Yamashita Naoya 山下直也

… Alternative Names

Naoya YAMASHITA 山下直也

YAMASHITA Naoya 山下直也

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Researcher Number	40508793
Other IDs
Affiliation (Current)	2025: 神奈川工科大学, 工学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 神奈川工科大学, 応用バイオ科学部, 准教授 2020: 順天堂大学, 医学部, 講師 2014: 横浜市立大学, 医学(系)研究科(研究院), その他 2014: 横浜市立大学, 医学(系)研究科(研究院), 客員講師 2014: 横浜市立大学, 医学研究科, 客員講師 2009 – 2013: Yokohama City University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Anesthesiology/Resuscitation studies / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator セマフォリン / アルツハイマー病 / 軸索輸送 / NGF / トランスサイトーシス / 逆行性シグナル / 樹状突起成熟 / グルタミン酸受容体 / プレキシン / シグナル伝搬 / シグナル伝播 / 神経栄養因子 … More Except Principal Investigator … More NMDA受容体 / シグナルパスウェイ / 疼痛メカニズム / 神経成長因子 / 神経ガイダンス因子 / 神経因性疼痛 / 線虫 / フィラミン / Filamin / リン酸化 / Filamin-A / CRMP1 / Sema3A / セマフォリン / アクチン / 細胞骨格 / 神経回路形成 / 生理学 / 細胞・組織 / 脳・神経 / 神経科学 / ニューロン / TH陽性細胞 / AVPV / 脳 / 性分化 / ドーパミン作動性ニューロン / ノックアウトマウス / プロテオミクス解析 / CRMP4 / 前腹側脳室周囲核 / 脳の性分化 Less

Role of retrograde signaling coupled with anterograde axonal transport in neuronal morphology and its medical applicationsPrincipal Investigator
- Principal Investigator
  
  山下直也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kanagawa Institute of Technology
Regulation of retrograde signaling through axonal transport and its role in the onset of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Naoya YAMASHITA
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kanagawa Institute of Technology
  Juntendo University
Interaction of CRMP1 and Filamin-A regulates F-actin-cytoskeleton.
- Principal Investigator
  
  NAKAMURA Fumio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama City University
The role of the trafficking of PlexinA4-containing vesicles in dendritic developmentPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Naoya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama City University
Elucidation of Sema3A signaling pathway in mechanisms of neuropathic pain
- Principal Investigator
  
  KAMIYA Yoshinori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Niigata University
The role of Collapsin Response Mediator Protein 4(CRMMP4) in sexual differentiation of the brain
- Principal Investigator
  
  KANEKO Ritsuko (OHTANI Ritsuko)
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Toyo University
The propagation mechanism of Semaphorin3A signaling in neuronsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Naoya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 軸索ガイダンスおよびシナプス形成とCdk5.蛋白質・核酸・酵素2009
- Author(s)
  山下直也, 中村史雄, 五嶋良郎
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function2023
- Author(s)
  Blaine Connor, Guillermo Moya-Alvarado, Naoya Yamashita, Rejji Kuruvilla
- Journal Title
  
  The Proceedings of the National Academy of Sciences
  
  Volume: 120(6) Issue: 6 Pages: 1-12
- DOI
  10.1073/pnas.2205426120
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07742
[Journal Article] NGF Signaling in Endosomes2021
- Author(s)
  Yamashita N
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1331 Pages: 19-29
- DOI
  10.1007/978-3-030-74046-7_3
- ISBN
  9783030740450, 9783030740467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07742
[Journal Article] Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia2021
- Author(s)
  Nomoto Munetaka、Konopaske Glenn T.、Yamashita Naoya、Hirayasu Yoshio、Snyder Evan Y.、Goshima Yoshio et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 31 Pages: 1-7
- DOI
  10.1073/pnas.2100032118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08024, KAKENHI-PROJECT-20K07742, KAKENHI-PROJECT-20K15937
[Journal Article] Activity‐induced secretion of semaphorin 3A mediates learning2021
- Author(s)
  Jitsuki‐Takahashi Aoi、Jitsuki Susumu、Yamashita Naoya、Kawamura Meiko、Abe Manabu、Sakimura Kenji、Sano Akane、Nakamura Fumio、Goshima Yoshio、Takahashi Takuya
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 00 Issue: 10 Pages: 1-15
- DOI
  10.1111/ejn.15210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07742, KAKENHI-PLANNED-20H05922, KAKENHI-PROJECT-20H00549, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18K06488, KAKENHI-ORGANIZER-20H05914, KAKENHI-PROJECT-20K15937
[Journal Article] Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP42020
- Author(s)
  Yamazaki Yuki、Nagai Jun、Akinaga Satoshi、Koga Yumeno、Hasegawa Masaya、Takahashi Miyuki、Yamashita Naoya、Kolattukudy Papachan、Goshima Yoshio、Ohshima Toshio
- Journal Title
  
