Ochi Yoshihiro、Ono Maiko、Maeda Jun、Tomita Yutaka、Sahara Naruhiko、Near Jamie、Aoki Ichio、Shibata Kazuhisa、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 42 Issue: 1 Pages: 197-212
- DOI
  10.1177/0271678x211045449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-19H01041, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
[Journal Article] Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models2021
- Author(s)
  Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao M.N. Duarte, Hiroyuki Takuwa et al.,
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06542
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Journal Article] Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow2018
- Author(s)
  Takahashi Manami、Urushihata Takuya、Takuwa Hiroyuki、Sakata Kazumi、Takado Yuhei、Shimizu Eiji、Suhara Tetsuya、Higuchi Makoto、Ito Hiroshi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 11 Pages: 723-723
- DOI
  10.3389/fnins.2017.00723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06361, KAKENHI-PROJECT-16K19875, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-16K10356
[Journal Article] Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells2018
- Author(s)
  Obata Takayuki、Kershaw Jeff、Tachibana Yasuhiko、Miyauchi Takayuki、Abe Yoichiro、Shibata Sayaka、Kawaguchi Hiroshi、Ikoma Yoko、Takuwa Hiroyuki、Aoki Ichio、Yasui Masato
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17954-17954
- DOI
  10.1038/s41598-018-36264-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-15H04910, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-17K19637, KAKENHI-PROJECT-16H05134
[Journal Article] Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with <sup>64</sup>Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts2018
- Author(s)
  Yoshii Yukie、Yoshimoto Mitsuyoshi、Matsumoto Hiroki、Tashima Hideaki、Iwao Yuma、Takuwa Hiroyuki、Yoshida Eiji、Wakizaka Hidekatsu、Yamaya Taiga、Zhang Ming-Rong、Sugyo Aya、Hanadate Sayaka、Tsuji Atsushi B.、Higashi Tatsuya
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 48 Pages: 28935-28950
- DOI
  10.18632/oncotarget.25649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-16K10375
[Journal Article] Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow2018
- Author(s)
  Urushihata Takuya、Takuwa Hiroyuki、 Seki Chie、 Tachibana Yasuhiko、Takahashi Manami、Jeff Kershaw、Takado Yuhei 、Aoki Ichio、Higuchi Makoto、Ito Hiroshi、Obata Takayuki
- Journal Title
  
  MRMS
  
  Volume: 17 Issue: 4 Pages: 318-324
- DOI
  10.2463/mrms.mp.2017-0149
- NAID
  130007496873
- ISSN
  1347-3182, 1880-2206
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J06361, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-15H04910, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K10356
[Journal Article] Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope.2017
- Author(s)
  Ito H, Takuwa H, Tajima Y, Kawaguchi H, Urushihata T, Taniguchi J, Ikoma Y, Seki C, Ibaraki M, Masamoto K, Kanno I.
- Journal Title
  
  J Physiol Sci.
  
  Volume: 67 Issue: 2 Pages: 325-330
- DOI
  10.1007/s12576-016-0466-z
- NAID
  40021113958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19875, KAKENHI-PROJECT-16K10356
[Journal Article] Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia.2017
- Author(s)
  Kanno I, Seki C, Takuwa H, Jin ZH, Boturyn D, Dumy P, Furukawa T, Saga T, Ito H, Masamoto K.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism
  
  Volume: 印刷中 Issue: 4 Pages: 687-696
- DOI
  10.1177/0271678x16689800
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K01944, KAKENHI-PROJECT-16K19875, KAKENHI-PROJECT-16K10356
[Journal Article] Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors2017
- Author(s)
  Ito H, Kawaguchi H, Kodaka F, Takuwa H, Ikoma Y, Shimada H, Kimura Y, Seki C, Kubo H, Ishii S, Takano H, Suhara T
- Journal Title
  