  Brain Research
  
  Volume: 1736 Pages: 146762-146762
- DOI
  10.1016/j.brainres.2020.146762
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07742
[Journal Article] Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice2015
- Author(s)
  Naoya Yamashita, Aoi Jitsuki-Takahashi, Miyuki Ogawara, Wataru Ohkubo, Tomomi Araki, Chie Hotta, Tomohiko Tamura, Shu-ichi Hashimoto, Takashi Yabuki, Toru Tsuji, Yukie Sasakura, Hiromi Okumura, Aki Takaiwa, Chika Koyama, Koji Murakami and Yoshio Goshima
- Journal Title
  
  International immunology
  
  Volume: 印刷中 Issue: 9 Pages: 1-8
- DOI
  10.1093/intimm/dxv014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J09533, KAKENHI-PROJECT-24500444
[Journal Article] The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.2014
- Author(s)
  Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T, Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I, Goshima Y
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 171 Issue: 2 Pages: 403-414
- DOI
  10.1111/bph.12459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390062, KAKENHI-PROJECT-24500443
[Journal Article] lexinA4-dependent retrograde Semaphorin3A signaling regulates the dendritic localization of GluA2-containing AMPA receptors.2014
- Author(s)
  1) Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., Goshima, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 3424-3424
- DOI
  10.1038/ncomms4424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23500452, KAKENHI-PUBLICLY-24111539, KAKENHI-PUBLICLY-24115713, KAKENHI-PROJECT-24500443, KAKENHI-PROJECT-24500444, KAKENHI-PROJECT-24590236, KAKENHI-PROJECT-25430031, KAKENHI-PUBLICLY-26111718, KAKENHI-PROJECT-26290024
[Journal Article] Semaphorin3A-induced axonal transport mediated through phosphorylation of Axin-1 by GSK3β.2014
- Author(s)
  Hida T, Nakamura F, Usui H, Takeuchi K, Yamashita N, Goshima Y.
- Journal Title
  
  Brain Research
  
  Volume: 1598 Pages: 46-56
- DOI
  10.1016/j.brainres.2014.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500444
[Journal Article] Amino and carboxyl terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A-signaling2014
- Author(s)
  Fumio Nakamura, Kosuke Kumeta, Tomonobu Hida, Toshinari Isono, Yuichi Nakayama, Emiko Kuramata-Matsuoka, Naoya Yamashita, Yutaka Uchida, Ken-ichi Ogura, Keiko Gengyo-Ando, Shohei Mitani, Toshio Ogino, and Yoshio Goshima
- Journal Title
  
  Nat. Commun.
  
  Volume: 5　5325 Issue: 1 Pages: 1-14
- DOI
  10.1038/ncomms6325
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24360013, KAKENHI-PROJECT-24390053, KAKENHI-PROJECT-24500443, KAKENHI-PROJECT-25600096, KAKENHI-PROJECT-25640004
[Journal Article] Amyloid-β25–35 induces impairment of cognitive function andlong-term potentiation through phosphorylation of collapsinresponse mediator protein 2.2013
- Author(s)
  Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y
- Journal Title
  
  Neurosci Res
  
  Volume: 77 Issue: 3 Pages: 180-185
- DOI
  10.1016/j.neures.2013.08.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500443, KAKENHI-PROJECT-24500444, KAKENHI-PROJECT-25221002
[Journal Article] Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice.2013
- Author(s)
  Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda M, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.
- Journal Title
  
  Dev Neurobiol.
  
  Volume: 237 Issue: 7 Pages: 502-517
- DOI
  10.1002/dneu.22076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500315, KAKENHI-PROJECT-23240057, KAKENHI-PROJECT-23310043, KAKENHI-PROJECT-24500444, KAKENHI-PROJECT-25430042, KAKENHI-PROJECT-25670114
[Journal Article] Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired leaming and memory, and impaired prepulse inhibition2013
- Author(s)
  Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y
- Journal Title
  
  Frontiers in Behavioral Neuroscience
  
  Volume: 7巻 Pages: 216-226
- DOI
  10.3389/fnbeh.2013.00216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J09533, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24500444, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25242078, KAKENHI-PROJECT-25350989
[Journal Article] Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons.2012
- Author(s)
  Niisato E, Nagai1 J, Yamashita N, Nakamura F, Goshima Y, Ohshima T
- Journal Title
  
  Developmental neurobiology
  
  Volume: 73 Issue: 2 Pages: 142-151
- DOI
  10.1002/dneu.22048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500444
[Journal Article] Phosphorylation of CRMP2 (collapsin response mediator protein 2) is involved in proper dendritic field organization.2012
- Author(s)
  Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y
- Journal Title
  
  The Journal of neuroscience
  
  Volume: 32 Pages: 1360-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500444
[Journal Article] Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Fisld Organization2012
- Author(s)
  Yamashita N
- Journal Title
  
  J Neurosci
  
  Volume: 32(4) Issue: 4 Pages: 1360-1365
- DOI
  10.1523/jneurosci.5563-11.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-21700411
[Journal Article] GSK3β/Axin-1/β-Catenin Complex Is Involved in Semaphorin3A Signaling.2012
- Author(s)
  Hida T, Yamashita N, Usui H, Nakamura F, Sasaki Y, Kikuchi A, Goshima Y
- Journal Title
  
  The Journal of neuroscience
  
  Volume: 32 Pages: 11905-11918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500444
[Journal Article] Class 3 semaphorins as a therapeutic target2012
- Author(s)
  Goshima Y., Sasaki Y., Yamashita N., Nakamura F
- Journal Title
  
  Expert Opin.Ther. Targets
  
  Volume: 16 Issue: 9 Pages: 933-944
- DOI
  10.1517/14728222.2012.710201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500336, KAKENHI-PROJECT-24500444, KAKENHI-PUBLICLY-24115713
[Journal Article] Semaphorin3A facilitates axonal transport through a local calcium signaling and tetrodotoxin-sensitive voltage-gated sodium channels2012
- Author(s)
  Yamane M, Yamashita N, Yamamoto H, Iizuka A, Shouji M, Usui H, Goshima Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 422(2) Issue: 2 Pages: 333-38
- DOI
  10.1016/j.bbrc.2012.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-24500444
[Journal Article] Collapsin Response Mediator Proteins Regulate Neuronal Development and Plasticity by Switching Their Phosphorylation Status2012
- Author(s)
  Yamashita N, Goshima Y.
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 45(2) Issue: 2 Pages: 234-46
- DOI
  10.1007/s12035-012-8242-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-24500444
[Journal Article] CRMP5(collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells2011
- Author(s)
  Yamashita N, Mosinger B, Roy A, Miyazaki M, Ugajin K, Nakamura F, Sasaki Y, Yamaguchi K, Kolattukudy P, Goshima Y.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 31(5) Issue: 5 Pages: 1773-79
- DOI
  10.1523/jneurosci.5337-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-22500336, KAKENHI-PROJECT-23500472
[Journal Article] Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites2011
- Author(s)
  Nishiyama M, Togashi K, von Schimmelmann MJ, Lim CS, Maeda S, Yamashita N, Goshima Y, Ishii S, Hong K.
- Journal Title
  
  Nature Neuroscience
  
  Volume: 13(6) Issue: 6 Pages: 676-85
- DOI
  10.1038/ncb2255
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.2011
- Author(s)
  山下直也, 等
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 31 Pages: 1773-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport2010
- Author(s)
  Goshima Y, Usui H, Shiozawa T, Hida T, Kuraoka S, Takeshita S, Yamashita N, Ichikawa Y, Kamiya Y, Gotoh T, Gotoh T.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Issue: 2 Pages: 168-179
- DOI
  10.1254/jphs.09352FP
- NAID
  130000336362
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] Structural basis for semaphorin signalling through the plexin receptor2010
- Author(s)
  Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
- Journal Title
  