  Neuroimage
  
  Volume: 158 Pages: 12-17
- DOI
  10.1016/j.neuroimage.2017.06.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10356, KAKENHI-PROJECT-16K19875
[Journal Article] Dynamic flow velocity mapping from fluorescent dye transit times in the brain surface microcirculation of anesthetized rats and mice.2016
- Author(s)
  Hoshikawa R, Kawaguchi H, Takuwa H, Ikoma Y, Tomita Y, Unekawa M, Suzuki N, Kanno I, Masamoto K.
- Journal Title
  
  Microcirculation
  
  Volume: 26 Issue: 6 Pages: 416-425
- DOI
  10.1111/micc.12285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861028, KAKENHI-PROJECT-15K06760, KAKENHI-PROJECT-26350981
[Journal Article] Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model.2016
- Author(s)
  Nishino A, Tajima Y, Takuwa H, Masamoto K, Taniguchi J, Wakizaka H, Kokuryo D, Urushihata T, Aoki I, Kanno I, Tomita Y, Suzuki N, Ikoma Y, Ito H.
- Journal Title
  
  Scientific reports
  
  Volume: 27 Issue: 1 Pages: 25072-25072
- DOI
  10.1038/srep25072
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861028, KAKENHI-PROJECT-16K19002, KAKENHI-PROJECT-15K06760
[Journal Article] Development of a simultaneous optical/PET imaging system for awake mice.2016
- Author(s)
  Takuwa H, Ikoma Y, Yoshida E, Tashima H, Wakizaka H, Shinaji T, Yamaya T.
- Journal Title
  
  Phys Med Biol.
  
  Volume: 61 Issue: 17 Pages: 6430-40
- DOI
  10.1088/0031-9155/61/17/6430
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19875
[Journal Article] [11C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study2015
- Author(s)
  Takuwa H, Maeda J, Ikoma Y, Tokunaga M, Wakizaka H, Uchida S, Kanno I, Taniguchi J, Ito H, Higuchi M
- Journal Title
  
  Synapse
  
  Volume: 69 Issue: 12 Pages: 600-606
- DOI
  10.1002/syn.21864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461862, KAKENHI-PROJECT-26861028
[Journal Article] Vasodilation Mechanism of Cerebral Microvessels Induced by Neural Activation under High Baseline Cerebral Blood Flow Level Results from Hypercapnia in Awake Mice.2015
- Author(s)
  Nishino A, Takuwa H, Urushihata T, Ito H, Ikoma Y, Matsuura T.
- Journal Title
  
  Microcirculation
  
  Volume: 22 Pages: 744-752
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26861028
[Journal Article] Pial arteries respond earlier than penetrating arterioles to neural activation in the somatosensory cortex in awake mice exposed to chronic hypoxia: an additional mechanism to proximal integration signaling?2014
- Author(s)
  Sekiguchi Y, Takuwa H, Kawaguchi H, Kikuchi T, Okada E, Kanno I, Ito H, Tomita Y, Itoh Y, Suzuki N, Sudo R, Tanishita K, Masamoto K.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 34 Issue: 11 Pages: 1761-1770
- DOI
  10.1038/jcbfm.2014.140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500422, KAKENHI-PROJECT-25249018, KAKENHI-PROJECT-26861028
[Journal Article] Development of new optical imaging systems of oxygen metabolism and simultaneous measurement in hemodynamic changes using awake mice2014
- Author(s)
  Takuwa H, Matsuura T, Nishino A, Sakata K, Tajima Y, Ito H
- Journal Title
  
  Journal of neuroscience methods
  
  Volume: 30 Pages: 9-15
- DOI
  10.1016/j.jneumeth.2014.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460280, KAKENHI-PROJECT-26861028
[Journal Article] Cerebral hemodynamic response to acute hyperoxia in awake mice2014
- Author(s)
  Yosuke Tajima, Hiroyuki Takuwa, Asuka Nishino, Tetsuya Matsuura, Hiroshi Kawaguchi, Yoko Ikoma, Junko Taniguchi, Chie Seki, Kazuto Masamoto, Iwao Kanno, Naokatsu Saeki, Hiroshi Ito
- Journal Title
  