  Nature
  
  Volume: 467(7319) Issue: 7319 Pages: 1123-7
- DOI
  10.1038/nature09473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-22370039
[Journal Article] Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 322009
- Author(s)
  Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 284(40) Issue: 40 Pages: 27393-401
- DOI
  10.1074/jbc.m109.000240
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] 軸索ガイダンスおよびシナプス形成とCdk52009
- Author(s)
  山下直也、中村史雄、五嶋良郎
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 802-807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.2009
- Author(s)
  中村史雄、宇賀神梢、山下直也, 等
- Journal Title
  
  The Journal of Comlparative Neurology 516
  
  Pages: 360-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411
[Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in Sema3A mutant mice2009
- Author(s)
  Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Takako Okada, Yutaka Uchida, Masahiko Taniguchi, Toshio Ohshima and Yoshio Goshima
- Journal Title
  
  J. Comp. Neurol.
  
  Volume: 216 Issue: 5 Pages: 360-375
- DOI
  10.1002/cne.22125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590196, KAKENHI-PROJECT-21700411
[Journal Article] Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphoryl ation of collapsin response mediator protein 2 at tyrosine 32.2009
- Author(s)
  内田穣、大島登志男、山下直也, 等
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 27393-27401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Axonal targeting of TrkA-APP complex via transcytosis2023
- Author(s)
  Naoya Yamashita
- Organizer
  Neurotrophic Mechanisms in Health and Disease Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2023
- Author(s)
  杉山黎、林克儀、中村史雄、櫻井隆、五嶋良郎、山下直也
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K06814
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2023
- Author(s)
  杉山黎、林克儀、中村史雄、櫻井隆、五嶋良郎、山下直也
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Aβ産生制御におけるAPP-PlexinAシグナルの機能解析2023
- Author(s)
  関口拓己、櫻井隆、山下直也
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-23K06814
[Presentation] Aβ産生制御におけるAPP-PlexinAシグナルの機能解析2023
- Author(s)
  関口拓己、櫻井隆、山下直也
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Role of APP-PlexinA interaction in NGF-dependent APP metabolism2023
- Author(s)
  Takumi Sekiguchi, Takashi Sakurai, Naoya Yamashita
- Organizer
  Neurotrophic Mechanisms in Health and Disease Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06814
[Presentation] Role of APP-PlexinA interaction in NGF-dependent APP metabolism2023
- Author(s)
  Takumi Sekiguchi, Takashi Sakurai, Naoya Yamashita
- Organizer
  Neurotrophic Mechanisms in Health and Disease Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Axonal targeting of TrkA-APP complex via transcytosis2023
- Author(s)
  Naoya Yamashita
- Organizer
  Neurotrophic Mechanisms in Health and Disease Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06814
[Presentation] Semaphorin3A-PlexinAシグナルがアミロイドβ前駆タンパク質の機能や代謝に与える影響.2022
- Author(s)
  関口拓己, 櫻井隆, 山下直也
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立.2022
- Author(s)
  古川涼音, 小林瑞季, 林克儀, 中村史雄, 櫻井隆, 五嶋良郎, 山下直也
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2022
- Author(s)
  山下直也、水谷由衣、實木-高橋葵、林　克儀、中村史雄、櫻井隆、五嶋良郎
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Axonal targeting of TrkA-APP complex via transcytosis2021
- Author(s)
  山下直也、櫻井隆
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Axonal targeting of TrkA-APP complex via transcytosis2021
- Author(s)
  Yamashita Naoya、Sakurai Takashi
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] Axonal targeting of TrkA signaling complex via transcytosis2020
- Author(s)
  Yamashita Naoya、Sakurai Takashi
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07742
[Presentation] A retrograde axonal transport elicited by Semaphorin3A drives AMPA receptor subunit GluA2 to dendrites.2013
- Author(s)
  山下直也、五嶋良郎
- Organizer
  日本生理学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24500444
[Presentation] A retrograde axonal transport elicited by Semaphorin3A regulates dendritic arborization through　localization of AMPA receptor subunit GluA2 in dendrites2013
- Author(s)
  山下直也、五嶋良郎
- Organizer
  Neuro2013
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-24500444
[Presentation] Keystone symposia “Cell Biology and Pathology of Axons”.2013
- Author(s)
  Yamashita N, Goshima Y
- Organizer
  A Retrograde axonal transport elicited by Semaphorin3A Drives AMPA Receptor Subunit GluA2 to Dendrites.
- Place of Presentation
  Tahoe Citｙ, USA
- Data Source
  KAKENHI-PROJECT-24500444
[Presentation] CRMP4遺伝子欠損が新生仔マウスの嗅覚および嗅球に及ぼす影響2012
- Author(s)
  土屋貴大,山下直也,西原真杉,五嶋良郎,大谷-金子律子
- Organizer
  日本動物学会
- Place of Presentation
  大阪大学豊中キャンパス(大阪)
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] CRMP4 遺伝子欠損が新生仔マウスの嗅覚および嗅球に及ぼす影響2012
- Author(s)
  土屋貴大，山下直也，西原真杉，五嶋良郎，大谷-金子律子
- Organizer
  日本動物学会
- Place of Presentation
  大阪大学豊中キャンパス(大阪）
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Effect of collapsin response mediator protein 4 (CRMP4) knockout on the olfactory bulb2012
- Author(s)
  Tsutiya　A, Yamashita N, Goshima Y, Ohtani-Kaneko R.
- Organizer
  The International Symposium on Olfaction and Taste (ISOT)
- Place of Presentation
  ストックホルム,　スウェーデン
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Cold Spring Harbor Laboratory meeting “Axon Guidance, Synapse Formation and Regeneration”2012
- Author(s)
  Yamashita N, Chen S, Goshima Y
- Organizer
  Semaphorin3A drives AMPA Receptor Subunit GluA2 to dendrites by a retrograde signaling via axonal transport.
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-24500444
[Presentation] Effect of collapsin response mediator protein 4 (CRMP4) knockout on the olfactory bulb2012
- Author(s)
  Tsutiya A, Yamashita N, Goshima Y, Ohtani-Kaneko R.
- Organizer
  The International Symposium on Olfaction and Taste (ISOT)
- Place of Presentation
  ストックホルム, スウェーデン
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Collapsin response mediator protein-4 (CRMP4) affects dopaminergic neurons in the AVPV2011
- Author(s)
  M. Sakoh, T. Iwakura, A. Tsutiya, N.Yamashita, T. Shiga, Y. Goshima & R. Ohtani-Kaneko
- Organizer
  8th IBRO world congress of neuroscience
- Place of Presentation
  Fortezza da Basso, Florence?Italy
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Postnatal expression of CRMP4 mRNA in the brain and structural changes in the olfactory bulb of CRMP4-knockout mice2011
- Author(s)
  A.Tsutiya, M.Sakoh, N.Yamashita, Y.Goshima, R.Ohtani-Kaneko
- Organizer
  8th IBRO world congress of neuroscience
- Place of Presentation
  Fortezza da Basso, Florence-Italy
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Collapsin response mediator protein-4 (CRMP4) affects dopaminergic neurons in the AVPV2011
- Author(s)
  M.Sakoh, T.Iwakura, A.Tsutiya, N.Yamashita, T.Shiga, Y.Goshima, R.Ohtani-Kaneko
- Organizer
  8th IBRO world congress of neuroscience
- Place of Presentation
  Fortezza da Basso, Florence-Italy
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Semaphorin3A drives AMPA receptor subunit GluR2 to dendrites by a retrograde transport of PlexinA4 along axon2011
- Author(s)
  Yamashita N, Chen S, Goshima Y
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] セマフォリン3Aは軸索におけるPlexinA4の逆行性輸送を介してAMPA型受容体・GluR2の樹状突起への輸送を亢進する2011
- Author(s)
  山下直也, 等
- Organizer
  Neuro2011
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Postnatal expression of CRMP4 mRNA in the brain and structural changes in theolfactory bulb of CRMP4-knockout mice2011
- Author(s)
  A. Tsutiya, M. Sakoh, N. Yamashita, Y.Goshima & R. Ohtani-Kaneko
- Organizer
  8th IBRO world congress of neuroscience
- Place of Presentation
  Fortezza da Basso, Florence - Italy
- Data Source
  KAKENHI-PROJECT-22500315
[Presentation] Evidence for cross-talk between Sema3A and NGF signaling2011
- Author(s)
  Yamane M, Yamashita N, Goshima Y
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Semaphorin3A facilitates the axonal transport of PlexinA4 through interaction of PlexinA4 with TrkA2011
- Author(s)
  Yamane M, Yamashita N, Sasaki Y, Nakamura F, Goshima Y
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] セマフォリン3AはAMPA型受容体・GluR2の樹状突起への輸送を亢進する2010
- Author(s)
  山下直也, 等
- Organizer
  Neuro2010
- Place of Presentation
  神戸コンベンションセンター(兵庫)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Semaphorin3A drives AMPA receptor subunit GluR2 to dendrites2010
- Author(s)
  Yamashita N, Usui H, Chen S, Goshima Y
- Organizer
  Neuro2010
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Semaphorin3A drives AMPA receptor subunit GluR2 to bendrites.2009
- Author(s)
  山下直也, 等
- Organizer
  日本神経科学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Comprehensive behavioral analysis of the crmp1 knockout mice2009
- Author(s)
  Yamashita N, Takao K, Miyakawa T, Goshima Y
- Organizer
  Japan-United States Joint Seminar/2nd Cdk5 International Symposium
- Place of Presentation
  首都大学東京
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Semaphorin3A drives AMPA receptor subunit GluR2 to dendrites2009
- Author(s)
  Yamashita N, Usui H, Chen S, Goshima Y
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700411
[Presentation] Paradoxical Expression Profiles of Sema3A and CDK5 in Spinal Dorsal Horn and Dorsal Root Ganglion of Neuropathic Pain Model Rat
- Author(s)
  Kensuke Saeki, Yoshinori Kamiya, Yusuke Nakahashi, Naoya Yamashita, Kengo Funakoshi,
- Organizer
  the ANESTHESIOLOGY 2012 annual meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24592352
[Presentation] CDK5, CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain model
- Author(s)
  Yoshinori Kamiya, Kensuke Saeki, Naoya Yamashita, Masato Takiguchi, Yusuke Nakahash, Kengo Funakoshi
- Organizer
  Euroanaesthesia 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24592352