  Brain Research
  
  Volume: 1557 Pages: 155-163
- DOI
  10.1016/j.brainres.2014.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460280
[Journal Article] Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy.2014
- Author(s)
  Tajima Y, Takuwa H, Kokuryo D, Kawaguchi H, Seki C, Masamoto K, Ikoma Y, Taniguchi J, Aoki I, Tomita Y, Suzuki N, Kanno I, Saeki N, Ito H.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 34 Issue: 8 Pages: 1363-1372
- DOI
  10.1038/jcbfm.2014.91
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500422, KAKENHI-PROJECT-24659578, KAKENHI-PROJECT-26861028
[Journal Article] “Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis.”2013
- Author(s)
  Takuwa H, Tajima Y, Kokuryo D, Matsuura T, Kawaguchi H, Masamoto K, Taniguchi J, Ikoma Y, Seki C, Aoki I, Tomita Y, Suzuki N, Kanno I, ItoH.
- Journal Title
  
  Brain Res.
  
  Volume: 1537 Pages: 350-355
- DOI
  10.1016/j.brainres.2013.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500422, KAKENHI-PROJECT-25460280
[Patent] 四足動物保定装置2017
- Inventor(s)
  樋口　真人, 田桑　弘之, 高堂　裕平, 漆畑　拓弥
- Industrial Property Rights Holder
  量研機構
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19875
[Presentation] タウ凝集体を有する神経細胞を貪食・輸送して脳外へと排出する脳クリアランスシステム2024
- Author(s)
  田桑弘之
- Organizer
  第４２回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 免疫細胞による異常タウを有する神経細胞の貪食と脳外排出2024
- Author(s)
  田桑弘之
- Organizer
  第 42 回埼玉認知症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 量子計測技術を用いた生体脳における炎症イメージング2024
- Author(s)
  田桑弘之
- Organizer
  Neurovascular Unit 研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 脳疾患における免疫細胞の多様な機能変化をとらえる量子計測技術の構築2024
- Author(s)
  田桑弘之
- Organizer
  日本生物精神医学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 広視野2光子顕微鏡による生体脳内の複数領野・各層における多細胞同時イメージング2024
- Author(s)
  田桑弘之
- Organizer
  レーザー学会学術講演会第44回年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] ミクログリアと髄膜マクロファージが連携して脳老廃物を貪食・輸送して血中へと排出する新たな脳外排出メカニズム2022
- Author(s)
  田桑　弘之
- Organizer
  日本解剖学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 生体ナノ量子センサ系の構築と疾患モデルマウスへの応用の可能性2022
- Author(s)
  田桑弘之
- Organizer
  量子生命科学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 認知症マウスにおける神経回路のカルシウムイメージングと画像解析2022
- Author(s)
  田桑　弘之
- Organizer
  第26回酸素ダイナミクス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 慢性低灌流モデル動物を用いた脳神経機能障害機序の解明　～生体脳イメージングを用いた病態研究～2021
- Author(s)
  田桑弘之
- Organizer
  第11回日本脳血管・認知症学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] 脳内外の免疫細胞によるタウ凝集体を有する神経細胞の貪食とクリアランス2021
- Author(s)
  田桑　弘之
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] Investigation of a possible microglia and macrophage cooperative pathway responsible for the clearance of waste from the mouse brain in dementia.2021
- Author(s)
  田桑　弘之
- Organizer
  第64回日本神経化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21399
[Presentation] In vivo multiscale imaging of glymphatic clearance of tau and alpha-synuclein from the brain2020
- Author(s)
  Hiroyuki Takuwa
- Organizer
  Neuro 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542
[Presentation] 認知症の病原性タンパクを脳外に排出する免疫細胞の新たな役割2020
- Author(s)
  田桑　弘之
- Organizer
  第24 回Neurology SPECT 定量検討会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06542
[Presentation] 新たに発見された「自浄」と「自傷」の脳内不要物排出メカニズムと認知症病態2020
- Author(s)
  田桑　弘之
- Organizer
  第37回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06542
[Presentation] 脳の自浄システムとしてのアストロサイトとglymphaticシステム2018
- Author(s)
  田桑弘之
- Organizer
  日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06542
[Presentation] In vivo multi-scale brain imaging with the Multiphoton Mesoscope2018
- Author(s)
  田桑弘之
- Organizer
  Neuro 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542
[Presentation] In vivo brain imaging for studying possible linkage between pathological hallmark of tauopathy and neuronal loss2017
- Author(s)
  田桑弘之
- Organizer
  BRAIN & BRAIN PET 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19875
[Presentation] In vivo brain imaging for studying possible linkage between pathological hallmark of tauopathy and neuronal loss2017
- Author(s)
  Hiroyuki Takuwa, Ai Ishikawa, Takuya Urushihata, Takeharu Minamihisamatsu, Masaki Tokunaga, Masafumi Shimojo, Shouko Uchida, Izumi Matsumoto, Ming-Rong Zhang, Tetsuya Suhara, and Makoto Higuchi, Naruhiko Sahara
- Organizer
  Brain & Brain PET 2017
- Place of Presentation
  ドイツ　ベルリン
- Year and Date
  2017-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19875
[Presentation] 同一のトレーサーによるタウ病変モデルのマルチスケールイメージング2017
- Author(s)
  田桑弘之
- Organizer
  第６０回日本循環器学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K19875
[Presentation] PETと生体光イメージングの融合研究　～覚醒マウスの脳機能測定～2016
- Author(s)
  田桑弘之
- Organizer
  小動物インビボイメージング研究会
- Place of Presentation
  福島県立医大　福島市　福島県
- Year and Date
  2016-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-16K19875
[Presentation] PET技術と生体光イメージング技術の融合と脳疾患研究2016
- Author(s)
  田桑弘之
- Organizer
  JAEA放射光科学シンポジウム2016
- Place of Presentation
  兵庫県　播磨
- Year and Date
  2016-02-25
- Invited
- Data Source
  KAKENHI-PROJECT-26861028
[Presentation] DIAMETER CHANGES TO CEREBRAL BLOOD VESSELS DURING NEURAL ACTIVATION AND DEACTIVATION MEASURED BY TWO-PHOTON MICROSCOPY IN AWAKE MICE2015
- Author(s)
  田桑弘之
- Organizer
  XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIIth International Conference
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2015-06-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861028
[Presentation] 覚醒マウスの脳機能におけるマルチモダルイメージング2014
- Author(s)
  田桑　弘之
- Organizer
  日本光学会
- Place of Presentation
  東京（筑波大学）
- Year and Date
  2014-11-05
- Invited
- Data Source
  KAKENHI-PROJECT-26861028
[Presentation] Newly optical imaging systems of change in oxygen metabolism and hemodynamic using awake mice brain2014
- Author(s)
  田桑　弘之
- Organizer
  日本神経科学学会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-26861028
[Presentation] HEMODYNAMIC CHANGES DURING WHISKER STIMULATION IN AWAKE AND ANESTHETIZED MICE EXAMINED BY LASER-DOPPLER FLOWMETRY2013
- Author(s)
  Tetsuya Matsuura, Hiroyuki Takuwa, Takayuki Obata, Hiroshi Kawaguchi, Iwao Kanno, and Hiroshi Ito
- Organizer
  The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET
- Place of Presentation
  Shanghai International Convention Center, Shanghai, China
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] 覚醒マウスにおける脳表イメージングシステムの構築
- Author(s)
  松浦哲也, 田桑弘之, 西野明日香, 坂田和実, 伊藤浩
- Organizer
  第85回日本動物学会
- Place of Presentation
  仙台市(東北大学)
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] 覚醒マウスを用いた脳循環動態および酸素代謝の光イメージングシステムの構築
- Author(s)
  西野明日香, 田桑弘之, 松浦哲也, 坂田和実, 田島祐介, 伊藤浩
- Organizer
  第26回日本脳循環代謝学会
- Place of Presentation
  岡山市(岡山コンベンションセンター)
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] 覚醒マウス脳表における神経活動および脳血流変化の同時計測システムの構築
- Author(s)
  田桑弘之, 西野明日香, 川口拓之, 正本和人, 松浦哲也, 菅野巖, 伊藤浩
- Organizer
  レーザー学会第452回研究会（ニューロフォトニクス）
- Place of Presentation
  ホテルグランドヒル市ヶ谷（東京都）
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] 覚醒マウスを用いた新たな脳表イメージングシステムの開発
- Author(s)
  松浦哲也, 田桑弘之, 西野明日香, 坂田和実, 伊藤浩
- Organizer
  日本動物学平成26年度東北支部大会
- Place of Presentation
  盛岡市(岩手大学)
- Year and Date
  2014-07-12 – 2014-07-13
- Description
  (口頭発表)
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] Development of a microscope/PET simultaneous measurement system for awake mice
- Author(s)
  田桑弘之
- Organizer
  World molecular imaging congress
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2014-09-17 – 2014-09-20
- Description
  (口頭発表)
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] Newly optical imaging systems of change in oxygen metabolism and hemodynamic using awake mice brain
- Author(s)
  田桑弘之, 西野明日香, 松浦哲也, 坂田和実, 田島祐介, 伊藤浩
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] Development of newly optical imaging systems of simultaneous measurement of changes in cerebral oxygen metabolism and hemodynamics by awake-mice
- Author(s)
  T Matsuura, H Takuwa, A Nishino, K Sakata, Y Tajima, H Ito
- Organizer
  NEUROSCIENCE 2014
- Place of Presentation
  アメリカ(ワシントンD.C.)
- Year and Date
  2014-11-15 – 2014-11-19
- Description
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-25460280
[Presentation] 覚醒マウスの脳機能におけるマルチモダルイメージング
- Author(s)
  田桑弘之, 松浦哲也, 川口拓之, 伊藤浩
- Organizer
  日本光学会
- Place of Presentation
  東京(筑波大学)
- Year and Date
  2014-11-05 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-25460280