1. KANEKO Ritsuko (00161183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. NAKAMURA Fumio (10262023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. ARITA Kyohei (40549648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HASHIMOTO Hiroshi (40336590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAMIYA Yoshinori (90381491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. FUNAKOSHI Kengo (60291572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YAMANE Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 五嶋良郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 野本宗孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐々木幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 谷口雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹居光太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 荻野俊郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Naoya 山下 直也

Naoya YAMASHITA 山下 直也

YAMASHITA Naoya 山下 直也

Research Projects

Research Products

Co-Researchers

Role of retrograde signaling coupled with anterograde axonal transport in neuronal morphology and its medical applicationsPrincipal Investigator

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Regulation of retrograde signaling through axonal transport and its role in the onset of Alzheimer's diseasePrincipal Investigator

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Interaction of CRMP1 and Filamin-A regulates F-actin-cytoskeleton.

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The role of the trafficking of PlexinA4-containing vesicles in dendritic developmentPrincipal Investigator

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Elucidation of Sema3A signaling pathway in mechanisms of neuropathic pain

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The role of Collapsin Response Mediator Protein 4(CRMMP4) in sexual differentiation of the brain

Principal Investigator

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The propagation mechanism of Semaphorin3A signaling in neuronsPrincipal Investigator

Principal Investigator

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[Book] 軸索ガイダンスおよびシナプス形成とCdk5.蛋白質・核酸・酵素2009

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[Journal Article] Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function2023

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[Journal Article] NGF Signaling in Endosomes2021

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[Journal Article] Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia2021

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[Journal Article] Activity‐induced secretion of semaphorin 3A mediates learning2021

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[Journal Article] Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP42020

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[Journal Article] Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice2015

Author(s)

Yamashita Naoya 山下直也

Naoya YAMASHITA 山下直也

YAMASHITA Naoya 山下直也