1. OBATA Takayuki (00285107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ITO Hiroshi (20360357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. JEFFREY Kershaw (50508801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. AOKI Ichio (10319519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAWAGUCHI Hiroshi (60510394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KANNO Iwao (10360356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. OKADA Eiji (40221840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASAMOTO Kazuo (60455384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 松浦哲也 (30361041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. 坂田和実 (80261163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 八幡憲明 (70409150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡野俊行 (40272471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 間島慶 (80735770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. AUTIO Joonas

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. CHRISTOPH Leuze

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIBATA Sayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIMADA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. Higuchi Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. TOMITA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
20. TACHIBANA Yasuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 久保田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 佐原成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
23. 畝川美悠紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 久保均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKUWA HIROYUKI 田桑 弘之

TAKUWA Hiroyuki 田桑 弘之

Research Projects

Research Products

Co-Researchers

量子計測技術による脳内炎症の１細胞レベルでの可視化と制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

広域カルシウムイメージングとVRシステム行動実験による磁覚情報処理の神経機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳萎縮を引き起こす免疫細胞主体の老廃物脳外排出メカニズムの解明と制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism for the propagation and clearance of tau and alpha-synuclein proteins in neurodegenerative diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Simultaneous fluorescence microscope and PET Imaging System for Awake MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chronic effects of cerebral hypoperfusion on neural density and function using misery perfusion animal modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウスの感覚機能補償にともなう神経活動と血流動態の適応機序に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relation between optical intrinsic signal imaging on regulation of microcirculation on mice somatosensory cortex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo tissue characterization for normal and disease models using diffusion spectral imaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 比較生理生化学 vol37 no12019

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学 vol37 No62019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases2024

Author(s)

Journal Title

Data Source

[Journal Article] Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Capillary responses to functional and pathological activations rely on the capillary states at rest2023

Author(s)

TAKUWA HIROYUKI 田桑弘之

TAKUWA Hiroyuki 田桑弘之

[Book] 比較生理生化学　vol37 no12019

[Book] 実験医学　vol37 No62019